2) Examine the relationship between conditioned pain modulation scores and VR-induced effects on secondary hyperalgesia.
3) Examine the relationship between the strength of functional connectivity between the medial prefrontal cortex and periaqueductal grey and VR-induced effects on secondary hyperalgesia.
This multimodal approach will help us to help better understand the top-down mechanisms associated with immersive VR therapy. Critically, this project will highlight the potential of psychophysical and neuroimaging techniques to be used as part of future phenotype stratified trials with VR in chronic pain patients with deficient descending pain control.
This project is funded by an Academy of Medical Sciences Springboard grant.