Peninsula Clinical Trials Unit: Study Portfolio

APHID

Title: A novel way to understand and communicate the burden of Antipsychotic Prescribing for Adults across Specialist Intellectual Disability Services in England and Wales
Chief Investigator: Professor Rohit Shankar, Faculty of Health, University of Plymouth

D-PACT 2

Title: Realist informed mixed methods evaluation of the Dementia-Personalised Aligned Care Team intervention (D-PACT): a complex intervention for individuals with dementia and carers
Chief Investigator: Professor Richard Byng, Faculty of Health, University of Plymouth

ENRICH

Title: Randomised, Phase II open label study of Rituximab/Ibritinib vs Rituximab/Chemo in older patients with mantle cell lymphoma
Chief Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust

EPI-REG

Title: Neuropsychiatric Research Register for people with Intellectual Disabilities and Epilepsy
Chief Investigator: Professor Rohit Shankar, Faculty of Health, University of Plymouth

MCL Biobank

Title: Establishing a biobank and database as a national resource for characterising indolent and aggressive forms of mantle cell lymphoma.
Chief Investigator: Professor Simon Rule, University Hospitals Plymouth NHS Trust

MIRAGE

Title: Functional imagery training to reduce alcohol-related harm in patients with alcohol-related liver disease: a pilot randomised trial.
Chief Investigator: Dr Ashwin Dhanda, University Hospitals Plymouth NHS Trust

Oasis II

Title: A randomized phase II trial evaluating Ibrutinib plus CD20 Ab and Ibrutinib-Venetoclax plus CD20 Ab in patients with untreated mantle cell lymphoma.
Chief Investigator: Professor Steven Le Gouill, Institut Curie – Paris
Associate Coordinating Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust

OBtAIN-PD

Title: Developing an occupation-based complex intervention for living well with anxiety in Parkinson's.
Chief Investigator: Chris Lovegrove, Royal Devon & Exeter NHS Foundation Trust/ University of Plymouth

PD COVID-19

Title: To understand the outcome and mortality of hospital admission with COVID-19 in people with Parkinson’s disease and atypical parkinsonian syndromes (PD/APS), to inform patients and future design of health, social care and charity services.
Chief Investigator: Dr Camille Carroll, Faculty of Health, University of Plymouth

RECAP

Title: Older people with intellectual disabilities and epilepsy – recognising and correcting anticholinergic inducing polypharmacy
Chief Investigator: Professor Rohit Shankar, Faculty of Health, University of Plymouth

RESOLVE

Title: Reducing SteatOsis Prior to Liver Resection – A feasibility multi-centre randomised controlled trial to test if a pre-operative two-week very low-calorie diet with dietitian education and support reduces intra-operative blood loss and improves post-operative outcomes following liver surgery, compared with a control group
Chief Investigator: Mr Somaiah Aroori, Faculty of Health, University of Plymouth

STEPS 2

Title: The Efficacy of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: An Assessor Blinded Randomised Controlled Trial
Chief Investigator: Professor Paul Taylor, Salisbury NHS Foundation Trust