Peninsula Clinical Trials Unit: Study Portfolio
Trials and other well designed studies that we are involved in
APHID
Title: A novel way to understand and communicate the burden of Antipsychotic Prescribing for Adults across Specialist Intellectual Disability Services in England and Wales.
Chief Investigator:
Professor Rohit Shankar
, Faculty of Health, University of Plymouth
At-home EEG Solution
Title: Developing community-based EEG solutions for diagnosis and management of people with suspected seizures.
Chief Investigator: John Terry, University of Birmingham
BOOST
Title: Β-hydroxy β-methylbutyrate (HMB) supplementation to optimise outcomes in advanced liver cirrhosis: a multicentre double blind placebo controlled
randomised trial.
randomised trial.
Chief Investigator:
Professor Ashwin Dhanda
, Faculty of Health, University of Plymouth
CALM
Title: Co-production, refinement and evaluation of a model of psychosocial peer support and liaison with alcohol, liver and mental health services to improve quality of life and clinical outcomes for people with alcohol-related liver disease.
Chief Investigator:
Professor Ashwin Dhanda
, Faculty of Health, University of Plymouth
CANABID-LD
Title: How a medication called cannabidiol (brand name Epidyolex) affects adults who have certain rare and severe epilepsy conditions (Dravet syndrome, Lennox-Gastaut syndrome and tuberous sclerosis complex).
Chief Investigator:
Professor Rohit Shankar
, University of Plymouth
CO-ACTION
Title: Personalised social and self-management support for better living with multiple long-term conditions in the community.
Chief Investigator: Dr Dorit Kunkel, University of Southampton
CoCoA-PaD
Title: The Co-Development and Evaluation of the Computerised Cognitive Assessment in Preclinical Alzheimer's Disease.
Chief Investigator:
Dr Donnchadh Murphy
, Peninsula Medical School, Faculty of Health
DAYDREAM
Title: A feasibility randomised controlled trial, of administering daytime only enteral feeding compared to standard continuous enteral feeding, to reduce delirium in mechanically ventilated, critically ill adults.
Chief Investigator:
Dr Jessie Welbourne
, University Hospitals Plymouth NHS Trust
DECISION
Title: Dementia and Mild Cognitive Impairment in prison care pathway and training package: A realist informed feasibility study.
Chief Investigator: Dr Katrina Forsyth, University of Manchester
D-PACT: Dementia – Person Aligned Care Team
Chief Investigator:
Professor Richard Byng
, Faculty of Health, University of Plymouth
D-PACT 2
Title: Realist informed mixed methods evaluation of the Dementia-Personalised Aligned Care Team intervention (D-PACT): a complex intervention for individuals with dementia and carers.
Chief Investigator:
Professor Richard Byng
, Faculty of Health, University of Plymouth
Empowered Together: Coordinated Social Care in Prison
Title: A feasibility and definitive randomised controlled trial, with embedded realised informed process evaluation.
Chief Investigator: Dr Katrina Forsyth, University of Manchester
ENGAGE-PD
Title: Adapting the ENGAGE-PD physical activity coaching intervention for individuals newly diagnosed with Parkinson’s to be delivered by physiotherapists in NHS rehabilitation settings: a feasibility cluster-randomised controlled trial utilising co-design, implementation science principles, and an embedded qualitative component.
Chief Investigator:
Jonathan Gilby
, School of Health Professions, University of Plymouth
ENRICH
Title: Randomised, Phase II open label study of Rituximab/Ibritinib vs Rituximab/Chemo in older patients with mantle cell lymphoma.
Chief Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust
ERASE
Title: Evaluating the efficacy of Remdesivir for the improvement of lung function, perfusion, and symptom profile in long-covid patients.
Chief Investigator: Dr Mark Faghy, University of Derby
FRECycl-D
Title: Does in-bed Cycling delivered within 48 hours of mechanical ventilation, rEduce the occurrence of Delirium in critically ill patients: A mixed-methods Feasibility Randomised controlled trial protocol.
Chief Investigator:
Jacqueline Bennion
MCL Biobank
Title: Establishing a biobank and database as a national resource for characterising indolent and aggressive forms of mantle cell lymphoma.
Chief Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust
CRUK / Janssen Pharmaceuticals
Oasis II
Title: A randomized phase II trial evaluating Ibrutinib plus CD20 Ab and Ibrutinib-Venetoclax plus CD20 Ab in patients with untreated mantle cell lymphoma.
Chief Investigator: Professor Steven Le Gouill, Institut Curie – Paris
Associate Coordinating Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust
PROGROUP
Chief Investigator:
Professor Jonathan Pinkney
, Faculty of Health, University of Plymouth
RAPID-COP
Title: RAtionalising Psychotropic medications for adults with Intellectual Disabilities: sCOPing
Chief Investigator: Professor Shoumitro Deb, Imperial College London
RECAP
Title: Older people with intellectual disabilities and epilepsy – recognising and correcting anticholinergic inducing polypharmacy
Chief Investigator:
Professor Rohit Shankar
, Faculty of Health, University of Plymouth
REFINE
Title: Neuropsychiatric Research Databases for People with Intellectual Disabilities and Epilepsy.
Chief Investigator:
Professor Rohit Shankar
, Faculty of Health, University of Plymouth
REFRESH
Title: nutRition intervEntions For malnouRished oldEr adultS in care Homes: a parallel, superiority, three-arm cluster randomised controlled trial.
Joint Chief Investigator:
Professor Mary Hickson
, Faculty of Health, University of Plymouth
Joint Chief Investigator: Professor Jane Murphy, Bournemouth University
RETREAT
Title: Repurposing anti-retroviral drugs to treat NF2 related tumours
Chief Investigator:
Professor Oliver Hanemann
, Faculty of Health, University of Plymouth
SAFE 2
Title: A randomised controlled trial to evaluate the effectiveness and cost effectiveness of SAFE (Systemic Autism-related Family Enabling), an intervention for families of autistic children.
Chief Investigator: Dr Becky Stancer, Faculty of Health, University of Plymouth
STEPS 2
Title: The Efficacy of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: An Assessor Blinded Randomised Controlled Trial
Chief Investigator: Professor Paul Taylor, Salisbury NHS Foundation Trust
SWIMS
Title: The South West Impact of Multiple Sclerosis (SWIMS) project – a patient-orientated longitudinal study of the impact of multiple sclerosis in South West England.
Chief Investigator:
Professor Jeremy Hobart
, Faculty of Health, University of Plymouth
