Professor Jonathan Pinkney
Profiles

Professor Jonathan Pinkney

Professor of Endocrinology and Diabetes

Clinical Trials and Health Research - Translational and Stratified Medicine (Peninsula Schools of Medicine and Dentistry)

Role

Jonathan Pinkney is Professor of Endocrinology and Diabetes at PUPSMD and Honorary Consultant Physician in Endocrinolopy and Diabetes at Plymouth Hospitals NHS Trust. He undertook speciality training at University College London and the University of Bristol, and was Wellcome Travelling Fellow at Pennington Research Centre, Louisiana State Unviersity. He held Senior Lecturerships at the University of Liverpool and PCMD before taking up his present post in 2010.

His clinical interests include all general adult endocrinology and diabetes, within which he has special interests in hypothalamic and pituitary endocrinology, obesity and bariatric surgery, reproductive and transgender endocrinology and transitional care of children, and inherited endocrine tumour syndromes such as MEN. His outreach activities have included work for the Pituitary Foundation, support of pituitary and endocrine patients, and of pituitary foundation and other patient organisation conferences. He has also been at the forefront of developing specialist services for weight management and raising the profile of obesity as an important clinical problem.

His portfolio of research interests include both biomedical and health services research on aspects of obesity, its environmental and molecular origins, its metabolic and social complications, the impact of obesity on people with diabetes and other endocrine conditions, and developing new approaches to treatment. He writes and speaks widely on these subjects.

Qualifications

BSc (hons) 2:1 University of London King's College, 1982.
MB BS University of London, 1985.
MRCP 1988.
MD University College London, 1997.
FRCP 2003.

Professional membership

Royal College of Physicians (Fellow)
Endocrine Society
American Diabetes Association
Association for the Study of Obesity

Roles on external bodies

Association for the Study of Obesity (Trustee)
Pituitary Foundation (Medical Committee Member)
Society for Endocrinology Obesity Special Interest Group
Endocrinology and Metabolism Research Network (Clinical lead)

Key publications are highlighted

Journals
Articles
Pinkney J, Rance S, Benger J, Brant H, Joel-Edgar S, Swancutt D, Westlake D, Pearson M, Thomas D & Holme I 2016 'How can frontline expertise and new models of care best contribute to safely reducing avoidable acute admissions? A mixed-methods study of four acute hospitals' Health Services Delivery Research 4, (3) 1-1 Publisher Site , DOI PEARL
Redfern KM, Rees GA & Pinkney JH 2016 'Maternal Lifestyle Factors and Fetal Macrosomia Risk: A Review' EMJ Reproductive Health PEARL
Cooper R, Pinkney J & Ayling RM 2015 'Appropriateness of prescribing thyroxine in primary care' Ann Clin Biochem 52, (Pt 4) 497-501 Author Site , DOI
Aljwaid H, White DL, Collard KJ, Moody AJ & Pinkney JH 2015 'Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes' Journal of Diabetes and its Complications 29, (7) 943-949 , DOI PEARL
Pinkney JH, Streeter A, Hosking J, Mohammod M, Jeffery AN & Wilkin TJ 2014 'Adiposity, Chronic Inflammation and the Prepubertal Decline of Sex Hormone Binding Globulin in Children: Evidence for Associations with the Timing of Puberty (EarlyBird 58)' Journal of Clinical Endocrinology and Metabolism
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T 2014 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Clarke-Harris R, Wilkin TJ, Hosking J, Pinkney J, Jeffery AN, Metcalf BS, Godfrey KM, Voss LD, Lillycrop KA & Burdge GC 2014 'PGC1α promoter methylation in blood at 5-7 years predicts adiposity from 9 to 14 years (EarlyBird 50)' Diabetes 63, (7) 2528-2537 Author Site , DOI
Ashurst EJ, Jones RB, Abraham C, Jenner M, Boddy K, Besser REJ, Hammersley S & Pinkney J 2014 'The Diabetes App Challenge: User-Led Development and Piloting of Internet Applications Enabling Young People With Diabetes to Set the Focus for Their Diabetes Consultations' JOURNAL OF MEDICAL INTERNET RESEARCH 16, (11) Author Site , DOI
Pinkney J 2014 'The role of ghrelin in metabolic regulation' Curr Opin Clin Nutr Metab Care 17, (6) 497-502 Author Site , DOI
Frost J, Anderson R, Argyle C, Daly M, Harris-Golesworthy F, Harris J, Gibson A, Ingram W, Pinkney J & Ukoumunne OC 2013 'A pilot randomised controlled trial of a preconsultation web-based intervention to improve the care quality and clinical outcomes of diabetes outpatients (DIAT)' BMJ Open 3, (7) Author Site , DOI
Daousi C, Pinkney JH, Cleator J, Wilding JP & Ranganath LR 2013 'Acute peripheral administration of synthetic human GLP-1 (7–36 amide) decreases circulating IL-6 in obese patients with type 2 diabetes mellitus: A potential role for GLP-1 in modulation of the diabetic pro-inflammatory state?' Regulatory Peptides 183, 54-61 , DOI
Jones R, Cleverly L, Hammersley S, Ashurst E & Pinkney J 2013 'Apps and online resources for young people with diabetes: The facts' Journal of Diabetes Nursing 17, 20-26
Ajala O, English P & Pinkney J 2013 'Low-carbohydrate, high-protein diets for management of type 2 diabetes Reply' AMERICAN JOURNAL OF CLINICAL NUTRITION 98, (1) 248-248 Author Site , DOI
Huda MSB, Mani H, Durham BH, Dovey TM, Halford JCG, Aditya BS, Pinkney JH, Wilding JP & Hart IK 2013 'Plasma obestatin and autonomic function are altered in orexin-deficient narcolepsy, but ghrelin is unchanged' Endocrine 43, (3) 696-704 Author Site , DOI
Tomlinson J, Letherby G, Pinkney J, Millward A & Stenhouse E 2013 'Raising awareness of polycystic ovary syndrome' Nurs Stand 27, (40) 35-39 Author Site
Ajala O, English P & Pinkney J 2013 'Reply to R Pawlak' American Journal of Clinical Nutrition 98, (1) 248-248 , DOI
Ajala O, English P & Pinkney J 2013 'Systematic review and meta-analysis of different dietary approaches to the management of type 2 diabetes' Am J Clin Nutr 97, (3) 505-516 Author Site , DOI
Pinkney J 2011 'Consensus at last? The International Diabetes Federation statement on bariatric surgery in the treatment of obese Type 2 diabetes' DIABETIC MEDICINE 28, (8) 884-885 Author Site , DOI
Huda MSB, Dovey TM, Wong SP, English PJ, Halford JCG, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K 2011 'Ghrelin does not orchestrate the metabolic changes seen in fasting but has significant effects on lipid mobilisation and substrate utilisation' Eur J Endocrinol 165, (1) 45-55 Author Site , DOI
Kos K, Wong S, Tan BK, Kerrigan D, Randeva HS, Pinkney JH & Wilding JPH 2011 'Human RBP4 adipose tissue expression is gender specific and influenced by leptin' Clin Endocrinol (Oxf) 74, (2) 197-205 Author Site , DOI
Huda MSB, Mani H, Dovey T, Halford JCG, Boyland E, Daousi C, Wilding JPH & Pinkney J 2010 'Ghrelin inhibits autonomic function in healthy controls, but has no effect on obese and vagotomized subjects' Clin Endocrinol (Oxf) 73, (5) 678-685 Author Site , DOI
White HD, Blair J, Pinkney J, Cuthbertson DJ, Day R, Weber A & MacFarlane IA 2010 'Improvement in the care of multiple endocrine neoplasia type 1 through a regional multidisciplinary clinic' QJM 103, (5) 337-345 Author Site , DOI
Kos K, Wong SPY, Huda MSB, Cakir M, Jernas M, Carlsson L, Kerrigan D, Wilding JPH & Pinkney JH 2010 'In humans the adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' Diabetes Obes Metab 12, (4) 360-363 Author Site , DOI
Pinkney JH 2010 'Obesity surgery Big questions remain unanswered' BRITISH MEDICAL JOURNAL 341, Author Site , DOI
Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, Trayhurn P & Bing C 2010 'The adipokine zinc-α2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity' Clinical Endocrinology 72, (3) 334-341 , DOI
Pinkney JH, Johnson AB & Gale EAM 2010 'The big fat bariatric bandwagon' Diabetologia 53, (9) 1815-1822 Author Site , DOI
Deepak D, Daousi C, Javadpour M, Clark D, Perry Y, Pinkney J & Macfarlane IA 2010 'The influence of growth hormone replacement on peripheral inflammatory and cardiovascular risk markers in adults with severe growth hormone deficiency' Growth Horm IGF Res 20, (3) 220-225 Author Site , DOI
Tomlinson J, Millward A, Stenhouse E & Pinkney J 2010 'Type 2 diabetes and cardiovascular disease in polycystic ovary syndrome: what are the risks and can they be reduced?' Diabet Med 27, (5) 498-515 Author Site , DOI
Daousi C, Wilding JPH, Aditya S, Durham BH, Cleator J, Pinkney JH & Ranganath LR 2009 'Effects of peripheral administration of synthetic human glucose-dependent insulinotropic peptide (GIP) on energy expenditure and subjective appetite sensations in healthy normal weight subjects and obese patients with type 2 diabetes' Clin Endocrinol (Oxf) 71, (2) 195-201 Author Site , DOI
Huda MSB, Dovey T, Wong SP, English PJ, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K 2009 'Ghrelin restores 'lean-type' hunger and energy expenditure profiles in morbidly obese subjects but has no effect on postgastrectomy subjects' Int J Obes (Lond) 33, (3) 317-325 Author Site , DOI
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, LMS C & Randeva H 2009 'Regularion of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin , insulin and glucose' Diabetes 8, (58) 1780-1780
Kos K, Wong S, Kerrigan D, Wilding JPH & Pinkney JH 2008 'Adipose tissue derived SPARC and obesity related inflammation in healthy' DIABETOLOGIA 51, S330-S331 Author Site
Harrold JA, Dovey T, Cai X-J, Halford JCG & Pinkney J 2008 'Autoradiographic analysis of ghrelin receptors in the rat hypothalamus' Brain Res 1196, 59-64 Author Site , DOI
Pinkney JH, Wong SPY, Kerrigan D, Kos K & Wilding JPH 2008 'Distribution and characteristics of adiponectin R1 and R2 receptor in RNA gene expression in human visceral and subcutaneous adipose tissue' DIABETOLOGIA 51, S90-S90 Author Site
Deepak D, Daousi C, Boyland E, Pinkney JH, Wilding JPH & MacFarlane IA 2008 'Growth hormone and changes in energy balance in growth hormone deficient adults' Eur J Clin Invest 38, (9) 622-627 Author Site , DOI
Huda MSB, Durham BH, Wong SP, Deepak D, Kerrigan D, McCulloch P, Ranganath L, Pinkney J & Wilding JPH 2008 'Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal' Int J Obes (Lond) 32, (1) 129-135 Author Site , DOI
Huda MSB, Durham BH, Wong SP, Dovey TM, McCulloch P, Kerrigan D, Pinkney JH, Fraser WD & Wilding JPH 2007 'Lack of an acute effect of ghrelin on markers of bone turnover in healthy controls and post-gastrectomy subjects' Bone 41, (3) 406-413 Author Site , DOI
Huda MSB, Wilding JPH & Pinkney JH 2006 'Gut peptides and the regulation of appetite' Obes Rev 7, (2) 163-182 Author Site , DOI
Daousi C, Casson IF, Gill GV, MacFarlane IA, Wilding JPH & Pinkney JH 2006 'Prevalence of obesity in type 2 diabetes in secondary care: association with cardiovascular risk factors' Postgrad Med J 82, (966) 280-284 Author Site , DOI
Pinkney J 2005 'Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C' Diabetologia 48 (12), 2641-9 , DOI
Wong SPY, Huda M, English P, Bargiotta A, Wilding JPH, Johnson A, Corrall R & Pinkney JH 2005 'Adipokines and the insulin resistance syndrome in familial partial lipodystrophy caused by a mutation in lamin A/C' Diabetologia 48, (12) 2641-2649 Author Site , DOI
Daousi C, Dunn AJ, Foy PM, MacFarlane IA & Pinkney JH 2005 'Endocrine and neuroanatomic features associated with weight gain and obesity in adult patients with hypothalamic damage' Am J Med 118, (1) 45-50 Author Site , DOI
Pinkney J 2005 'Is there a role for ghrelin and peptide-YY (3-36) in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?' Journal of Clinical Endocrinology & Metabolism 90 (9), 5025-30 , DOI
Daousi C, MacFarlane IA, English PJ, Wilding JPH, Patterson M, Dovey TM, Halford JCG, Ghatei MA & Pinkney JH 2005 'Is there a role for ghrelin and peptide-YY in the pathogenesis of obesity in adults with acquired structural hypothalamic damage?' J Clin Endocrinol Metab 90, (9) 5025-5030 Author Site , DOI
Pinkney J & Kerrigan D 2004 'Current status of bariatric surgery in the treatment of type 2 diabetes' Obes Rev 5, (1) 69-78 Author Site
MacFarlane IA, Gill GV, Finnegan D & Pinkney J 2004 'Diabetes in a high secure hospital' Postgrad Med J 80, (939) 35-37 Author Site
Wong S & Pinkney J 2004 'Role of cytokines in regulating feeding behaviour' Curr Drug Targets 5, (3) 251-263 Author Site
Flower L, Gray R, Pinkney J & Mohamed-Ali V 2003 'Stimulation of interleukin-6 release by interleukin-1β from isolated human adipocytes' Cytokine 21, (1) 32-37 , DOI
Pinkney J & Williams G 2002 'Ghrelin gets hungry' Lancet 359, (9315) 1360-1361 Author Site , DOI
Pinkney J, Wilding J, Williams G & MacFarlane I 2002 'Hypothalamic obesity in humans: what do we know and what can be done?' Obes Rev 3, (1) 27-34 Author Site
Pinkney J 2002 'Prevention and cure of type 2 diabetes - Weight loss is the key to controlling the diabetes epidemic' BRITISH MEDICAL JOURNAL 325, (7358) 232-233 Author Site , DOI
Mohamed-Ali V, Flower L, Sethi J, Hotamisligil G, Gray R, Humphries SE, York DA & Pinkney J 2001 'beta-adrenergic regulation of IL-6 release from adipose tissue: In vivo and in vitro studies' JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 86, (12) 5864-5869 Author Site , DOI
Pinkney J 2001 'beta-Adrenergic regulation of IL-6 release from adipose tissue: in vivo and in vitro studies' Journal of Clinical Endocrinology & Metabolism 86 (12), 5864-9 , DOI
Mohamed-Ali V, Armstrong L, Clarke D, Bolton CH & Pinkney JH 2001 'Evidence for the regulation of levels of plasma adhesion molecules by proinflammatory cytokines and their soluble receptors in type 1 diabetes' JOURNAL OF INTERNAL MEDICINE 250, (5) 415-421 Author Site , DOI
Pinkney JH, Vernon P, Carstensen E, Gillies S, Phillips DI & Yudkin JS 2001 'Intracellular pH, intrauterine growth and the insulin resistance syndrome' Clin Physiol 21, (6) 640-647 Author Site
Pinkney JH, Sjöström CD & Gale EA 2001 'Should surgeons treat diabetes in severely obese people?' Lancet 357, (9265) 1357-1359 Author Site , DOI
Pinkney 0 'Selecting GLP-1 agonists in the management of type 2 diabetes: differential pharmacology and therapeutic benefits of liraglutide and exenatide' Therapeutics and Clinical Risk Management 401-401 , DOI
Conference Papers
Pinkney J, Mari A, Tura A, Bond K, Stenhouse E, Vincent RP & Tomlinson J 2015 'Insulin sensitivity with reactive hypoglycaemia: a metabolic subtype of polycystic ovary syndrome with reduced risks of type 2 diabetes and cardiovascular disease' //0 //0 S302-S302
Tomlinson J, Mari A, Tura A, Bond K, Stenhouse E, Vincent RP & Pinkney J 2015 'The beta cell and insulin resistance in polycystic ovary syndrome: new insights into the origins and prevention of type 2 diabetes' //0 //0 S190-S190
Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LMS & Randeva HS 2009 'Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose' United States //0 //0 1780-1788 , DOI
Kos KT, Wong S, Jernas M, Kerrigan D, Carlsson L, Wilding JPH & Pinkney JH 2009 'The human adiponectin receptor R2 is expressed predominantly in adipose tissue and linked to the adipose tissue expression of MMIF-1' //0 //0 S282-S282
Huda M, Dovey T, Wong S, English P, Halford J, McCulloch P, Cleator J, Martin B, Cashen J & Hayden K 2008 'Endocrine adaptations to short term fasting are preserved after gastrectomy but impaired in morbid obesity' //0 //0 S74-S74
Kos K, Wong S, Kerrigan D, Wilding JPH & Pinkney JH 2008 'Gender differences of RBP4 expression, relation of plasma, VAT and SCAT expression and its relation with insulin resistance and inflammation' //0 //0 S15-S15
Huda M, Mani H, Durham B, Dovey T, Halford J, Aditya S, Pinkney J, Wilding J & Hart I 2007 'Changes in circulating plasma ghrelin and obestatin in narcolepsy-cataplexy' //0 //0 A218-A219
Internet Publications
Pinkney J 2007 'Plasma obestatin levels are lower in obese and post-gastrectomy subjects, but do not change in response to a meal' , DOI