Dr Ashwin Dhanda
Profiles

Dr Ashwin Dhanda

Clinical Lecturer in Gastroenterology

Biomedical Research - Institute of Translational & Stratified Medicine (Faculty of Medicine and Dentistry)

Role

I am a clinician scientist with an interest in translational research relating to inflammatory liver diseases, particularly alcohol related liver disease. I am currently leading a project to develop a novel test to identify patients who do not respond to steroid treatment for alcoholic hepatitis. In addition I am investigating some of the immune mechanisms of alcohol related liver disease. I work closely with clinical colleagues in the South West Liver Unit at Derriford Hospital and am supported by our Hepatology Research Group.


On a national level I am a topic expert committee member of the NICE Clinical Guidelines Update Committee for Alcohol Use Disorders and I am part of the British Society of Gastroenterology Liver Clinical Research Group, which supports development of novel clinical trials.

I am also an active clinician and spend time in specialist hepatology clinical training (outpatient clinics, liver transplant assessments, endoscopy and inpatient work).

Qualifications

BSc (Hons), University of Edinburgh 2000

M BChB, University of Edinburgh 2003

MRCP, Royal College of Physicians of London 2006

PGCert Health Education, St George's University of London 2007

PhD, University of Bristol 2014



Roles on external bodies

Topic Expert for NICE Clinical Guidelines Update Committee for Alcohol Use Disorders

Committee member of the British Society of Gastroenterology Liver Clinical Research Group

Key publications are highlighted

Journals
Articles
Dhanda AD, Sinha A, Hunt V, Saleem S, Cramp ME & Collins PL 2017 'Infection does not increase long-term mortality in patients with acute severe alcoholic hepatitis treated with corticosteroids' World Journal of Gastroenterology 23, (11) 2052-2052 , DOI PEARL
Williams EL, Stimpson ML, Collins PL, Enki DG, Sinha A, Lee RW & Dhanda AD 2016 'Development and validation of a novel bioassay to determine glucocorticoid sensitivity' Biomarker Research 4, 26-26 , DOI PEARL
Liu B, Dhanda A, Hirani S, Williams EL, Sen HN, Martinez Estrada F, Ling D, Thompson I, Casady M & Li Z 2015 'CD14 ++ CD16 + Monocytes Are Enriched by Glucocorticoid Treatment and Are Functionally Attenuated in Driving Effector T Cell Responses' The Journal of Immunology 194, (11) 5150-5160 , DOI
Schewitz-Bowers LP, Lait PJP, Copland DA, Chen P, Wu W, Dhanda AD, Vistica BP, Williams EL, Liu B & Jawad S 2015 'Glucocorticoid-resistant Th17 cells are selectively attenuated by cyclosporine A' Proceedings of the National Academy of Sciences 112, (13) 4080-4085 , DOI
Dhanda AD 2015 'Immune dysfunction in acute alcoholic hepatitis' World Journal of Gastroenterology 21, (42) 11904-11904 , DOI
Powter L, Beale A, Probert B & Dhanda A 2014 'Development and validation of a tool to select patients for admission to medical short stay units' Clinical Medicine 14, (4) 371-375 , DOI
Dhanda AD, di Mambro AJ, Hunt VL, McCune CA, Dayan CM, Dick AD, Lee RWJ & Collins PL 2014 'Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity' Hepatology 61, (3) 1099-1099 , DOI
Hanna MS, Portal AJ, Dhanda AD & Przemioslo R 2013 'UK wide survey on the prevention of post-ERCP pancreatitis' Frontline Gastroenterology 5, (2) 103-110 , DOI
Dhanda AD 2013 'Is liver biopsy necessary in the management of alcoholic hepatitis?' World Journal of Gastroenterology 19, (44) 7825-7825 , DOI
Dhanda AD, Creed TJ, Greenwood R, Sands BE & Probert CS 2012 'Can endoscopy be avoided in the assessment of ulcerative colitis in clinical trials?' Inflammatory Bowel Diseases 18, (11) 2056-2062 , DOI
Sands BE, Sandborn WJ, Creed TJ, Dayan CM, Dhanda AD, Van Assche GA, Greguš M, Sood A, Choudhuri G & Stempien MJ 2012 'Basiliximab Does Not Increase Efficacy of Corticosteroids in Patients With Steroid-Refractory Ulcerative Colitis' Gastroenterology 143, (2) 356-364.e1 , DOI
Ayres LRO, Clarke S, Digby-Bell J, Dhanda AD, Dharmasiri S, Caddick K & Collins PL 2012 'Fragility fracture risk in cirrhosis: a comparison of the fracture risk assessment tool, British Society of Gastroenterology and National Institute for Health and Clinical Excellence guidelines' Frontline Gastroenterology 3, (4) 220-227 , DOI
Dhanda A, Lee R & Collins P 2012 'Is primary biliary cirrhosis a steroid-sensitive autoimmune disease?' Hepatology Research 42, (6) 619-620 , DOI
Dhanda AD 2012 'Molecular targets in the treatment of alcoholic hepatitis' World Journal of Gastroenterology 18, (39) 5504-5504 , DOI
Dawson C, Dhanda A, Conway-Campbell B, DiMambro A, Lightman S & Dayan C 2011 'NFκB and glucocorticoid receptor activity in steroid resistance' Journal of Receptors and Signal Transduction 32, (1) 29-35 , DOI
Conference Papers
Yates E, Cramp M & Dhanda A 2017 'A NOVEL FUNCTIONAL BIOASSAY PREDICTS 90-DAY SURVIVAL IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS' A99-A100 , DOI
Dhanda A, Atkinson S & Thursz M 2017 'Variation in the use of corticosteroids for the treatment of acute severe alcoholic hepatitis in the post-STOPAH era: results of a UK national survey' S345-S346 , DOI
Ahmed A, Dhanda A, Hegazy D, Felmlee D, Sheridan D & Cramp M 2016 'Sustained viral clearance of HCV with DAA treatment is associated with restoration of effector T cell phenotype' 745A-745A
Posters
Dhanda A, Williams E, Yates E, Collins P, Lee R & Cramp M Dhanda A, Williams E, Yates E, Collins P, Lee R & Cramp M 0 'Intermediate (CD14++CD16+) monocytes from patients with acute severe alcoholic hepatitis are activated and functionally similar to classical (CD14++CD16−) monocytes' 0 0 , DOI