Professor Mathew Upton

Professor Mathew Upton

Associate Head of School (Research)

School of Biomedical Sciences (Faculty of Health)

Mathew can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Microbiology
  • Molecular biology
  • Disinfection
  • Aquatic biofilms
  • Novel antimicrobials
  • Antibiotic resistance
  • Bacteria
  • Pathogens


Follow me on Twitter - @mat_upton

August 2018 - Professor of Medical Microbiology

June 2018 - Founder and Chief Scientific Officer at Amprologix Ltd (@amprologix)

May 2013 - Reader in Medical Microbiology, University of Plymouth

April 2014 - Co-founder and Director at Spectromics Ltd (

June 2011 - Senior Lecturer in Medical Microbiology, University of Manchester

June 2001 - Lecturer in Medical Microbiology, University of Manchester

Following BSc and PhD studies in Newcastle, I completed a number of postdoc projects in Aberdeen, Antarctica, Bristol, Liverpool and New Zealand, before taking up a lectureship in Manchester.

Lead for Antibiotic Resistant Pathogens Research Group


Current group members

Dr Florie Desriac (PDRA)
Dr Michelle Vang Mouritzen (PDRA)
Dr Garry Farnham (PDRA)
Dr Katie Sealy (PDRA)
Mr Nizar Saeedi (PhD candidate)
Mr Abdu Aldarhami (PhD candidate)
Mr Robert O'Hara (PhD candidate)
Mr Matthew Koch (PhD candidate)
Ms Vick Bennett (Visiting Placement Student, University of Bath)


BSc (Hons) Microbiology, University of Newcastle

PhD Microbial Ecology, University of Newcastle

Professional membership

Fellow of the Royal Society of Biology

Member of the Microbiology Society

Member of the Society for Applied Microbiology

Member of the American Society for Microbiology

Member of the European Society for Clinical Microbiology

Roles on external bodies

Editor, Journal of Applied Microbiology
Editor, Letters in Applied Microbiology
Panel member and author, HigherEducation Academy National Subject Profile in Microbiology (2008)

Teaching interests

Areas of teaching interest relate to medical microbiology, bacterial genomics and antibiotic resistance.

MSc Biomedical Sciences
Module Lead for BIOM5003 Contemporary Science of Infection and Immunity
Contributing to modules BIOM5005 (Project Design and Development), BIOM5006 (Research Project), BIOM5008 (Clinical Microbiology), BIOM5010 (Personalised Medicine)

BSc Biomedical Sciences
Contributing to Modules BHCS1001, BHCS2007, BIOM3001, BIOM3003, BIOM3015, BIOM3016

Research interests

Lead for Antibiotic Resistant Pathogens Research Group

Discovery and development of first in class antibiotics

The WHO have declared that antibiotic resistance is one of the major threats to human health. England's Chief Medical Officer has often raised this issue nationally and the topic was even highlighted at the G8 summit in June 2013. However, there is still a real need to discover novel antibiotics. Infections caused by drug resistant pathogens are a significant cause of morbidity and mortality and pan-resistant organisms are becoming less rare. The UK Government commissioned O'Neill review suggests that drug resistant infections will kill 10 million people a year by 2050 if we are not able to slow the development and spread of these infections.

I run a programme of natural product screening for discovery of bacteriocins, antimicrobial peptides produced by bacteria. The programme is supported by use of next generation sequencing methods to determine bacterial genome sequences and generate metagenomic datasets that can be interrogated with various software tools for identification of putative bacteriocins. Candidate antimicrobials are screened against clinically relevant pathogens, examined for toxicity and efficacy in vivo (including the Galleria mellonella insect assay). Working with industrial biotechnology leaders, Ingenza, we are developing systems for commercially viable production of bacteriocins, some that will be produced using cognitive computing design approaches, in collaboration with the National Physical Laboratory. Most recently, I have begun to explore the biodiversity and bioactivity of marine sponges in collaboration with members of the University of Plymouth Marine Institute.

Lead compounds are being developed towards clinical use with commercially focused funding from BBSRC, Innovate UK, Society for Applied Microbiology and other sources.

Collaborators in this work are located in Plymouth (Dr Howell, University of Plymouth Marine Institute), Scotland (Dr Ian Fotheringham, Ingenza Ltd), London (Dr Max Ryadnov, National Physical Laboratory) and Denmark (Prof Jenssen, Roskilde University)

Understanding the inner workings of bacterial pathogens

The vast majority of bacteria that live in and on our bodies contribute significantly to our health and well-being. However, sometimes we succumb to bacterial infections and, increasingly, these are becoming harder to treat due to antibiotic resistance. My group focuses on investigation of E. coli strains that cause urinary tract infections, a very common infection that is often mild, but can lead to severe debilitation, or death. The introduction of next generation DNA sequencing technologies has revolutionized the way we examine the mechanisms that pathogenic bacteria use to cause disease or evade the action of antibiotics. By studying their genomes, we aim to understand these bacteria and will be able to develop specific molecular assays for rapid detection and for outbreak investigation.

The above work is carried out in collaboration with colleagues in Plymouth (Dr Peter Jenks, Derriford Hospital) and at University of Queesnland, Brisbane (Drs Scott Beatson and Makrina Totsika and Prof Mark Schembri) and King Abdullah Medical Research Centre, Riyadh, Saudi Arabia (Dr Algohribi).

Scopus author ID - 35593933700

ResearchGate profile - Mathew_Upton

Research degrees awarded to supervised students

I have supervised 20 PhD students and over 70 MSc research projects. These projects have all been in the field of medical microbiology and have involved collaborators at UK universities, Public Health England (formerly HPA) and NHS Trusts.

Current PhD students (Director of studies)
Nizar Saeedi (2014-2018) - Pathogenenesis of ST127 uropathogenic E coli
Rob O'Hara (2015-2018) - Epidemiology of ST127 uropathogenic E coli
Abdu Aldarhami (2015-2019) - Novel antimicrobials for therapy of Gram positive infections
Matthew Koch (2017-2020) - Discovery of novel antimicrobials from deep sea sponges

Current PhD students (Co-supervisor)
Sam Gould (2015-2018) - 3D models to study oral infections
Connor Wood (2015-2018) - Superinfection of influenza virus
Barbara Durante (2015-2018) - Immunological effects of antimicrobial peptides
Poppy Best (2017-2020) - Bioactivity and ecology of bacteria from deep sea sponges
Jonathan Butler (2018-2021) - Novel antimicrobial surfaces to reduce healthcare associated infections

Grants & contracts

Recent funding

SBRI/InnovateUK/Department of Health and Social Care. AMR in Humans call. Feb 2019-Jan 2021. (PI on behalf of Amprologix Ltd, awarded contract of £1.18m)

UKRI GCRF One Ocean Hub. April 2019 - March 2024. (Co-I awarded £100k as part of University of Plymouth work package. Lead organisation, University of Strathclyde. International consortium awarded £19m). 

InnovateUK/Department of Health and Social Care. UK-China AMR call. Development of attenuated bovine herpesvirus-4 as a safe,inexpensive, single dose vaccine to control Streptococcus suis infection indomestic pigs. April 2019-March 2022. (Lead academic awarded £294k, with The Vaccine Group; total project award £700k).

Society for Applied Microbiology. Mining deep-sea sponges for novel antimicrobial biologics. Oct 2017-Sept 2020. (PI awarded £65k) 

InnovateUK. Biomedical Catalyst. Developing a pipeline of bacteriocin-based antibiotics. Aug 2017-July 2020. (Lead Academic awarded £299k with Ingenza and National Physical Laboratory; total award £933k)

InnovateUK. Industrial Strategy Challenge Fund. Economic Biosecurity Surveillance Service. Sept 2017-April 2018. (Lead Academic awarded £33k, with Applied Genomics Ltd; Total award £150k)

InnovateUK. Capital Equipment for AMR research. Jan-March 2017.(Lead Academic awarded £85k, with Ingenza Ltd; total award £143k)

Innovate UK/BBSRC Efficient production of first in class antimicrobial therapeutics from an integrated synthetic biology approach.Industrial Biocatalyst award with Ingenza Ltd, Edinburgh - May 2015-APril 2017(Lead Academic, awarded £217,000)

Public Health England. PhD Studentship Co-infection during influenza. October 2014 - September 2017 (Co-I; £90,000)

Healthcare Infection Society. MRSA genome sequence analysis. March 2014 (PI; £9,900)

Plymouth Hospitals NHS Trust Charitable Funds. Investigation of water-borne pathogens in Critical Care Areas using genomic approaches. May2013 (Co-I; £11,850) 

BBSRC, Follow on Fund. Development of epidermicin for nasal decolonisation of MRSA carriage. March 2012 (PI; £132,000)

UMIP, University of Manchester. Development of methods for rapid detection of UTI. August 2012 (Co-PI; £102,000)

UMIP, University of Manchester. Recombinant expression ofantimicrobial peptides. July 2011 (PI; £23,000)

Department of Health, UK National Innovation Centre and UMIP, Universityof Manchester, Development of point of care diagnostics for urinary tract infection.July 2011 (Co-PI; £54,000)

Department of Health, UK National Innovation Centre and UMIP, Universityof Manchester, Development of an in-situ indicator of catheter colonisation. July2011 (Co-PI; £80,000)

Welcome Trust, Understanding UPEC biology. March 2011 (CoI with CWinstanley, Liverpool;£113,500)

BBSRC, Regulatory and market consultancy for a novel antibiotic. September2010 (PI; £15,500)

UMIP, University of Manchester. Antimicrobial peptidesactive against staphylococci. December 2008 (PI; £75,000)

Key publications are highlighted

Hammond K, Lewis H, Halliwell S, Desriac F, Nardone B, Ravi J, Hoogenboom BW, Upton M, Derrick JP & Ryadnov MG 2020 'Flowering poration – a synergistic multi-mode antibacterial mechanism by a bacteriocin fold' iScience 101423-101423 , DOI
Aldarhami A, Felek A, Sharma V & Upton M 2020 'Purification and characterization of nisin P produced by a strain of Streptococcus gallolyticus' Journal of Medical Microbiology , DOI PEARL
Alghoribi MF, Doumith M, Upton M, Al Johani SM, Alzayer M, Woodford N, Ellington MJ & Balkhy HH 2019 'Complete Genome Sequence of a Colistin-Resistant Uropathogenic Escherichia coli Sequence Type 131 fimH22 Strain Harboring mcr-1 on an IncHI2 Plasmid, Isolated in Riyadh, Saudi Arabia' Microbiology Resource Announcements 8, (18) , DOI PEARL
O'Hara RW, Jenks PJ, Emery M & Upton M 2018 'Rapid detection of extra-intestinal pathogenic Escherichia coli multi-locus sequence type 127 using a specific PCR assay' Journal of Medical Microbiology Author Site , DOI PEARL
Castelino M, Eyre S, Moat J, Fox G, Martin P, Ho P, Upton M & Barton A 2017 'Optimisation of methods for bacterial skin microbiome investigation: primer selection and comparison of the 454 versus MiSeq platform' BMC Microbiology 17, (1) , DOI PEARL
Halliwell S, Warn P, Sattar A, Derrick JP & Upton M 2016 'A single dose of epidermicin NI01 is sufficient to eradicate MRSA from the nares of cotton rats' Journal of Antimicrobial Chemotherapy dkw457-dkw457 , DOI PEARL
Sarkar S, Roberts LW, Phan M-D, Tan L, Lo AW, Peters KM, Paterson DL, Upton M, Ulett GC & Beatson SA 2016 'Comprehensive analysis of type 1 fimbriae regulation in fimB -null strains from the multidrug resistant Escherichia coli ST131 clone' Molecular Microbiology , DOI PEARL
Moat J, Rizoulis A, Fox G & Upton M 2016 'Domestic shower hose biofilms contain fungal species capable of causing opportunistic infection' Journal of Water and Health , DOI PEARL
Forde BM, Phan M-D, Gawthorne JA, Ashcroft MM, Stanton-Cook M, Sarkar S, Peters KM, Chan K-G, Chong TM & Yin W-F 2015 'Lineage-Specific Methyltransferases Define the Methylome of the Globally Disseminated Escherichia coli ST131 Clone' mBio 6, (6) , DOI PEARL
Alghoribi MF, Gibreel TM, Farnham G, Al Johani SM, Balkhy HH & Upton M 2015 'Antibiotic-resistant ST38, ST131 and ST405 strains are the leading uropathogenic Escherichia coli clones in Riyadh, Saudi Arabia' J Antimicrob Chemother 70, (10) 2757-2762 Author Site , DOI PEARL
Morra R, Shankar J, Robinson CJ, Halliwell S, Butler L, Upton M, Hay S, Micklefield J & Dixon N 2015 'Dual transcriptional-translational cascade permits cellular level tuneable expression control' Nucleic Acids Research 44, (3) e21-e21 , DOI PEARL
Phan M-D, Peters KM, Sarkar S, Forde BM, Lo AW, Stanton-Cook M, Roberts LW, Upton M, Beatson SA & Schembri MA 2015 'Third-generation cephalosporin resistance conferred by a chromosomally encoded blaCMY-23 gene in the Escherichia coli ST131 reference strain EC958' J Antimicrob Chemother 70, (7) 1969-1972 Author Site , DOI PEARL
Phan MD, Forde BM, Peters KM, Sarkar S, Hancock S, Stanton-Cook M, Ben Zakour NL, Upton M, Beatson SA & Schembri MA 2015 'Molecular characterization of a multidrug resistance IncF plasmid from the globally disseminated Escherichia coli ST131 clone' PLoS One 10, (4) Author Site , DOI PEARL
AlRabiah H, Xu Y, Rattray NJW, Vaughan AA, Gibreel T, Sayqal A, Upton M, Allwood JW & Goodacre R 2014 'Multiple metabolomics of uropathogenic E. coli reveal different information content in terms of metabolic potential compared to virulence factors' Analyst 139, (17) 4193-4199 Author Site , DOI PEARL
Dawson SE, Gibreel T, Nicolaou N, AlRabiah H, Xu Y, Goodacre R & Upton M 2014 'Implementation of Fourier transform infrared spectroscopy for the rapid typing of uropathogenic Escherichia coli' Eur J Clin Microbiol Infect Dis 33, (6) 983-988 Author Site , DOI PEARL
Castelino M, Eyre S, Upton M, Ho P & Barton A 2014 'The bacterial skin microbiome in psoriatic arthritis, an unexplored link in pathogenesis: challenges and opportunities offered by recent technological advances' Rheumatology (Oxford) 53, (5) 777-784 Author Site , DOI PEARL
Petty NK, Ben Zakour NL, Stanton-Cook M, Skippington E, Totsika M, Forde BM, Phan M-D, Gomes Moriel D, Peters KM & Davies M 2014 'Global dissemination of a multidrug resistant Escherichia coli clone' Proc Natl Acad Sci U S A 111, (15) 5694-5699 Author Site , DOI PEARL
Petty NK, Zakour NLB, Stanton-Cook M, Skippington E, Totsika M, Forde BM, Phan MD, Moriel DG, Peters KM & Davies M 2014 'Global dissemination of a multidrug resistant Escherichia coli clone' Proceedings of the National Academy of Sciences of the United States of America 111, (15) 5694-5699 , DOI
Allwood JW, AlRabiah H, Correa E, Vaughan A, Xu Y, Upton M & Goodacre R 2014 'A workflow for bacterial metabolic fingerprinting and lipid profiling: application to Ciprofloxacin challenged Escherichia coli' Metabolomics 1-16 Author Site , DOI PEARL
Alghoribi MF, Gibreel TM, Dodgson AR, Beatson SA & Upton M 2014 'Galleria mellonella infection model demonstrates high lethality of ST69 and ST127 uropathogenic E. coli' PLoS One 9, (7) Author Site , DOI PEARL
Forde BM, Ben Zakour NL, Stanton-Cook M, Phan M-D, Totsika M, Peters KM, Chan KG, Schembri MA, Upton M & Beatson SA 2014 'The complete genome sequence of Escherichia coli EC958: a high quality reference sequence for the globally disseminated multidrug resistant E. coli O25b:H4-ST131 clone' PLoS One 9, (8) Author Site , DOI PEARL
Voets GM, Leverstein-van Hall MA, Kolbe-Busch S, van der Zanden A, Church D, Kaase M, Grisold A, Upton M, Cloutman-Green E & Cantón R 2013 'International multicenter evaluation of the DiversiLab bacterial typing system for Escherichia coli and Klebsiella spp' J Clin Microbiol 51, (12) 3944-3949 Author Site , DOI PEARL
Phan MD, Peters KM, Sarkar S, Lukowski SW, Allsopp LP, Moriel D, Achard ME, Totsika M, Marshall VM & Upton M 2013 'The Serum Resistome of a Globally Disseminated Multidrug Resistant Uropathogenic <italic>Escherichia coli</italic> Clone' PLoS Genet 9, e1003834-e1003834 Publisher Site , DOI PEARL
Totsika M, Kostakioti M, Hannan TJ, Upton M, Beatson SA, Janetka JW, Hultgren SJ & Schembri MA 2013 'A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug-resistant uropathogenic Escherichia coli ST131' J Infect Dis 208, (6) 921-928 Author Site , DOI PEARL
Gibreel TM & Upton M 2013 'Synthetic epidermicin NI01 can protect Galleria mellonella larvae from infection with Staphylococcus aureus' Journal of Antimicrobial Chemotherapy , DOI PEARL
Handley KM, Upton M, Beatson SA, Héry M & Lloyd JR 2013 'Genome Sequence of Hydrothermal Arsenic-Respiring Bacterium Marinobacter santoriniensis NKSG1T' Genome Announc 1, (3) Author Site , DOI PEARL
Govindji N, Wills P, Upton M, Tirelli N, Yeates S & Webb M 2013 'The antibiofilm effects of Byotrol™ G32' J Appl Microbiol 114, (5) 1285-1293 Author Site , DOI
AlRabiah H, Correa E, Upton M & Goodacre R 2013 'High-throughput phenotyping of uropathogenic E. coli isolates with Fourier transform infrared spectroscopy' Analyst 138, (5) 1363-1369 Author Site , DOI PEARL
Floyd RV, Upton M, Hultgren SJ, Wray S, Burdyga TV & Winstanley C 2012 'Escherichia coli-mediated impairment of ureteric contractility is uropathogenic E. coli specific' J Infect Dis 206, (10) 1589-1596 Author Site , DOI PEARL
Gibreel TM, Dodgson AR, Cheesbrough J, Bolton FJ, Fox AJ & Upton M 2012 'High metabolic potential may contribute to the success of ST131 uropathogenic Escherichia coli' J Clin Microbiol 50, (10) 3202-3207 Author Site , DOI PEARL
Sandiford S & Upton M 2012 'Identification, characterization, and recombinant expression of epidermicin NI01, a novel unmodified bacteriocin produced by Staphylococcus epidermidis that displays potent activity against Staphylococci' Antimicrob Agents Chemother 56, (3) 1539-1547 Author Site , DOI
Gibreel TM, Dodgson AR, Cheesbrough J, Fox AJ, Bolton FJ & Upton M 2012 'Population structure, virulence potential and antibiotic susceptibility of uropathogenic Escherichia coli from Northwest England' J Antimicrob Chemother 67, (2) 346-356 Author Site , DOI
Upton M, Cotter P & Tagg J 2012 'Antimicrobial peptides as therapeutic agents' Int J Microbiol 2012, Author Site , DOI PEARL
Totsika M, Beatson SA, Sarkar S, Phan M-D, Petty NK, Bachmann N, Szubert M, Sidjabat HE, Paterson DL & Upton M 2011 'Insights into a Multidrug Resistant Escherichia coli Pathogen of the Globally Disseminated ST131 Lineage: Genome Analysis and Virulence Mechanisms' PLOS ONE 6, (10) Author Site , DOI PEARL
Al-Hamad A, Burnie J & Upton M 2011 'Enhancement of antibiotic susceptibility of Stenotrophomonas maltophilia using a polyclonal antibody developed against an ABC multidrug efflux pump' Can J Microbiol 57, (10) 820-828 Author Site , DOI
Al-Mahrous MM, Jack RW, Sandiford SK, Tagg JR, Beatson SA & Upton M 2011 'Identification of a haemolysin-like peptide with antibacterial activity using the draft genome sequence of Staphylococcus epidermidis strain A487' FEMS Immunol Med Microbiol 62, (3) 273-282 Author Site , DOI
Wescombe PA, Upton M, Renault P, Wirawan RE, Power D, Burton JP, Chilcott CN & Tagg JR 2011 'Salivaricin 9, a new lantibiotic produced by Streptococcus salivarius' Microbiology 157, (Pt 5) 1290-1299 Author Site , DOI
Al-Mahrous MM & Upton M 2011 'Discovery and development of lantibiotics; antimicrobial agents that have significant potential for medical application' Expert Opin Drug Discov 6, (2) 155-170 Author Site , DOI
Al-Mahrous M, Sandiford SK, Tagg JR & Upton M 2010 'Purification and characterization of a novel delta-lysin variant that inhibits Staphylococcus aureus and has limited hemolytic activity' Peptides 31, (9) 1661-1668 Author Site , DOI
Ben-Darif E, De Pinna E, Threlfall EJ, Bolton FJ, Upton M & Fox AJ 2010 'Comparison of a semi-automated rep-PCR system and multilocus sequence typing for differentiation of Salmonella enterica isolates' J Microbiol Methods 81, (1) 11-16 Author Site , DOI
Ben-Darif E, Jury F, De Pinna E, Threlfall EJ, Bolton FJ, Fox AJ & Upton M 2010 'Development of a multiplex primer extension assay for rapid detection of Salmonella isolates of diverse serotypes' J Clin Microbiol 48, (4) 1055-1060 Author Site , DOI
Lau SH, Cheesborough J, Kaufmann ME, Woodford N, Dodgson AR, Dodgson KJ, Bolton EJ, Fox AJ & Upton M 2010 'Rapid identification of uropathogenic Escherichia coli of the O25:H4-ST131 clonal lineage using the DiversiLab repetitive sequence-based PCR system' Clin Microbiol Infect 16, (3) 232-237 Author Site , DOI
Daly KM, Upton M, Sandiford SK, Draper LA, Wescombe PA, Jack RW, O'Connor PM, Rossney A, Goetz F & Hill C 2010 'Production of the Bsa Lantibiotic by Community-Acquired Staphylococcus aureus Strains' JOURNAL OF BACTERIOLOGY 192, (4) 1131-1142 Author Site , DOI
Cargill JS & Upton M 2009 'Low concentrations of vancomycin stimulate biofilm formation in some clinical isolates of Staphylococcus epidermidis' J Clin Pathol 62, (12) 1112-1116 Author Site , DOI
Macintosh RL, Brittan JL, Bhattacharya R, Jenkinson HF, Derrick J, Upton M & Handley PS 2009 'The terminal A domain of the fibrillar accumulation-associated protein (Aap) of Staphylococcus epidermidis mediates adhesion to human corneocytes' J Bacteriol 191, (22) 7007-7016 Author Site , DOI
Al-Hamad A, Upton M & Burnie J 2009 'Molecular cloning and characterization of SmrA, a novel ABC multidrug efflux pump from Stenotrophomonas maltophilia' J Antimicrob Chemother 64, (4) 731-734 Author Site , DOI
Moat J, Cargill J, Shone J & Upton M 2009 'Application of a novel decontamination process using gaseous ozone' Can J Microbiol 55, (8) 928-933 Author Site , DOI
Clermont O, Dhanji H, Upton M, Gibreel T, Fox A, Boyd D, Mulvey MR, Nordmann P, Ruppe E & Sarthou JL 2009 'Rapid detection of the O25b-ST131 clone of Escherichia coli encompassing the CTX-M-15-producing strains' JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 64, (2) 274-277 Author Site , DOI
Jones GL, Warren RE, Skidmore SJ, Davies VA, Gibreel T & Upton M 2008 'Prevalence and distribution of plasmid-mediated quinolone resistance genes in clinical isolates of Escherichia coli lacking extended-spectrum beta-lactamases' JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 62, (6) 1245-1251 Author Site , DOI
Lau SH, Kaufmann ME, Livermore DM, Woodford N, Willshaw GA, Cheasty T, Stamper K, Reddy S, Cheesbrough J & Bolton FJ 2008 'UK epidemic Escherichia coli strains A-E, with CTX-M-15 beta-lactamase, all belong to the international O25:H4-ST131 clone' J Antimicrob Chemother 62, (6) 1241-1244 Author Site , DOI
Kwan PSL, Barrigas M, Bolton FJ, French NP, Gowland P, Kemp R, Leatherbarrow H, Upton M & Fox AJ 2008 'Molecular epidemiology of Campylobacter jejuni populations in dairy cattle, wildlife, and the environment in a farmland area' Appl Environ Microbiol 74, (16) 5130-5138 Author Site , DOI
Kwan PSL, Birtles A, Bolton FJ, French NP, Robinson SE, Newbold LS, Upton M & Fox AJ 2008 'Longitudinal study of the molecular epidemiology of Campylobacter jejuni in cattle on dairy farms' Appl Environ Microbiol 74, (12) 3626-3633 Author Site , DOI
Lau SH, Reddy S, Cheesbrough J, Bolton FJ, Willshaw G, Cheasty T, Fox AJ & Upton M 2008 'Major uropathogenic Escherichia coli strain isolated in the northwest of England identified by multilocus sequence typing' J Clin Microbiol 46, (3) 1076-1080 Author Site , DOI
Banner MA, Cunniffe JG, Macintosh RL, Foster TJ, Rohde H, Mack D, Hoyes E, Derrick J, Upton M & Handley PS 2007 'Localized tufts of fibrils on Staphylococcus epidermidis NCTC 11047 are comprised of the accumulation-associated protein' J Bacteriol 189, (7) 2793-2804 Author Site , DOI
Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP & Tagg JR 2007 'Salivaricin A2 and the novel lantibiotic salivaricin B are encoded at adjacent loci on a 190-kilobase transmissible megaplasmid in the oral probiotic strain Streptococcus salivarius K12' Appl Environ Microbiol 73, (4) 1107-1113 Author Site , DOI
Kwan PSL, Bolton FJ, Upton M & Fox AJ 2007 'A lack of polymorphic tandem repeats in Campylobacter jejuni genome limits the development of multiple-locus variable number of tandem repeat analysis typing schemes' ZOONOSES AND PUBLIC HEALTH 54, 40-40 Author Site
Kwan PSL, Barrigas M, Bolton FJ, Gowland P, Kemp R, Leatherbarrow H, French NP, Upton M & Fox AJ 2007 'The molecular epidemiology of Campylobacter jejuni populations in a farmland environment' ZOONOSES AND PUBLIC HEALTH 54, 137-138 Author Site
Jury F, Al-Mahrous M, Apostolou M, Sandiford S, Fox A, Ollier W & Upton M 2006 'Rapid cost-effective subtyping of meticillin-resistant Staphylococcus aureus by denaturing HPLC' J Med Microbiol 55, (Pt 8) 1053-1060 Author Site , DOI
Wescombe PA, Upton M, Dierksen KP, Ragland NL, Sivabalan S, Wirawan RE, Inglis MA, Moore CJ, Walker GV & Chilcott CN 2006 'Production of the lantibiotic salivaricin A and its variants by oral streptococci and use of a specific induction assay to detect their presence in human saliva' Appl Environ Microbiol 72, (2) 1459-1466 Author Site , DOI
Upton M, Tagg JR, Wescombe P & Jenkinson HF 2001 'Intra- and interspecies signaling between Streptococcus salivarius and Streptococcus pyogenes mediated by SalA and SalA1 lantibiotic peptides' JOURNAL OF BACTERIOLOGY 183, (13) 3931-3938 Author Site , DOI
Upton M, Hill B, Edwards C, Saunders JR, Ritchie DA & Lloyd D 2000 'Combined molecular ecological and confocal laser scanning microscopic analysis of peat bog methanogen populations' FEMS Microbiol Lett 193, (2) 275-281 Author Site , DOI
Upton M 2000 'Combined molecular ecological and confocal laser scanning microscopic analysis of peat bog methanogen populations' FEMS Microbiology Letters 193, (2) 275-281 , DOI
Upton M & Upton C 1999 'Novel nitrated derivatives of 5,8-diazabenzo[c] phenanthrene and 9,14-diazadibenz[a,e] acephenanthrylene: new classes of potent mutagenic compounds' MUTAGENESIS 14, (6) 587-593 Author Site , DOI
McDonald IR, Upton M, Hall G, Pickup RW, Edwards C, Saunders JR, Ritchie DA & Murrell JC 1999 'Molecular ecological analysis of methanogens and methanotrophs in blanket bog peat' MICROBIAL ECOLOGY 38, (3) 225-233 Author Site , DOI
Nercessian D, Upton M, Lloyd D & Edwards C 1999 'Phylogenetic analysis of peat bog methanogen populations' FEMS MICROBIOLOGY LETTERS 173, (2) 425-429 Author Site , DOI
Nercessian D 1999 'Phylogenetic analysis of peat bog methanogen populations' FEMS Microbiology Letters 173, (2) 425-429 , DOI
Edwards C, Hales BA, Hall GH, McDonald IR, Murrell JC, Pickup R, Ritchie DA, Saunders JR, Simon BM & Upton M 1998 'Microbiological processes in the terrestrial carbon cycle: Methane cycling in peat' ATMOSPHERIC ENVIRONMENT 32, (19) 3247-3255 Author Site , DOI
Upton M, Jaeda MI & Upton C 1998 'Novel 5,8-diazabenzo[c]phenanthrenes: Synthesis and mutagenicity' JOURNAL OF PHARMACY AND PHARMACOLOGY 50, (5) 475-482 Author Site , DOI
Lloyd D, Thomas KL, Hayes A, Hill B, Hales BA, Edwards C, Saunders JR, Ritchie DA & Upton M 1998 'Micro-ecology of peat: minimally invasive analysis using confocal laser scanning microscopy, membrane inlet mass spectrometry and PCR amplification of methanogen-specific gene sequences' FEMS MICROBIOLOGY ECOLOGY 25, (2) 179-188 Author Site , DOI
Lloyd D 1998 'Micro-ecology of peat: minimally invasive analysis using confocal laser scanning microscopy, membrane inlet mass spectrometry and PCR amplification of methanogen-specific gene sequences' FEMS Microbiology Ecology 25, (2) 179-188 , DOI
Upton M, Pennington TH, Haston W & Forbes KJ 1997 'Detection of human commensals in the area around an Antarctic research station' ANTARCTIC SCIENCE 9, (2) 156-161 Author Site , DOI
Upton M, Carter PE, Orange G & Pennington TH 1996 'Genetic heterogeneity of M type 3 group A streptococci causing severe infections in Tayside, Scotland' J Clin Microbiol 34, (1) 196-198 Author Site , DOI
Upton M, Carter PE, Morgan M, Edwards GF & Pennington TH 1995 'Clonal structure of invasive Streptococcus pyogenes in Northern Scotland' Epidemiol Infect 115, (2) 231-241 Author Site , DOI
Upton M 0 'Analysis of DNA Sequences' Environmental Monitoring of Bacteria Humana Press 119-126 , DOI
Upton M 0 'Automated Sequencing of DNA Retrieved from Environmental Samples' Environmental Monitoring of Bacteria Humana Press 109-118 , DOI
Conference Papers
Castelino M, Tutino M, Moat J, Ijaz UZ, Parslew R, Al-Sharqi A, Warren RB, Quince C, Ho P & Upton M 2017 'AB0115 Comparison of the bacterial stool microbiota in established psoriatic arthritis (PSA) and psoriasis (PSC) - exploratory analysis of pilot data' Annual European Congress of Rheumatology, 14–17 June, 2017 1-/-0/1900 1-/-0/1900 BMJ Publishing Group Ltd and European League Against Rheumatism , DOI PEARL
Castelino M, Eyre S, Tutino M, Moat J, Martin P, Ijaz U, Quince C, Ho P, Upton M & Barton A 2015 'Bacterial Skin Microbiome in Psoriatic Arthritis (A)over-tildec(a)over-cap, (a)over-cap(sic)oe Pilot Data from Psoriatic Plaques on Dry Skin Sites from Patients with Psoriasis (PsC) and Psoriatic Arthritis (PsA)' 1-/-0/1900 1-/-0/1900
Castelino M, Eyre S, Moat J, Fox G, Martin P, Ijaz U, Quince C, Ho P, Upton M & Barton A 2015 'The skin microbiome in psoriatic arthritis: methodology development and pilot data' 1-/-0/1900 1-/-0/1900 Elsevier BV S27-S27 , DOI
Abdellatif E, Upton M & Freemont AJ 2012 'Synovial Fluid (SF) Antibacterial Effect and the Possibility of Using this Feature as a Diagnostic Test for Septic Arthritis (SA)' 1-/-0/1900 1-/-0/1900 S32-S32
Efstratiou A, George RC, Tanna A, Hookey JV, Caugant D, Holm SE, Kriz P, Martin D, Upton M & Cartwright KAV 1997 'Characterisation of Group A Streptococci from Necrotising Fasciitis Cases in Gloucestershire, United Kingdom' 1-/-0/1900 1-/-0/1900 Springer US 91-93 , DOI
Fotheringham I & Upton M 2016 MICROBIAL PRODUCTION - Cutting-edge inABLE® technology: The key to cost-effective production of a novel antimicrobial peptide with potential for the treatment of MRSA.

Other academic activities

Patents granted or filed

  1. Tagg, JR., K. Dierksen & M. Upton. Salivaricin B, a novelstreptococcal lantibiotic with therapeutic potential. 500261 (NZ, October2000); 09/913,763(USA August 2004).
  2. Upton, M., & SK. Sandiford. Novel peptide antibiotic. PCT/GB2010/052106. Filed December 2010.
  3. Two additional patents filed in 2014, both now progressed to PCT

I have acted as a consultant for the following external organisations:

Omnia-Chem - 2012

SGS International - 2010

Footprint International Ltd - 2010

TrueReflections – 2009