Dr Tina Joshi
Lecturer in Molecular Microbiology
Plymouth University Peninsula Schools of Medicine and Dentistry
Lecturer in Molecular Microbiology (2017-)
Teaching and Research
ORCID ID: 0000-0002-5965-4055
After completing BSc and PhD studies at Cardiff University, I undertook several postdoctoral roles from 2012-2017 before commencement of a Lectureship at the University of Plymouth.
Associate Fellow Higher Education Academy
Member of Royal Society of Biology (MRSB)
Member of Society for Applied Microbiology
Member of Microbiology Society
Roles on external bodies
Molecular microbiology in infection disease, clinical microbiology, molecular diagnosis of microbial infections and bacterial genomics. This includes supervision of PG and UG students.
Rapid point of care detection of Antimicrobial resistant (AMR) bacteria
By 2050 it is estimated that 10 million people world-wide will die as a result of being infected with drug- resistant bacteria (Lord Jim O’Neil, 2014). Bacteria which were previously susceptible to antibiotic treatment have evolved to develop resistance to commonly used antibiotics, rendering them ineffective to combat infection. Now there are fewer antibiotics available to treat patients with certain infections. Hence, there is a global drive not only to discover new antibiotics to combat these bacteria, but also to develop new types of diagnostics that can help diagnose infection at point of care.
My research focusses on designing rapid, point of care nucleic acid-based assays for detection of AMR resistance genes. This research is highly interdisciplinary in nature utilising microwave engineering (in collaboration with Cardiff University) to liberate bacterial/spore DNA and DNA electrochemistry within the assay itself. A key part of this research includes integration of the assay into novel label-free biosensors (in collaboration with Plymouth University) and understanding the mechanisms by which microwaves interact with the bacterial DNA.
I have 10 years of experience in development of novel microwave enhanced rapid diagnostics for microbial detection.
INTERVIEW on my research (Royal Society of Biology): https://www.youtube.com/watch?v=jC9Qy_o8e3U
Areas of expertise associated with the above include: Field effect transistors, thin-film transistors, Microwave engineering, aptamer design, aptamer-functionalisation of nanoparticles, microwave-accelerated metal enhanced fluorescence, microbial bioinformatics and biosensor development.
C. difficile Infection control:
Clostridium difficile is the primary cause of hospital acquired infection globally. In the US it contributes to 14 000 deaths/year, costing ~$1 billion annually (CDC, USA), while in the UK between 2006-2011 it was responsible for 29 425 deaths, (Office for National Statistics) costing £500 million/year. Its spores are resistant to desiccation and microbicide treatment and are able to persist on surfaces for months. My research focusses on understanding how C. difficile spores adhere to varying clinical surfaces and respond to biocidal insult, as well as using next generation sequencing techniques to understand spore epidemiology.
I have an ongoing interest in the discovery and activity of novel antimicrobial peptides from invertebrates.
Research degrees awarded to supervised students
Grants & contracts
Adherence of C. difficile spores to surgical gowns
Dr. Robert Burky & Rideout Hospital, California, USA, & University of California (UCLA)
Cardiff School of Pharmacy and Pharmaceutical Sciences Travel Grant. Biology of Anthrax, Tampa, Florida. November 2016
Key publications are highlightedJournals
Other academic activities
Baillie, L & Joshi L.T. PCT/GB2013/051149 & PCT/GB2013/051151. A screening method for the detection of Clostridium difficile.
New Scientist Live! “Ask a Biologist” Expert. “Could microwaves save my life?”. Royal Society of Biology. Excel Arena, London. Saturday 30th September 2017
Science and the Assembly- Antimicrobial Resistance. Invited Expert Panel Member. Detection of Antimicrobial Resistance. Now and the Future. National Assembly of Wales, Royal Society of Chemistry, 6th June 2017
STEM Event at Pontypridd High School 20th June 2016
“RS Accessing the Scientists” event at Houses of Parliament, Westminster, UK (23rd November 2015).
Stem Live! Promoting Engineering to KS3 school pupils. Cardiff University 16th September 2015.
BBC Radio Wales interview about “Women in Science” June 2015.
“SoapBox Science Swansea June 2015” promoting and disseminating research done by female scientists in STEM. Given to Public. “Microwaving superbugs – transforming point-of-care diagnostics” & BBC Radio Wales interview
SET for Britain Finalist March 2015. Houses of Parliament, Westminster, UK.
Broadcast on Radio Cardiff December 2014 to explain my research into rapid detection of AMR
Institute of Engineering Schools Christmas Lecture December 2014 “Bug busting- new microwave assisted approaches for detecting antibiotic resistant bacteria”. Given to pupils from high schools in the local area to encourage interest in STEM subjects.
Environment Day 2014:28th October, St Davids Centre: honey as a source of new medicines.
“Biology Rocks” at National Museum, Cardiff, 2014; encouraging children at primary school level to learn about antibiotic resistant bacteria
Cardiff Science Festival 2014: Institute of Engineering and Technology (IET) Public Lecture,Cardiff Science Festival July 2014. “Bug busting- new microwave assisted approaches for detecting antibiotic resistant bacteria”. Informing public about antimicrobial resistance.