Hepatology Research Group

The hepatology research group (HRG) is an integral part of the Institute of Translational and Stratified Medicine (ITSMed). We utilise state of the art laboratory facilities based in the John Bull Building, and the world class clinical research strengths of PUPSMD and Plymouth Hospitals NHS Trust (PHNT). 

We work in unison with the South West Liver Unit, at Plymouth Hospitals NHS Trust, providing a full range and secondary, tertiary and community Hepatology services to the South West region, including assessment for liver transplantation, TIPS and liver cancer therapy. 

The research team run several commercially sponsored clinical trials in hepatitis C therapy, non-alcoholic steatohepatitis (NASH), primary biliary cholangiopathy (PBC), alcoholic liver disease and liver failure amongst others, through the clinical research facilities of The Lind Research Centre at Derriford Hospital.

The broad themes of the hepatology research group are:

  • Protection from hepatitis C virus infection – PI Professor Matthew Cramp
  • Lipid metabolism and the pathogenesis & treatment of non-alcoholic steatohepatitis – PI Dr David Sheridan
  • Alcoholic hepatitis – PI Ashwin Dhanda
  • Molecular virology of hepatitis C and other hepatitis viruses – PI Dr Dan Felmlee

Research funding

Research projects are supported by:

  • Medical Research Council (Stop HCV)
  • NIHR
  • Mary Kinross Trust
  • Plymouth Hospital NHS Trust

Research opportunities 

  • Clinical Research Fellow in Hepatology: find out more information and how to apply for this role on the NHS website
  • PhD Studentship starting 1 October 2016: Investigation of methylamines and mitochondrial dysfunction in the progression from non-alcoholic fatty liver [NAFL] (simple steatosis) to non-alcoholic steatohepatitis (NASH)
  • Clinical Research Fellow position: registrar who wishes to undertake research leading to a PhD working with the South West Liver Unit, Plymouth University Peninsula Schools of Medicine and Dentistry (Prof M E Cramp and Dr M Jarvis) and the Institute of Liver Studies King's College Hospital (Dr A Quaglia).

Contact us

John Bull Building, Plymouth University Peninsula Schools of Medicine and Dentistry, Plymouth Science Park, Plymouth, PL6 8BU