Hepatology Research Group

The hepatology research group (HRG) is an integral part of the Institute of Translational and Stratified Medicine (ITSMed). We utilise state of the art laboratory facilities based in the John Bull Building, and the world class clinical research strengths of the Faculty of Health and Plymouth Hospitals NHS Trust (PHNT).

We work in unison with the South West Liver Unit, at Plymouth Hospitals NHS Trust, providing a full range and secondary, tertiary and community Hepatology services to the South West region, including assessment for liver transplantation, TIPS and liver cancer therapy.

The research team run several commercially sponsored clinical trials in hepatitis C therapy, non-alcoholic steatohepatitis (NASH), primary biliary cholangiopathy (PBC), alcoholic liver disease and liver failure amongst others, through the clinical research facilities of The Lind Research Centre at Derriford Hospital.

Hepatology Research Group Annual Reports

The broad themes of the hepatology research group are:

The Hepatology Research Group is managed by Dr Doha Hegazy

Hepatology Research Group on Twitter


Williams R, Alexander G, Aspinall R, Bosanquet J, Camps-Walsh G, Cramp M, Day N, Dhawan A, Dillon J, Dyson J, Ferguson J, Foster G, Gardner R, Gilmore SI, Hardman L, Hudson M, Kelly D, Langford A, Liversedge S, Moriarty K, Newsome P, O'Grady J, Pryke R, Rolfe L, Rutter H, Ryder S, Samyn M, Sheron N, Taylor A, Thompson J, Verne J, Yeoman A (2017) ‘New metrics for the Lancet Standing Commission on Liver Disease in the UK’ Lancet 389, (10083) 2053-2080

Sheridan DA, Hajarizadeh B, Fenwick FI, Matthews GV, Applegate T, Douglas M, Neely D, Askew B, Dore GJ, Lloyd AR, George J, Bassendine MF, Grebely J. (2016) ‘Maximum levels of hepatitis C virus lipoviral particles are associated with early and persistent infection’ Liver Int. 36, (12) 1774-1782

Williams EL, Stimpson ML, Collins PL, Enki DG, Sinha A, Lee RW, Dhanda AD (2016) ‘Development and validation of a novel bioassay to determine glucocorticoid sensitivity’ Biomark Res. 4, 26

Swann RE, Mandalou P, Robinson MW, Ow MM, Foung SK, McLauchlan J, Patel AH, Cramp ME (2016) ‘Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection’ J Viral Hepat. 23, (11) 873-880

Shariff MI, Kim JU, Ladep NG, Crossey MM, Koomson LK, Zabron A, Reeves H, Cramp M, Ryder S, Greer S, Cox IJ, Williams R, Holmes E, Nash K, Taylor-Robinson SD (2016) ‘Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy’ J Clin Exp Hepatol. 6, (3)186-194

Hepatology research team

Meet the hepatology research team and our collaborators.

Find out more about our researchers

OPINION - The escalating cost of alcohol misuse, obesity and viral hepatitis

Liver disease has become one of the most common causes of premature death in the UK, with a cost not just in lives but also to health services and society.

Read the full article from Matthew Cramp

Contact us

John Bull Building, Faculty of Health, Plymouth Science Park, Plymouth, PL6 8BU

Patient participation group

Patient led group with the remit of supporting development clinical services in the South West Liver Unit and Hepatology Research in Plymouth.

To get involved or for more information please contact Jayne Davies jaynedavies@nhs.net.

For patient support please contact Friends of Liver Lifeline.