Professor Matthew Cramp
Profiles

Professor Matthew Cramp

Chair in Hepatology

Peninsula Medical School (Faculty of Health)

Matthew can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Hepatitis
  • Liver
  • Obesity
  • COVID-19
  • Hepatology 
  • Liver disease
  • Alcohol misuse
  • Liver transplants
Biography

Biography

Publications

Publications

Key publications

Key publications are highlighted

Journals
Articles
Alsaleh M, Leftley Z, O’Connor T, Hughes T, Barbera TA, Koomson LK, Zabron A, Reeves H, Cramp M & Ryder SD (2021) 'Mapping of population disparities in the cholangiocarcinoma urinary metabolome' Scientific Reports 11, (1) , DOI Open access
Vergara C, Duggal P, Thio CL, Valencia A, O’Brien TR, Latanich R, Timp W, Johnson EO, Kral AH & Mangia A (2020) 'Correction: Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection' Genes & Immunity 21, (6-8) 420-420 , DOI
Johnson PJ, Berhane S, Walker AJ, Gordon FH, Ryder SD, McPherson S, Sreedharan A, Ustianowski AA, Agarwal K & Mutimer D (2020) 'Impact of direct‐acting antiviral agents on liver function in patients with chronic hepatitis C virus infection' Journal of Viral Hepatitis 28, (1) 168-176 , DOI
Vergara C, Valencia A, Thio CL, Goedert JJ, Mangia A, Piazzolla V, Johnson E, Kral AH, O’Brien TR & Mehta SH (2020) 'A Multiancestry Sex-Stratified Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus' The Journal of Infectious Diseases , DOI
Vergara C, Duggal P, Thio CL, Valencia A, O’Brien TR, Latanich R, Timp W, Johnson EO, Kral AH & Mangia A (2020) 'Multi-ancestry fine mapping of interferon lambda and the outcome of acute hepatitis C virus infection' Genes & Immunity 21, (5) 348-359 , DOI
Tan HK, Streeter A, Cramp ME & Dhanda AD (2020) 'Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis' World Journal of Hepatology 12, (7) 389-398 , DOI Open access
Dhanda A, Atkinson S, Vergis N, Enki D, Fisher A, Clough R, Cramp M & Thursz M (2020) 'Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis' Alimentary Pharmacology & Therapeutics , DOI Open access
Millson C, Considine A, Cramp ME, Holt A, Hubscher S, Hutchinson J, Jones K, Leithead J, Masson S & Menon K (2020) 'Adult liver transplantation: A UK clinical guideline - part 1: pre-operation' Frontline Gastroenterology 11, (5) 375-384 , DOI
Millson C, Considine A, Cramp ME, Holt A, Hubscher S, Hutchinson J, Jones K, Leithead J, Masson S & Menon K (2020) 'Adult liver transplantation: UK clinical guideline - part 2: surgery and post-operation' Frontline Gastroenterology 11, (5) 385-396 , DOI
Sánchez-Fueyo A, Whitehouse G, Grageda N, Cramp ME, Lim TY, Romano M, Thirkell S, Lowe K, Fry L & Heward J (2020) 'Applicability, safety, and biological activity of regulatory T cell therapy in liver transplantation' American Journal of Transplantation 20, (4) 1125-1136 , DOI Open access
Lim TY, McPhail MJ, Shah A, Mahgoub S, Nayagam J, Cramp M, Bernal W, Menon K, Jassem W & Joshi D (2020) 'Sequential Cohort Analysis After Liver Transplantation Shows de Novo Extended Release Tacrolimus Is Safe, Efficacious, and Minimizes Renal Dysfunction' Transplantation Direct 6, (2) , DOI Open access
Alsaleh M, Leftley Z, Barbera TA, Koomson LK, Zabron A, Crossey MME, Reeves HL, Cramp M, Ryder S & Greer S (2020) 'Characterisation of the Serum Metabolic Signature of Cholangiocarcinoma in a United Kingdom Cohort' Journal of Clinical and Experimental Hepatology 10, (1) 17-29 , DOI
Williams R, Aithal G, Alexander GJ, Allison M, Armstrong I, Aspinall R, Baker A, Batterham R, Brown K & Burton R (2020) 'Unacceptable failures: the final report of the Lancet Commission into liver disease in the UK' The Lancet 395, (10219) 226-239 , DOI
Dhanda AD, Yates E, Schewitz-Bowers LP, Lait PJ, Lee RWJ & Cramp ME (2019) 'Ex Vivo T Cell Cytokine Expression Predicts Survival in Patients with Severe Alcoholic Hepatitis' Gut and Liver , DOI Open access
Dhanda AD, Williams EL, Yates E, Lait PJP, Schewitz-Bowers LP, Hegazy D, Cramp ME, Collins PL & Lee RWJ (2019) 'Intermediate Monocytes in Acute Alcoholic Hepatitis Are Functionally Activated and Induce IL-17 Expression in CD4+T Cells' The Journal of Immunology 203, (12) 3190-3198 , DOI
Norton BC, Srivastava A, Ramos K, Vine L, Taylor R, Aluvihare V, Heaton N & Cramp ME (2019) 'Risk-adjusted survival in liver transplant patients assessed and managed by a non-transplanting centre: South West Liver Unit experience' Frontline Gastroenterology 11, (3) 202-208 , DOI
Lawitz E, Gane E, Feld JJ, Buti M, Foster GR, Rabinovitz M, Burnevich E, Katchman H, Tomasiewicz K & Lahser F (2019) 'Efficacy and safety of a two‐drug direct‐acting antiviral agent regimen ruzasvir 180 mg and uprifosbuvir 450 mg for 12 weeks in adults with chronic hepatitis C virus genotype 1, 2, 3, 4, 5 or 6' Journal of Viral Hepatitis , DOI
Bennett K, Enki DG, Thursz M, Cramp ME & Dhanda AD (2019) 'Systematic review with meta‐analysis: high mortality in patients with non‐severe alcoholic hepatitis' Alimentary Pharmacology and Therapeutics , DOI Open access
Borgia SM, Dearden J, Yoshida EM, Shafran SD, Brown A, Ben-Ari Z, Cramp ME, Cooper C, Foxton M & Rodriguez CF (2019) 'Sofosbuvir/velpatasvir for 12 weeks in hepatitis C virus-infected patients with end-stage renal disease undergoing dialysis' Journal of Hepatology 71, (4) 660-665 , DOI Open access
Vergara C, Thio CL, Johnson E, Kral AH, O’Brien TR, Goedert JJ, Mangia A, Piazzolla V, Mehta SH & Kirk GD (2019) 'Multi-Ancestry Genome-Wide Association Study of Spontaneous Clearance of Hepatitis C Virus' Gastroenterology 156, (5) 1496-1507.e7 , DOI
Williams R, Alexander G, Aspinall R, Batterham R, Bhala N, Bosanquet N, Severi K, Burton A, Burton R & Cramp ME (2018) 'Gathering momentum for the way ahead: fifth report of the Lancet Standing Commission on Liver Disease in the UK' The Lancet 392, (10162) 2398-2412 , DOI
Dyson JK, Wong LL, Bigirumurame T, Hirschfield GM, Kendrick S, Oo YH, Lohse AW, Heneghan MA & Jones DEJ (2018) 'Inequity of care provision and outcome disparity in autoimmune hepatitis in the United Kingdom' Alimentary Pharmacology & Therapeutics 48, (9) 951-960 , DOI
Carbone M, Nardi A, Flack S, Carpino G, Varvaropoulou N, Gavrila C, Spicer A, Badrock J, Bernuzzi F & Cardinale V (2018) 'Pretreatment prediction of response to ursodeoxycholic acid in primary biliary cholangitis: development and validation of the UDCA Response Score' The Lancet Gastroenterology & Hepatology 3, (9) 626-634 , DOI
Foster GR, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM (2018) 'Elbasvir/grazoprevir and sofosbuvir for hepatitis C virus genotype 3 infection with compensated cirrhosis: A randomized trial' Hepatology 67, (6) 2113-2126 , DOI
Williams R, Alexander G, Armstrong I, Baker A, Bhala N, Camps-Walsh G, Cramp ME, de Lusignan S, Day N & Dhawan A (2017) 'Disease burden and costs from excess alcohol consumption, obesity, and viral hepatitis: fourth report of the Lancet Standing Commission on Liver Disease in the UK' The Lancet 391, (10125) 1097-1107 , DOI
Ow MM, Hegazy D, Warshow UM & Cramp ME (2017) 'Enhanced natural killer cell activity is found in exposed uninfected recipients of hepatitis C-contaminated blood' Journal of Viral Hepatitis 25, (3) 245-253 , DOI Open access
Huang H, Duggal P, Thio CL, Latanich R, Goedert JJ, Mangia A, Cox AL, Kirk GD, Mehta S & Aneja J (2017) 'Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection' Scientific Reports 7, Author Site , DOI Open access
Shawa IT, Sheridan DA, Felmlee DJ & Cramp ME (2017) 'Lipid interactions influence hepatitis C virus susceptibility and resistance to infection' Clinical Liver Disease 10, (1) 17-20 , DOI Open access
Shawa IT, Felmlee DJ, Hegazy D, Sheridan DA & Cramp ME (2017) 'Exploration of potential mechanisms of HCV resistance in exposed uninfected intravenous drug users' Journal of Viral Hepatitis , DOI Open access
Razavi H, Robbins S, Zeuzem S, Negro F, Buti M, Duberg A-S, Roudot-Thoraval F, Craxi A, Manns M & Marinho RT (2017) 'Hepatitis C virus prevalence and level of intervention required to achieve the WHO targets for elimination in the European Union by 2030: a modelling study' The Lancet Gastroenterology & Hepatology 2, (5) 325-336 , DOI
Williams R, Alexander G, Aspinall R, Bosanquet J, Camps-Walsh G, Cramp M, Day N, Dhawan A, Dillon J & Dyson J (2017) 'New metrics for the Lancet Standing Commission on Liver Disease in the UK' The Lancet 389, (10083) 2053-2080 , DOI
Blach S, Zeuzem S, Manns M, Altraif I, Duberg A-S, Muljono DH, Waked I, Alavian SM, Lee M-H & Negro F (2017) 'Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study' The Lancet Gastroenterology & Hepatology 2, (3) 161-176 , DOI
Dhanda AD, Sinha A, Hunt V, Saleem S, Cramp ME & Collins PL (2017) 'Infection does not increase long-term mortality in patients with acute severe alcoholic hepatitis treated with corticosteroids' World Journal of Gastroenterology 23, (11) 2052-2052 , DOI Open access
Acevedo JG & Cramp ME (2017) 'Hepatorenal syndrome: Update on diagnosis and therapy' World Journal of Hepatology 9, (6) 293-293 , DOI Open access
Shariff MIF, Kim JU, Ladep NG, Crossey MME, Koomson LK, Zabron A, Reeves H, Cramp M, Ryder S & Greer S (2016) 'Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy' Journal of Clinical and Experimental Hepatology 6, (3) 186-194 , DOI
Swann RE, Mandalou P, Robinson MW, Ow MM, Foung SKH, McLauchlan J, Patel AH & Cramp ME (2016) 'Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection' Journal of Viral Hepatitis 23, (11) 873-880 , DOI Open access
Vine LJ, Sieberhagen C & Cramp ME (2015) 'Diagnosis and management of hepatitis C' British Journal of Hospital Medicine 76, (11) 625-630 , DOI
Williams R, Ashton K, Aspinall R, Bellis MA, Bosanquet J, Cramp ME, Day N, Dhawan A, Dillon J & Dyson J (2015) 'Implementation of the Lancet Standing Commission on Liver Disease in the UK' The Lancet 386, (10008) 2098-2111 , DOI
Carbone M, Sharp SJ, Flack S, Paximadas D, Spiess K, Adgey C, Griffiths L, Lim R, Trembling P & Williamson K (2015) 'The UK-PBC risk scores: Derivation and validation of a scoring system for long-term prediction of end-stage liver disease in primary biliary cholangitis' Hepatology 63, (3) 930-950 , DOI
Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM, Greene CS, Xie G, Juran BD, Zhu D & Qian DC (2015) 'International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways' Nature Communications 6, (1) , DOI Open access
Houldsworth A, Metzner M, Hodgkinson A, Shaw S, Kaminski E, Demaine AG & Cramp ME (2015) 'Haplotype analysis finds linkage disequilibrium in the IL-12 gene in patients with HCV' J Med Virol 87, (7) 1207-1217 Author Site , DOI
Martin NK, Foster GR, Vilar J, Ryder S, Cramp ME, Gordon F, Dillon JF, Craine N, Busse H & Clements A (2015) 'HCV treatment rates and sustained viral response among people who inject drugs in seven UK sites: real world results and modelling of treatment impact' JOURNAL OF VIRAL HEPATITIS 22, (4) 399-408 Author Site , DOI Open access
Williams R, Aspinall R, Bellis M, Camps-Walsh G, Cramp M, Dhawan A, Ferguson J, Forton D, Foster G & Gilmore I (2014) 'Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis' Lancet 384, (9958) 1953-1997 Author Site , DOI
Williams R, Aspinall R, Bellis M, Camps-Walsh G, Cramp M, Dhawan A, Ferguson J, Forton D, Foster G & Gilmore I (2014) 'Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis' Lancet 384, (9958) 1953-1997 Author Site
Ow MMG, Erasmus P, Minto G, Struthers R, Joseph M, Smith A, Warshow UM, Cramp ME & Cross TJS (2014) 'Impaired functional capacity in potential liver transplant candidates predicts short-term mortality before transplantation' Liver Transpl 20, (9) 1081-1088 Author Site , DOI
Jothimani D, Cramp ME & Cross TJS (2014) 'Role of mycophenolate mofetil for the treatment of autoimmune hepatitis-an observational study' J Clin Exp Hepatol 4, (3) 221-225 Author Site , DOI
Cramp ME, Rosenberg WM, Ryder SD, Blach S & Parkes J (2014) 'Modelling the impact of improving screening and treatment of chronic hepatitis C virus infection on future hepatocellular carcinoma rates and liver-related mortality' BMC Gastroenterol 14, Author Site , DOI Open access
Houldsworth A, Metzner M, Shaw S, Kaminski E, Demaine AG & Cramp ME (2014) 'Polymorphic differences in SOD-2 may influence HCV viral clearance' J Med Virol 86, (6) 941-947 Author Site , DOI
Bruggmann P, Berg T, Øvrehus ALH, Moreno C, Brandão Mello CE, Roudot-Thoraval F, Marinho RT, Sherman M, Ryder SD & Sperl J (2014) 'Historical epidemiology of hepatitis C virus (HCV) in selected countries' J Viral Hepat 21 Suppl 1, 5-33 Author Site , DOI
Wedemeyer H, Duberg AS, Buti M, Rosenberg WM, Frankova S, Esmat G, Örmeci N, Van Vlierberghe H, Gschwantler M & Akarca U (2014) 'Strategies to manage hepatitis C virus (HCV) disease burden' J Viral Hepat 21 Suppl 1, 60-89 Author Site , DOI
Razavi H, Waked I, Sarrazin C, Myers RP, Idilman R, Calinas F, Vogel W, Mendes Correa MC, Hézode C & Lázaro P (2014) 'The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm' J Viral Hepat 21 Suppl 1, 34-59 Author Site , DOI
Houldsworth A, Metzner MM, Demaine A, Hodgkinson A, Kaminski E & Cramp M (2014) 'CD81 sequence and susceptibility to hepatitis C infection' JOURNAL OF MEDICAL VIROLOGY 86, (1) 162-168 Author Site , DOI
Ashraf S, Nitschke K, Warshow UM, Brooks CR, Kim AY, Lauer GM, Hydes TJ, Cramp ME, Alexander G & Little A-M (2013) 'Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection' Hepatology 58, (3) 881-889 Author Site , DOI
Duggal P, Thio CL, Wojcik GL, Goedert JJ, Mangia A, Latanich R, Kim AY, Lauer GM, Chung RT & Peters MG (2013) 'Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts' Ann Intern Med 158, (4) 235-245 Author Site , DOI
Saunders M, Sieberhagen C, Taylor L, Fry F, McKenna M, Needs S, Chimakurthi R & Cramp M (2012) 'POTENTIAL IMPACT OF PROTEASE INHIBITORS IN THE SOUTH WEST PENINSULA HEPATITIS C POPULATION' GUT 61, A140-A141 Author Site , DOI
Warshow UM, Riva A, Hegazy D, Thurairajah PH, Kaminski ER, Chokshi S & Cramp ME (2012) 'Cytokine profiles in high risk injection drug users suggests innate as opposed to adaptive immunity in apparent resistance to hepatitis C virus infection' J Viral Hepat 19, (7) 501-508 Author Site , DOI
Tanwar S, Wright M, Foster GR, Ryder SD, Mills PR, Cramp ME, Parkes J & Rosenberg WM (2012) 'Randomized clinical trial: a pilot study investigating the safety and effectiveness of an escalating dose of peginterferon α-2a monotherapy for 48 weeks compared with standard clinical care in patients with hepatitis C cirrhosis' Eur J Gastroenterol Hepatol 24, (5) 543-550 Author Site , DOI
Ashraf S, Knapp S, Becford-Tackoir C, Brooks C, Little A-M, Alexander G, Cramp M & Khakoo SI (2011) 'OP04 Synergistic influence of tapasin and HLA class I protection against chronic Hepatitis C virus infection' Gut 60, (Suppl 2) A51-A52 , DOI
Warshow U, Sieberhagen C, Hegazy D, Kaminski E, Knapp S, Khakoo S & Cramp ME (2011) 'P45 Natural killer cell cytotoxicity is enhanced in injection drug users with apparent resistance to hepatitis C virus infection' Gut 60, (Suppl 2) A21-A22 , DOI
Petrova M, Fung M, Cramp ME, Mitchell JD & Cross TJS (2011) 'P80 Patient characteristics and outcomes in a 'Hub and Spoke Model' for liver transplantation provision: The South West Liver Unit/King's College Experience' Gut 60, (Suppl 2) A37-A37 , DOI
Knapp S, Warshow U, Ho KMA, Hegazy D, Little A-M, Fowell A, Alexander G, Thursz M, Cramp M & Khakoo SI (2011) 'A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection' GASTROENTEROLOGY 141, (1) 320-U419 Author Site , DOI
Jothimani D, Cramp ME, Mitchell JD & Cross TJS (2011) 'Treatment of autoimmune hepatitis: a review of current and evolving therapies' J Gastroenterol Hepatol 26, (4) 619-627 Author Site , DOI
Thurairajah PH, Hegazy D, Demaine A, Kaminski ER & Cramp ME (2011) 'Loss of virus-specific T-cell responses in HCV exposed uninfected injection drug users with drug rehabilitation' J Infect Dis 203, (6) 847-853 Author Site , DOI
Knapp S, Warshow U, Hegazy D, Brackenbury L, Guha IN, Fowell A, Little A-M, Alexander GJ, Rosenberg WMC & Cramp ME (2010) 'Consistent Beneficial Effects of Killer Cell Immunoglobulin-Like Receptor 2DL3 and Group 1 Human Leukocyte Antigen-C Following Exposure to Hepatitis C Virus' HEPATOLOGY 51, (4) 1168-1175 Author Site , DOI
Rashid M, Mitchell JD, Cramp ME & Cross TJS (2010) 'Limitations of the Algorithm for the SAFE Biopsy: A Noninvasive Fibrosis Measure in Chronic Hepatitis C' HEPATOLOGY 51, (1) 354-355 Author Site , DOI
Cross TJS, Mitchell JD & Cramp ME (2009) 'Elastography for the non-invasive assessment of liver disease: limitations and future developments' GUT 58, (8) 1171-1172 Author Site
Marcellin P, Reesink H, Berg T, Cramp M, Flisiak R, Van Vlierberghe H, Verloes R, Lenz O, Peeters M & Sekar V (2009) 'ANTIVIRAL ACTIVITY AND SAFETY OF TMC435 COMBINED WITH PEGINTERFERON ALPHA-2A AND RIBAVIRIN IN PATIENTS WITH GENOTYPE 1 HEPATITIS C INFECTION WHO FAILED PREVIOUS IFN-BASED THERAPY' JOURNAL OF HEPATOLOGY 50, S385-S385 Author Site , DOI
Hegazy D, Thurairajah P, Metzner M, Houldsworth A, Shaw S, Kaminski E, Demaine AG & Cramp ME (2008) 'Interleukin 12B gene polymorphism and apparent resistance to hepatitis C virus infection' Clin Exp Immunol 152, (3) 538-541 Author Site , DOI
Thompson Coon J, Rogers G, Hewson P, Wright D, Anderson R, Jackson S, Ryder S, Cramp M & Stein K (2008) 'Surveillance of cirrhosis for hepatocellular carcinoma: a cost-utility analysis' Br J Cancer 98, (7) 1166-1175 Author Site , DOI Open access
Thompson Coon J, Rogers G, Hewson P, Wright D, Anderson R, Cramp M, Jackson S, Ryder S, Price A & Stein K (2007) 'Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis' Health Technol Assess 11, (34) 1-206 Author Site , DOI
Coon JT, Rogers G, Hewson P, Wright D, Anderson R, Cramp M, Jackson S, Ryder S, Price A & Stein K (2007) 'Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis' Health Technology Assessment 11, (34) 1-+
Thompson Coon J, Castelnuovo E, Pitt M, Cramp M, Siebert U & Stein K (2006) 'Case finding for hepatitis C in primary care: a cost utility analysis' Fam Pract 23, (4) 393-406 Author Site , DOI
Castelnuovo E, Thompson-Coon J, Pitt M, Cramp M, Siebert U, Price A & Stein K (2006) 'The cost-effectiveness of testing for hepatitis C in former injecting drug users' Health Technology Assessment 10, (32) 1-+
Clark SJ, Creighton S, Horner M, Smith HM, Portmann B, Taylor C & Cramp ME (2006) 'Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression' Int J STD AIDS 17, (1) 67-69 Author Site , DOI
Awasthi AK & Cramp ME (2005) 'Hepatic hydrothorax' Br J Hosp Med (Lond) 66, (9) 540-541 Author Site , DOI
Houldsworth A, Metzner M, Rossol S, Shaw S, Kaminski E, Demaine AG & Cramp ME (2005) 'Polymorphisms in the IL-12B gene and outcome of HCV infection' J Interferon Cytokine Res 25, (5) 271-276 Author Site , DOI
Ijaz S, Arnold E, Banks M, Bendall RP, Cramp ME, Cunningham R, Dalton HR, Harrison TJ, Hill SF & MacFarlane L (2005) 'Non-travel-associated Hepatitis C in England and Wales: Demographic, clinical, and molecular epidemiological characteristics' Journal of Infectious Diseases 192, (7) 1166-1172
Khakoo SI, Thio CL, Martin MP, Brooks CR, Gao X, Astemborski J, Cheng J, Goedert JJ, Vlahov D & Hilgartner M (2004) 'HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection' Science 305, (5685) 872-874 Author Site , DOI
Torre F, Cramp M, Owsianka A, Dornan E, Marsden H, Carman W, Williams R & Naoumov NV (2004) 'Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity' J Med Virol 72, (3) 370-376 Author Site , DOI
Horne JA, Clements AJ, Drennan P, Stein K & Cramp ME (2004) 'Screening for hepatitis C virus in the Dartmoor prison population: an observational study' Journal of Public Health 26, (4) 372-375
Kyrlagkitsis L, Portmann B, Smith H, O'Grady J & Cramp ME (2003) 'Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT' AMERICAN JOURNAL OF GASTROENTEROLOGY 98, (7) 1588-1593 Author Site , DOI
Kyrlagkitsis I, Portmann B, Smith H, O'Grady J & Cramp ME (2003) 'Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT' Am J Gastroenterol 98, (7) 1588-1593 Author Site , DOI
Metzner M, Maulayah P, Benshemesh C & Cramp ME (2003) 'Traditional Chinese medicine in the treatment of chronic HCV infection' Gut 52, (5)
Constantini PK, Wawrzynowicz-Syczewska M, Clare M, Boron-Kaczmarska A, McFarlane IG, Cramp ME & Donaldson PT (2002) 'Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy' Liver 22, (5) 404-412 Author Site , DOI
Saravanan R & Cramp ME (2002) 'Investigation and treatment of ascites' Clin Med (Lond) 2, (4) 310-313 Author Site , DOI
Katona SJ, Cooper PC, Cramp ME & Kaminski ER (2002) 'Re: Whither smooth muscle antibodies in the third millennium?' J Clin Pathol 55, (7) 558-559 Author Site , DOI
Kyrlagkitsis I, Cramp ME, Smith H, Portmann B & O'Grady J (2002) 'Acute hepatitis A virus infection: a review of prognostic factors from 25 years experience in a tertiary referral center' Hepatogastroenterology 49, (44) 524-528 Author Site
Clark SJ, Creighton S, Portmann B, Taylor C, Wendon JA & Cramp ME (2002) 'Acute liver failure associated with antiretroviral treatment for HIV: a report of six cases' J Hepatol 36, (2) 295-301 Author Site , DOI
Prachalias AA, Pozniak A, Taylor C, Srinivasan P, Muiesan P, Wendon J, Cramp M, Williams R, O'Grady J & Rela M (2001) 'Liver transplantation in adults coinfected with HIV' Transplantation 72, (10) 1684-1688 Author Site , DOI
Prachalias AA, Pozniak A, Taylor C, Srinivasan P, Muiesan P, Wendon J, Cramp M, Williams R, O???Grady J & Rela M (2001) 'Liver Transplantation in Adults Coinfected With HIV. Transplantation 2001; 72: 1684' Transplantation 72, (10) 1594-1595 , DOI
Kyrlagkitsis I, Portmann B & Cramp ME (2000) 'Liver histology and progression of fibrosis in individuals with chronic hepatitis C virus infection and persistently normal ALT' HEPATOLOGY 32, (4) 285A-285A Author Site
Lister RK, Jolles S, Whittaker S, Black C, Forgacs I, Cramp M, Potter M & Rustin MHA (2000) 'Scleromyxedema: Response to high-dose intravenous immunoglobulin (hdIVIg)' Journal of the American Academy of Dermatology 43, (2) 403-408 , DOI
Lister RK, Jolles S, Whittaker S, Black C, Forgacs I, Cramp M, Potter M & Rustin MH (2000) 'Scleromyxedema: response to high-dose intravenous immunoglobulin (hdIVIg)' J Am Acad Dermatol 43, (2 Pt 2) 403-408 Author Site , DOI
Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R & Naoumov NV (2000) 'Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C' Gastroenterology 118, (2) 346-355 Author Site , DOI
Cramp ME (1999) 'HBV + HCV = HCC?' Gut 45, (2) 168-169 Author Site , DOI
Cramp ME (1999) 'HBV plus HCV=HCC?' GUT 45, (2) 168-169 Author Site , DOI
Datz C, Cramp M, Haas T, Dietze O, Nitschko H, Froesner G, Muss N, Sandhofer F & Vogel W (1999) 'The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre' Gut 44, (4) 563-567 Author Site , DOI
Cramp ME, Carucci P, Rossol S, Chokshi S, Maertens G, Williams R & Naoumov NV (1999) 'Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia' Gut 44, (3) 424-429 Author Site , DOI
Cramp ME, Carucci P, Underhill J, Naoumov NV, Williams R & Donaldson PT (1998) 'Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia' J Hepatol 29, (2) 207-213 Author Site , DOI
CRAMP ME & WILLIAMS R (1997) 'Hepatitis in alcohol and drug misusers: practical issues' Addiction Biology 2, (4) 411-420 , DOI
Cramp ME, Grundy HC, Perinpanayagam RM & Barnado DE (1996) 'Seroprevalence of hepatitis B and C virus in two institutions caring for mentally handicapped adults' J R Soc Med 89, (7) 401-402 Author Site
Cramp ME, Hing MC, Marriott DJ, Freund J & Cooper DA (1996) 'Bile acid malabsorption in HIV infected patients with chronic diarrhoea' Aust N Z J Med 26, (3) 368-371 Author Site , DOI
Inwald D, Nelson M, Cramp M, Francis N & Gazzard B (1994) 'Cutaneous manifestations of mycobacterial infection in patients with AIDS' Br J Dermatol 130, (1) 111-114 Author Site , DOI
Cramp ME, Hickey MM & Gazzard MM (1993) 'Re-emergence of tuberculosis' BMJ 306, (6882) Author Site , DOI
Grange JM & Yates MD (1993) 'Re-emergence of tuberculosis' BMJ 306, (6882) 931-932 , DOI
Collins CD, Blanshard C, Cramp M, Gazzard B & Gleeson JA (1992) 'Case report: pneumatosis intestinalis occurring in association with cryptosporidiosis and HIV infection' Clin Radiol 46, (6) 410-411 Author Site , DOI
Tattersall JE, Cramp M, Shannon M, Farrington K & Greenwood RN (1992) 'Rapid high-flux dialysis can cure uraemic peripheral neuropathy' Nephrol Dial Transplant 7, (6) 539-540 Author Site
Chapters
Cyril S & Cramp ME (2013) 'Clinical and Pathological Features, and Diagnosis' Viral Hepatitis John Wiley & Sons, Ltd 442-449 , DOI
Palmer DH & Cramp ME (2011) 'Systemic Therapy for Hepatocellular Carcinoma: Future Directions' Clinical Dilemmas in Primary Liver Cancer Wiley-Blackwell 199-211 , DOI
Conference Papers
Mathurin P, Dufour J-F, Bzowej NH, Shiffman ML, Arterburn S, Nguyen T, Billin A, Chung C, Subramanian M & Myers RP (2018) 'Selonsertib in Combination with Prednisolone for the Treatment of Severe Alcoholic Hepatitis: A Phase 2 Randomized Controlled Trial' 8A-9A
Foster GR, Agarwal K, Cramp M, Moreea S, Barclay ST, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM (2016) 'C-ISLE: Grazoprevir/Elbasvir plus Sofosbuvir in Treatment-naive and Treatment-experienced HCV GT3 Cirrhotic Patients Treated for 8, 12 or 16 weeks' 39A-40A
Agarwal K, Schultz M, Pianko S, Bank L, Collier J, George J, Priest M, Ryder SD, Burman BE & Cheent K (2016) 'Sofosbuvir plus Peginterferon plus Ribavirin for 12 Weeks in Genotype 3 HCV Infected Patients and Treatment-Experienced Cirrhotic Patients with Genotype 2 HCV Who Did Not Achieve SVR after 16 or 24 Weeks of Sofosbuvir plus Ribavirin' 455A-456A
Ahmed A, Dhanda A, Hegazy D, Felmlee D, Sheridan D & Cramp M (2016) 'Sustained viral clearance of HCV with DAA treatment is associated with restoration of effector T cell phenotype' 745A-745A
Jothimani D, Govil S, Vij M, Sheridan D, Cramp M & Rela M (2016) 'Predicting Fatty Liver Disease in Healthy Potential Liver Donors' Elsevier BV S479-S479 , DOI
Asselah T, Shafran S, Bourgeois S, Lai C-L, Cramp M, Mathurin P, Willems B, Nguyen MH, Davis MN & Huang KC (2016) 'SOFOSBUVIR/VELPATASVIR FIXED DOSE COMBINATION FOR 12 WEEKS IN HCV INFECTED PATIENTS PREVIOUSLY TREATED WITH PLACEBO: RESULTS OF THE DEFERRED TREATMENT STUDY (GS-US-342-1446 STUDY)' S827-S828
Mandalou P, Robinson MW, Felmlee D, Sieberhagen C, Mindos T, Hegazy D, MacLaughlan J & Cramp ME (2015) 'PTH-100 A comparative gene expression study between individuals with apparent resistance, spontaneous clearance, or chronic infection from hcv' BMJ A452.1-A452 , DOI
Norton BC, Adebayo D, Ramos K, Smith A & Cramp M (2015) 'PTH-124 Liver transplant outcomes in patients with care devolved to a non-transplanting centre: south west liver unit experience' BMJ A462.2-A463 , DOI
Dhar A, Tschotazis E, Brown R, Manousou P, Millson C, Aldersley M, Forbes S, Aggarwal K, Gera A & Cramp M (2015) 'LP11 : Warfarin anticoagulation for liver fibrosis in patients transplanted for hepatitis C (WAFT-C): results at one year' Elsevier BV S268-S269 , DOI
Ow M, Hegazy D & Cramp ME (2014) 'P210 ALTERATIONS IN CXCR3/CXCL10 BUT NOT CCR5 IN HCV ARE ASSOCIATED WITH VIRAL INHIBITION WITH INTERFERON-FREE DIRECT ACTING ANTIVIRAL THERAPY' Elsevier BV S136-S136 , DOI
Rosenberg WM, Cramp M, Davis M, Parkes J, Ryder S, Razavi H & Hindman S (2014) 'P790 REDUCING THE DISEASE BURDEN OF CHRONIC HEPATITIS C VIRUS (HCV) INFECTION IN ENGLAND' Elsevier BV S333-S334 , DOI
Ow MM, Hegazy D, Warshow U & Cramp ME (2014) 'High-Level Resistance to Hepatitis C - A Possible Role for Innate Immunity' 1064A-1064A
Mandalou P, Swann R, Patel AH & Cramp ME (2014) 'Neutralising anti-envelope antibodies in uninfected individuals that are repeatedly exposed to HCV' 1057A-1057A
Martin NK, Vickerman P, Clements A, Cramp M, De Angeles D, Dillon JF, Fahey S, Foster GR, Goldberg DJ & Gordon F (2013) 'ARE CURRENT TREATMENT RATES SUFFICIENT TO REDUCE HCV PREVALENCE AMONG PEOPLE WHO INJECT DRUGS? MODEL PROJECTIONS IN SEVEN UK SETTINGS' S356-S356 , DOI
Joseph M, Erasmus P, Minto G, Mitchell J, Cramp M & Cross TJ (2013) 'THE USE OF CARDIOPULMONARY EXERCISE TESTING IN PREDICTING PRE- AND POST-OPERATIVE MORTALITY IN LIVER TRANSPLANT CANDIDATES' S412-S412 , DOI
Petrova M, Fung M & Cramp M (2012) 'HPS AND INTRAPULMONARY VASCULAR SHUNTS IN LIVER TRANSPLANT CANDIDATES' S254-S254 , DOI
Ashraf S, Knapp S, Becford-Tackoir C, Brooks C, Little A-M, Alexander G, Cramp M & Khakoo SI (2011) 'Synergistic influence of tapasin and HLA class I protection against chronic hepatitis C virus infection' 173-173
Warshow U, Sieberhagen C, Hegazy DM, Kaminski E, Knapp S, Khakoo S & Cramp ME (2011) 'NATURAL KILLER CELL CYTOTOXICITY IS ENHANCED IN INJECTION DRUG USERS WITH APPARENT RESISTANCE TO HEPATITIS C VIRUS INFECTION' 1322A-1322A
Knapp S, Ho KM, Warshow U, Heqazy D, Little A-M, Alexander G, Thursz M, Cramp ME & Khakoo SI (2011) 'ABSENCE OF IL-28B PROTECTION IN INDIVIDUALS EXPOSED TO HEPATITIS C VIRUS DEMONSTRATES DISCRETE GENETIC PATHWAYS FOR PROTECTION AGAINST CHRONIC HCV INFECTION' S38-S39 , DOI
Tanwar S, Wright M, Foster GR, Ryder SD, Mills PR, Cramp ME, Parkes J & Rosenberg WM (2010) 'INDIVIDUALIZED CONCENTRATION MONITORED HIGH DOSE RIBAVIRIN IN COMBINATION WITH PEGINTERFERON TO HEPATITIS C GENOTYPE 1 PATIENTS WITH PREVIOUS NONRESPONSE' 710A-711A
Tanwar S, Wright M, Foster GR, Ryder SD, Mills PR, Cramp ME, Parkes J & Rosenberg WM (2010) 'PACIFIC: A PHASE III, RANDOMIZED, MULTICENTER, DOSE ESCALATION, EFFICACY AND SAFETY STUDY EXAMINING THE EFFECTS OF TREATMENT WITH PEGINTERFERON ALFA-2A IN PATIENTS WITH CHILD'S A OR B CIRRHOSIS IN CHRONIC HEPATITIS C VIRUS INFECTION' 710A-710A
Sieberhagen C, Brown ASM, Demuth DG, Livingstone JA & Cramp ME (2010) 'PREDICTORS OF HEPATITIS C TREATMENT OUTCOME IN GENOTYPE 1 PATIENTS IN A "REAL WORLD" SETTING' A77-A77 , DOI
Warshow U, Knapp S, Brackenbury LS, Hegazy D, Thurairajah PH, Khakoo S & Cramp ME (2009) 'ASSOCIATION OF HLA AND NK CELL INHIBITORY RECEPTOR WITH APPARENT RESISTANCE TO HEPATITIS C INFECTION' 386A-386A
Hegazy D, Edwards P, Warshow U & Cramp ME (2009) 'CELLULAR DISTRIBUTION OF CLAUDIN 1 IN LIVER TISSUE IN HEPATITIS C AND OTHER LIVER DISEASES' 950A-950A
Warshow U, Riva A, Thurairajah PH, Hegazy D, Chokshi S & Cramp ME (2009) 'CYTOKINE PROFILES IN HCV EXPOSED BUT UNINFECTED CASES WITH APPARENT RESISTANCE TO HCV INFECTION' 936A-936A
Thurairajah P, Warshow U, Demaine A, Kaminski E, Hegazy D & Cramp ME (2009) 'LONGITUDINAL ANALYSIS OF HEPATITIS C VIRUS SPECIFIC T CELL RESPONSES IN EXPOSED UNINFECTED INTRAVENOUS DRUG USERS' A17-A17
Thurairajah P, Warshow U, Demaine A, Kaminski E, Hegazy D & Cramp ME (2009) 'LONGITUDINAL ANALYSIS OF HCV SPECIFIC T-CELL RESPONSES IN EXPOSED UNINFECTED INTRAVENOUS DRUG USERS' S326-S326 , DOI
Thurairajah PH, Hegazy D, Chokshi S, Shaw S, Demaine A, Kaminski ER, Naoumov NV & Cramp ME (2008) 'Hepatitis C virus (HCV)--specific T cell responses in injection drug users with apparent resistance to HCV infection' United States 1749-1755 , DOI
Barnardo AT, Walters L, Cramp M & Mitchell J (2008) 'Audit of management of alcohol withdrawal at derriford hospital' A72-A72
Barnardo AT, Warshow U, Mitchell J & Cramp M (2008) 'Mycophenolate mofetil in patients with refractory autoimmune hepatitis' A71-A72
Thurairajah PH, Hegazy DM, Richardon SJ, Demaine AG, Kaminski ER & Cramp ME (2007) 'HCV-specific cellular immune responses in intravenous drug users without HCV infection' 240A-241A
Hegazy DM, Thurairajah PH, Metzner M, Houldsworth A, Kaminski E, Demaine A & Cramp ME (2007) 'Interleukin 12B gene polymorphism and apparent resistance to HCV infection' 890A-891A
Thurairajah PH, Hegazy D, Kaminski E, Demaine A & Cramp ME (2007) 'Single nucleotide polymorphism of the SRB1 gene and susceptibility to HCV infection' A134-A135
Thurairajah PH, Hegazy D, Kaminski E, Demaine A, Cunningham R & Cramp ME (2006) 'Late spontaneous clearance of hepatitis C' A43-A43
Houldsworth A, Metzner M, Demaine AG, Kaminski E & Cramp ME (2005) 'CD81 sequence and susceptibility to HCV infection' A47-A47
Metzner M, Houldsworth A, Demaine AG, Kaminski E & Cramp ME (2005) 'HCV-specific cellular immune responses in subjects exposed to but uninfected by HCV' A6-A7
Metzner MK, Houldsworth A, Demaine A, Kaminski E & Cramp ME (2005) 'HCV-specific cellular immune responses in subjects exposed, but uninfected by HCV' A712-A712 Open access
Beckly JB, Jackson S, Cramp ME & Beckly DE (2004) 'Endoscopic sphincterotomy is sufficient treatment for most post cholecystectomy bile leaks' A44-A44
Houldsworth A, Metzner M, Rossol S, Kaminski E, Demaine AG & Cramp ME (2003) 'IL-12 gene polymorphism and outcome of HCV infection' 356A-356A
Kyrlagkitsis I, Metzner M, Smith H, Depla E, Sablon E & Cramp ME (2003) 'Specific antibody titres vary over time in individuals with chronic HCV infection and persistently negative HCV RNA'
Kyrlagkitsis I, Metzner MK, Smith H, Depla E, Sablon E & Cramp ME (2002) 'Specific antibody titres vary over time in individuals with chronic HCV infection and persistently negative HCV RNA' 552A-552A
Metzner MK, Maulayah P, Benshemesh C & Cramp ME (2002) 'Traditional Chinese medicine in the treatment of chronic HCV infection' 569A-569A
Clark SJ, Creighton S, Horner M, Portmann BC, Cramp M & Taylor C (2000) 'Reactivation of latent hepatitis B virus infection with HIV related immunosuppression' 454A-454A
Clare MA, Portmann BC & Cramp ME (1999) 'The association of the Arg25Pro polymorphism in the TGF beta 1 gene with fibrosis in chronic hepatitis C patients' 331A-331A
Cramp ME, Maertens G, O'Grady J & Rossol S (1999) 'HCV-specific immune responses in HCV exposed but uninfected cases' A97-A97
Cramp ME & Rossol S (1998) 'HCV-specific T helper cell responses in HCV exposed but uninfected cases' 200A-200A
Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R & Naoumov NV (1998) 'HLA class III and class II alleles in hepatitis C virus infection and outcome' 159-160
Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R & Naoumov NV (1998) 'Interferon induced virus specific T helper cell responses are associated with viral clearance in chronic HCV infection' 155-155
Torre F, Cramp M, Owsianka A, Carman W, Williams R & Naoumov NV (1998) 'Mutations within a promiscuous immunodominant epitope in hepatitis B core protein and their effect on T helper cell response' 156-157
Cramp ME, Rossol S, Carucci P, Williams R, Naoumov NV & Donaldson PT (1998) 'The influence of the HLA class II allele DQB1*0301 on HCV specific T helper cell responses' A21-A21
Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R & Naoumov NV (1997) 'Interferon induced virus specific T helper cell responses are associated with viral clearance in chronic HCV infection' 1111-1111
Rossol S, Cramp ME, Carucci P, Singer MV, Williams R & Naoumov NV (1997) 'Reduced production of interleukin-12 by PBMC from patients with chronic hepatitis C' 1121-1121
Torre F, Cramp ME, Owsianka A, Carman W, Williams R & Naoumov NV (1997) 'T helper cell response to mutations within a promiscuous immunodominant epitope in acute and chronic hepatitis B' 1953-1953
Bernal W, Cramp M, Underhill JA, Carucci P & Donaldson PT (1997) 'Tumor necrosis factor gene polymorphisms in hepatitis C virus infection' 1413-1413
Cramp ME, Chokshi S, Tzampouras N, Torre F, Williams R & Naoumov NV (1997) 'Beneficial in vitro effects of tucaresol on the immune response to hepatitis C virus' TH119-TH119
Cramp ME, Carucci P, Chokshi S, Rossol S, Donaldson PT, Williams R & Naoumov NV (1996) 'A multispecific T lymphocyte response to hepatitis C virus proteins occurs in patients with viral clearance and persists many years after exposure' 503-503
Cramp ME, Carucci P, Donaldson PT, Underhill J, Tibbs C, Naoumov NV & Williams R (1996) 'Evidence that HLA class II genotype may be associated with clearance of hepatitis C virus' 99-99
Reports
Castelnuovo E, Thompson-Coon J, Pitt M, Cramp M, Siebert U, Price A & Stein K (2006) The cost-effectiveness of testing for hepatitis C in former injecting drug users. Author Site , DOI
Posters
Haber B, Foster GR, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD & Ustianowski A Haber B, Foster GR, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD & Ustianowski A 'Elbasvir/Grazoprevir Plus Sofosbuvir in Treatment-Naive and Treatment-Experienced Cirrhotic Patients with Hepatitis C Virus Genotype 3 Infection Treated for 8, 12 or 16 Weeks: Final Results of the C-ISLE Study' , DOI
Yates E, Cramp M & Dhanda A Yates E, Cramp M & Dhanda A 'A NOVEL FUNCTIONAL BIOASSAY PREDICTS 90-DAY SURVIVAL IN PATIENTS WITH SEVERE ALCOHOLIC HEPATITIS' Author Site , DOI Open access
Foster GR, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM Foster GR, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM 'Elbasvir/grazoprevir plus sofosbuvir in treatment-naive and treatment-experienced cirrhotic patients with hepatitis C virus genotype 3 infection treated for 8, 12, or 16 weeks: final results of the C-ISLE study' , DOI
Dhanda A, Williams E, Yates E, Collins P, Lee R & Cramp M Dhanda A, Williams E, Yates E, Collins P, Lee R & Cramp M 'Intermediate (CD14++CD16+) monocytes from patients with acute severe alcoholic hepatitis are activated and functionally similar to classical (CD14++CD16−) monocytes' , DOI
Foster G, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM Foster G, Agarwal K, Cramp ME, Moreea S, Barclay S, Collier J, Brown AS, Ryder SD, Ustianowski A & Forton DM 'Successful treatment of patients with HCV GT3 infection and cirrhosis with elbasvir/grazoprevir plus sofosbuvir does not correct insulin resistance by 12 weeks post-treatment' , DOI