Profiles
Professor Matthew Cramp
Chair in Hepatology
Biomedical Research - Institute of Translational & Stratified Medicine (Plymouth University Peninsula Schools of Medicine and De
Key publications are highlighted
Journals
Articles
2016
'Anti-envelope antibody responses in individuals at high risk of hepatitis C virus who resist infection'
Journal of Viral Hepatitis
23,
(11)
873-880
, DOI
PEARL
2016
'Urinary Metabotyping of Hepatocellular Carcinoma in a UK Cohort Using Proton Nuclear Magnetic Resonance Spectroscopy'
Journal of Clinical and Experimental Hepatology
6,
(3)
186-194
, DOI
2015
'Diagnosis and management of hepatitis C'
British Journal of Hospital Medicine
76,
(11)
625-630
, DOI
2015
'Haplotype analysis finds linkage disequilibrium in the IL-12 gene in patients with HCV'
J Med Virol
87,
(7)
1207-1217
, DOI
2015
'HCV treatment rates and sustained viral response among people who inject drugs in seven UK sites: real world results and modelling of treatment impact'
JOURNAL OF VIRAL HEPATITIS
22,
(4)
399-408
, DOI
PEARL
2015
'Implementation of the Lancet Standing Commission on Liver Disease in the UK'
The Lancet
386,
(10008)
2098-2111
, DOI
2014
'Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis'
Lancet
384,
(9958)
1953-1997
, DOI
2014
'Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis'
Lancet
384,
(9958)
1953-1997
2014
'CD81 sequence and susceptibility to hepatitis C infection'
JOURNAL OF MEDICAL VIROLOGY
86,
(1)
162-168
, DOI
2014
'Historical epidemiology of hepatitis C virus (HCV) in selected countries'
J Viral Hepat
21 Suppl 1,
5-33
, DOI
2014
'Impaired functional capacity in potential liver transplant candidates predicts short-term mortality before transplantation'
Liver Transpl
20,
(9)
1081-1088
, DOI
2014
'Modelling the impact of improving screening and treatment of chronic hepatitis C virus infection on future hepatocellular carcinoma rates and liver-related mortality'
BMC Gastroenterol
14,
, DOI
PEARL
2014
'Polymorphic differences in SOD-2 may influence HCV viral clearance'
J Med Virol
86,
(6)
941-947
, DOI
2014
'Role of Mycophenolate Mofetil for the Treatment of Autoimmune Hepatitis—An Observational Study'
Journal of Clinical and Experimental Hepatology
4,
(3)
221-225
, DOI
2014
'Strategies to manage hepatitis C virus (HCV) disease burden'
J Viral Hepat
21 Suppl 1,
60-89
, DOI
2014
'The present and future disease burden of hepatitis C virus (HCV) infection with today's treatment paradigm'
J Viral Hepat
21 Suppl 1,
34-59
, DOI
2013
'Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts'
Ann Intern Med
158,
(4)
235-245
, DOI
2013
'Synergism of tapasin and human leukocyte antigens in resolving hepatitis C virus infection'
Hepatology
58,
(3)
881-889
, DOI
2012
'Cytokine profiles in high risk injection drug users suggests innate as opposed to adaptive immunity in apparent resistance to hepatitis C virus infection'
J Viral Hepat
19,
(7)
501-508
, DOI
2012
'POTENTIAL IMPACT OF PROTEASE INHIBITORS IN THE SOUTH WEST PENINSULA HEPATITIS C POPULATION'
GUT
61,
A140-A141
, DOI
2012
'Randomized clinical trial: a pilot study investigating the safety and effectiveness of an escalating dose of peginterferon α-2a monotherapy for 48 weeks compared with standard clinical care in patients with hepatitis C cirrhosis'
Eur J Gastroenterol Hepatol
24,
(5)
543-550
, DOI
2011
'A Polymorphism in IL28B Distinguishes Exposed, Uninfected Individuals From Spontaneous Resolvers of HCV Infection'
GASTROENTEROLOGY
141,
(1)
320-U419
, DOI
2011
'Loss of virus-specific T-cell responses in HCV exposed uninfected injection drug users with drug rehabilitation'
J Infect Dis
203,
(6)
847-853
, DOI
2011
'OP04 Synergistic influence of tapasin and HLA class I protection against chronic Hepatitis C virus infection'
Gut
60,
(Suppl 2)
A51-A52
, DOI
2011
'P45 Natural killer cell cytotoxicity is enhanced in injection drug users with apparent resistance to hepatitis C virus infection'
Gut
60,
(Suppl 2)
A21-A22
, DOI
2011
'P80 Patient characteristics and outcomes in a 'Hub and Spoke Model' for liver transplantation provision: The South West Liver Unit/King's College Experience'
Gut
60,
(Suppl 2)
A37-A37
, DOI
2011
'Treatment of autoimmune hepatitis: a review of current and evolving therapies'
J Gastroenterol Hepatol
26,
(4)
619-627
, DOI
2010
'Consistent Beneficial Effects of Killer Cell Immunoglobulin-Like Receptor 2DL3 and Group 1 Human Leukocyte Antigen-C Following Exposure to Hepatitis C Virus'
HEPATOLOGY
51,
(4)
1168-1175
, DOI
2010
'Limitations of the Algorithm for the SAFE Biopsy: A Noninvasive Fibrosis Measure in Chronic Hepatitis C'
HEPATOLOGY
51,
(1)
354-355
, DOI
2009
'ANTIVIRAL ACTIVITY AND SAFETY OF TMC435 COMBINED WITH PEGINTERFERON ALPHA-2A AND RIBAVIRIN IN PATIENTS WITH GENOTYPE 1 HEPATITIS C INFECTION WHO FAILED PREVIOUS IFN-BASED THERAPY'
JOURNAL OF HEPATOLOGY
50,
S385-S385
2009
'Elastography for the non-invasive assessment of liver disease: limitations and future developments'
GUT
58,
(8)
1171-1172
2008
'Interleukin 12B gene polymorphism and apparent resistance to hepatitis C virus infection'
Clin Exp Immunol
152,
(3)
538-541
, DOI
2008
'Surveillance of cirrhosis for hepatocellular carcinoma: a cost–utility analysis'
British Journal of Cancer
98,
(7)
1166-1175
, DOI
PEARL
2007
'Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis'
Health Technol Assess
11,
(34)
1-206
2006
'Case finding for hepatitis C in primary care: a cost utility analysis'
Fam Pract
23,
(4)
393-406
, DOI
2006
'Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression'
Int J STD AIDS
17,
(1)
67-69
, DOI
2005
'Non-travel-associated Hepatitis C in England and Wales: Demographic, clinical, and molecular epidemiological characteristics'
Journal of Infectious Diseases
192,
(7)
1166-1172
2005
'Polymorphisms in the IL-12B gene and outcome of HCV infection'
J Interferon Cytokine Res
25,
(5)
271-276
, DOI
2004
'Direct evidence that naturally occurring mutations within hepatitis B core epitope alter CD4+ T-cell reactivity'
J Med Virol
72,
(3)
370-376
, DOI
2004
'HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection'
Science
305,
(5685)
872-874
, DOI
2004
'Screening for hepatitis C virus in the Dartmoor prison population: an observational study'
Journal of Public Health
26,
(4)
372-375
2003
'Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT'
AMERICAN JOURNAL OF GASTROENTEROLOGY
98,
(7)
1588-1593
, DOI
2003
'Liver histology and progression of fibrosis in individuals with chronic hepatitis C and persistently normal ALT'
Am J Gastroenterol
98,
(7)
1588-1593
, DOI
2003
'Traditional Chinese medicine in the treatment of chronic HCV infection'
Gut
52,
(5)
2002
'Acute hepatitis A virus infection: a review of prognostic factors from 25 years experience in a tertiary referral center'
Hepatogastroenterology
49,
(44)
524-528
2002
'Acute liver failure associated with antiretroviral treatment for HIV: a report of six cases'
J Hepatol
36,
(2)
295-301
2002
'Interleukin-1, interleukin-10 and tumour necrosis factor-alpha gene polymorphisms in hepatitis C virus infection: an investigation of the relationships with spontaneous viral clearance and response to alpha-interferon therapy'
Liver
22,
(5)
404-412
2002
'Investigation and treatment of ascites'
Clin Med (Lond)
2,
(4)
310-313
2002
'Re: Whither smooth muscle antibodies in the third millennium?'
J Clin Pathol
55,
(7)
558-559
2001
'Liver transplantation in adults coinfected with HIV'
Transplantation
72,
(10)
1684-1688
2000
'Hepatitis C virus–specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C'
Gastroenterology
118,
(2)
346-355
, DOI
2000
'Liver histology and progression of fibrosis in individuals with chronic hepatitis C virus infection and persistently normal ALT'
HEPATOLOGY
32,
(4)
285A-285A
2000
'Scleromyxedema: response to high-dose intravenous immunoglobulin (hdIVIg)'
J Am Acad Dermatol
43,
(2 Pt 2)
403-408
1999
'HBV + HCV = HCC?'
Gut
45,
(2)
168-169
1999
'Hepatitis C virus (HCV) specific immune responses in anti-HCV positive patients without hepatitis C viraemia'
Gut
44,
(3)
424-429
1999
'The natural course of hepatitis C virus infection 18 years after an epidemic outbreak of non-A, non-B hepatitis in a plasmapheresis centre'
Gut
44,
(4)
563-567
, DOI
1998
'Association between HLA class II genotype and spontaneous clearance of hepatitis C viraemia'
J Hepatol
29,
(2)
207-213
1997
'Hepatitis in alcohol and drug misusers: practical issues'
Addiction Biology
2,
(4)
411-420
, DOI
1996
'Bile acid malabsorption in HIV infected patients with chronic diarrhoea'
Aust N Z J Med
26,
(3)
368-371
1996
'Seroprevalence of hepatitis B and C virus in two institutions caring for mentally handicapped adults'
J R Soc Med
89,
(7)
401-402
1994
'Cutaneous manifestations of mycobacterial infection in patients with AIDS'
Br J Dermatol
130,
(1)
111-114
1993
'Re-emergence of tuberculosis'
BMJ
306,
(6882)
1992
'Case report: pneumatosis intestinalis occurring in association with cryptosporidiosis and HIV infection'
Clin Radiol
46,
(6)
410-411
1992
'Rapid high-flux dialysis can cure uraemic peripheral neuropathy'
Nephrol Dial Transplant
7,
(6)
539-540
Conference Papers
2016
'C-ISLE: Grazoprevir/Elbasvir plus Sofosbuvir in Treatment-naive and Treatment-experienced HCV GT3 Cirrhotic Patients Treated for 8, 12 or 16 weeks'
39A-40A
2016
'Sofosbuvir plus Peginterferon plus Ribavirin for 12 Weeks in Genotype 3 HCV Infected Patients and Treatment-Experienced Cirrhotic Patients with Genotype 2 HCV Who Did Not Achieve SVR after 16 or 24 Weeks of Sofosbuvir plus Ribavirin'
455A-456A
2016
'Sustained viral clearance of HCV with DAA treatment is associated with restoration of effector T cell phenotype'
745A-745A
2015
'WARFARIN ANTICOAGULATION FOR LIVER FIBROSIS IN PATIENTS TRANSPLANTED FOR HEPATITIS C (WAFT-C): RESULTS AT ONE YEAR'
S268-S269
2014
'ALTERATIONS IN CXCR3/CXCL10 BUT NOT CCR5 IN HCV ARE ASSOCIATED WITH VIRAL INHIBITION WITH INTERFERON-FREE DIRECT ACTING ANTIVIRAL THERAPY'
S136-S136
2014
'High-Level Resistance to Hepatitis C - A Possible Role for Innate Immunity'
1064A-1064A
2014
'Neutralising anti-envelope antibodies in uninfected individuals that are repeatedly exposed to HCV'
1057A-1057A
2014
'REDUCING THE DISEASE BURDEN OF CHRONIC HEPATITIS C VIRUS (HCV) INFECTION IN ENGLAND'
S333-S334
2013
'ARE CURRENT TREATMENT RATES SUFFICIENT TO REDUCE HCV PREVALENCE AMONG PEOPLE WHO INJECT DRUGS? MODEL PROJECTIONS IN SEVEN UK SETTINGS'
S356-S356
2013
'THE USE OF CARDIOPULMONARY EXERCISE TESTING IN PREDICTING PRE- AND POST-OPERATIVE MORTALITY IN LIVER TRANSPLANT CANDIDATES'
S412-S412
2012
'HPS AND INTRAPULMONARY VASCULAR SHUNTS IN LIVER TRANSPLANT CANDIDATES'
S254-S254
2011
'ABSENCE OF IL-28B PROTECTION IN INDIVIDUALS EXPOSED TO HEPATITIS C VIRUS DEMONSTRATES DISCRETE GENETIC PATHWAYS FOR PROTECTION AGAINST CHRONIC HCV INFECTION'
S38-S39
2011
'NATURAL KILLER CELL CYTOTOXICITY IS ENHANCED IN INJECTION DRUG USERS WITH APPARENT RESISTANCE TO HEPATITIS C VIRUS INFECTION'
1322A-1322A
2011
'Synergistic influence of tapasin and HLA class I protection against chronic hepatitis C virus infection'
173-173
2010
'INDIVIDUALIZED CONCENTRATION MONITORED HIGH DOSE RIBAVIRIN IN COMBINATION WITH PEGINTERFERON TO HEPATITIS C GENOTYPE 1 PATIENTS WITH PREVIOUS NONRESPONSE'
710A-711A
2010
'PACIFIC: A PHASE III, RANDOMIZED, MULTICENTER, DOSE ESCALATION, EFFICACY AND SAFETY STUDY EXAMINING THE EFFECTS OF TREATMENT WITH PEGINTERFERON ALFA-2A IN PATIENTS WITH CHILD'S A OR B CIRRHOSIS IN CHRONIC HEPATITIS C VIRUS INFECTION'
710A-710A
2010
'PREDICTORS OF HEPATITIS C TREATMENT OUTCOME IN GENOTYPE 1 PATIENTS IN A "REAL WORLD" SETTING'
A77-A77
, DOI
2009
'ASSOCIATION OF HLA AND NK CELL INHIBITORY RECEPTOR WITH APPARENT RESISTANCE TO HEPATITIS C INFECTION'
386A-386A
2009
'CELLULAR DISTRIBUTION OF CLAUDIN 1 IN LIVER TISSUE IN HEPATITIS C AND OTHER LIVER DISEASES'
950A-950A
2009
'CYTOKINE PROFILES IN HCV EXPOSED BUT UNINFECTED CASES WITH APPARENT RESISTANCE TO HCV INFECTION'
936A-936A
2009
'LONGITUDINAL ANALYSIS OF HCV SPECIFIC T-CELL RESPONSES IN EXPOSED UNINFECTED INTRAVENOUS DRUG USERS'
S326-S326
2009
'LONGITUDINAL ANALYSIS OF HEPATITIS C VIRUS SPECIFIC T CELL RESPONSES IN EXPOSED UNINFECTED INTRAVENOUS DRUG USERS'
A17-A17
2008
'Audit of management of alcohol withdrawal at derriford hospital'
A72-A72
2008
'Hepatitis C virus (HCV)--specific T cell responses in injection drug users with apparent resistance to HCV infection'
United States
1749-1755
, DOI
2008
'Mycophenolate mofetil in patients with refractory autoimmune hepatitis'
A71-A72
2007
'HCV-specific cellular immune responses in intravenous drug users without HCV infection'
240A-241A
2007
'Interleukin 12B gene polymorphism and apparent resistance to HCV infection'
890A-891A
2007
'Single nucleotide polymorphism of the SRB1 gene and susceptibility to HCV infection'
A134-A135
2006
'Late spontaneous clearance of hepatitis C'
A43-A43
2005
'CD81 sequence and susceptibility to HCV infection'
A47-A47
2005
'HCV-specific cellular immune responses in subjects exposed to but uninfected by HCV'
A6-A7
2005
'HCV-specific cellular immune responses in subjects exposed, but uninfected by HCV'
A712-A712
PEARL
2004
'Endoscopic sphincterotomy is sufficient treatment for most post cholecystectomy bile leaks'
A44-A44
2003
'IL-12 gene polymorphism and outcome of HCV infection'
356A-356A
2003
'Specific antibody titres vary over time in individuals with chronic HCV infection and persistently negative HCV RNA'
2002
'Specific antibody titres vary over time in individuals with chronic HCV infection and persistently negative HCV RNA'
552A-552A
2002
'Traditional Chinese medicine in the treatment of chronic HCV infection'
569A-569A
Reports
2006
The cost-effectiveness of testing for hepatitis C in former injecting drug users.