Peripheral nerve development, repair and the biology of nervous system tumours
Research group studying regeneration and links to tumour formation in the nervous system

Another major research focus in the lab is the development of tumours in the nervous system. Our work has shown that mechanisms that regulate PNS repair are also important in the development of schwannomas and meningiomas, two common tumour types within our nervous system. A protein called Merlin and its regulation of a pathway known as the Hippo pathway are key and we are using both genetic approaches in a mouse model and the use of primary human tumour cells to try out new therapies for these tumour types in vitro and in vivo.
Institute of Translational and Stratified Medicine, University of Plymouth Faculty of Health, Plymouth Science Park, Plymouth, PL6 8BU, UK