Another major research focus in the lab is the development of tumours in the nervous system. Our work has shown that mechanisms that regulate PNS repair are also important in the development of schwannomas and meningiomas, two common tumour types within our nervous system. A protein called Merlin and its regulation of a pathway known as the Hippo pathway are key and we are using both genetic approaches in a mouse model and the use of primary human tumour cells to try out new therapies for these tumour types in vitro and in vivo.
Key research collaborations
- Dr Xinpeng Dun, University of Plymouth. Schwann cell biology and PNS repair.
- Professor Oliver Hanemann, University of Plymouth. Merlin and nervous system tumours.
- Dr Maurizio D’Antonio, San Raffaele research Institute, Italy. Schwann cell development and peripheral neuropathies.
- Dr Helen Morrison, Fritz Lipmann Institute, Germany. Merlin function and schwannoma tumour biology.
- Professor Alison Lloyd, University College London. Schwann cell biology and PNS repair.
- Professor Christian Mawrin, Magdeburg, Germany. Meningioma tumour biology and modelling.
- Dr Ashwin Woodhoo, CIC bioGUNE, Dario, Spain. Schwann cell biology and tumourigenesis.