Professor David Parkinson
Profiles

Professor David Parkinson

Professor of Neuroscience

Biomedical Research - Institute of Translational & Stratified Medicine (Plymouth University Peninsula Schools of Medicine and De

Role

Professor of Neuroscience.

Research interests

My research interest in the control of myelination and repair in the peripheral nervous system (PNS). The  PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity. 

Key publications are highlighted

Journals
Articles
Carr L, Parkinson DB & Dun X-P 2017 'Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system' PLoS One 12, (2) e0172736-e0172736 Author Site , DOI PEARL
Mindos T, Dun X-P, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL & Shivane A 2017 'Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity' The Journal of Cell Biology jcb.201606052-jcb.201606052 , DOI PEARL
Dun X-P & Parkinson D 2017 'Role of Netrin-1 Signaling in Nerve Regeneration' International Journal of Molecular Sciences 18, (3) 491-491 , DOI PEARL
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, D'Antonio M & Parkinson DB 2017 'Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve' Development Author Site , DOI PEARL
Roberts SL, Dun X-P, Dee G, Gray B, Mindos T & Parkinson DB 2017 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of Neurochemistry , DOI PEARL
Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB & Gehlhausen JR 2016 'The importance of nerve microenvironment for schwannoma development' Acta neuropathologica PEARL
Dun X-P & Parkinson DB 2015 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) Author Site , DOI PEARL
Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM & Giovannini M 2014 'Update from the 2013 International Neurofibromatosis Conference' AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164, (12) 2969-2978 Author Site , DOI
Shivane A, Parkinson DB, Ammoun S & Hanemann CO 2013 'Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas' HISTOPATHOLOGY 62, (4) 651-656 Author Site , DOI
Doddrell RDS, Dun X-P, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO & Parkinson DB 2013 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 Author Site , DOI PEARL
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C & Mautner V-F 2013 'Merlin isoform 2 in neurofibromatosis type 2–associated polyneuropathy' Nature Neuroscience 16, (4) 426-433 , DOI
Kim HA, Mindos T & Parkinson DB 2013 'Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System' STEM CELLS TRANSLATIONAL MEDICINE 2, (8) 553-557 Author Site , DOI
Yang DP, Kim J, Syed N, Tung Y-J, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P & Parkinson DB 2012 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' J Neurosci 32, (21) 7158-7168 Author Site , DOI
Yang DP, Kim J, Syed N, Tung YJ, Bhaskaran A, Mindos TC, Mirsky R, Jessen KR, Maurel P & Parkinson DB 2012 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' The Journal of Neuroscience 32(21), 7158-7168
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB 2012 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' GLIA 60, (9) 1269-1278 Author Site , DOI
Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R & Jessen KR 2011 'Mouse schwann cells need both NRG1 and cyclic AMP to myelinate' Glia 59, (5) 720-733 Author Site , DOI
Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH & Lloyd AC 2010 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 Author Site , DOI
Whiteman M, Li L, Rose P, Tan C-H, Parkinson DB & Moore PK 2010 'The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages' Antioxid Redox Signal 12, (10) 1147-1154 Author Site , DOI
Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P & Shen J 2009 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 Author Site , DOI
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A & Mirsky R 2008 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 Author Site , DOI PEARL
Flaiz C, Utermark T, Parkinson DB, Poetsch A & Hanemann CO 2008 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 Author Site , DOI
Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A & Jessen KR 2008 'Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation' J Peripher Nerv Syst 13, (2) 122-135 Author Site , DOI
Parkinson D, Bhaskaran A, rthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K 2007 'A central role for c-Jun in regulating the differentiation of Schwann cells' Neuron Glia Biology 2, S38-S38
Parkinson D, Bhaskaran A, Arthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K 2007 'A central role for c-Jun in regulating the differentiation of Schwann cells' NEURON GLIA BIOLOGY 2, S38-S38 Author Site
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR 2007 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' Journal of the Peripheral Nervous System 12, 2-2
Hossain S, Parkinson DB, Mushynski WE & Almazan G 2007 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' NEURON GLIA BIOLOGY 2, S138-S139 Author Site
Hossain S, Parkinson DB, Mushynski WE & Almazan G 2007 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' Neuron Glia Biology 2, S138-S139
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR 2007 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' NEURON GLIA BIOLOGY 2, S42-S42 Author Site
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR 2007 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' Neuron Glia Biology 2, S42-S42
Arthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K 2007 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' NEURON GLIA BIOLOGY 2, S133-S133 Author Site
rthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K 2007 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' Neuron Glia Biology 2, S133-S133
Parkinson D, Arthur-Farraj P, Jessen K & Mirsky R 2006 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24, (1) 159-169 , DOI
Parkinson 2006 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24 (1), 159-69 , DOI
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR 2005 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' Journal of Neurochemistry 94, 139-139
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'The function of Notch and stress kinase signals in early Schwann cell development' Journal of Neurochemistry 94, 2-2
Parkinson D, Bhaskaran A, Dickinson S & Droggiti A 2004 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' The Journal of Cell Biology 164, (3) 385-394 , DOI PEARL
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R & Jessen KR 2004 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC 2004 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' EMBO J 23, (15) 3061-3071 Author Site , DOI
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC 2004 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' Embo Journal 23, (15) 3061-3071
Parkinson D, Bhaskaran A, Dickinson S & Kinsella M 2003 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Mol Cell Neurosci 23, (1) 13-27 , DOI
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Alonso MBD, Mirsky R & Jessen KR 2003 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Molecular and Cellular Neuroscience 23, (1) 13-27
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N 2003 'Signals that regulate Schwann cell generation and myelination' Glia 7-7
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R 2002 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' GLIA S69-S69 Author Site
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R 2002 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' Glia S69-S69
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2002 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' GLIA S73-S73 Author Site
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2002 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' Glia S73-S73
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong Z, Meier C, Parmantier E & Lawson D 2002 'Schwann cells as regulators of nerve development' J Physiol Paris 96, (1-2) 17-24 Author Site
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong ZP, Meier C, Parmantier E & Lawson D 2002 'Schwann cells as regulators of nerve development' Journal of Physiology-Paris 96, (1-2) 17-24
Parkinson DB, Langner K, Namini SS, Jessen KR & Mirsky R 2002 'β-Neuregulin and Autocrine Mediated Survival of Schwann Cells Requires Activity of Ets Family Transcription Factors' Molecular and Cellular Neuroscience 20, (1) 154-167 , DOI
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2001 'Krox-20 protects Schwann cells from TGF beta mediated cell death' Molecular Biology of the Cell 12, 28A-28A
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R 2001 'Krox-20 protects Schwann cells from TGF beta mediated cell death' MOLECULAR BIOLOGY OF THE CELL 12, 28A-28A Author Site
Mirsky R, Parkinson DB, Dong Z, Meier C, Calle E, Brennan A, Topilko P, Harris BS, Stewart HJ & Jessen KR 2001 'Regulation of genes involved in Schwann cell development and differentiation' Prog Brain Res 132, 3-11 Author Site , DOI
Parkinson DB, Dong ZP, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R & Jeesen KR 2001 'Transforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation' Journal of Neuroscience 21, (21) 8572-8585
Parkinson D, Bunting H, Dong Z & Whitfield J 2001 'Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation' J Neuroscience 21, (21) 8572-8585
Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R & Jessen KR 1999 'Schwann cell development in embryonic mouse nerves' J Neurosci Res 56, (4) 334-348 Author Site , DOI
Reviews
Kim HA, Mindos TC & Parkinson DB 2014 'Plastic fantastic: Schwann cells and repair of the peripheral nervous system' Stem Cells Translational Medicine 2 (8), 553-557
Conference Papers
Mindos T, Dun X-P, North K, Schulz A, Gray B, Pan D, Edwards P, Shivane A, Morrison H & Parkinson D 2017 'The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling' E40-E41
Mindos T, Edwards P, Shivane AG & Parkinson DB 2017 'The role of macrophages in human schwannomas' 18-18
Roberts S, Dunn XP, Doddrell R & Parkinson D 2015 'Analysing the role of Sox2 in regulating Schwann cell myelination during development and after injury' E274-E275
Mindos T, Roberts S, Dun X-P, Edwards P, Doddrell R, Shivane A & Parkinson D 2015 'The Merlin tumour suppressor is critical for peripheral nerve regeneration and repair' E423-E424
North K, Mindos T, Dun X-P & Parkinson D 2015 'The role of Hippo/YAP signalling in Schwann cell development and peripheral nerve repair' E437-E437
Mindos T, Roberts S, Doddrell R, Mortimer G, Dun XP, Edwards P, Shivane A & Parkinson D 2015 'The role of the Merlin tumour suppressor in the developing and injured adult peripheral nerve' 54-54
Mortimer G, Dun X, Doddrell RDS, Wrabetz L, Feltri ML & Parkinson DB 2013 'EXAMINING THE ROLE OF THE MERLIN TUMOUR SUPPRESSOR IN PERIPHERAL NERVE DEVELOPMENT AND REPAIR' 75-75
Schulz A, Baader S, Niwa-Kawakita M, Bauer R, Jung J, Zoch A, Schacke S, Hagel C, Mautner V & Hanemann O 2013 'THE ROLE OF MERLIN ISOFORM 2 IN NEUROFIBROMATOSIS TYPE 2-ASSOCIATED POLYNEUROPATHY' S104-S104
Shivane A, Ammoun S, Parkinson DB & Hanemann CO 2012 'EXPRESSION OF C-JUN & SOX-2 IN HUMAN SCHWANNOMAS AND TRAUMATIC NEUROMAS' 9-10
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB 2012 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' United States 1269-1278 , DOI
Doddrell RDS, Goodchild E & Parkinson DB 2010 'Role of the transcription factor Sox-2 in the control of peripheral nerve development and repair' S20-S20 , DOI
Doddrell R, Hanemann CO & Parkinson DB 2009 'REGULATION OF CELL DIFFERENTIATION IN MERLIN NULL TUMOURS' S170-S170
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR 2007 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' 2-2
Woodhoo A, Duran Alonso M, Parkinson DB, Mirsky R, Jessen KR & MEDIMOND 2005 'Factors affecting the early life of a Schwann cell' 139-143
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR 2005 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' 139-139
Parkinson DB, Bhaskaran A, Mirsky R, Jessen KR & MEDIMOND 2005 'Regulation of the myelinating phenotype of Schwann cells by Krox-20' 37-42
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'Signals that control glial cell specification in the PNS' 148-148
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A 2005 'The function of Notch and stress kinase signals in early Schwann cell development' 2-2 , DOI
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N 2003 'Signals that regulate Schwann cell generation and myelination' 7-7