Professor David Parkinson
Profiles

Professor David Parkinson

Professor of Neuroscience

Peninsula Medical School (Faculty of Health)

Professor David Parkinson can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Cancer
  • Brain tumour
  • Peripheral nervous system
Biography

Biography

Professor of Neuroscience.

Inspire lead for the Medical School
Home Office Named Information Officer for Plymouth University

Qualifications

BSc Biochemistry King's College

PhD Human Genetics University College London

PGCE (Clinical Education) Plymouth University

Key publications

Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P & Shen J (2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 Author Site , DOI
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A & Mirsky R (2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 Author Site , DOI Open access
Flaiz C, Utermark T, Parkinson DB, Poetsch A & Hanemann CO (2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 Author Site , DOI
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R & Jessen KR (2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH & Lloyd AC (2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 Author Site , DOI
View all publications
Teaching

Teaching

Teaching interests

Neuroscience and developmental biology

Cell signalling and cancer

Research

Research

Research interests

My research interest in the control of myelination and repair in the peripheral nervous system (PNS). The PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity. 

Research groups

Publications

Publications

Key publications

Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P & Shen J (2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 Author Site , DOI
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A & Mirsky R (2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 Author Site , DOI Open access
Flaiz C, Utermark T, Parkinson DB, Poetsch A & Hanemann CO (2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 Author Site , DOI
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R & Jessen KR (2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH & Lloyd AC (2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 Author Site , DOI

Key publications are highlighted

Journals
Articles
Laraba L, Hillson L, de Guibert JG, Hewitt A, Jaques MR, Tang TT, Post L, Ercolano E, Rai G & Yang SM (2022) 'Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma' Brain , DOI
Maze EA, Agit B, Reeves S, Hilton DA, Parkinson DB, Laraba L, Ercolano E, Kurian KM, Hanemann CO & Belshaw RD (2021) 'Human endogenous retrovirus type K promotes proliferation and confers sensitivity to anti-retroviral drugs in Merlin-negative schwannoma and meningioma' Cancer Research , DOI Open access
Li M, Banton MC, Min Q, Parkinson DB & Dun X (2021) 'Meta-Analysis Reveals Transcription Factor Upregulation in Cells of Injured Mouse Sciatic Nerve' Frontiers in Cellular Neuroscience 15, , DOI Open access
Chen B, Banton MC, Singh L, Parkinson DB & Dun X-P (2021) 'Single Cell Transcriptome Data Analysis Defines the Heterogeneity of Peripheral Nerve Cells in Homeostasis and Regeneration' Frontiers in Cellular Neuroscience 15, , DOI Open access
Rafipay A, Dun X, Parkinson DB, Erskine L & Vargesson N (2021) 'Knockdown of slit signaling during limb development leads to a reduction in humerus length' Developmental Dynamics 250, (9) 1340-1357 , DOI
Chen B, Hu R, Min Q, Li Y, Parkinson DB & Dun X-P (2020) 'FGF5 Regulates Schwann Cell Migration and Adhesion' Frontiers in Cellular Neuroscience 14, , DOI Open access
Min Q, Parkinson DB & Dun X (2020) 'Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge' Glia , DOI Open access
Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D & Fernández-Ramos D (2020) 'HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis' Journal of Clinical Investigation 130, (7) 3848-3864 , DOI Open access
Dun X (2019) 'Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration' Frontiers in Neuroscience , DOI Open access
Chen B, Chen Q, Parkinson DB & Dun X-P (2019) 'Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge' Frontiers in Molecular Neuroscience 12, , DOI Open access
Dun X-P & Parkinson D (2019) 'Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration' Neural Regeneration Research 15, (1) 6-6 , DOI Open access
Dun X, Carr L, Woodley P, Barry R, Drake L, Mindos T, Robert S, Lloyd A & Parkinson D (2019) 'Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge' Cell Reports 26, (6) , DOI Open access
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, Lloyd AC & D'Antonio M (2017) 'Sox2 expression in Schwann cells inhibits myelination <i>in vivo</i> and induces influx of macrophages to the nerve' Journal of Cell Science 130, (18) e1.2-e1.2 , DOI
Dun X-P & Parkinson D (2017) 'Role of Netrin-1 Signaling in Nerve Regeneration' International Journal of Molecular Sciences 18, (3) 491-491 , DOI Open access
Carr L, Parkinson DB & Dun X-P (2017) 'Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system' PLoS One 12, (2) e0172736-e0172736 Author Site , DOI Open access
Mindos T, Dun X-P, North K, Doddrell RDS, Schulz A, Edwards P, Russell J, Gray B, Roberts SL & Shivane A (2017) 'Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity' Journal of Cell Biology 495-510 , DOI Open access
Mindos T, Dun X-P, North K, Schulz A, Gray B, Pan D, Edwards P, Shivane A, Morrison H & Parkinson D (2017) 'The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling' Journal of Cell Biology 65, E40-E41 , DOI Open access
Roberts SL, Dun X-P, Dee G, Gray B, Mindos T & Parkinson DB (2017) 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of Neurochemistry , DOI Open access
Roberts SL, Dun X-P, Doddrell RDS, Mindos T, Drake LK, Onaitis MW, Florio F, Quattrini A, D'Antonio M & Parkinson DB (2017) 'Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve' Development Author Site , DOI Open access
Schulz A, Büttner R, Hagel C, Baader SL, Kluwe L, Salamon J, Mautner VF, Mindos T, Parkinson DB & Gehlhausen JR (2016) 'The importance of nerve microenvironment for schwannoma development' Acta neuropathologica , DOI Open access
Dun X-P & Parkinson DB (2015) 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) Author Site , DOI Open access
Plotkin SR, Albers AC, Babovic-Vuksanovic D, Blakeley JO, Breakefield XO, Dunn CM, Evans DG, Fisher MJ, Friedman JM & Giovannini M (2014) 'Update from the 2013 International Neurofibromatosis Conference' AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164, (12) 2969-2978 Author Site , DOI
Kim HA, Mindos T & Parkinson DB (2013) 'Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System' STEM CELLS TRANSLATIONAL MEDICINE 2, (8) 553-557 Author Site , DOI
Schulz A, Baader SL, Niwa-Kawakita M, Jung MJ, Bauer R, Garcia C, Zoch A, Schacke S, Hagel C & Mautner V-F (2013) 'Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy' NATURE NEUROSCIENCE 16, (4) 426-U86 Author Site , DOI
Shivane A, Parkinson DB, Ammoun S & Hanemann CO (2013) 'Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas' HISTOPATHOLOGY 62, (4) 651-656 Author Site , DOI
Doddrell RDS, Dun X-P, Shivane A, Feltri ML, Wrabetz L, Wegner M, Sock E, Hanemann CO & Parkinson DB (2013) 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 Author Site , DOI Open access
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB (2012) 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' GLIA 60, (9) 1269-1278 Author Site , DOI
Yang DP, Kim J, Syed N, Tung YJ, Bhaskaran A, Mindos TC, Mirsky R, Jessen KR, Maurel P & Parkinson DB (2012) 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' The Journal of Neuroscience 32(21), 7158-7168
Yang DP, Kim J, Syed N, Tung Y-J, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P & Parkinson DB (2012) 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' J Neurosci 32, (21) 7158-7168 Author Site , DOI
Arthur-Farraj P, Wanek K, Hantke J, Davis CM, Jayakar A, Parkinson DB, Mirsky R & Jessen KR (2011) 'Mouse schwann cells need both NRG1 and cyclic AMP to myelinate' Glia 59, (5) 720-733 Author Site , DOI
Mustafa MK, Nabok A, Parkinson D, Tothill IE, Salam F & Tsargorodskaya A (2010) 'Detection of β-amyloid peptide (1–16) and amyloid precursor protein (APP770) using spectroscopic ellipsometry and QCM techniques: A step forward towards Alzheimers disease diagnostics' Biosensors and Bioelectronics 26, (4) 1332-1336 , DOI
Parrinello S, Napoli I, Ribeiro S, Wingfield Digby P, Fedorova M, Parkinson DB, Doddrell RDS, Nakayama M, Adams RH & Lloyd AC (2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 Author Site , DOI
Whiteman M, Li L, Rose P, Tan C-H, Parkinson DB & Moore PK (2010) 'The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages' Antioxid Redox Signal 12, (10) 1147-1154 Author Site , DOI
Woodhoo A, Alonso MBD, Droggiti A, Turmaine M, D'Antonio M, Parkinson DB, Wilton DK, Al-Shawi R, Simons P & Shen J (2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 Author Site , DOI
Mirsky R, Woodhoo A, Parkinson DB, Arthur-Farraj P, Bhaskaran A & Jessen KR (2008) 'Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation' J Peripher Nerv Syst 13, (2) 122-135 Author Site , DOI
Parkinson DB, Bhaskaran A, Arthur-Farraj P, Noon LA, Woodhoo A, Lloyd AC, Feltri ML, Wrabetz L, Behrens A & Mirsky R (2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 Author Site , DOI Open access
Flaiz C, Utermark T, Parkinson DB, Poetsch A & Hanemann CO (2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 Author Site , DOI
Parkinson D, Bhaskaran A, rthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K (2007) 'A central role for c-Jun in regulating the differentiation of Schwann cells' Neuron Glia Biology 2, S38-S38
Parkinson D, Bhaskaran A, Arthur-Farraj P, Noon L, Lloyd A, Behrens A, Feltri L, Wrabetz L, Mirsky R & Lessen K (2007) 'A central role for c-Jun in regulating the differentiation of Schwann cells' NEURON GLIA BIOLOGY 2, S38-S38 Author Site
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR (2007) 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' Journal of the Peripheral Nervous System 12, 2-2
Hossain S, Parkinson DB, Mushynski WE & Almazan G (2007) 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' NEURON GLIA BIOLOGY 2, S138-S139 Author Site
Hossain S, Parkinson DB, Mushynski WE & Almazan G (2007) 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' Neuron Glia Biology 2, S138-S139
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR (2007) 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' NEURON GLIA BIOLOGY 2, S42-S42 Author Site
Bhaskaran A, Parkinson D, Mirsky R & Jessen KR (2007) 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' Neuron Glia Biology 2, S42-S42
Arthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K (2007) 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' NEURON GLIA BIOLOGY 2, S133-S133 Author Site
rthur-Farraj P, Bhaskaran A, Parkinson D, Turmaine M, Feltri L, Wrabetz L, Behrens A, Mirsky R & Lessen K (2007) 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' Neuron Glia Biology 2, S133-S133
Newton JRA, Parkinson D & Clench MR (2006) 'Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms' Analytical and Bioanalytical Chemistry 385, (4) 692-699 , DOI
Parkinson D, Arthur-Farraj P, Jessen K & Mirsky R (2006) 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24, (1) 159-169 , DOI
Parkinson (2006) 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24 (1), 159-69 , DOI
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR (2005) 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' Journal of Neurochemistry 94, 139-139
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A (2005) 'The function of Notch and stress kinase signals in early Schwann cell development' Journal of Neurochemistry 94, 2-2
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC (2004) 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' EMBO J 23, (15) 3061-3071 Author Site , DOI
Parkinson D, Bhaskaran A, Dickinson S & Droggiti A (2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' The Journal of Cell Biology 164, (3) 385-394 , DOI Open access
Parkinson DB, Bhaskaran A, Droggiti A, Dickinson S, D'Antonio M, Mirsky R & Jessen KR (2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
Harrisingh MC, Perez-Nadales E, Parkinson DB, Malcolm DS, Mudge AW & Lloyd AC (2004) 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' Embo Journal 23, (15) 3061-3071
Parkinson D, Bhaskaran A, Dickinson S & Kinsella M (2003) 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Mol Cell Neurosci 23, (1) 13-27 , DOI
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Sharghi-Namini S, Alonso MBD, Mirsky R & Jessen KR (2003) 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Molecular and Cellular Neuroscience 23, (1) 13-27
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N (2003) 'Signals that regulate Schwann cell generation and myelination' Glia 7-7
Parkinson DB, Langner K, Namini SS, Jessen KR & Mirsky R (2002) 'beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors' Mol Cell Neurosci 20, (1) 154-167 Author Site , DOI
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R (2002) 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' GLIA S69-S69 Author Site
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R (2002) 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' GLIA S73-S73 Author Site
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong Z, Meier C, Parmantier E & Lawson D (2002) 'Schwann cells as regulators of nerve development' J Physiol Paris 96, (1-2) 17-24 Author Site , DOI
Mirsky R, Jessen KR, Brennan A, Parkinson D, Dong ZP, Meier C, Parmantier E & Lawson D (2002) 'Schwann cells as regulators of nerve development' Journal of Physiology-Paris 96, (1-2) 17-24
Parkinson DB, Dickinson S, Bhaskaran A, Kinsella MT, Brophy PJ, Sherman DL, Namini SS, Alonso MBD, Jessen KR & Mirsky R (2002) 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' Glia S69-S69
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R (2002) 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' Glia S73-S73
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R (2001) 'Krox-20 protects Schwann cells from TGF beta mediated cell death' MOLECULAR BIOLOGY OF THE CELL 12, 28A-28A Author Site
Parkinson D, Bunting H, Dong Z & Whitfield J (2001) 'Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation' J Neuroscience 21, (21) 8572-8585
Bhaskaran A, Parkinson DB, von Hertzen L, Jessen KR & Mirsky R (2001) 'Krox-20 protects Schwann cells from TGF beta mediated cell death' Molecular Biology of the Cell 12, 28A-28A
Mirsky R, Parkinson DB, Dong Z, Meier C, Calle E, Brennan A, Topilko P, Harris BS, Stewart HJ & Jessen KR (2001) 'Regulation of genes involved in Schwann cell development and differentiation' Prog Brain Res 132, 3-11 Author Site , DOI
Parkinson DB, Dong ZP, Bunting H, Whitfield J, Meier C, Marie H, Mirsky R & Jeesen KR (2001) 'Transforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation' Journal of Neuroscience 21, (21) 8572-8585
Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R & Jessen KR (1999) 'Schwann cell development in embryonic mouse nerves' J Neurosci Res 56, (4) 334-348 Author Site , DOI
Dong Z, Sinanan A, Parkinson D, Parmantier E, Mirsky R & Jessen KR (1999) 'Schwann cell development in embryonic mouse nerves' Journal of Neuroscience Research 56, (4) 334-348 , DOI
Perlmutter JS, Tempel LW, Black KJ, Parkinson D & Todd RD (1997) 'MPTP induces dystonia and parkinsonism' Neurology 49, (5) 1432-1438 , DOI
Aguilar-Diosdado M, Parkinson D, Corbett JA, Kwon G, Marshall CA, Gingerich RL, Santiago JV & McDaniel ML (1994) 'Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface' Diabetes 43, (3) 418-425 Author Site , DOI
Parkinson DB, Shaw NJ, Himsworth RL & Thakker RV (1993) 'Parathyroid hormone gene analysis in autosomal hypoparathyroidism using an intragenic tetranucleotide (AAAT) n polymorphism' Human Genetics 91, (3) , DOI
Bilous RW, Murty G, Parkinson DB, Thakker RV, Coulthard MG, Burn J, Mathias D & Kendall-Taylor P (1992) 'Autosomal Dominant Familial Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia' New England Journal of Medicine 327, (15) 1069-1074 , DOI
Fiedorek FT & Parkinson D (1992) 'Carboxypeptidase H processing and secretion in rat clonal beta-cell lines' Endocrinology 131, (3) 1054-1062 , DOI
Parkinson D (1992) 'Carboxypeptidase H in bovine pituitary gland: Soluble forms are not processed at the C-terminus' Molecular and Cellular Endocrinology 86, (3) 221-233 , DOI
Parkinson DB & Thakker RV (1992) 'A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism' Nature Genetics 1, (2) 149-152 , DOI
Gredal O, Parkinson D & Nielsen M (1987) 'Binding of [3H]SCH 23390 to dopamine D-1 receptors in rat retina in vitro' European Journal of Pharmacology 137, (2-3) 241-245 , DOI
Loewy AD, Marson L, Parkinson D, Perry MA & Sawyer WB (1986) 'Descending noradrenergic pathways involved in the A5 depressor response' Brain Research 386, (1-2) 313-324 , DOI
Parkinson D (1985) 'Sensitive analysis of butyrophenone neuroleptics by high-performance liquid chromatography with ultraviolet detection at 254 nm' Journal of Chromatography B: Biomedical Sciences and Applications 341, 465-472 , DOI
Parkinson D & Redshaw JD (1984) 'Visible labeling of proteins for polyacrylamide gel electrophoresis with dabsyl chloride' Analytical Biochemistry 141, (1) 121-126 , DOI
Parkinson D & Rando RR (1984) 'Ontogenesis of dopaminergic neurons in the post-natal rabbit retina: Pre- and post-synaptic elements' Developmental Brain Research 13, (2) 207-217 , DOI
Parkinson D & Callingham BA (1982) 'Irradiation Inactivation Analysis of Acetylcholinesterase and the Effect of Buffer Salts' Radiation Research 90, (2) 252-252 , DOI
Parkinson D & Rando RR (1981) 'Evidence for a neurotransmitter role for 5-hydroxytryptamine in chick retina' The Journal of Neuroscience 1, (11) 1211-1217 , DOI
Callingham BA & Parkinson D (1977) 'The inhibition of human heart monoamine oxidase [proceedings]' Br J Pharmacol 61, (3) 470P-471P Author Site
Reviews
Kim HA, Mindos TC & Parkinson DB (2014) 'Plastic fantastic: Schwann cells and repair of the peripheral nervous system' Stem Cells Translational Medicine 2 (8), 553-557
Chapters
Parkinson DB & Svaren J (2020) 'Specification of macroglia by transcription factors' Patterning and Cell Type Specification in the Developing CNS and PNS Elsevier 937-951 , DOI
Bond P & Parkinson DB (2018) 'The Use of Low Vacuum Scanning Electron Microscopy (LVSEM) to Analyze Peripheral Nerve Samples' Methods in Molecular Biology Springer New York 349-357 , DOI
Dun X-P & Parkinson DB (2018) 'Transection and Crush Models of Nerve Injury to Measure Repair and Remyelination in Peripheral Nerve' Methods in Molecular Biology Springer New York 251-262 , DOI Open access
Dun X-P & Parkinson DB (2018) 'Whole Mount Immunostaining on Mouse Sciatic Nerves to Visualize Events of Peripheral Nerve Regeneration' Methods in Molecular Biology Springer New York 339-348 , DOI Open access
Conference Papers
Parkinson DB, Laraba L, Roy H, Whitehouse J, Gregario SM & Dun X-P (2019) 'Hippo signalling in peripheral nerve development, repair and tumourigenesis' E175-E176
Mindos T, Edwards P, Shivane AG & Parkinson DB (2017) 'The role of macrophages in human schwannomas' 18-18
Roberts S, Dunn XP, Doddrell R & Parkinson D (2015) 'Analysing the role of Sox2 in regulating Schwann cell myelination during development and after injury' E274-E275
Mindos T, Roberts S, Dun X-P, Edwards P, Doddrell R, Shivane A & Parkinson D (2015) 'The Merlin tumour suppressor is critical for peripheral nerve regeneration and repair' E423-E424
North K, Mindos T, Dun X-P & Parkinson D (2015) 'The role of Hippo/YAP signalling in Schwann cell development and peripheral nerve repair' E437-E437
Mindos T, Roberts S, Doddrell R, Mortimer G, Dun XP, Edwards P, Shivane A & Parkinson D (2015) 'The role of the Merlin tumour suppressor in the developing and injured adult peripheral nerve' 54-54
Schulz A, Baader S, Niwa-Kawakita M, Bauer R, Jung J, Zoch A, Schacke S, Hagel C, Mautner V & Hanemann O (2013) 'THE ROLE OF MERLIN ISOFORM 2 IN NEUROFIBROMATOSIS TYPE 2-ASSOCIATED POLYNEUROPATHY' S104-S104
Mortimer G, Dun X, Doddrell RDS, Wrabetz L, Feltri ML & Parkinson DB (2013) 'EXAMINING THE ROLE OF THE MERLIN TUMOUR SUPPRESSOR IN PERIPHERAL NERVE DEVELOPMENT AND REPAIR' 75-75
Doddrell RDS, Dun X-P, Moate RM, Jessen KR, Mirsky R & Parkinson DB (2012) 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' United States 1269-1278 , DOI
Shivane A, Ammoun S, Parkinson DB & Hanemann CO (2012) 'EXPRESSION OF C-JUN & SOX-2 IN HUMAN SCHWANNOMAS AND TRAUMATIC NEUROMAS' 9-10
Doddrell RDS, Goodchild E & Parkinson DB (2010) 'Role of the transcription factor Sox-2 in the control of peripheral nerve development and repair' S20-S20 , DOI
Doddrell R, Hanemann CO & Parkinson DB (2009) 'REGULATION OF CELL DIFFERENTIATION IN MERLIN NULL TUMOURS' S170-S170
Mirsky R, Woodhoo A, Parkinson DB, Banerjee A, Sharghi-Namini S & Jessen KR (2007) 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' 2-2
MAINS RE, ZHOU AN & PARKINSON D (2006) 'The Biosynthetic Processing and Secretion of Endogenous Carboxypeptidase H in Mouse Pituitary Cellsa' Wiley 10-18 , DOI
Parkinson DB, Bhaskaran A, Mirsky R & Jessen KR (2005) 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' 139-139
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A (2005) 'Signals that control glial cell specification in the PNS' 148-148
Jessen KR, Mirsky R, Woodhoo A, Parkinson D & Bhaskaran A (2005) 'The function of Notch and stress kinase signals in early Schwann cell development' 2-2 , DOI
Woodhoo A, Duran Alonso M, Parkinson DB, Mirsky R, Jessen KR & MEDIMOND (2005) 'Factors affecting the early life of a Schwann cell' 139-143
Parkinson DB, Bhaskaran A, Mirsky R, Jessen KR & MEDIMOND (2005) 'Regulation of the myelinating phenotype of Schwann cells by Krox-20' 37-42
Jessen KR, Mirsky R, Parkinson D, Bhaskaran A & Kazakova N (2003) 'Signals that regulate Schwann cell generation and myelination' 7-7
Moerlein SM, Perlmutter JS, Bockhorst JL, Parkinson D & Welch MJ (1994) 'N-alkylated analogues of [F-18]benperidol as dopaminergic D-2 receptor ligands' 462-463
Presentations and posters
Laraba L, Ferluga S, Ercolano E, Adams C, Shivane A, Edwards P, Futschik M, Lenis V, de Guibert JG & Moller S Laraba L, Ferluga S, Ercolano E, Adams C, Shivane A, Edwards P, Futschik M, Lenis V, de Guibert JG & Moller S 'The cancer stem cell marker ALDH1A1 is upregulated and drives proliferation in merlin null meningioma and schwannoma' Author Site
Woodhouse E, Laraba L, Lespade C, Srotyr M, Lloyd AC & Parkinson DB Woodhouse E, Laraba L, Lespade C, Srotyr M, Lloyd AC & Parkinson DB 'Activation of MAPK/ERK signalling in Merlin-null Schwann cells leads to increased and sustained immune cell infiltration in the peripheral nervous system' , DOI
Hillson L, Laraba L, Shivane AG, Edwards P, Bantukallu G, Simeonov A, Martinez NJ, Yang S-M & Parkinson DB Hillson L, Laraba L, Shivane AG, Edwards P, Bantukallu G, Simeonov A, Martinez NJ, Yang S-M & Parkinson DB 'Abstract 5957: Roles for the cancer stem cell marker Aldh1A1 in Merlin null nervous system tumors' , DOI
Hanemann CO, Maze E, Agit B, Reeves S, Hilton D, Parkinson DB, Laraba L, Ercolano E, Kurian K & Belshaw R Hanemann CO, Maze E, Agit B, Reeves S, Hilton D, Parkinson DB, Laraba L, Ercolano E, Kurian K & Belshaw R 'Human Endogenous Retrovirus Type K promotes proliferation of Merlin-negative schwannoma and meningioma which can be inhibited by anti-retroviral and anti-TEAD drugs' , DOI Open access
Lespade C, Laraba L, Woodhouse E, Srotyr M, Lloyd AC & Parkinson DB Lespade C, Laraba L, Woodhouse E, Srotyr M, Lloyd AC & Parkinson DB 'Activation of Raf signalling in NF2-null Schwann cells leads to sustained proliferation; an investigation of a new and inducible model for human schwannoma' , DOI
Laraba L, de Guibert JG, Tang TT, Post L & Parkinson DB Laraba L, de Guibert JG, Tang TT, Post L & Parkinson DB 'Abstract 6384: TEAD inhibition reduces tumor proliferation in Merlin null meningioma and schwannoma' , DOI
Srotyr M, Laraba L, Harper GM, Lespade C, Woodhouse E, Lloyd AC & Parkinson DB Srotyr M, Laraba L, Harper GM, Lespade C, Woodhouse E, Lloyd AC & Parkinson DB 'Use of a new mouse schwannoma tumour model to monitor changes in peripheral nerve morphology in Merlin null Schwann cells' , DOI