- Plymouth University School of Medicine and Dentistry, John Bull Building, Drake Circus, Plymouth, PL4 8AA
- +44 1752 583203
- david.parkinson@plymouth.ac.uk
Profiles
Professor David Parkinson
Professor of Neuroscience
Peninsula Medical School (Faculty of Health)
Professor David Parkinson can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Cancer
- Brain tumour
- Peripheral nervous system
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
Professor of Neuroscience.
Inspire lead for the Medical School
Home Office Named Information Officer for Plymouth University
Qualifications
BSc Biochemistry King's College
PhD Human Genetics University College London
PGCE (Clinical Education) Plymouth University
Key publications
(2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 , DOI
(2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 , DOI Open access
(2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 , DOI
(2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
(2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 , DOI
Teaching
Teaching
Teaching interests
Neuroscience and developmental biology
Cell signalling and cancer
Research
Research
Research interests
My research interest in the control of myelination and repair in the peripheral nervous system (PNS). The PNS is myelinated by Schwann cells which ensheathe and myelinate the large caliber axons and allow rapid (saltatory) conduction of nerve impulses. I have studied the transcription factor Krox-20 and how this protein co-ordinates the proliferation, survival and myelination of Schwann cells. My lab also researches what underlies the remarkable ability of Schwann cells to regenerate and repair injury in the peripheral nervous system and how proteins such as c-Jun, Sox-2 and the Merlin tumour suppressor facilitate this repair and cell plasticity.
Research groups
Publications
Publications
Key publications
(2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 , DOI
(2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 , DOI Open access
(2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 , DOI
(2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
(2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 , DOI
Key publications are highlighted
Journals
Articles
(2023) 'Retraction Notice to: Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge' Cell Reports 42, (5) 112517-112517 , DOI
(2022) 'Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma' Brain , DOI Open access
(2022) 'Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma' Brain , DOI Open access
(2021) 'Human endogenous retrovirus type K promotes proliferation and confers sensitivity to anti-retroviral drugs in Merlin-negative schwannoma and meningioma' Cancer Research , DOI Open access
(2021) 'Meta-Analysis Reveals Transcription Factor Upregulation in Cells of Injured Mouse Sciatic Nerve' Frontiers in Cellular Neuroscience 15, , DOI Open access
(2021) 'Single Cell Transcriptome Data Analysis Defines the Heterogeneity of Peripheral Nerve Cells in Homeostasis and Regeneration' Frontiers in Cellular Neuroscience 15, , DOI Open access
(2021) 'Knockdown of slit signaling during limb development leads to a reduction in humerus length' Developmental Dynamics 250, (9) 1340-1357 , DOI
(2020) 'FGF5 Regulates Schwann Cell Migration and Adhesion' Frontiers in Cellular Neuroscience 14, , DOI Open access
(2020) 'Migrating Schwann cells direct axon regeneration within the peripheral nerve bridge' Glia , DOI Open access
(2020) 'HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis' Journal of Clinical Investigation 130, (7) 3848-3864 , DOI Open access
(2019) 'Distinct VIP and PACAP Functions in the Distal Nerve Stump During Peripheral Nerve Regeneration' Frontiers in Neuroscience , DOI Open access
(2019) 'Analysis of Schwann Cell Migration and Axon Regeneration Following Nerve Injury in the Sciatic Nerve Bridge' Frontiers in Molecular Neuroscience 12, , DOI Open access
(2019) 'Classic axon guidance molecules control correct nerve bridge tissue formation and precise axon regeneration' Neural Regeneration Research 15, (1) 6-6 , DOI Open access
(2019) 'Macrophage-Derived Slit3 Controls Cell Migration and Axon Pathfinding in the Peripheral Nerve Bridge' Cell Reports 26, (6) , DOI Open access
(2017) 'Sox2 expression in Schwann cells inhibits myelination <i>in vivo</i> and induces influx of macrophages to the nerve' Journal of Cell Science 130, (18) e1.2-e1.2 , DOI
(2017) 'Role of Netrin-1 Signaling in Nerve Regeneration' International Journal of Molecular Sciences 18, (3) 491-491 , DOI Open access
(2017) 'Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system' PLoS One 12, (2) e0172736-e0172736 , DOI Open access
(2017) 'Merlin controls the repair capacity of Schwann cells after injury by regulating Hippo/YAP activity' Journal of Cell Biology 495-510 , DOI Open access
(2017) 'The Merlin tumour suppressor controls the repair capacity of Schwann cells following injury by regulating Hippo pathway signalling' Journal of Cell Biology 65, E40-E41 , DOI Open access
(2017) 'The role of p38alpha in Schwann cells in regulating peripheral nerve myelination and repair' Journal of Neurochemistry , DOI Open access
(2017) 'Sox2 expression in Schwann cells inhibits myelination in vivo and induces influx of macrophages to the nerve' Development , DOI Open access
(2016) 'The importance of nerve microenvironment for schwannoma development' Acta neuropathologica , DOI Open access
(2015) 'Visualizing peripheral nerve regeneration by whole mount staining' PLoS One 10, (3) , DOI Open access
(2014) 'Update from the 2013 International Neurofibromatosis Conference' AMERICAN JOURNAL OF MEDICAL GENETICS PART A 164, (12) 2969-2978 , DOI
(2013) 'Plastic Fantastic: Schwann Cells and Repair of the Peripheral Nervous System' STEM CELLS TRANSLATIONAL MEDICINE 2, (8) 553-557 , DOI
(2013) 'Merlin isoform 2 in neurofibromatosis type 2-associated polyneuropathy' NATURE NEUROSCIENCE 16, (4) 426-U86 , DOI
(2013) 'Expression of c-Jun and Sox-2 in human schwannomas and traumatic neuromas' HISTOPATHOLOGY 62, (4) 651-656 , DOI
(2013) 'Loss of SOX10 function contributes to the phenotype of human Merlin-null schwannoma cells' Brain 136, (Pt 2) 549-563 , DOI Open access
(2012) 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' GLIA 60, (9) 1269-1278 , DOI
(2012) 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' The Journal of Neuroscience 32(21), 7158-7168
(2012) 'p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination' J Neurosci 32, (21) 7158-7168 , DOI
(2010) 'Detection of β-amyloid peptide (1–16) and amyloid precursor protein (APP770) using spectroscopic ellipsometry and QCM techniques: A step forward towards Alzheimers disease diagnostics' Biosensors and Bioelectronics 26, (4) 1332-1336 , DOI
(2010) 'EphB signaling directs peripheral nerve regeneration through Sox2-dependent Schwann cell sorting' Cell 143, (1) 145-155 , DOI
(2010) 'The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages' Antioxid Redox Signal 12, (10) 1147-1154 , DOI
(2009) 'Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity' Nat Neurosci 12, (7) 839-847 , DOI
(2008) 'Novel signals controlling embryonic Schwann cell development, myelination and dedifferentiation' J Peripher Nerv Syst 13, (2) 122-135 , DOI
(2008) 'c-Jun is a negative regulator of myelination' J Cell Biol 181, (4) 625-637 , DOI Open access
(2008) 'Impaired intercellular adhesion and immature adherens junctions in merlin-deficient human primary schwannoma cells' Glia 56, (5) 506-515 , DOI
(2007) 'A central role for c-Jun in regulating the differentiation of Schwann cells' Neuron Glia Biology 2, S38-S38
(2007) 'A central role for c-Jun in regulating the differentiation of Schwann cells' NEURON GLIA BIOLOGY 2, S38-S38
(2007) 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' Journal of the Peripheral Nervous System 12, 2-2
(2007) 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' NEURON GLIA BIOLOGY 2, S138-S139
(2007) 'Mitogen Activated Protein Kinase p38 regulates transcription factor Krox-20 and Schwann cell differentiation' Neuron Glia Biology 2, S138-S139
(2007) 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' NEURON GLIA BIOLOGY 2, S42-S42
(2007) 'Schwann cell myelination is inhibited by c-jun and p38 mitogen activated protein kinase pathways' Neuron Glia Biology 2, S42-S42
(2007) 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' NEURON GLIA BIOLOGY 2, S133-S133
(2007) 'The transcription factor c-Jun, controls Schwann cell demyelination and dedifferentiation after peripheral nerve injury' Neuron Glia Biology 2, S133-S133
(2006) 'Strategies for examination of Alzheimer’s disease amyloid precursor protein isoforms' Analytical and Bioanalytical Chemistry 385, (4) 692-699 , DOI
(2006) 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24, (1) 159-169 , DOI
(2006) 'A double point mutation in the DNA-binding region of Egr2 switches its function from inhibition to induction of proliferation: A potential contribution to the development of congenital hypomyelinating neuropathy' Neurobiology of Disease 24 (1), 159-69 , DOI
(2005) 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' Journal of Neurochemistry 94, 139-139
(2005) 'The function of Notch and stress kinase signals in early Schwann cell development' Journal of Neurochemistry 94, 2-2
(2004) 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' EMBO J 23, (15) 3061-3071 , DOI
(2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' The Journal of Cell Biology 164, (3) 385-394 , DOI Open access
(2004) 'Krox-20 inhibits Jun-NH2-terminal kinase/c-Jun to control Schwann cell proliferation and death' Journal of Cell Biology 164, (3) 385-394
(2004) 'The Ras/Raf/ERK signalling pathway drives Schwann cell dedifferentiation' Embo Journal 23, (15) 3061-3071
(2003) 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Mol Cell Neurosci 23, (1) 13-27 , DOI
(2003) 'Regulation of the myelin gene periaxin provides evidence for Krox-20-independent myelin-related signalling in Schwann cells' Molecular and Cellular Neuroscience 23, (1) 13-27
(2003) 'Signals that regulate Schwann cell generation and myelination' Glia 7-7
(2002) 'beta-Neuregulin and autocrine mediated survival of Schwann cells requires activity of Ets family transcription factors' Mol Cell Neurosci 20, (1) 154-167 , DOI
(2002) 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' GLIA S69-S69
(2002) 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' GLIA S73-S73
(2002) 'Schwann cells as regulators of nerve development' Journal of Physiology-Paris 96, (1-2) 17-24
(2002) 'Krox-20 activates a set of complex changes in Schwann cells that characterize myelination' Glia S69-S69
(2002) 'Krox-20 protects Schwann cells from TGF-beta mediated cell death' Glia S73-S73
(2001) 'Krox-20 protects Schwann cells from TGF beta mediated cell death' MOLECULAR BIOLOGY OF THE CELL 12, 28A-28A
(2001) 'Transforming growth factor beta (TGFbeta) mediates Schwann cell death in vitro and in vivo: examination of c-Jun activation, interactions with survival signals, and the relationship of TGFbeta-mediated death to Schwann cell differentiation' J Neuroscience 21, (21) 8572-8585
(2001) 'Krox-20 protects Schwann cells from TGF beta mediated cell death' Molecular Biology of the Cell 12, 28A-28A
(2001) 'Regulation of genes involved in Schwann cell development and differentiation' Prog Brain Res 132, 3-11 , DOI
(2001) 'Transforming growth factor beta (TGF beta) mediates schwann cell death in vitro and in vivo: Examination of c-jun activation, interactions with survival signals, and the relationship of TGF beta-mediated death to schwann cell differentiation' Journal of Neuroscience 21, (21) 8572-8585
(1999) 'Schwann cell development in embryonic mouse nerves' Journal of Neuroscience Research 56, (4) 334-348 , DOI
(1994) 'Potential autoantigens in IDDM. Expression of carboxypeptidase-H and insulin but not glutamate decarboxylase on the beta-cell surface' Diabetes 43, (3) 418-425 , DOI
(1993) 'Parathyroid hormone gene analysis in autosomal hypoparathyroidism using an intragenic tetranucleotide (AAAT) n polymorphism' Human Genetics 91, (3) , DOI
(1992) 'Autosomal Dominant Familial Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia' New England Journal of Medicine 327, (15) 1069-1074 , DOI
(1992) 'Carboxypeptidase H processing and secretion in rat clonal beta-cell lines' Endocrinology 131, (3) 1054-1062 , DOI
(1992) 'Carboxypeptidase H in bovine pituitary gland: Soluble forms are not processed at the C-terminus' Molecular and Cellular Endocrinology 86, (3) 221-233 , DOI
(1992) 'A donor splice site mutation in the parathyroid hormone gene is associated with autosomal recessive hypoparathyroidism' Nature Genetics 1, (2) 149-152 , DOI
(1987) 'Binding of [3H]SCH 23390 to dopamine D-1 receptors in rat retina in vitro' European Journal of Pharmacology 137, (2-3) 241-245 , DOI
(1986) 'Descending noradrenergic pathways involved in the A5 depressor response' Brain Research 386, (1-2) 313-324 , DOI
(1985) 'Sensitive analysis of butyrophenone neuroleptics by high-performance liquid chromatography with ultraviolet detection at 254 nm' Journal of Chromatography B: Biomedical Sciences and Applications 341, 465-472 , DOI
(1984) 'Visible labeling of proteins for polyacrylamide gel electrophoresis with dabsyl chloride' Analytical Biochemistry 141, (1) 121-126 , DOI
(1984) 'Ontogenesis of dopaminergic neurons in the post-natal rabbit retina: Pre- and post-synaptic elements' Developmental Brain Research 13, (2) 207-217 , DOI
(1982) 'Irradiation Inactivation Analysis of Acetylcholinesterase and the Effect of Buffer Salts' Radiation Research 90, (2) 252-252 , DOI
(1981) 'Evidence for a neurotransmitter role for 5-hydroxytryptamine in chick retina' The Journal of Neuroscience 1, (11) 1211-1217 , DOI
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Reviews
(2014) 'Plastic fantastic: Schwann cells and repair of the peripheral nervous system' Stem Cells Translational Medicine 2 (8), 553-557
Chapters
(2020) 'Specification of macroglia by transcription factors' Patterning and Cell Type Specification in the Developing CNS and PNS Elsevier 937-951 , DOI
(2020) 'Specification of macroglia by transcription factors: Schwann cells' Patterning and Cell Type Specification in the Developing CNS and PNS: Comprehensive Developmental Neuroscience, Second Edition 937-951 , DOI
(2018) 'The Use of Low Vacuum Scanning Electron Microscopy (LVSEM) to Analyze Peripheral Nerve Samples' Methods in Molecular Biology Springer New York 349-357 , DOI
(2018) 'Transection and Crush Models of Nerve Injury to Measure Repair and Remyelination in Peripheral Nerve' Methods in Molecular Biology Springer New York 251-262 , DOI Open access
(2018) 'Whole Mount Immunostaining on Mouse Sciatic Nerves to Visualize Events of Peripheral Nerve Regeneration' Methods in Molecular Biology Springer New York 339-348 , DOI Open access
Conference Papers
(2017) 'The role of macrophages in human schwannomas' 18-18
(2015) 'Analysing the role of Sox2 in regulating Schwann cell myelination during development and after injury' E274-E275
(2015) 'The Merlin tumour suppressor is critical for peripheral nerve regeneration and repair' E423-E424
(2015) 'The role of Hippo/YAP signalling in Schwann cell development and peripheral nerve repair' E437-E437
(2015) 'The role of the Merlin tumour suppressor in the developing and injured adult peripheral nerve' 54-54
(2013) 'THE ROLE OF MERLIN ISOFORM 2 IN NEUROFIBROMATOSIS TYPE 2-ASSOCIATED POLYNEUROPATHY' S104-S104
(2013) 'EXAMINING THE ROLE OF THE MERLIN TUMOUR SUPPRESSOR IN PERIPHERAL NERVE DEVELOPMENT AND REPAIR' 75-75
(2012) 'Regulation of Schwann cell differentiation and proliferation by the Pax-3 transcription factor' United States 1269-1278 , DOI
(2012) 'EXPRESSION OF C-JUN & SOX-2 IN HUMAN SCHWANNOMAS AND TRAUMATIC NEUROMAS' 9-10
(2010) 'Role of the transcription factor Sox-2 in the control of peripheral nerve development and repair' S20-S20 , DOI
(2009) 'REGULATION OF CELL DIFFERENTIATION IN MERLIN NULL TUMOURS' S170-S170
(2007) 'GBS/CIDP foundation international lecture - Signals that control Schwann cell development and myelination' 2-2
(2006) 'The Biosynthetic Processing and Secretion of Endogenous Carboxypeptidase H in Mouse Pituitary Cellsa' Wiley 10-18 , DOI
(2005) 'Krox-20 inhibits the Jun-n-terminal kinase/C-Jun pathway to regulate the myelinating phenotype of Schwann cells' 139-139
(2005) 'Signals that control glial cell specification in the PNS' 148-148
(2005) 'The function of Notch and stress kinase signals in early Schwann cell development' 2-2 , DOI
(2005) 'Factors affecting the early life of a Schwann cell' 139-143
(2005) 'Regulation of the myelinating phenotype of Schwann cells by Krox-20' 37-42
(2003) 'Signals that regulate Schwann cell generation and myelination' 7-7
(1994) 'N-alkylated analogues of [F-18]benperidol as dopaminergic D-2 receptor ligands' 462-463
Presentations and posters
'Hippo signalling in peripheral nerve development, repair and tumourigenesis'
'Abstract 5957: Roles for the cancer stem cell marker Aldh1A1 in Merlin null nervous system tumors' , DOI
'Abstract 6384: TEAD inhibition reduces tumor proliferation in Merlin null meningioma and schwannoma' , DOI
'Human Endogenous Retrovirus Type K promotes proliferation of Merlin-negative schwannoma and meningioma which can be inhibited by anti-retroviral and anti-TEAD drugs' , DOI Open access
'The cancer stem cell marker ALDH1A1 is upregulated and drives proliferation in merlin null meningioma and schwannoma'
'Activation of MAPK/ERK signalling in Merlin-null Schwann cells leads to increased and sustained immune cell infiltration in the peripheral nervous system' , DOI
'Activation of Raf signalling in NF2-null Schwann cells leads to sustained proliferation; an investigation of a new and inducible model for human schwannoma' , DOI
'Use of a new mouse schwannoma tumour model to monitor changes in peripheral nerve morphology in Merlin null Schwann cells' , DOI
Other Publications
(2022) Novel signalling pathways resolving the inflammatory response during peripheral nerve regeneration.