Mat Upton Plymouth Pioneers. Deep sea. coral reef

An international research collaboration has received funding to discover and accelerate the development of new antibiotics.

The three-year, £1.9 million project is funded by the Newton Fund through the UK Medical Research Council, which is part of UK Research and Innovation (UKRI), and the South African Medical Research Council. It aims to discover novel compounds from natural sources that have the potential to be developed into new antimicrobial drugs.

The project will bring together scientists from the UK and South Africa, to establish an Antibiotic Accelerator Hub to significantly boost capacity for discovery of new antibiotics. The focus will be on unexplored, biodiversity-rich habitats, including deep sea and polar environments, offering real potential for new ‘natural product’-derived drugs.

There is an urgent need for new antibiotic discoveries to counter the danger posed by antimicrobial resistance (AMR), widely regarded as one of the greatest threats to global public health.

The impact of AMR is particularly severe in low and middle income countries (LMICs), and in addition to the growing list of bacterial pathogens known to be resistant to treatment, there is increasing concern over sexually transmitted infections caused by resistant Neisseria gonorrhoea.

Alongside medical benefits, the project aims to support future growth in the bio-economies of both countries, ensuring fair and equitable sharing of the benefits of any new drugs arising from the research with communities from LMICs.

Led by the University of Plymouth in the UK and Rhodes University in South Africa, the Hub research consortium also includes partners in South Africa, who will make up the Natural Product Research Network that will be established as part of the Hub. In the UK, partners include those at universities in Bristol, Leeds, Aberdeen and St Andrews.

The £1.9 million includes £412,000 for a seed project, which will explore the diversity of antimicrobial peptides in South Africa to identify potential new antibiotics. This element is led by Dr James Mason at King's College London and Professor Anabella Gaspar at the University of Pretoria, with contributions from the Universities of Warwick and Sheffield and Public Health England.

Professor in Medical Microbiology Mat Upton is leading the project from the UK. He said: “We know there is an urgent global need to accelerate the discovery of new antimicrobial drugs and bring them to market, and this project brings together expertise from the UK and South Africa to create the infrastructure for that to happen.

“Natural products and their synthetic analogues are the basis for the majority of antibiotics in clinical use today, and the hope is that this collaboration will go some way towards unlocking the potential resources contained in marine and terrestrial biota in South Africa, one of the world’s most bio-diverse places.”

Professor Mat Upton - pioneer photography

Professor Rosemary Dorrington, Department of Science and Technology/National Research Foundation South African Research Chairs Initiative (DST/NRF SARChI), Professor in Marine Natural Products Research at Rhodes University, in the Eastern Cape Province, said:

“This initiative will lay the foundation for a multi-disciplinary drug discovery platform in a region known to be a terrestrial and marine biodiversity hotspot. The establishment of a Natural Products Research Network representing fourteen South African partner institutions, will provide unprecedented access to the chemical diversity of our extraordinarily rich natural resources."

Antibiotic resistant pathogens research group

Antibiotic resistant infections are one of the leading threats to human health and modern medicine. The WHO and international governments have stated that urgent measures are needed to avert the crisis we face.

In our group, we have a programme of drug discovery to help meet the need for new antibiotics. Our lead antimicrobial, epidermicin, has unique activity in a relevant infection model and is in pre-clinical testing. 

These antibiotics are of a new class (bacteriocins), have novel mechanisms of action and have excellent potential for development into the next generation of powerful antibiotics to treat and prevent drug resistant infections.

Antibiotic resistant pathogens with ITSMED visual mark

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