Local anaesthetic may affect the development of children’s teeth

A study led by Dr Bing Hu at Plymouth University Peninsula Schools of Medicine and Dentistry, and involving other researchers from China and Switzerland, suggests for the first time that the use of local anaesthetic may affect tooth cell growth and the development of children’s teeth.

The study is published today, Monday 7 September 2015, in Cell Death Discovery, a new leading translational medical research journal from Nature Publishing Group, and comes at a time when more children than ever before are subjected to dental surgery – and local anaesthetic - because of tooth decay or the other orthodontic conditions.

Using pig teeth and human young permanent tooth pulp cells, the research has identified that local anaesthetics commonly used in clinics can affect the proliferation of tooth cells. It is the first time that evidence has been found to suggest that local anaesthetic could affect tooth cell growth and potentially impact upon tooth development.

According to the research team, dental treatment involves more frequent use of local anaesthetic than any other clinical area. Although the maximum dosage of various local anaesthetics is established, their side effects on dental tissue have until now not been fully investigated.

The study found that the longer duration of exposure to high concentrations of local anaesthetic was most harmful because it interferes with the function of mitochondria, the ‘batteries’ of the cell, and induce a cell death mechanism named “autophagy”. The research team investigated the majority kind of local anaesthetics currently used in dental clinics in the UK, Switzerland and China.

While the study has identified a potential harmful effect of local anaesthetic on developing teeth, the research team is keen to emphasise that further clinical studies are required before there is enough data to change clinical guidelines, and that parents should not be alarmed or withdraw their children from treatment if they need it.

The study was led by Dr Bing Hu, Associate Professor in Oral and Dental Health Research at Plymouth University Peninsula Schools of Medicine and Dentistry.

He said: “Our study has shown for the first time the evidence that local anaesthetic may affect the development of children’s teeth in cellular and molecular levels. We accept that we need to carry out further clinical studies and we do not wish for our findings to alarm parents unnecessarily, but we do expect, in time, to improve clinical guidelines through our research to minimise the dosage of local anaesthetic drugs.”
He added: “Our findings emphasise the need for parents to help their children to avoid the need for dental surgery, such as tooth extractions, in the first place by paying attention to diet and good oral hygiene, and regular visits to the dentist.”
A GB patent application has been filed by Plymouth University for the technology used as part of this study.

Local anaesthetics induce autophagy in young permanent tooth pulp cells

Citation: Cell Death Discovery (2015) 1, 15024; doi:10.1038/cddiscovery.2015.24

www.nature.com/cddiscovery


About Plymouth University Peninsula Schools of Medicine and Dentistry

Plymouth University Peninsula Schools of Medicine and Dentistry (PU PSMD) focuses on medical, dental and biomedical education and research. In education it takes the lead in using innovative, evidence-based learning techniques which nurture future doctors, dentists and biomedical scientists who are clinically excellent, have immense empathy for those in their care, and who are well-prepared for roles in an ever-changing health service. Research covers the areas of clinical neurosciences; cancer; inflammation, infection and immunity; diagnostics; genomics; stratification; prevention; personalised integrated care; and novel health technologies. 

The Research Excellence Framework 2014 ranked the organisation top in the UK for the quality of its research outputs. It is one of the lead academic partners in the Alzheimer’s Research UK South West Research Network, and one of four Research Centres of Excellence for charity Brain Tumour Research. PU PSMD holds the Athena SWAN Bronze Award. The awards recognise institutional and departmental commitment to advancing women’s careers in science, technology, engineering, mathematics and medicine/dentistry in Higher Education and Research.