Dr Bing Hu

Dr Bing Hu

Associate Professor (Reader) in Oral & Dental Health Research

Peninsula Dental School (Plymouth University Peninsula Schools of Medicine and Dentistry)




Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Schools of Medicine and Dentistry, Plymouth University, UK


Distinguished expert, People's Government of Beijing Municipality, China


External Expert, School of Dentistry, University of Geneva, Switzerland.


Lecturer, Department of Biochemistry, University of Lausanne, Switzerland


Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland


Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France


Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France


Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China



Ph.D. in Developmental Biology/Molecular and Cell Biology (awarded date: July 7th, 2006). School of Life Science, University of Strasbourg.




M.D. in Orthodontics/Oral biology.  Faculty of Stomatology, Capital Medical University, Beijing, China

Master/D.D.S. in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China


Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China

Professional membership

International Association of Dental Research

European Orthodontic Society

Roles on external bodies

External Expert, School of Dental Medicine, University of Geneva, Switzerland

Examiner: PhD degree, King's College, UK

Reviewer activity: Medical Research Council (UK); Biotechnology and Biological Sciences Research Council (UK); Royal College of Surgeons (UK); Daphne Jackson Trust (UK); Beijing Natural Science Foundation (China).

Teaching interests

Developmental Biology; Craniofacial Biology; Cancer Biology; Tissue Engineering

Staff serving as external examiners


- King's College, UK (for PhD degrees).

Research interests

Research models:

(1) Skin and oral cancer; 

(2) Craniofacial development and tissue engineering;

(3) Salivary gland development and diseases.

Other research

Group members:

Research Fellow: Dr. Wai Ling Kok

Research Assistant & PhD student: Mr Donald Singer 

PhD student:  Miss Jemma Walker 

PhD Student: Mr Jonathan Davis

PhD Student & Research Associate: Miss Portia Grayson

PhD Student: Miss Chloe Walker 

PhD Student & Research Associate: Miss Charlotte Illsley

Visiting Scientist: Miss Yuying Liu

Scientists associated to the group: 

Dr Louise Belfield (Lecturer in Biomedical Sciences)

Dr Zoe Brookes (Clinical Lecturer in Dental Undergraduate Studies)

Secretary: Mrs Jacqueline Kinvig


Previous Group members:

Dr Heng Zhuang (Current address: Associate Chief Clinician at Peking University School and Hospital of Somatology, China)

Dr Qingguo Lai  (Current address: Professor at 1st Affiliated Hospital, Shan Dong University, China)

Dr Kingyin Lee

Dr Tulay Gulsen (Current address: University London Cancer Institute)

Miss Yan Gao

External honorary contract (PhD co-supervisors):

Prof. Fai Ng, Newcastle University

Dr Denis Corbeil, Technical University of Dresden (Germany)

Prof. Basem Abdallah, University of Southern Denmark

Grants & contracts


EuropeanRegional Development Fund (£400,000, PI)

NationalNatural Science Foundation of China (¥600,000, Co-PI)



MarieCurie Career Integration Grant, European Union (€100,000, PI)



BBSRCresearch grant, UK (£426,000, PI)



ChinaScholarship Council (¥130,000, Supervisor)

NationalNatural Science Foundation of China ( ¥160,000, Co-PI)



StateNational Science & TechnologyAwards, Grade II (China, the highest levelscientific award in China)



Science& Technology Awards of Beijing City, Grade I

NationalNatural Science Foundation of China (¥120,000, Co-PI)



Carl StormInternational Diversity Fellowship



“New StarProject” of Beijing City, China (¥300,000, declined)

William J.Gies Awards (the mostimportant prize in dental research, awarded by theInternational Association of Dental Research)

The Coverof the Year Award for Journalof Dental Research

Prize of“Promoting Research”, fromFrench-Chinese Association of Science and Technology



NationalNatural Science Foundation of China (¥260,000)

ChinaNational Prize for Doctoral Study in Abroad



Fellowshipof Dental Institute of France;



Science& Technology Awards of Beijing City, Grade II.

Research groups

Selected original publications:

Heng Zhuang, Kamran Ali, Stefano Ardu, Christopher Tredwin, Bing Hu. Autophagy in Dental Tissues: A Double-edged Sword. Invited review. Cell Death and Disease (2016) 7, e;doi:10.1038/cddis.2016.103

Heng Zhuang, Dawei Hu, Donald Singer, Jemma V. Walker, Raid B. Nisr, Kim Tieu, Kamran Ali, Christopher Tredwin, Shouqing Luo, Stefano Ardu, Bing Hu. Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024 (2015); ​doi:10.1038/cddiscovery.2015.24

Button RW, Lin F, Ercolano E, Vincent JH, Hu B, Hanemann CO, Luo S. Artesunate induces necrotic cell death inschwannoma cells. Cell Death Disease.2014 Oct 16;5:e1466. doi:10.1038/cddis.2014.434.

Wang F, Liu Y, Hu B, Fan ZP, Shi S, Wang S. Functional tooth regeneration. Science, 2012, 336(6080), s48-50. (special issue). 

Hu B, Castillo E, Hairewood L, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GFL, Dotto GP. Loss of mesenchymal CSL signaling leads to a field cancerization phenotype with multifocal epithelial tumor development. Cell. 2012, 149 (6), 1207-1220.

Ferone G, Thomason HA, Antonini D, De RosaL, Hu B, Gemei M, Zhou H, Ambrosio R, Rice DP, Acampora D, van Bokhoven H, Del Vecchio L, Koster MI, Tadini G, Spencer-Dene B, Dixon M, Dixon J, Missero C. Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine. 2012, 4(1): 1-14.

Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP. Control of hair follicle cell fate by underlying mesenchyme through a CSL - Wnt5a - FoxN1 regulatory axis. Genes & Development. 2010, 24(14), 1519-1532.

Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R. The p63 target HBP1 isrequired for skin differentiation and stratification. Cell Death and Differentiation. 2010, Dec;17(12):1896-907.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin M, Ostano P, Dummer R, Brissette JL, DottoGP. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation. 2009, Oct;119(10):3127-37.

Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. EGFR signalling as a negative regulator of Notch1 gene transcription and function inproliferating keratinocytes and cancer. Nature Cell Biology. 2008, Aug;10(8):902-11;

Nait Lechguer A, Kuchler-Bopp S, Hu B, Haïkel Y, Lesot H. Tooth Tissue Engineering: Kinetic of Vascularization. Journalof Dental Research, 2008, Dec;87(12)1138-1143. 

Li JY, Hu B, Wang SL. Temporal and Spatial Patterns of Transforming Growth Factor-b2 Expression in Developing Mouse Lower First Molar. European Journal of Histochemistry, 2008, October-December; 52(4): 243-250.

Li Y, Hu B, Liu Y, Ding G, Zhang C, Wang S. The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation. 2009, Nov;36(11):781-5.

Nadiri A, Kuchler-Bopp S, Mjahed H, Hu B, HaikelY, Schaaf P, Voegel JC, Benkirane-Jessel N. Cell Apoptosis Control Using BMP4 and Noggin Embedded in a Polyelectrolyte Multilayer Film. SMALL. 2007, Aug 20;3(9):1577-1583. 

Hu B, Nadiri A, Kuchler-Bopp S, Perrin-Schmitt F, Peters H, Lesot H. Tissue engineering of tooth crown, rootand periodontium. Tissue Engineering. 2006, (8), 2069-2075.

Hu B, Unda F, Bopp-Kuchler S, Jimenez L, Wang XJ, Haïkel Y, Wang SL, Lesot H. Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research. 2006, 85(5):416-421.

Hu B, Nadiri A, Bopp-Küchler S, Perrin-Schmitt F, Lesot H. Dental epithelial histo-morphogenesis in vitro. Journal of Dental Research. 2005,Jun;84(6):521-525. 

Hu B, Nadiri A, Bopp-Kuchler S, Perrin-Schmitt F, Wang S, Lesot H. Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Archives of Oral Biology. 2005, Feb;50(2):131-136.


WO 2017009658 

Reports & invited lectures


The 3rd International Conference on Dental and Craniofacial Stem Cells; University of Sheffield; University of Birmingham; University of Geneva; Capital Medical University; Shandong University; Shenyang Hospital of Stomatology.


University of Bradford, UK; Capital Medical University, Beijing; Tian Jin Medical University (China).


Gordon Conference on Epithelial Differentiation & Keratinization


University of Zurich, Switzerland

University of Copenhagen, Denmark


China Society of Oral Biology, the first annual meeting.


University of Zurich, Switzerland


University of Bern, Switzerland           


Wuhan University, China        


The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany


Capital Medical University, Beijing, China


National University of Singapore, Singapore


Beijing University, China