Dr Bing Hu
Associate Professor (Reader) in Oral & Dental Health Research
Peninsula Dental School (Faculty of Health: Medicine, Dentistry and Human Sciences)
Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Schools of Medicine and Dentistry, Plymouth University, UK
Distinguished Professor, School of Stomatology, Zhe Jiang Chinese Medicine University
Visiting Professor, Shen Yang Hospital for Stomatology (Faculty of Stomatology, Da Lian University)
External Expert, School of Dentistry, University of Geneva, Switzerland.
Lecturer, Department of Biochemistry, University of Lausanne, Switzerland
Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland
Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France
Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France
Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China
Ph.D. in Developmental Biology/Molecular and Cell Biology. School of Life Science/Faculty of Dentistry, University of Strasbourg.
M.D. in Orthodontics/Oral biology. Faculty of Stomatology, Capital Medical University, Beijing, China
Master/D.D.S. in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China
Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China
International Association of Dental Research
European Orthodontic Society
UK Cilia Network
Roles on external bodies
External Expert, School of Dental Medicine, University of Geneva, Switzerland
Examiner: PhD degree, King's College, UK
Grant reviewer activities:
European Research Council
UKRI Peer Review College (UK)
Medical Research Council (UK)
Biotechnology and Biological Sciences Research Council (UK)
Engineering and Physical Sciences Research Council (UK)
Royal College of Surgeons (UK)
Daphne Jackson Trust (UK)
Beijing Natural Science Foundation (China)
Journal reviewer activities: more than 20 international high impact journals.
Developmental Biology; Craniofacial Biology; Cancer Biology; Regenerative Medicine
Staff serving as external examiners
ORCID iD: 0000-0001-5085-3114
Research areas & models:
(1) Skin and oral cancer & regeneration including 3D printing;
(2) Tooth development and tissue engineering;
(3) Salivary gland development and diseases.
Research Fellow: Dr Wai Ling Kok
Honorary Associate Professor: Mr Malcolm Bruce
PhD Student & Research Associate: Charlotte Illsley (2018 faculty research day oral presentation prize winner).
PhD Student & Research Associate: Chloe Bolton
PhD Student: Portia Grayson (currently working at the University of Cardiff)
Visiting PhD student: Zehan Li (Nanjing Medical University, China)
Donald Singer PhD (Current address: Field manager at Roche Diagnostics, 2015 BSODR Unilever Prize Winner)
Jemma Walker PhD (Current address: University of Birmingham, 2017 UK Science Council RSci CPD Awards Winner)
Jonathan Davis PhD(Current address: Research fellow at the University of Exeter, 2017 BSODR Unilever Prize Winner)
Dr Heng Zhuang (Current address: Associate Chief Clinician at Peking University School and Hospital of Somatology, China)
Dr Qingguo Lai (Current address: Professor at 1st Affiliated Hospital, Shan Dong University, China)
Dr Kingyin Lee (Current address: University College of London)
Dr Tulay Gulsen (Current address: University London Cancer Institute)
Miss. Yuying Liu (Current address: Clinical residence at Shen Yang Stomatological Hospital, China)
Miss. Yan Gao (Current address: MSc student at Capital Medical University, Beijing, China)
Emeritus student: Balazs Denes MD-PhD (University of Geneva)
Research degrees awarded to supervised students
Donald Singer (PhD) , as DoS, 2019
Jemma Walker (PhD), as DoS, 2019
Jonathan Davis (PhD), as DoS, 2019
Grants & contracts
European Regional Development Fund (£500,000, PI)
National Natural Science Foundation of China (¥600,000, Co-PI)
Marie Curie Career Integration Grant, European Union (€100,000, PI)
BBSRCresearch grant, UK (£426,000, PI)
China Scholarship Council (¥130,000, Supervisor)
National Natural Science Foundation of China ( ¥160,000, Co-PI)
State National Science & TechnologyAwards, Grade II (China, the highest level scientific award in China)
Science & Technology Awards of Beijing City, Grade I
National Natural Science Foundation of China (¥120,000, Co-PI)
Carl Storm International Diversity Fellowship
“New Star Project” of Beijing City, China (¥300,000, declined)
William J.Gies Awards (the most important prize in dental research, awarded by the International Association of Dental Research)
The Cover of the Year Award for Journal of Dental Research
Prize of “Promoting Research”, from French-Chinese Association of Science and Technology
National Natural Science Foundation of China (¥260,000)
China National Prize for Doctoral Study in Abroad
Fellowship of Dental Institute of France;
Science& Technology Awards of Beijing City, Grade II.
Key publications are highlightedJournals
Walker, J.V., Zhuang, H., Singer, D., Illsley, C., Kok, W.L., Sivaraj, K.K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P.R.C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K., Bai, Y., Tredwin, C., Zambon, A.C., Corbeil, D., Adams, R., Abdallah, B.M., Hu, B. (2019). Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nature Communications,10:3596. doi: 10.1038/s41467-019-11611-0. (the paper has been widely reported by global media, such as The Telegraph and has been selected as the Biomedical Picture of the Day (Medical Research Council, London Institute of Medical Sciences)).
Denes, B.J., Bolton, C., Illsley, C., Kok, W., Walker, J.V., Poetsch, A., Tredwin, C., Kiliaridis, S., Hu, B.(2019). Notch signalling coordinates periodontal ligament maturation through regulating Lamin A. Journal of Dental Research. doi:10.1177/0022034519871448.
Yang, Y., Willis, T., Button, R., Strang, Conor., Fu, Y., Wen, X., Grayson, P., Evans, T., Sipthorpe, R., Roberts, S., Hu, B., Zhang, J., Lu, B., Luo, S. (2019).Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nature Communications, 2019, 10:3759. doi:10.1038/s41467-019-11671-2Singer, D., Thamm, K., Zhuang, H., Karbanová, J., Gao, Y., Walker, J.V., Jin, H., Wu, X., Coveney, C. R., Marangoni, P., Lu, D., Grayson, P.R.C., Gulsen, T., Liu, J.K., Ardu, S., Wann, A., Luo, S., Zambon, A.C., Jetten, A.M., Tredwin, C., Klein, O.D., Attanasio, M., Carmeliet, P., Huttner, W.B., Corbeil, D., Hu,B. (2018). Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J, 2018. doi:10.15252/embj.201899845. (The paper has been selected by the GE Reports, as the 5 Coolest Things On Earth This Week: https://www.ge.com/reports/5-coolest-things-earth-week-83/).
Zhuang, H., Hu, D., Singer, D., Walker, J. V., Nisr, R. B., Tieu, K., Tredwin, C., Luo, S., Ardu, S., Hu, B. (2015). Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024. doi:10.1038/cddiscovery.2015.24
Button, R. W., Lin, F., Ercolano, E., Vincent, J. H., Hu, B., Hanemann, C. O., & Luo, S. (2014). Artesunate induces necrotic cell death in schwannoma cells. Cell Death Diseases, 5, e1466.doi:10.1038/cddis.2014.434
Hu, B., Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer, R., Raffoul, W., Hoetzenecker, W., Hofbauer, G.F., Dotto, G. P. (2012). Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell, 149(6), 1207-1220. doi:10.1016/j.cell.2012.03.048.(The paper has been selected as Faculty of 1000 paper and has been commented by Cell, Nature Reviews of Cancer and Nature Medicine).
Wang, F., Liu, Y., Hu, B., Fan, Z.P., Shi, S., Wang, S. (2012). Functional tooth regeneration. Science, 336(6080), s48-50. (special issue). doi: 10.1126/science.336.6080.497-c
Ferone, G., Thomason, H. A., Antonini, D., De Rosa, L., Hu, B., Gemei, M., Zhou, H., Ambrosio, R., Rice, D.P., Acampora, D., van Bokhoven, H., Del, Vecchio, L., Koster, M.I., Tadini, G., Spencer-Dene, B., Dixon, J., Missero, C. (2012). Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine, 4(3), 192-205.doi:10.1002/emmm.201100199
Hu, B., Lefort, K., Qiu, W., Nguyen, B. C., Rajaram, R. D., Castillo, E., He, F., Chen, Y., Angel, P., Brisken, C., Dotto, G. P. (2010). Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes & Development, 24(14), 1519-1532.doi:10.1101/gad.1886910.
Borrelli, S., Candi, E., Hu, B., Dolfini, D., Ravo, M., Grober, O. M., Weisz, A., Dotto, G.P., Melino, G., Vigano, M.A., Mantovani, R. (2010). The p63 target HBP1 is required forskin differentiation and stratification. Cell Death Differentiation, 17(12), 1896-1907.doi:10.1038/cdd.2010.59
Mandinova, A., Kolev, V., Neel, V., Hu, B., Stonely, W., Lieb, J., Wu, X., Colli, C., Han, R., Pazin, M.J., Ostano, P., Dummer, R., Brissette, J.L., Dotto, G. P. (2009). A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation, 119(10), 3127-3137.doi:10.1172/JCI38543
Li, Y., Hu, B., Liu, Y., Ding, G., Zhang, C., & Wang, S. (2009). The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation, 36(11),781-785.doi:10.1111/j.1365-2842.2009.01993.x
Nait Lechguer, A., Kuchler-Bopp, S., Hu, B., Haikel, Y., & Lesot, H. (2008). Vascularization of engineered teeth. Journal of Dental Research, 87(12), 1138-1143.doi:10.1177/154405910808701216
Li, J. Y., Hu, B., Wang, X. J., & Wang, S. L. (2008). Temporal and spatial expression of TGF-beta2 in tooth crown development in mouse first lower molar. European Journal of Histochemistry, 52(4), 243-250
Kolev, V., Mandinova, A., Guinea-Viniegra, J., Hu, B., Lefort, K., Lambertini, C., Neel, V., Dummer, R., Wagner, E.F., Dotto, G. P. (2008). EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature Cell Biology, 10(8), 902-911.doi:10.1038/ncb1750
Nadiri, A., Kuchler-Bopp, S., Mjahed, H., Hu, B., Haikel, Y., Schaaf, P., Voegel, JC., Benkirane-Jessel, N. (2007). Cell apoptosis control using BMP4 and noggin embedded in a polyelectrolyte multilayer film. Small, 3(9),1577-1583. doi:10.1002/smll.200700115
Hu, B., Unda, F., Bopp-Kuchler, S., Jimenez, L., Wang, X.J., Haikel, Y., Wang, S.L., Lesot, H. (2006). Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research, 85(5),416-421. doi:10.1177/154405910608500504. (The paper has been selected as the cover of the year of Journal of Dental Research and have received William Gies Award from International Association of Dental Research).
Hu, B., Nadiri, A., Kuchler-Bopp, S., Perrin-Schmitt, F., Peters, H., Lesot, H. (2006). Tissue engineering of tooth crown, root, and periodontium. Tissue Engineering, 12(8), 2069-2075.doi:10.1089/ten.2006.12.2069.
Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F., Lesot, H. (2005). Dental Epithelial Histomorphogenesis in vitro. Journal of Dental Research, 84(6), 521-525.doi:10.1177/15440591050840060. (Cover article).
Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F., Wang, S., Lesot, H. (2005). Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Archives of Oral Biology, 50(2), 131-136.doi:10.1016/j.archoralbio.2004.09.007
Reviews (peer reviewed journals)
Zhuang, H., Ali, K., Ardu, S., Tredwin, C., & Hu, B. (2016). Autophagy in dental tissues: a double-edged sword. Cell Death Diseases, 7, e2192.doi:10.1038/cddis.2016.103
Hu, B., Liu, Y., Wang, SL. (2005). Tooth tissue engineering: from cells to organ, an odyssey far from finished. Shanghai Journal of Stomatology. Editorial, 14(2):99-102.
Title: Method of Treatment of Dental Disorders
Inventors: HU Bing; ZHUANG Heng; TREDWIN Christopher Jeremy
Reports & invited lectures
University of Leeds
Nanjing Medical University
Zhejiang University of Chinese Medicine
Capital Medical University
The 17thChinese Orthodontic Society Conference
Capital Medical University
Shen Yang Stomatological Hospital
The 3rd International Conference on Dental and Craniofacial Stem Cells
University of Sheffield
University of Birmingham
University of Geneva
Capital Medical University
Shenyang Hospital of Stomatology
University of Bradford, UK
Capital Medical University, Beijing
Tian Jin Medical University
Gordon Conference on Epithelial Differentiation & Keratinization
University of Zurich, Switzerland
University of Copenhagen, Denmark
China Society of Oral Biology, the first annual meeting.
University of Zurich, Switzerland
University of Bern, Switzerland
Wuhan University, China
The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany
Capital Medical University, Beijing, China
National University of Singapore, Singapore
Beijing University, China