Professor Bing Hu
Profiles

Professor Bing Hu

Professor of Oral Biology (Research)

Peninsula Dental School (Faculty of Health)

Professor Bing Hu can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Tooth development
  • Regenerative medicine
  • Skin cancer
  • Stem cell
  • Wound healing
  • Oral cancer
  • 3D printing
  • Salivary gland regeneration
Biography

Biography

Professor Bing Hu is the Associate Head of School (Research) at Peninsula Dental School, Faculty of Health, University of Plymouth in the United Kingdom, where he is also Professor of Oral Biology and Director of the Stem Cells & Regenerative Medicine Laboratory. 

Professor Hu obtained his general dentistry (BDS) and orthodontics degrees (MSc) from Capital Medical University, Beijing and two doctoral degrees: orthodontics and oral biology from Capital Medical University, and cellular & molecular biology from University of Strasbourg. 

He has received postdoctoral training at Professor Gian Paolo-Dotto’s lab (University of Lausanne and Harvard Medical School) and worked as Lecturer at the Department of Biochemistry, University of Lausanne before he relocated to Plymouth. Professor Hu has been working in tooth development, stem cells and regeneration, and skin development and cancer. His works have been published in Cell, Genes & Development, EMBO J, Nature Communications, Journal of Dental Research etc. and he has received many international prizes including the IADR’s William J. Gies Award and the Cover of the Year Award for Journal of Dental Research in 2006. 

Professor Hu’s PhD students have also won the 2015 and 2017 BSODR Unilever prize. Professor Hu serves as a member of the UKRI Peer Review College and is the reviewer for most of the UK and EU funding agencies. Professor Hu has also received the prestige EU Marie Curie fellowship. 

  • 2020.8 - Professor of Oral Biology & Associate Head of School (Research), Peninsula Dental School, Faculty of Health, University of Plymouth, UK
  • 2020.4 - Associate Head of School (Research), Peninsula Dental School, Faculty of Health, University of Plymouth, UK
  • 2019.10 - Distinguished Professor, School of Stomatology, Zhe Jiang Chinese Medicine University, China
  • 2018.9 - Visiting Professor, Shen Yang Hospital for Stomatology, Faculty of Stomatology, Da Lian University, China
  • 2013.7 - 2020.7, Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Dental School, Faculty of Health, University of Plymouth, UK
  • 2013.4 - 2017.4, External Expert, School of Dentistry, University of Geneva, Switzerland
  • 2009.1 - 2013.6, Lecturer, Department of Biochemistry, University of Lausanne, Switzerland
  • 2006 – 2009, Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland
  • 2002 – 2006, Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France
  • 2003 – 2005, Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France
  • 1997 – 2002, Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China

Qualifications

  • 2006, PhD in Developmental Biology/Molecular and Cell Biology. School of Life Science/Faculty of Dentistry, University of Strasbourg
  • 2004, DDS in Orthodontics/Oral biology. Faculty of Stomatology, Capital Medical University, Beijing, China 
  • 2000, Master in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China
  • 1997, Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China
  • Registered dentist and orthodontist: since 2000 (China)

Professional membership

  • International Association of Dental Research
  • British Society for Oral and Dental Research
  • European Orthodontic Society
  • British Orthodontic Society
  • UK Cilia Network

Roles on external bodies

Chair for the Healthcare Committe, UK-JIANGSU WORLD CLASS UNIVERSITY CONSORTIUM (2021), which has 32 universities in China and 16 UK universities participated.

External examiner: PhD degree, King's College, UK

Program and Grant reviewer activities:  

  • European Research Council
  • UKRI Peer Review College (UK)
  • Medical Research Council (UK)
  • Biotechnology and Biological Sciences Research Council (UK)
  • Engineering and Physical Sciences Research Council (UK)
  • Royal College of Surgeons (UK)
  • Daphne Jackson Trust (UK)
  • Canada Research Chairs Program (Canada)
  • Ministry of Education of the People's Republic of China
  • Beijing Natural Science Foundation (China) 
  • A list of top universities in North America, Europe, Mid-East, and Asia.

Journal reviewer activities: more than 40 international high impact journals.



Teaching

Teaching

Teaching interests

Developmental Biology; Craniofacial Biology; Cancer Biology; Regenerative Medicine


Academic tutor for: BDS students

Staff serving as external examiners

Active: 

- King's College, UK (for PhD degrees).

Research

Research

Research interests

ORCID iD: 0000-0001-5085-3114

Research areas & models:

(1) Skin and oral cancer & regeneration including 3D printing;

(2) Tooth development and tissue engineering;

(3) Salivary gland development and diseases.

Other research

Group members:

Research Fellow: Dr Wai Ling Kok

PhD Student & Research Assistant: Yan Gao

PhD Student : Fan Yan

Honorary Associate Professor: Mr Malcolm Bruce

Alumni:

Charlotte Illsley PhD (Current position: Lecturer, Peninsula Dental School, University of Plymouth, UK).

Yi Yang PhD

Zehan Li PhD (Current position: School of Stomatology, Nanjing Medical University, China)

Donald Singer PhD (Current position: Field specialist at Roche Diagnostics, 2015 BSODR Unilever Prize Winner)

Jemma Walker PhD (Current position: Clinical Embryologist at Herts & Essex Fertility Centre, 2017 UK Science Council RSci CPD Awards Winner)

Jonathan Davis PhD (Current position: Research fellow at the University of Exeter, 2017 BSODR Unilever Prize Winner)

Chloe Bolton PhD (Current position: Research Associate at the University of Exeter)

Portia Grayson PhD

Dr Heng Zhuang (Associate Chief Clinician at Peking University School and Hospital of Somatology, China)

Dr Qingguo Lai  (Current position: Professor at 1st Affiliated Hospital, Shan Dong University, China)

Dr Kingyin Lee (Current position: University College of London)

Dr Tulay Gulsen (Current position: University London Cancer Institute)

Miss Yuying Liu (Current position: Clinical residence at Shen Yang Stomatological Hospital, China)

Emeritus student: Balazs Denes MD-PhD (University of Geneva) 

Emeritus student: Zehan Li (Nanjing Medical University, China)

Research degrees awarded to supervised students

Donald Singer (PhD) , as DoS, 2019

Jemma Walker (PhD),  as DoS, 2019

Jonathan Davis (PhD), as DoS, 2019

Chloe Walker (PhD), as DoS, 2021

Portia Grayson (PhD), as DoS, 2021

Grants & contracts

2021-2023 European Orthodontic Society research grant (£28,300, PI)

2020-2021 Industry contract researches on biomaterials (£300,000, PI)

2020-2023 Peninsula Dental Society Enterprise postdoctoral fellowships x2 (£260,000, PI)

2017-2020 European Regional Development Fund (£500,000, PI)

2017-2021 National Natural Science Foundation of China (¥600,000, Co-PI)

2014-2018 Marie Curie Career Integration Grant, European Union (€100,000, PI)

2014-2017 BBSRCresearch grant, UK (£426,000, PI)

2013 China Scholarship Council (¥130,000, Supervisor)

2013 National Natural Science Foundation of China ( ¥160,000, Co-PI)

2011 State National Science & TechnologyAwards, Grade II (China, the highest level scientific award in China)

2009 Science & Technology Awards of Beijing City, Grade I

2009 National Natural Science Foundation of China (¥120,000, Co-PI)

2007 Carl Storm International Diversity Fellowship

2006 “New Star Project” of Beijing City, China (¥300,000, declined)

2006 William J.Gies Awards (the most important prize in dental research, awarded by the International Association of Dental Research)

2006 The Cover of the Year Award for Journal of Dental Research

2006 Prize of “Promoting Research”, from French-Chinese Association of Science and Technology

2005 National Natural Science Foundation of China (¥260,000, PI)

2005 China National Prize for Doctoral Study in Abroad

2003 Fellowship of Dental Institute of France

2000 Science& Technology Awards of Beijing City, Grade II

Publications

Publications

Journals

Gao, Y., Kok, WL., Sharma, V., Illsley, C., Hanks, S., Tredwin, C., Hu, B. SARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation. Cell Death Discovery, 2023. doi:10.1038/s41420-023-01474-2 

Maria Arcentales, Raquel Martn-Sampedro, Ralph Santos-Oliveira, Mohamed F. Attia, Jeffrey N. Anker, Daniel C. Whitehead, Alexis Debut, Liquan Deng, Yuanna Zheng, Bing Hu, Maria Paulina Romero, Floralba Lopez, Frank Alexis. Ligninocellulosic-based Nanoparticles with Photoluminescent Properties for Bioimaging. ACS Applied Materials & Interfaces, 2023. https://doi.org/10.1021/acsami.3c05248

Gao, Y., Walker, J.V., Tredwin, C., Hu, B. Deletion of RBP-Jkappa gene in mesenchymal cells causes rickets like symptoms in the mouse. Current Medicine, 2022. doi:10.1007/s44194-022-00007-w 

Group authors. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 2021 Feb 8;1-382. doi: 10.1080/15548627.2020.1797280

Alexander Zambon, Tom Hsu, Seunghee Kim, Miranda Klinck, Jennifer Stowe, Lindsay Henderson, Donald Singer, Leomar Patam, Curtis Lim, Andrew McCulloch, Bing Hu, Anna Hickerson. Methods and Sensors For Functional Genomic Studies of Cell-Cycle Transitions in Single Cells. Physiological Genomics, https://doi.org/10.1152/physiolgenomics.00065.2020

Walker, J.V., Zhuang, H., Singer, D., Illsley, C., Kok, W.L., Sivaraj, K.K., Gao, Y., Bolton, C., Liu, Y., Zhao, M., Grayson, P.R.C., Wang, S., Karbanová, J., Lee, T., Ardu, S., Lai, Q., Liu, J., Kassem, M., Chen, S., Yang, K., Bai, Y., Tredwin, C., Zambon, A.C., Corbeil, D., Adams, R., Abdallah, B.M., Hu, B. (2019). Transit amplifying cells coordinate mouse incisor mesenchymal stem cell activation. Nature Communications,10:3596. doi: 10.1038/s41467-019-11611-0. (the paper has been widely reported by global media, such as The Telegraph and has been selected as the Biomedical Picture of the Day (Medical Research Council, London Institute of Medical Sciences)).

Denes, B.J., Bolton, C., Illsley, C., Kok, W., Walker, J.V., Poetsch, A., Tredwin, C., Kiliaridis, S., Hu, B. (2019). Notch signalling coordinates periodontal ligament maturation through regulating Lamin A. Journal of Dental Research. doi:10.1177/0022034519871448. 

Yang, Y., Willis, T., Button, R., Strang, Conor., Fu, Y., Wen, X., Grayson, P., Evans, T., Sipthorpe, R., Roberts, S., Hu, B., Zhang, J., Lu, B., Luo, S. (2019).Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response. Nature Communications, 2019, 10:3759. doi:10.1038/s41467-019-11671-2

Singer, D., Thamm, K., Zhuang, H., Karbanová, J., Gao, Y., Walker, J.V., Jin, H., Wu, X., Coveney, C. R., Marangoni, P., Lu, D., Grayson, P.R.C., Gulsen, T., Liu, J.K., Ardu, S., Wann, A., Luo, S., Zambon, A.C., Jetten, A.M., Tredwin, C., Klein, O.D., Attanasio, M., Carmeliet, P., Huttner, W.B., Corbeil, D., Hu,B. (2018). Prominin-1 controls stem cell activation by orchestrating ciliary dynamics. EMBO J, 2018. doi:10.15252/embj.201899845. (The paper has been selected by the GE Reports, as the 5 Coolest Things On Earth This Week: https://www.ge.com/reports/5-coolest-things-earth-week-83/).

Zhuang, H., Hu, D., Singer, D., Walker, J. V., Nisr, R. B., Tieu, K., Tredwin, C., Luo, S., Ardu, S., Hu, B. (2015). Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024. doi:10.1038/cddiscovery.2015.24

Button, R. W., Lin, F., Ercolano, E., Vincent, J. H., Hu, B., Hanemann, C. O., & Luo, S. (2014). Artesunate induces necrotic cell death in schwannoma cells. Cell Death Diseases, 5, e1466.doi:10.1038/cddis.2014.434

Hu, B., Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer, R., Raffoul, W., Hoetzenecker, W., Hofbauer, G.F., Dotto, G. P. (2012). Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell, 149(6), 1207-1220. doi:10.1016/j.cell.2012.03.048.(The paper has been selected as Faculty of 1000 paper and has been commented by Cell, Nature Reviews of Cancer and Nature Medicine).

Wang, F., Liu, Y., Hu, B., Fan, Z.P., Shi, S., Wang, S. (2012). Functional tooth regeneration. Science, 336(6080), s48-50. (special issue). doi: 10.1126/science.336.6080.497-c

Ferone, G., Thomason, H. A., Antonini, D., De Rosa, L., Hu, B., Gemei, M., Zhou, H., Ambrosio, R., Rice, D.P., Acampora, D., van Bokhoven, H., Del, Vecchio, L., Koster, M.I., Tadini, G., Spencer-Dene, B., Dixon, J., Missero, C. (2012). Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine, 4(3), 192-205.doi:10.1002/emmm.201100199

Hu, B., Lefort, K., Qiu, W., Nguyen, B. C., Rajaram, R. D., Castillo, E., He, F., Chen, Y., Angel, P., Brisken, C., Dotto, G. P. (2010). Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes & Development, 24(14), 1519-1532.doi:10.1101/gad.1886910.

Borrelli, S., Candi, E., Hu, B., Dolfini, D., Ravo, M., Grober, O. M., Weisz, A., Dotto, G.P., Melino, G., Vigano, M.A., Mantovani, R. (2010). The p63 target HBP1 is required forskin differentiation and stratification. Cell Death Differentiation, 17(12), 1896-1907.doi:10.1038/cdd.2010.59

Mandinova, A., Kolev, V., Neel, V., Hu, B., Stonely, W., Lieb, J., Wu, X., Colli, C., Han, R., Pazin, M.J., Ostano, P., Dummer, R., Brissette, J.L., Dotto, G. P. (2009). A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation, 119(10), 3127-3137.doi:10.1172/JCI38543

Li, Y., Hu, B., Liu, Y., Ding, G., Zhang, C., & Wang, S. (2009). The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation, 36(11),781-785.doi:10.1111/j.1365-2842.2009.01993.x

Nait Lechguer, A., Kuchler-Bopp, S., Hu, B., Haikel, Y., & Lesot, H. (2008). Vascularization of engineered teeth. Journal of Dental Research, 87(12), 1138-1143.doi:10.1177/154405910808701216

Li, J. Y., Hu, B., Wang, X. J., & Wang, S. L. (2008). Temporal and spatial expression of TGF-beta2 in tooth crown development in mouse first lower molar. European Journal of Histochemistry, 52(4), 243-250

Kolev, V., Mandinova, A., Guinea-Viniegra, J., Hu, B., Lefort, K., Lambertini, C., Neel, V., Dummer, R., Wagner, E.F., Dotto, G. P. (2008). EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature Cell Biology, 10(8), 902-911.doi:10.1038/ncb1750

Nadiri, A., Kuchler-Bopp, S., Mjahed, H., Hu, B., Haikel, Y., Schaaf, P., Voegel, JC., Benkirane-Jessel, N. (2007). Cell apoptosis control using BMP4 and noggin embedded in a polyelectrolyte multilayer film. Small, 3(9),1577-1583. doi:10.1002/smll.200700115

Hu, B., Unda, F., Bopp-Kuchler, S., Jimenez, L., Wang, X.J., Haikel, Y., Wang, S.L., Lesot, H. (2006). Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research, 85(5),416-421. doi:10.1177/154405910608500504. (The paper has been selected as the cover of the year of Journal of Dental Research and have received William Gies Award from International Association of Dental Research).

Hu, B., Nadiri, A., Kuchler-Bopp, S., Perrin-Schmitt, F., Peters, H., Lesot, H. (2006). Tissue engineering of tooth crown, root, and periodontium. Tissue Engineering, 12(8), 2069-2075.doi:10.1089/ten.2006.12.2069. 

Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F., Lesot, H. (2005). Dental Epithelial Histomorphogenesis in vitro. Journal of Dental Research, 84(6), 521-525.doi:10.1177/15440591050840060. (Cover article).

Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F., Wang, S., Lesot, H. (2005). Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Archives of Oral Biology, 50(2), 131-136.doi:10.1016/j.archoralbio.2004.09.007

 

Reviews (peer reviewed journals)

Zhuang, H., Ali, K., Ardu, S., Tredwin, C., & Hu, B. (2016). Autophagy in dental tissues: a double-edged sword. Cell Death Diseases, 7, e2192.doi:10.1038/cddis.2016.103

Hu, B., Liu, Y., Wang, SL. (2005). Tooth tissue engineering: from cells to organ, an odyssey far from finished. Shanghai Journal of Stomatology. Editorial, 14(2):99-102.


Patents

Patent: WO/2017/009658

Title: Method of Treatment of Dental Disorders

Inventors: HU Bing; ZHUANG Heng; TREDWIN Christopher Jeremy

Personal

Personal

Reports & invited lectures

2019

University of Leeds

BSODR

Nanjing Medical University

Zhejiang University of Chinese Medicine

Capital Medical University

2018

The 17thChinese Orthodontic Society Conference

Wuhan University

Capital Medical University

Shen Yang Stomatological Hospital

 

2016

The 3rd International Conference on Dental and Craniofacial Stem Cells

University of Sheffield

University of Birmingham

University of Geneva

Capital Medical University

Shandong University

Shenyang Hospital of Stomatology

 

2015

University of Bradford, UK

Capital Medical University, Beijing

Tian Jin Medical University

 

2013

Gordon Conference on Epithelial Differentiation & Keratinization

 

2012

University of Zurich, Switzerland

University of Copenhagen, Denmark

 

2011

China Society of Oral Biology, the first annual meeting.

University of Zurich, Switzerland

University of Bern, Switzerland           

 

2010

Wuhan University, China        

The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany

 

2009

Capital Medical University, Beijing, China

 

2008

National University of Singapore, Singapore

Beijing University, China