Dr Bing Hu
Associate Professor (Reader) in Oral & Dental Health Research
Peninsula Dental School (Plymouth University Peninsula Schools of Medicine and Dentistry)
Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Schools of Medicine and Dentistry, Plymouth University, UK
Distinguished expert, People's Government of Beijing Municipality, China
External Expert, School of Dentistry, University of Geneva, Switzerland.
Lecturer, Department of Biochemistry, University of Lausanne, Switzerland
Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland
Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France
Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France
Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China
Ph.D. in Developmental Biology/Molecular and Cell Biology (awarded date: July 7th, 2006). School of Life Science, University of Strasbourg.
M.D. in Orthodontics/Oral biology. Faculty of Stomatology, Capital Medical University, Beijing, China
Master/D.D.S. in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China
Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China
International Association of Dental Research
European Orthodontic Society
Roles on external bodies
External Expert, School of Dental Medicine, University of Geneva, Switzerland
Developmental Biology; Craniofacial Biology; Cancer Biology; Tissue Engineering
(1) Skin and oral cancer;
(2) Craniofacial development and tissue engineering;
(3) Salivary gland development and diseases.
European Regional Development Fund (£400,000, PI)
National Natural Science Foundation of China (¥600,000, Co-PI)
Marie Curie Career Integration Grant, European Union (€100,000, PI)
BBSRC research grant, UK (£426,000, PI)
China Scholarship Council (¥130,000, Supervisor)
National Natural Science Foundation of China ( ¥160,000, Co-PI)
State National Science & TechnologyAwards, Grade II (China, the highest level scientific award in China)
Science & Technology Awards of Beijing City, Grade I
National Natural Science Foundation of China (¥120,000, Co-PI)
Carl Storm International Diversity Fellowship
“New Star Project” of Beijing City, China (¥300,000, declined)
William J. Gies Awards (the mostimportant prize in dental research, awarded by the International Association of Dental Research)
The Cover of the Year Award for Journalof Dental Research
Prize of “Promoting Research”, fromFrench-Chinese Association of Science and Technology
National Natural Science Foundation of China (¥260,000)
China National Prize for Doctoral Study in Abroad
Fellowship of Dental Institute of France;
Science & Technology Awards of Beijing City, Grade II.
Research Assistant & PhD student: Mr Donald Singer
Research Assistant & PhD student: Miss Jemma Walker
PhD Student: Mr Jonathan Davis
PhD Student: Miss Portia Grayson
PhD Student: Miss Chloe Walker
PhD Student: Miss Charlotte Illsley
Visiting student: Miss Yan Gao
Scientists associated to the group:
Dr Louise Belfield (Lecturer in Biomedical Sciences)
Dr Zoe Brookes (Clinical Lecturer in Dental Undergraduate Studies)
Secretary: Mrs Jacqueline Kinvig
Previous Group members:
Dr Heng Zhuang (Current address: Associate Chief Clinician at Peking University School and Hospital of Somatology, China)
Dr Qingguo Lai (Current address: Professor at 1st Affiliated Hospital, Shan Dong University, China)
Dr Kingyin Lee
Dr Tulay Gulsen
External honorary contract (PhD co-supervisors):
Prof. Fai Ng, Newcastle University
Dr Denis Corbeil, Technical University of Dresden (Germany)
Prof. Basem Abdallah, University of Southern Denmark
Selected original publications:
Heng Zhuang, Kamran Ali, Stefano Ardu, Christopher Tredwin, Bing Hu. Autophagy in Dental Tissues: A Double-edged Sword. Invited review. Cell Death and Disease (2016) 7, e;doi:10.1038/cddis.2016.103
Heng Zhuang, Dawei Hu, Donald Singer, Jemma V. Walker, Raid B. Nisr, Kim Tieu, Kamran Ali, Christopher Tredwin, Shouqing Luo, Stefano Ardu, Bing Hu. Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024 (2015); doi:10.1038/cddiscovery.2015.24
Button RW, Lin F, Ercolano E, Vincent JH, Hu B, Hanemann CO, Luo S. Artesunate induces necrotic cell death inschwannoma cells. Cell Death Disease.2014 Oct 16;5:e1466. doi:10.1038/cddis.2014.434.
Wang F, Liu Y, Hu B, Fan ZP, Shi S, Wang S. Functional tooth regeneration. Science, 2012, 336(6080), s48-50. (special issue).
Hu B, Castillo E, Hairewood L, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GFL, Dotto GP. Loss of mesenchymal CSL signaling leads to a field cancerization phenotype with multifocal epithelial tumor development. Cell. 2012, 149 (6), 1207-1220.
Ferone G, Thomason HA, Antonini D, De RosaL, Hu B, Gemei M, Zhou H, Ambrosio R, Rice DP, Acampora D, van Bokhoven H, Del Vecchio L, Koster MI, Tadini G, Spencer-Dene B, Dixon M, Dixon J, Missero C. Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine. 2012, 4(1): 1-14.
Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP. Control of hair follicle cell fate by underlying mesenchyme through a CSL - Wnt5a - FoxN1 regulatory axis. Genes & Development. 2010, 24(14), 1519-1532.
Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R. The p63 target HBP1 isrequired for skin differentiation and stratification. Cell Death and Differentiation. 2010, Dec;17(12):1896-907.
Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin M, Ostano P, Dummer R, Brissette JL, DottoGP. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation. 2009, Oct;119(10):3127-37.
Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. EGFR signalling as a negative regulator of Notch1 gene transcription and function inproliferating keratinocytes and cancer. Nature Cell Biology. 2008, Aug;10(8):902-11;
Nait Lechguer A, Kuchler-Bopp S, Hu B, Haïkel Y, Lesot H. Tooth Tissue Engineering: Kinetic of Vascularization. Journalof Dental Research, 2008, Dec;87(12)1138-1143.
Li JY, Hu B, Wang SL. Temporal and Spatial Patterns of Transforming Growth Factor-b2 Expression in Developing Mouse Lower First Molar. European Journal of Histochemistry, 2008, October-December; 52(4): 243-250.
Li Y, Hu B, Liu Y, Ding G, Zhang C, Wang S. The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation. 2009, Nov;36(11):781-5.
Nadiri A, Kuchler-Bopp S, Mjahed H, Hu B, HaikelY, Schaaf P, Voegel JC, Benkirane-Jessel N. Cell Apoptosis Control Using BMP4 and Noggin Embedded in a Polyelectrolyte Multilayer Film. SMALL. 2007, Aug 20;3(9):1577-1583.
Hu B, Nadiri A, Kuchler-Bopp S, Perrin-Schmitt F, Peters H, Lesot H. Tissue engineering of tooth crown, rootand periodontium. Tissue Engineering. 2006, (8), 2069-2075.
Hu B, Unda F, Bopp-Kuchler S, Jimenez L, Wang XJ, Haïkel Y, Wang SL, Lesot H. Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research. 2006, 85(5):416-421.
Hu B, Nadiri A, Bopp-Küchler S, Perrin-Schmitt F, Lesot H. Dental epithelial histo-morphogenesis in vitro. Journal of Dental Research. 2005,Jun;84(6):521-525.
Hu B, Nadiri A, Bopp-Kuchler S, Perrin-Schmitt F, Wang S, Lesot H. Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Archives of Oral Biology. 2005, Feb;50(2):131-136.
Reports & invited lectures
The 3rd International Conference on Dental and Craniofacial Stem Cells; University of Sheffield; University of Birmingham; University of Geneva; Capital Medical University; Shandong University; Shenyang Hospital of Stomatology.
University of Bradford, UK; Capital Medical University, Beijing; Tian Jin Medical University (China).
Gordon Conference on Epithelial Differentiation & Keratinization
University of Zurich, Switzerland
University of Copenhagen, Denmark
China Society of Oral Biology, the first annual meeting.
University of Zurich, Switzerland
University of Bern, Switzerland
Wuhan University, China
The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany
Capital Medical University, Beijing, China
National University of Singapore, Singapore
Beijing University, China