Dr Bing Hu
Profiles

Dr Bing Hu

Associate Professor (Reader) in Oral & Dental Health Research

Peninsula Dental School (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

2013.7-

 

Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Schools of Medicine and Dentistry, Plymouth University, UK

2016.1-

Distinguished expert, People's Government of Beijing Municipality, China

2013.4-

External Expert, School of Dentistry, University of Geneva, Switzerland.

2009-2013.6

Lecturer, Department of Biochemistry, University of Lausanne, Switzerland

2006-2009

Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland

2002-2006

Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France

2003-2005

Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France

1997-2002

Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China

Qualifications

2006      

Ph.D. in Developmental Biology/Molecular and Cell Biology (awarded date: July 7th, 2006). School of Life Science, University of Strasbourg.

2004

 

2000

M.D. in Orthodontics/Oral biology.  Faculty of Stomatology, Capital Medical University, Beijing, China

Master/D.D.S. in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China

1997

Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China

Professional membership

International Association of Dental Research

European Orthodontic Society


Roles on external bodies

External Expert, School of Dental Medicine, University of Geneva, Switzerland

Examiner: PhD degree, King's College, UK

Reviewer activity: Medical Research Council (UK); Biotechnology and Biological Sciences Research Council (UK); Royal College of Surgeons (UK); Daphne Jackson Trust (UK); Beijing Natural Science Foundation (China).

Teaching interests

Developmental Biology; Craniofacial Biology; Cancer Biology; Tissue Engineering

Staff serving as external examiners

Active: 

- King's College, UK (for PhD degrees).

Research interests

Research models:

(1) Skin and oral cancer; 

(2) Craniofacial development and tissue engineering;

(3) Salivary gland development and diseases.

Other research

Group members:

Research Fellow: Dr. Wai Ling Kok

Research Assistant & PhD student: Mr Donald Singer 

PhD student:  Miss Jemma Walker 

PhD Student: Mr Jonathan Davis

PhD Student & Research Associate: Miss Portia Grayson

PhD Student: Miss Chloe Walker 

PhD Student & Research Associate: Miss Charlotte Illsley

Visiting Scientist: Miss Yuying Liu

Scientists associated to the group: 

Dr Louise Belfield (Lecturer in Biomedical Sciences)

Dr Zoe Brookes (Clinical Lecturer in Dental Undergraduate Studies)

Secretary: Mrs Jacqueline Kinvig

 

Previous Group members:

Dr Heng Zhuang (Current address: Associate Chief Clinician at Peking University School and Hospital of Somatology, China)

Dr Qingguo Lai  (Current address: Professor at 1st Affiliated Hospital, Shan Dong University, China)

Dr Kingyin Lee

Dr Tulay Gulsen (Current address: University London Cancer Institute)

Miss Yan Gao

External honorary contract (PhD co-supervisors):

Prof. Fai Ng, Newcastle University

Dr Denis Corbeil, Technical University of Dresden (Germany)

Prof. Basem Abdallah, University of Southern Denmark

Grants & contracts

2017-2020 

EuropeanRegional Development Fund (£400,000, PI)

NationalNatural Science Foundation of China (¥600,000, Co-PI)

 

2014-2018  

MarieCurie Career Integration Grant, European Union (€100,000, PI)

 

2014-2017   

BBSRCresearch grant, UK (£426,000, PI)

 

2013

ChinaScholarship Council (¥130,000, Supervisor)

NationalNatural Science Foundation of China ( ¥160,000, Co-PI)

 

2011   

StateNational Science & TechnologyAwards, Grade II (China, the highest levelscientific award in China)

 

2009   

Science& Technology Awards of Beijing City, Grade I

NationalNatural Science Foundation of China (¥120,000, Co-PI)

 

2007   

Carl StormInternational Diversity Fellowship

 

2006   

“New StarProject” of Beijing City, China (¥300,000, declined)

William J.Gies Awards (the mostimportant prize in dental research, awarded by theInternational Association of Dental Research)

The Coverof the Year Award for Journalof Dental Research

Prize of“Promoting Research”, fromFrench-Chinese Association of Science and Technology

 

2005   

NationalNatural Science Foundation of China (¥260,000)

ChinaNational Prize for Doctoral Study in Abroad

 

2003   

Fellowshipof Dental Institute of France;

 

2000   

Science& Technology Awards of Beijing City, Grade II.

Research groups

Selected original publications:

Heng Zhuang, Kamran Ali, Stefano Ardu, Christopher Tredwin, Bing Hu. Autophagy in Dental Tissues: A Double-edged Sword. Invited review. Cell Death and Disease (2016) 7, e;doi:10.1038/cddis.2016.103

Heng Zhuang, Dawei Hu, Donald Singer, Jemma V. Walker, Raid B. Nisr, Kim Tieu, Kamran Ali, Christopher Tredwin, Shouqing Luo, Stefano Ardu, Bing Hu. Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024 (2015); ​doi:10.1038/cddiscovery.2015.24

Button RW, Lin F, Ercolano E, Vincent JH, Hu B, Hanemann CO, Luo S. Artesunate induces necrotic cell death inschwannoma cells. Cell Death Disease.2014 Oct 16;5:e1466. doi:10.1038/cddis.2014.434.

Wang F, Liu Y, Hu B, Fan ZP, Shi S, Wang S. Functional tooth regeneration. Science, 2012, 336(6080), s48-50. (special issue). 

Hu B, Castillo E, Hairewood L, Reymond A, Dummer R, Raffoul W, Hoetzenecker W, Hofbauer GFL, Dotto GP. Loss of mesenchymal CSL signaling leads to a field cancerization phenotype with multifocal epithelial tumor development. Cell. 2012, 149 (6), 1207-1220.

Ferone G, Thomason HA, Antonini D, De RosaL, Hu B, Gemei M, Zhou H, Ambrosio R, Rice DP, Acampora D, van Bokhoven H, Del Vecchio L, Koster MI, Tadini G, Spencer-Dene B, Dixon M, Dixon J, Missero C. Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine. 2012, 4(1): 1-14.

Hu B, Lefort K, Qiu W, Nguyen BC, Rajaram RD, Castillo E, He F, Chen Y, Angel P, Brisken C, Dotto GP. Control of hair follicle cell fate by underlying mesenchyme through a CSL - Wnt5a - FoxN1 regulatory axis. Genes & Development. 2010, 24(14), 1519-1532.

Borrelli S, Candi E, Hu B, Dolfini D, Ravo M, Grober OM, Weisz A, Dotto GP, Melino G, Viganò MA, Mantovani R. The p63 target HBP1 isrequired for skin differentiation and stratification. Cell Death and Differentiation. 2010, Dec;17(12):1896-907.

Mandinova A, Kolev V, Neel V, Hu B, Stonely W, Lieb J, Wu X, Colli C, Han R, Pazin M, Ostano P, Dummer R, Brissette JL, DottoGP. A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. Journal of Clinical Investigation. 2009, Oct;119(10):3127-37.

Kolev V, Mandinova A, Guinea-Viniegra J, Hu B, Lefort K, Lambertini C, Neel V, Dummer R, Wagner EF, Dotto GP. EGFR signalling as a negative regulator of Notch1 gene transcription and function inproliferating keratinocytes and cancer. Nature Cell Biology. 2008, Aug;10(8):902-11;

Nait Lechguer A, Kuchler-Bopp S, Hu B, Haïkel Y, Lesot H. Tooth Tissue Engineering: Kinetic of Vascularization. Journalof Dental Research, 2008, Dec;87(12)1138-1143. 

Li JY, Hu B, Wang SL. Temporal and Spatial Patterns of Transforming Growth Factor-b2 Expression in Developing Mouse Lower First Molar. European Journal of Histochemistry, 2008, October-December; 52(4): 243-250.

Li Y, Hu B, Liu Y, Ding G, Zhang C, Wang S. The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation. 2009, Nov;36(11):781-5.

Nadiri A, Kuchler-Bopp S, Mjahed H, Hu B, HaikelY, Schaaf P, Voegel JC, Benkirane-Jessel N. Cell Apoptosis Control Using BMP4 and Noggin Embedded in a Polyelectrolyte Multilayer Film. SMALL. 2007, Aug 20;3(9):1577-1583. 

Hu B, Nadiri A, Kuchler-Bopp S, Perrin-Schmitt F, Peters H, Lesot H. Tissue engineering of tooth crown, rootand periodontium. Tissue Engineering. 2006, (8), 2069-2075.

Hu B, Unda F, Bopp-Kuchler S, Jimenez L, Wang XJ, Haïkel Y, Wang SL, Lesot H. Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research. 2006, 85(5):416-421.

Hu B, Nadiri A, Bopp-Küchler S, Perrin-Schmitt F, Lesot H. Dental epithelial histo-morphogenesis in vitro. Journal of Dental Research. 2005,Jun;84(6):521-525. 

Hu B, Nadiri A, Bopp-Kuchler S, Perrin-Schmitt F, Wang S, Lesot H. Dental epithelial histo-morphogenesis in the mouse: positional information versus cell history. Archives of Oral Biology. 2005, Feb;50(2):131-136.

Patents

WO 2017009658 

Reports & invited lectures

2016

The 3rd International Conference on Dental and Craniofacial Stem Cells; University of Sheffield; University of Birmingham; University of Geneva; Capital Medical University; Shandong University; Shenyang Hospital of Stomatology.

2015

University of Bradford, UK; Capital Medical University, Beijing; Tian Jin Medical University (China).

2013

Gordon Conference on Epithelial Differentiation & Keratinization

2012

University of Zurich, Switzerland

University of Copenhagen, Denmark

2011

China Society of Oral Biology, the first annual meeting.

 

University of Zurich, Switzerland

 

University of Bern, Switzerland           

2010

Wuhan University, China        

 

The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany

2009

Capital Medical University, Beijing, China

2008

National University of Singapore, Singapore

 

Beijing University, China