Dr Bing Hu
Profiles

Dr Bing Hu

Associate Professor (Reader) in Oral & Dental Health Research

Peninsula Dental School (Faculty of Medicine and Dentistry)

Role

2013.7-

 

Associate Professor (Reader) in Oral and Dental Health Research, Peninsula Schools of Medicine and Dentistry, Plymouth University, UK

2013.4-

External Expert, School of Dentistry, University of Geneva, Switzerland.

2009-2013.6

Lecturer, Department of Biochemistry, University of Lausanne, Switzerland

2006-2009

Postdoctoral fellow, Department of Biochemistry, University of Lausanne, Switzerland

2002-2006

Research Assistant, Research Center, Faculty of Dentistry, University of Strasbourg, France

2003-2005

Clinical Resident, Department of Orthodontics, Faculty of Dentistry, University of Strasbourg, France

1997-2002

Clinical Resident, Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China

Qualifications

2006      

Ph.D. in Developmental Biology/Molecular and Cell Biology (awarded date: July 7th, 2006). School of Life Science, University of Strasbourg.

2004

 

2000

M.D. in Orthodontics/Oral biology.  Faculty of Stomatology, Capital Medical University, Beijing, China

Master/D.D.S. in Orthodontics. Department of Orthodontics, Faculty of Stomatology, Capital Medical University, Beijing, China

1997

Bachelor of Oral Medicine (for General Dentistry), Faculty of Stomatology, Capital Medical University, Beijing, China

Professional membership

International Association of Dental Research

European Orthodontic Society


Roles on external bodies

External Expert, School of Dental Medicine, University of Geneva, Switzerland

Examiner: PhD degree, King's College, UK

Grant reviewer activities: 
Medical Research Council (UK)
Biotechnology and Biological Sciences Research Council (UK)
Engineering and Physical Sciences Research Council (UK)
Royal College of Surgeons (UK)
Daphne Jackson Trust (UK)
Beijing Natural Science Foundation (China)

Teaching interests

Developmental Biology; Craniofacial Biology; Cancer Biology; Tissue Engineering

Staff serving as external examiners

Active: 

- King's College, UK (for PhD degrees).

Research interests

Research areas & models:

(1) Skin and oral cancer & regeneration;

(2) Tooth development and tissue engineering;

(3) Salivary gland development and diseases.

Other research

Group members:

Research Fellow: Dr. Wai Ling Kok

PhD student & Research Assistant: Donald Singer (2015 BSODR Unilever Prize Winner)

PhD Student & Research Associate: Portia Grayson

PhD Student & Research Associate: Charlotte Illsley

PhD student:  Jemma Walker (2017 UK Science Council RSci CPD Awards Winner)

PhD Student: Jonathan Davis  (2017 BSODR Unilever Prize Winner)

PhD Student: Chloe Walker 

Visiting Scientist: Yuying Liu

Visiting Student: Yan Gao

Volunteer research student: Emily Schenk

Volunteer research student: Nathalie Osbourne

Scientists associated to the group: 

Dr Louise Belfield (Lecturer in Biomedical Sciences)

Dr Zoe Brookes (Clinical Lecturer in Dental Undergraduate Studies)

Mr Malcolm Bruce (Associate Professor, Associate Head Teaching and Learning (Dentistry))

Secretary: Jacqueline Kinvig

 

Previous Group members:

Dr Heng Zhuang (Current address: Associate Chief Clinician at Peking University School and Hospital of Somatology, China)

Dr Qingguo Lai  (Current address: Professor at 1st Affiliated Hospital, Shan Dong University, China)

Dr Kingyin Lee (Current address: University College of London)

Dr Tulay Gulsen (Current address: University London Cancer Institute)

External honorary contract (PhD co-supervisors):

Prof. Fai Ng, Newcastle University

Dr Denis Corbeil, Technical University of Dresden (Germany)

Prof. Basem Abdallah, University of Southern Denmark

Grants & contracts

2017-2020 

European Regional Development Fund (£500,000, PI)

National Natural Science Foundation of China (¥600,000, Co-PI)

 

2014-2018  

Marie Curie Career Integration Grant, European Union (€100,000, PI)

 

2014-2017   

BBSRCresearch grant, UK (£426,000, PI)

 

2013

China Scholarship Council (¥130,000, Supervisor)

National Natural Science Foundation of China ( ¥160,000, Co-PI)

 

2011   

State National Science & TechnologyAwards, Grade II (China, the highest level scientific award in China)

 

2009   

Science & Technology Awards of Beijing City, Grade I

National Natural Science Foundation of China (¥120,000, Co-PI)

 

2007   

Carl Storm International Diversity Fellowship

 

2006   

“New Star Project” of Beijing City, China (¥300,000, declined)

William J.Gies Awards (the most important prize in dental research, awarded by the International Association of Dental Research)

The Cover of the Year Award for Journal of Dental Research

Prize of “Promoting Research”, from French-Chinese Association of Science and Technology

 

2005   

National Natural Science Foundation of China (¥260,000)

China National Prize for Doctoral Study in Abroad

 

2003   

Fellowship of Dental Institute of France;

 

2000   

Science& Technology Awards of Beijing City, Grade II.

Research groups

Singer, D., Thamm, K., Zhuang, H., Karbanová, J., Gao, Y., Walker, J.V., Jin, H., Wu, X., Coveney, C. R., Marangoni, P., Lu, D., Grayson, P.R.C., Gulsen, T., Liu, J.K., Ardu, S., Wann, A., Luo, S., Zambon, A.C., Jetten, A.M., Tredwin, C., Klein, O.D., Attanasio, M., Carmeliet, P., Huttner, W.B., Corbeil, D., Hu,B. (2018). Prominin-1 governs stem cell activation by orchestrating ciliary dynamics. EMBO J, in press. 

Zhuang, H.,Ali, K., Ardu, S., Tredwin, C., & Hu, B. (2016). Autophagy in dental tissues: a double-edged sword. Cell Death Diseases, 7, e2192.doi:10.1038/cddis.2016.103

Zhuang, H., Hu, D., Singer, D., Walker, J. V., Nisr, R. B.,Tieu, K., . . . Hu, B. (2015). Local anesthetics induce autophagy in young permanent tooth pulp cells. Cell Death Discovery, 1, 15024. doi:10.1038/cddiscovery.2015.24

Button, R. W., Lin, F., Ercolano, E., Vincent, J. H., Hu, B.,Hanemann, C. O., & Luo, S. (2014). Artesunate induces necrotic cell death in schwannoma cells. Cell Death Diseases, 5,e1466.doi:10.1038/cddis.2014.434

Hu, B., Castillo, E., Harewood, L., Ostano, P., Reymond, A., Dummer,R., . . . Dotto, G. P. (2012). Multifocal epithelial tumors and fieldcancerization from loss of mesenchymal CSL signaling. Cell, 149(6),1207-1220.doi:10.1016/j.cell.2012.03.048

Wang, F., Liu, Y., Hu, B., Fan, Z.P., Shi, S., Wang, S. (2012). Functional tooth regeneration. Science, 336(6080), s48-50. (special issue).DOI: 10.1126/science.336.6080.497-c

Ferone, G., Thomason, H. A., Antonini, D., De Rosa, L., Hu, B.,Gemei, M., . . .Missero, C. (2012). Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Molecular Medicine, 4(3),192-205.doi:10.1002/emmm.201100199

Hu, B., Lefort, K., Qiu, W., Nguyen, B. C., Rajaram, R. D., Castillo,E., . . . Dotto, G. P. (2010). Control of hair follicle cell fate by underlying mesenchyme through a CSL-Wnt5a-FoxN1 regulatory axis. Genes & Development, 24(14),1519-1532.doi:10.1101/gad.1886910

Borrelli, S., Candi, E., Hu, B., Dolfini, D., Ravo, M.,Grober, O. M., . . . Mantovani, R. (2010). The p63 target HBP1 is required forskin differentiation and stratification. Cell Death Differentiation, 17(12),1896-1907.doi:10.1038/cdd.2010.59

Mandinova, A., Kolev, V., Neel, V., Hu, B., Stonely, W., Lieb, J., . . .Dotto,G. P. (2009). A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans. J Clinical Investigation, 119(10),3127-3137.doi:10.1172/JCI38543

Li, Y., Hu, B., Liu, Y., Ding, G., Zhang,C., & Wang, S. (2009). The effects of fixed orthodontic appliances on saliva flow rate and saliva electrolyte concentrations. Journal of Oral Rehabilitation, 36(11),781-785.doi:10.1111/j.1365-2842.2009.01993.x

Nait Lechguer, A., Kuchler-Bopp, S., Hu, B.,Haikel, Y., & Lesot, H. (2008). Vascularization of engineered teeth. Journal of Dental Research, 87(12),1138-1143.doi:10.1177/154405910808701216

Li, J. Y., Hu, B., Wang, X. J., & Wang,S. L. (2008). Temporal and spatial expression of TGF-beta2 in tooth crown development in mouse first lower molar. European Journal of Histochemistry, 52(4), 243-250

Kolev, V., Mandinova, A., Guinea-Viniegra, J., Hu, B.,Lefort, K., Lambertini, C., . .. Dotto, G. P. (2008). EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nature Cell Biology, 10(8),902-911.doi:10.1038/ncb1750

Nadiri, A., Kuchler-Bopp, S., Mjahed, H., Hu, B.,Haikel, Y., Schaaf, P., . . .Benkirane-Jessel, N. (2007). Cell apoptosis control using BMP4 and noggin embedded in a polyelectrolyte multilayer film. Small, 3(9),1577-1583. doi:10.1002/smll.200700115

Hu, B., Unda, F., Bopp-Kuchler, S., Jimenez, L., Wang, X.J., Haikel,Y., . . . Lesot, H. (2006). Bone marrow cells can give rise to ameloblast-like cells. Journal of Dental Research, 85(5),416-421. doi:10.1177/154405910608500504

Hu, B., Nadiri, A., Kuchler-Bopp, S., Perrin-Schmitt, F.,Peters, H.,& Lesot, H. (2006). Tissue engineering of tooth crown, root, and periodontium. Tissue Engineering, 12(8),2069-2075.doi:10.1089/ten.2006.12.2069

Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F., &Lesot, H. (2005). Dental Epithelial Histomorphogenesis in vitro. Journal of Dental Research, 84(6),521-525.doi:10.1177/154405910508400607

Hu, B., Nadiri, A., Bopp-Kuchler, S., Perrin-Schmitt, F.,Wang, S.,& Lesot, H. (2005). Dental epithelial histo-morphogenesis in the mouse:positional information versus cell history. Archives of Oral Biology, 50(2),131-136.doi:10.1016/j.archoralbio.2004.09.007

 

Reports & invited lectures

2016

The 3rd International Conference on Dental and Craniofacial Stem Cells; University of Sheffield; University of Birmingham; University of Geneva; Capital Medical University; Shandong University; Shenyang Hospital of Stomatology.

2015

University of Bradford, UK; Capital Medical University, Beijing; Tian Jin Medical University (China).

2013

Gordon Conference on Epithelial Differentiation & Keratinization

2012

University of Zurich, Switzerland

University of Copenhagen, Denmark

2011

China Society of Oral Biology, the first annual meeting.

 

University of Zurich, Switzerland

 

University of Bern, Switzerland           

2010

Wuhan University, China        

 

The 10th International Conference on Tooth Morphogenesis and Differentiation, Berlin, Germany

2009

Capital Medical University, Beijing, China

2008

National University of Singapore, Singapore

 

Beijing University, China