Dr Svetislav Zaric

Dr Svetislav Zaric

Honorary Associate Professor

Peninsula Dental School (Faculty of Health)



Clinical Associate Professor in Biomedical Science.
Year 1 Lead for Bachelor of Dental Surgery and Dental Therapy and Hygiene Programmes, Peninsula Dental School.


2003. Bachelor of Dental Surgery, University of Belgrade, Serbia

2007. MClinDent in Periodontology and Oral Medicine, University of Belgrade, Serbia

2010. PhD in Microbiology/Immunology, Queen's University, Belfast

2014. Fellow of the Higher Education Academy

Previous positions:

2011-2013. Lecturer in Oral Biology, School of Dentistry, University of Aberdeen
2010-2011. Research Fellow, Centre for Infection and Immunity, Queen's University Belfast

Professional membership

- General Dental Council - 253538
- International Association for Dental Research
- British Society for Oral and Dental Research
- Association of Basic Science Teachers in Dentistry

Roles on external bodies

Editorial Board Member:

- Journal of Clinical Periodontology
- Plos One
- International Journal of Molecular Sciences
- Journal of Oral Health and Dental Management
- Cochrane Upper Gastrointestinal and Pancreatic Diseases Group



Teaching interests

Oral Microbiology and Immunology, Histology,  Periodontology, Enquiry-Based Learning.



Research interests

My research interests include microbiology of periodontal diseases, host-pathogen interactions, Toll-Like Receptors signalling, immunopathogenesis of chronic inflammation and mechanisms involved in the resolution of inflammatory response (endotoxin tolerance). I am particularly interested in the chemical composition of Porphyromonas gingivalis LPS, with regards to its lipid-A structure and sialylation, and in consequences these changes have on the host’s immune response.  Other areas of my research interest are molecular and cellular mechanisms responsible for tissue injury during inflammation, biomarkers of periodontal disease progression, personalised, point-of-care periodontal therapy and identification of therapeutic targets for resolution of inflammation.



Figure 1: Mitochondrial transmembrane potential in neutrophils incubated with naive and P.gingivalis LPS tolerized monocytes.

Research degrees awarded to supervised students

MSc project:  "Immunomodulatory effects of viral TLR ligands on subsequent bacterial infection", student: Ye Zhang.
PhD project: " Tolerogenic mechanisms and macrophage polarisation associated with periodontal pathogen Porphyromonas gingivalis", Alex Strachan.



Key publications

Key publications are highlighted

Lu EM-C & Zaric S (2024) 'Improving the use of Nabers probes for furcation detection during periodontal assessment in dental curricula' Faculty Dental Journal 15, (1) 24-29 Publisher Site , DOI
Cabrilo Lazic M, Puletic M, Radovic N, Vukovic B, Zaric S & Biocanin V (2023) 'Clinical applications of lasers in conventional periodontal care' Journal of Laser Applications 35, (1) , DOI
Biocanin V, Pejanovic D, Antonijevic D, Ciric M, Tambur Z & Zaric S (2023) 'Split crest technique - an effective method in dental implantology for narrow ridges: A case report' Serbian Dental Journal 70, (1) 39-44 , DOI
Zaric S, Strachan A, Kurushima Y, Dong A, McIlwaine C, Harrington Z, Nibali L, Foey A & Ide M (2022) 'Evaluating clinical utility of subgingival and salivary endotoxin activity levels as periodontal biomarkers' Frontiers in Oral Health 3, , DOI Open access
Zaric S, Ide M & Nibali L (2022) 'New Insights into the Pathogenesis of Periodontal Diseases' Dental Update 49, (4) 314-317 , DOI
Pussinen PJ, Kopra E, Pietiäinen M, Lehto M, Zaric S, Paju S & Salminen A (2022) 'Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia' Periodontology 2000 89, (1) 19-40 , DOI
Mcilwaine C, Strachan A, Harrington Z, Jerreat M, Belfield LA, Sandor V, Foey A & Zaric S (2019) 'Comparative analysis of total salivary lipopolysaccharide chemical and biological properties with periodontal status' Archives of Oral Biology 110, 104633-104633 , DOI Open access
Zahra D, Bennett J, Belfield L, Ali K, McIlwaine C, Bruce M, Jones G, Brookes ZL, Coelho C & Zaric S (2019) 'Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum' European Journal of Dental Education 0, (ja) Author Site , DOI Open access
McIlwaine C, Brookes ZLS, Zahra D, Ali K, Zaric S, Jones G & Belfield LA (2019) 'A novel, integrated curriculum for dental hygiene-therapists and dentists' British Dental Journal 226, 67-67 Author Site Open access
Strachan A, Harrington Z, McIlwaine C, Jerreat M, Belfield LA, Kilar A, Jackson SK, Foey A & Zaric S (2018) 'Subgingival lipid A profile and endotoxin activity in periodontal health and disease' Clinical Oral Investigations Author Site , DOI Open access
Zahra D, Belfield L, Bennett J, Zaric S & Mcilwaine C (2018) 'The benefits of integrating dental and dental therapy and hygiene students in undergraduate curricula' European Journal of Dental Education Author Site , DOI Open access
Zaric SS, Lappin MJ, Fulton CR, Lundy FT, Coulter WA & Irwin CR (2017) 'Sialylation of Porphyromonas gingivalis LPS and its effect on bacterial-host interactions' Innate immunity 23, (3) 319-326 , DOI Open access
Lappin MJ, Brown V, Zaric SS, Lundy FT, Coulter WA & Irwin CR (2016) 'Interferon-γ stimulates CD14, TLR2 and TLR4 mRNA expression in gingival fibroblasts increasing responsiveness to bacterial challenge' Arch Oral Biol 61, 36-43 Author Site , DOI
Zaric S, Bojic B, Popovic B & Milasin J (2015) 'Eradication of gastric Helicobacter pylori ameliorates halitosis and tongue coating' J Contemp Dent Pract 16, (3) 205-209 Author Site , DOI Open access
Zaric S & Belfield LA (2015) 'Objective Structured Clinical Examination (OSCE) with Immediate Feedback in Early (Preclinical) Stages of the Dental Curriculum' Creative Education 06, (06) 585-593 , DOI Open access
Yuen WY, Pasmooij AM, Stellingsma C & Jonkman MF (2012) 'Enamel Defects in Carriers of a Novel LAMA3 Mutation Underlying Epidermolysis Bullosa' Acta Derm Venereol , DOI Open access
Zaric SS, Coulter WA, Shelburne CE, Fulton CR, Zaric MS, Scott A, Lappin MJ, Fitzgerald DC, Irwin CR & Taggart CC (2011) 'Altered Toll-like receptor 2-mediated endotoxin tolerance is related to diminished interferon beta production' J Biol Chem 286, (34) 29492-29500 Author Site , DOI Open access
Zaric S, Shelburne C, Darveau R, Quinn DJ, Weldon S, Taggart CC & Coulter WA (2010) 'Impaired immune tolerance to Porphyromonas gingivalis lipopolysaccharide promotes neutrophil migration and decreased apoptosis' Infect Immun 78, (10) 4151-4156 Author Site , DOI Open access
Zaric S, Bojic B, Jankovic L, Dapcevic B, Popovic B, Cakic S & Milasin J (2009) 'Periodontal therapy improves gastric Helicobacter pylori eradication' J Dent Res 88, (10) 946-950 Author Site , DOI
Salih V & Zaric S (2016) 'The periodontal ligament (PDL)' in Creanor S Essential Clinical Oral Biology John Wiley & Sons 57-63


Additional information

- 2011. IADR/Hatton Divisional Award
- 2013. IADR/Lion Microbiology/Immunology Award
- 2013. GlaxoSmithKline/BSODR research grant