Dr Simon Fox
Profiles

Dr Simon Fox

Associate Head of School

School of Biomedical & Healthcare Sciences (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

Associate Professor (Senior Lecturer) in Molecular Pathology

Associate Head of Teaching and Learning

Qualifications

Ph.D. (1998) Cellular Biology; University of London

B.Sc. (Hons) (1992) Anatomical Science; University of Bristol

PG.Cert (2005) Learning and teaching in higher education.

Teaching interests

I am module leader for

BHCS1001 Biomedical Investigation and Experimentation


BHCS2001 Biology of Disease

BHCS2002 Evidence Based Practice in Biomedical Science

BHCS2009 Techniques in Microscopy and Molecular biology

BHCS2010 Evidence Based Practice in Healthcare Science

BHCS3002 Molecular and Cellular Pathology

BHCS3013 Cellular Pathology

BHCS3030 Biomedical Science: Placements

BIOM5011 Molecular and Cellular Pathology

Staff serving as external examiners

External examiner for BSc and MSc Applied Biosciences at the University of the West of Scotland 2011-2015

Research interests

My field of expertise lies in Bone Biology and the Cellular and Molecular techniques for assessing skeletal turnover.  My current areas of research are focused on understanding the effect of nutritional factors on bone cell differentiation and activity, the impact of oxygen and pressure on bone cell function and the mechanisms governing preferential metastasis of cancer cells to the skeleton.

Research degrees awarded to supervised students

(University of London) Alison Lovibond 2005, PhD

(Plymouth University) Matthew Owens 2011, PhD

(Plymouth University) Sahar Karieb 2012, PhD

(Plymouth University) Hadil Al Hadi 2013, PhD

Grants & contracts

Arthritis Research Campaign: (September 2002-August 2005, £ 104,834) Fox SW and Chambers TJ. To test the role of TGF-beta signalling pathways and SOCS expression in osteoclast/macrophage lineage commitment. (Ref F0558).
 

Wellcome Trust: (Awarded August 2005 for 36 months, £ 136,360) Fox SW. Analysis of the signalling mechanism by which TGF-beta determines osteoclast/macrophage lineage-switching.

Diving Diseases Research Centre: (Awarded October 2009 for 36 months, £10,500) Fox SW. Effect of hyperbaric oxygen therapy on osteoclast differentiation.

Seal Hayne Trust: (Awarded June 2009 for 6 months £4,750) Owens M, Davies S and Fox SW. Molecular analysis of telost bone remodelling.

 

Key publications are highlighted

Journals
Articles
Al Hadi H, Smerdon GR & Fox SW 2015 'Hyperbaric oxygen therapy accelerates osteoblast differentiation and promotes bone formation' J Dent 43, (3) 382-388 Author Site , DOI
Owen MAG, Eynon B, Woodgate S, Davies SJ & Fox S 2012 'Increased water current induces micro-architectural changes to the vertebral bone of juvenile rainbow trout (Oncorhynchus mykiss)' AQUACULTURE 344, 141-146 Author Site , DOI
Karieb S & Fox SW 2012 'Zinc modifies the effect of phyto-oestrogens on osteoblast and osteoclast differentiation in vitro' Br J Nutr 108, (10) 1736-1745 Author Site , DOI
Fox SW & Davies SJ 2011 'Corn-expressed dietary phytase augments vertebral and scale mineral content in juvenile rainbow trout (Oncorhynchus mykiss)' AQUACULTURE NUTRITION 17, (4) E840-E852 Author Site , DOI
Karieb S & Fox SW 2011 'Phytoestrogens directly inhibit TNF-α-induced bone resorption in RAW264.7 cells by suppressing c-fos-induced NFATc1 expression' J Cell Biochem 112, (2) 476-487 Author Site , DOI
Winrow VR, Mesher J, Meghji S, Morris CJ, Maguire M, Fox S, Coates ARM, Tormay P, Blake DR & Henderson B 2008 'The two homologous chaperonin 60 proteins of Mycobacterium tuberculosis have distinct effects on monocyte differentiation into osteoclasts' CELLULAR MICROBIOLOGY 10, (10) 2091-2104 Author Site , DOI
Fox SW, Evans KE & Lovibond AC 2008 'Transforming growth factor-beta enables NFATc1 expression during osteoclastogenesis' Biochem Biophys Res Commun 366, (1) 123-128 Author Site , DOI
Evans KE & Fox SW 2007 'Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus' BMC Cell Biol 8, Author Site , DOI
Evans KE & Fox SW 2007 'Interleukin-10 inhibits osteoclastogenesis by reducing NFATcI expression and preventing its translocation to the nucleus' BMC Cell Biology 8, (4)
Fox SW & Chambers TJ 2006 'Ovariectomy and oestrogen replacement have no effect on megakaryocyte or platelet number. :' International Journal of Cardiology 109, 359-366
Fox SW & Chambers TJ 2006 'The effect of oestrogen on megakaryocyte differentiation and platelet counts in vivo' International Journal of Cardiology 109, (3) 359-366
Fox SW & Lovibond AC 2005 'Current insights into the role of transforming growth factor-beta in bone resorption' Molecular and Cellular Endocrinology 243, (1-2) 19-26
Lovibond AC & Fox SW 2005 'Transforming growth factor-beta-induced changes in gene expression in murine bone marrow macrophage precursors' Journal of Bone and Mineral Research 20, (7) 1302-1302
Fox SW & Lovibond AC 2004 'Determining the time-point when TGF-beta acts to promote lineage diversion towards the osteoclastic phenotype' Journal of Bone and Mineral Research 19, S136-S136
Lovibond AC, Chambers TJ & Fox SW 2004 'Effect of transforming growth factor-beta on osteoclast precursor NFATc1 and c-fos expression' Journal of Bone and Mineral Research 19, (6) 1040-1040
Khastgir G, Studd JWW, Fox SW, Jones J, aghband-Zadeh J & Chow JWM 2003 'A longitudinal study of the effect of subcutaneous estrogen replacement on bone in young women with Turner's syndrome' Journal of Bone and Mineral Research 18, (5) 925-932
Lovibond AC, Chambers TJ & Fox SW 2003 'Interleukin-10 directly inhibits RANKL-induced osteoclast formation from mononuclear phagocyte precursors' Journal of Bone and Mineral Research 18, (7) 1369-1369
Lovibond AC, Haque SJ, Chambers TJ & Fox SW 2003 'TGF-beta-induced SOCS3 expression augments TNF-alpha-induced osteoclast formation' Biochemical and Biophysical Research Communications 309, (4) 762-767
Fox SW, Haque SJ, Lovibond AC & Chambers TJ 2003 'The possible role of TGF-beta-induced suppressors of cytokine signaling expression in osteoclast/macrophage lineage commitment in vitro' Journal of Immunology 170, (7) 3679-3687
Fox SW 2003 'The Possible Role of TGF-β-Induced Suppressors of Cytokine Signaling Expression in Osteoclast/Macrophage Lineage Commitment In Vitro' The Journal of Immunology 170 (7), 3679-3687
Fox SW & Chambers TJ 2002 'Possible role for TGF-beta-induced SOCS expression in osteoclast/macrophage lineage commitment in-vitro' Journal of Bone and Mineral Research 17, (7) 1328-1328
Fuller K, Murphy C, Kirstein B, Fox SW & Chambers TJ 2002 'TNFa potently activates osteoclasts, through a direct action independent of and strongly synergistic with RANKL' Endocrinology 143, (3) 1108-1118
Fox SW 2002 'TNFα Potently Activates Osteoclasts, through a Direct Action Independent of and Strongly Synergistic with RANKL' Endrocrinology 143 (3), 1108-1118
Khastgir G, Studd J, Holland N, Alaghband-Zadeh J, Fox S & Chow J 2001 'Anabolic effect of estrogen replacement on bone in postmenopausal women with osteoporosis: Histomorphometric evidence in a longitudinal study' Journal of Clinical Endocrinology and Metabolism 86, 289-295
Lean JM, Fuller K, Fox SW & Chambers TJ 2001 'Flt3 ligand can substitute for M-CSF in support of osteoclast differentiation and function' Bone 28, (5) S161-S161
Fuller K, Fox SW, Kirstein B & Chambers TJ 2001 'Osteoclast regulation by TNF-alpha occurs through distinct mechanisms in vitro versus in vivo' Journal of Bone and Mineral Research 16, S377-S377
Conference Papers
Karieb SS & Fox SW 2011 'The effect of phytoestrogens, zinc and vitamin K on osteoblastic differentiation and activity in-vitro' //0 //0 S120-S120 , DOI