Dr Nikitas Nikitas
Profiles

Dr Nikitas Nikitas

Honorary Clinical Lecturer

Peninsula Medical School (Faculty of Health)

Biography

Biography

  • Graduated from the Medical School of the National and Kapodistrian University of Athens [Ptychio Iatrikes – Diploma in Medicine (MD) (Honours)]
  • Specialty training in General (Internal) Medicine and Intensive Care Medicine 
  • Senior Clinical Fellow in General Critical Care and Neurocritical Care - Addenbrookes Hospital Cambridge 
  • Consultant in Intensive Care Medicine 
  • Academic research Fellow 2003-2006 University of Patras Medical School and Imperial college St Mary's Campus
  • PhD and postdoctoral academic research fellow 2007-2014 University of Athens Medical School 

Qualifications

Academic Qualifications

  • Ptychio Iatrikes – Diploma in Medicine [MD]. 2002. Medical School: National and Kapodistrian University of Athens, School of Health Sciences, Faculty of Medicine
  • PhD Degree in Medicine [Pharmacogenomics]. 2012 PhD Thesis: “Study of effect of single nucleotide polymorphisms and expression of ERCC1 gene on treatment outcome of advanced Urothelial cancer patients treated with platinum-based chemotherapy” National and Kapodistrian University of Athens, School of Health Sciences, Faculty of Medicine
  • MSc in Basic Medical Sciences Applications – Genomics. 2006. MSc Thesis: “Study of Molecular variations in the Core Promoter, Precore, and Core regions of Hepatitis B virus genome, and within the antigenic epitopes of HBcAg in viral strains isolated from Asymptomatic Carriers of the Hepatitis B Virus” University of Patras, Department of Medicine. Laboratory Research conducted at Imperial College London St Mary’s Campus


Clinical Qualifications

  • Associate Fellowship in Intensive Care Medicine [AFICM] 
  • Associate Membership of the Royal College of Physicians 
  • European Diploma in Intensive Care Medicine, EDIC [European Society of Intensive Care Medicine]
  • Specialty Certificate in Intensive Care Medicine 
  • Specialty Certificate in General [Internal] Medicine 
  • Educational Supervisor Accreditation [RCP] 
  • Focused Intensive Care Echocardiography [FICE] Accreditation – FICE Mentor

Professional membership

  • Associate Fellowship in Intensive Care Medicine [AFICM] 
  • Associate Membership of the Royal College of Physicians 
  • European Diploma in Intensive Care Medicine, EDIC [European Society of Intensive Care Medicine]

    • Fully registered medical practitioner with a license to practise in the UK and on the specialist register 

    Teaching

    Teaching

    Teaching interests

    • Undergraduate clinical medical teaching in Year 5, Year 4 medical students, Intercalated students in Critical Care, Elective students in Critical care
    • Mentor of Intercalated students in Critical care 
    • Clinical Teacher Lead for Intensive Care Medicine - Derriford Hospital 
    • Evidence in Practice Facilitator - Peninsula Medical school  

     

    Research

    Research

    Research interests

    • Somatosensory Evoked Potentials in Neurological Prognostication after cardiac arrest [current project]
    • Assessment and monitoring of Interstitial Tissue biochemistry in Critically ill patients by the use of Adipose Tissue Microdialysis
    • Study of the effect of single nucleotide polymorphisms in treatment response
    • Endocrine Dysregulation in Subarachnoid Haemorrhage
    • Viral reactivation in immunocompetent critically ill patients

    Clinical research lead for Critical Care Medicine - Derriford Hospital 

    Other research

    Research Experience – Research Projects

    Current research project 
    P25/30 Somatosensory Evoked Potentials and neurological outcome in comatose survivors of Out of Hospital Cardiac Arrest who are not treated with hypothermic targeted temperature management. University Hospitals Plymouth NHS Trust, Departments of Intensive Care Medicine and Neurophysiology. Chief investigator of the study

    Past Research Projects:

    “Assessment and monitoring of Interstitial Tissue biochemistry in Critically ill patients by the use of Adipose Tissue Microdialysis”.Post-doctoral research fellowship

    “Study of CMV reactivation in adult immunocompetent critically ill patients treated in a General Adult Intensive Care Unit” Post-doctoral research fellowship

    PhD Thesis: “Study of effect of single nucleotide polymorphisms and expression of ERCC1 gene on treatment outcome of advanced Urothelial cancer patients treated with platinum-based chemotherapy”

    MSc Dissertation: “Study of Molecular variations in the Core Promoter, Precore, and Core regions of Hepatitis B virus genome, and within the antigenic epitopes of HBcAg in viral strains isolated from Asymptomatic Carriers of the Hepatitis B Virus”

    Local PI of the following clinical trials: 

    REMAP – CAP: Randomised, Embedded, Multifactorial Adaptive Platform trial for Community-Acquired Pneumonia
    International multi-centre randomised clinical trial – NIHR priority study for the COVID-19 Pandemic

    BLING III study - Beta-Lactam InfusioN Group Study

    GENOMICC study – Genetics of Mortality In Critical Care

    PHIND study: Clinical evaluation of a POC assay to identify PHenotypes IN the Acute Respiratory Distress Syndrome

    Publications

    Publications

    Key publications

    Key publications are highlighted

    Journals
    Articles
    Gourd NM, Bigham C, Broomfield N, Nye L, Stapleton L, Stead E, Smith A, Baker A, Chynoweth J & Hosking J (2023) 'Enhanced analysis of somatosensory evoked potentials at 20–30 milliseconds can predict neurological outcome after cardiac arrest' Clinical Neurophysiology 153, 141-151 , DOI Open access
    Roe T, Welbourne J & Nikitas N (2022) 'Endocrine dysregulation in aneurysmal subarachnoid haemorrhage' British Journal of Neurosurgery 36, (3) 358-367 , DOI
    Pairo-Castineira E, Clohisey S, Klaric L, Bretherick AD, Rawlik K, Pasko D, Walker S, Parkinson N, Fourman MH & Russell CD (2020) 'Genetic mechanisms of critical illness in COVID-19' Nature 591, (7848) 92-98 , DOI
    West J, Everden S & Nikitas N (2020) 'A case of COVID-19 reinfection in the UK' Clinical Medicine 21, (1) e52-e53 , DOI
    MacCormick AP, Carr W & Nikitas N (2020) 'Herpes simplex encephalitis following successful coiling of aneurysmal subarachnoid haemorrhage' British Journal of Neurosurgery 37, (5) 1269-1270 , DOI
    Angus DC, Derde L, Al-Beidh F, Annane D, Arabi Y, Beane A, van Bentum-Puijk W, Berry L, Bhimani Z & Bonten M (2020) 'Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19' JAMA 324, (13) 1317-1317 , DOI
    Gourd NM & Nikitas N (2019) 'Multiple Organ Dysfunction Syndrome' Journal of Intensive Care Medicine 35, (12) 1564-1575 , DOI
    Ilias I, Apollonatou S, Nikitas N, Theodorakopoulou M, Vassiliou AG, Kotanidou A & Dimopoulou I (2018) 'Microdialysis-Assessed Adipose Tissue Metabolism, Circulating Cytokines and Outcome in Critical Illness' Metabolites 8, (4) 62-62 , DOI
    Ilias I, Nikitas N, Theodorakopoulou M & Dimopoulou I (2018) 'Microdialysis-Assessed Adipose Tissue Metabolism in Critically Ill Patients' Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 11, (1) 32-38 , DOI
    Ilias I, Apollonatou S, Vassiliadi D-A, Nikitas N, Theodorakopoulou M, Diamantakis A, Kotanidou A & Dimopoulou I (2018) 'Adipose Tissue Lactate Clearance but Not Blood Lactate Clearance Is Associated with Clinical Outcome in Sepsis or Septic Shock during the Post-Resuscitation Period' Metabolites 8, (2) 28-28 , DOI
    Cauchi M & Nikitas N (2015) 'Diarrhea and generalized weakness in a patient with metastatic melanoma and a lumbosacral mass, after initiation of therapy with a checkpoint inhibitor: A case report' International Journal of Case Reports and Images 6, (11) 682-682 , DOI
    Ilias I, Tzanela M, Nikitas N, Vassiliadi DA, Theodorakopoulou M, Apollonatou S, Tsagarakis S & Dimopoulou I (2015) 'Evidence of Subcutaneous Tissue Lipolysis Enhancement by Endogenous Cortisol in Critically Ill Patients Without Shock' IN VIVO 29, (4) 497-499
    Frantzeskaki FG, Karampi E-S, Kottaridi C, Alepaki M, Routsi C, Tzanela M, Vassiliadi DA, Douka E, Tsaousi S & Gennimata V (2014) 'Cytomegalovirus reactivation in a general, nonimmunosuppressed intensive care unit population: Incidence, risk factors, associations with organ dysfunction, and inflammatory biomarkers' Journal of Critical Care 30, (2) 276-281 , DOI
    Frantzeskaki F, Diakaki C, Rizos M, Theodorakopoulou M, Papadopoulos P, Antonopoulou A, Nikitas N, Lignos M, Brountzos E & Velegraki A (2014) 'Yeast central nervous system infection in a critically ill patient: a case report' Journal of Medical Case Reports 8, (1) , DOI
    Ilias I, Vassiliadi DA, Theodorakopoulou M, Boutati E, Maratou E, Mitrou P, Nikitas N, Apollonatou S, Dimitriadis G & Armaganidis A (2014) 'Adipose tissue lipolysis and circulating lipids in acute and subacute critical illness: Effects of shock and treatment' Journal of Critical Care 29, (6) 1130.e5-1130.e9 , DOI
    Ikonomidis I, Makavos G, Nikitas N, Paraskevaidis I, Diamantakis A, Kopterides P, Theodorakopoulou M, Parissis J, Lekakis J & Armaganidis A (2014) 'Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock' International Journal of Cardiology 172, (1) 103-108 , DOI
    Vassiliou AG, Maniatis NA, Kotanidou A, Kallergi M, Karystinaki FS, Letsiou E, Glynos C, Kopterides P, Vassiliadi D & Nikitas N (2013) 'Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients' Intensive Care Medicine 39, (10) 1752-1759 , DOI
    Nikitas N, Kopterides P, Ilias I, Theodorakopoulou M, Vassiliadi DA, Armaganidis A & Dimopoulou I (2013) 'Elevated adipose tissue lactate to pyruvate (L/P) ratio predicts poor outcome in critically ill patients with septic shock: a microdialysis study' MINERVA ANESTESIOLOGICA 79, (11) 1229-1237
    Dimopoulos G (2013) 'L-asparaginase fatal toxic encephalopathy during consolidation treatment in an adult with acute lymphoblastic leukemia' American Journal of Case Reports 14, 311-314 , DOI
    Nikitas N, Karadimou A, Tsitoura E, Soupos N, Tsiatas M, Karavasilis V, Pectasides D, Pavlidis N, Chrisofos M & Adamakis I (2012) 'Association of <i>ERCC1</i> SNPs with outcome in platinum-treated patients with advanced urothelial cancer: a Hellenic Cooperative Oncology Group study' Pharmacogenomics 13, (14) 1595-1607 , DOI
    Kopterides P, Theodorakopoulou M, Ilias I, Nikitas N, Frantzeskaki F, Vassiliadi DA, Armaganidis A & Dimopoulou I (2012) 'Interrelationship between blood and tissue lactate in a general intensive care unit: A subcutaneous adipose tissue microdialysis study on 162 critically ill patients' Journal of Critical Care 27, (6) 742.e9-742.e18 , DOI
    Vassiliadi DA, Ilias I, Tzanela M, Nikitas N, Theodorakopoulou M, Kopterides P, Maniatis N, Diamantakis A, Orfanos SE & Perogamvros I (2012) 'Interstitial cortisol obtained by microdialysis in mechanically ventilated septic patients: Correlations with total and free serum cortisol' Journal of Critical Care 28, (2) 158-165 , DOI
    Kopterides P, Theodorakopoulou M, Nikitas N, Ilias I, Vassiliadi DA, Orfanos SE, Tsangaris I, Maniatis NA, Tsantes AE & Travlou A (2012) 'Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis' Intensive Care Medicine 38, (11) 1843-1850 , DOI
    Dimopoulos MA, Roussou M, Gkotzamanidou M, Nikitas N, Psimenou E, Mparmparoussi D, Matsouka C, Spyropoulou-Vlachou M, Terpos E & Kastritis E (2012) 'The role of novel agents on the reversibility of renal impairment in newly diagnosed symptomatic patients with multiple myeloma' Leukemia 27, (2) 423-429 , DOI
    Pectasides D, Papaxoinis G, Kalogeras KT, Eleftheraki AG, Xanthakis I, Makatsoris T, Samantas E, Varthalitis I, Papakostas P & Nikitas N (2012) 'XELIRI-bevacizumab versus FOLFIRI-bevacizumab as first-line treatment in patients with metastatic colorectal cancer: a Hellenic Cooperative Oncology Group phase III trial with collateral biomarker analysis' BMC Cancer 12, (1) , DOI
    Vassiliadi DA, Tzanela M, Kotanidou A, Orfanos SE, Nikitas N, Armaganidis A, Koutsilieris M, Roussos C, Tsagarakis S & Dimopoulou I (2012) 'Serial changes in adiponectin and resistin in critically ill patients with sepsis: Associations with sepsis phase, severity, and circulating cytokine levels' Journal of Critical Care 27, (4) 400-409 , DOI
    Razis E, Kalogeras KT, Kotoula V, Eleftheraki AG, Nikitas N, Kronenwett R, Timotheadou E, Christodoulou C, Pectasides D & Gogas H (2012) 'Improved Outcome of High-Risk Early HER2 Positive Breast Cancer With High CXCL13-CXCR5 Messenger RNA Expression' Clinical Breast Cancer 12, (3) 183-193 , DOI
    Tasidou A, Roussou M, Terpos E, Kastritis E, Gkotzamanidou M, Gavriatopoulou M, Migkou M, Eleutherakis-Papaiakovou E, Nikitas N & Anagnostou D (2012) 'Increased expression of cyclin‐D1 on trephine bone marrow biopsies independently predicts for shorter overall survival in patients with multiple myeloma treated with novel agents' American Journal of Hematology 87, (7) 734-736 , DOI
    Kastritis E, Terpos E, Roussou M, Gavriatopoulou M, Pamboukas C, Boletis I, Marinaki S, Apostolou T, Nikitas N & Gkortzolidis G (2012) 'A phase 1/2 study of lenalidomide with low-dose oral cyclophosphamide and low-dose dexamethasone (RdC) in AL amyloidosis' Blood 119, (23) 5384-5390 , DOI
    Eleftherakis-Papapiakovou E, Kastritis E, Roussou M, Gkotzamanidou M, Grapsa I, Psimenou E, Nikitas N, Terpos E & Dimopoulos MA (2011) 'Renal impairment is not an independent adverse prognostic factor in patients with multiple myeloma treated upfront with novel agent-based regimens' Leukemia &amp; Lymphoma 52, (12) 2299-2303 , DOI
    Gkotzamanidou M, Kastritis E, Gavriatopoulou MRMMM, Nikitas N, Gika D, Mparmparousi D, Matsouka C, Terpos E & Dimopoulos MA (2011) 'Increased Serum Lactate Dehydrongenase Should Be Included Among the Variables That Define Very-High-Risk Multiple Myeloma' Clinical Lymphoma Myeloma and Leukemia 11, (5) 409-413 , DOI
    Migkou M, Kastritis E, Roussou M, Gkotzamanidou M, Gavriatopoulou M, Nikitas N, Mparmparoussi D, Matsouka C, Gika D & Terpos E (2011) 'Short progression‐free survival predicts for poor overall survival in older patients with multiple myeloma treated upfront with novel agent‐based therapy' European Journal of Haematology 87, (4) 323-329 , DOI
    Kopterides P, Nikitas N, Vassiliadi D, Orfanos SE, Theodorakopoulou M, Ilias I, Boutati E, Dimitriadis G, Maratou E & Diamantakis A (2011) 'Microdialysis-assessed interstitium alterations during sepsis: relationship to stage, infection, and pathogen' Intensive Care Medicine 37, (11) , DOI
    Zagouri F, Roussou M, Kastritis E, Koureas A, Tsokou E, Migkou M, Gavriatopoulou M, Nikitas N, Gkotzamanidou M & Terpos E (2011) 'Lenalidomide‐associated pneumonitis in patients with plasma cell dyscrasias' American Journal of Hematology 86, (10) 882-884 , DOI
    Terpos E, Anargyrou K, Katodritou E, Kastritis E, Papatheodorou A, Christoulas D, Pouli A, Michalis E, Delimpasi S & Gkotzamanidou M (2011) 'Circulating angiopoietin‐1 to angiopoietin‐2 ratio is an independent prognostic factor for survival in newly diagnosed patients with multiple myeloma who received therapy with novel antimyeloma agents' International Journal of Cancer 130, (3) 735-742 , DOI
    Dimopoulou I, Nikitas N, Orfanos SE, Theodorakopoulou M, Vassiliadi D, Ilias I, Ikonomidis I, Boutati E, Maratou E & Tsangaris I (2011) 'Kinetics of Adipose Tissue Microdialysis-Derived Metabolites in Critically Ill Septic Patients' Shock 35, (4) 343-348 , DOI
    Savvari P, Matsouka C, Barbaroussi D, Christoulas D, Nikitas N, Dimopoulos M-A & Papadimitriou CA (2010) 'Burkitt’s Lymphoma in Pregnancy with Bilateral Breast Involvement: Case Report with Review of the Literature' Onkologie 33, (8-9) 461-464 , DOI
    Zagouri F, Bozas G, Kafantari E, Tsiatas M, Nikitas N, Dimopoulos M-A & Papadimitriou CA (2010) 'Endometrial Cancer: What Is New in Adjuvant and Molecularly Targeted Therapy?' Obstetrics and Gynecology International 2010, 1-11 , DOI
    Papadimitriou CA, Markaki S, Lianos E, Peitsidis P, Vourli G, Nikitas N, Vlachos G, Rodolakis A, Antsaklis A & Dimopoulos MA (2009) 'Clinicopathological features of primary fallopian tube carcinoma: a single institution experience' EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY 30, (4) 389-395
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    https://orcid.org/0000-0002-1750-1579