Dr Marie-Louise Zeissler
Profiles

Dr Marie-Louise Zeissler

Parkinson's and Neurodegenerative Disease Research Assistant

Peninsula Medical School (Faculty of Health)

I am a molecular biologist by training with four years of experience in researching cannabinoids as neuroprotective agents in a cell culture model of Parkinson’s disease and more than 9 years of experience in laboratory based research. More recently, I joined the Applied Parkinson's Research Group to support efforts in developing a multi-arm multi-stage (MAMS) trial for Parkinson's disease.

Qualifications

2012 PhD  - Peninsula School of Medicine and Dentistry, Plymouth, UK

2009 MSci Biology – University of Bath, UK

Research interests

As part of the Applied Parkinson's Research Group led by Dr Camille Carroll and in collaboration with the Cure Parkinson's Trust I am exploring innovations in the design of trials aimed at investigating therapies to slow or delay the progression of Parkinson's disease. In particular we are looking to develop a multi-arm multi-stage (MAMS) trial platform for Parkinson's and my current research projects are centered around supporting this aim. To find out more about MAMS, please follow this link.

Key publications

Key publications are highlighted

Journals

Zeissler, M.-L., Li, V., Parmar, M. K. B., & Carroll, C. B. (2020). Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson's Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer. Journal of Parkinson’s Disease 10(2).

Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A, Honkimaa A, Hankaniemi MM, Flodström-Tullberg M, Hyöty H, Hytönen VP, Laitinen OH (2018) A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses. Scientific Reports 8(1).

Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L, Dahl-Jørgensen K, von Herrath M, Pugliese A, Atkinson MA, Morgan NG (2016) Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia 59(11).

Zeissler ML, Eastwood J, McCorry K, Hanemann CO, Zajicek JP, Carroll CB (2016) Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis. Oncotarget.

Carroll CB, Zeissler ML, Hanemann CO, Zajicek JP (2012) Δ 9 -tetrahydrocannabinol (Δ 9 -THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson’s disease. Neuropathology and Applied Neurobiology 38(6)

Carroll CB, Zeissler ML, Chadborn N, Gibson K, Williams G, Zajicek JP, Morrison KE, Hanemann CO (2011) Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson’s disease. Neurochemistry International 59(1).


Articles
Zeissler M-L, Li V, Parmar MKB & Carroll CB 2020 'Is It Possible to Conduct a Multi-Arm Multi-Stage Platform Trial in Parkinson’s Disease: Lessons Learned from Other Neurodegenerative Disorders and Cancer' Journal of Parkinson's Disease 10, (2) 413-428 , DOI PEARL
Saarinen NVV, Laiho JE, Richardson SJ, Zeissler M, Stone VM, Marjomäki V, Kantoluoto T, Horwitz MS, Sioofy-Khojine A & Honkimaa A 2018 'A novel rat CVB1-VP1 monoclonal antibody 3A6 detects a broad range of enteroviruses' Scientific Reports 8, (1) , DOI
Richardson SJ, Rodriguez-Calvo T, Gerling IC, Mathews CE, Kaddis JS, Russell MA, Zeissler M, Leete P, Krogvold L & Dahl-Jørgensen K 2016 'Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes' Diabetologia 59, (11) 2448-2458 , DOI
Zeissler M-L, Eastwood J, McCorry K, Hanemann OC, Zajicek JP & Carroll CB 2016 'Delta-9-tetrahydrocannabinol protects against MPP<sup>+</sup> toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis' Oncotarget , DOI PEARL
Carroll CB, Zeissler M-L, Hanemann CO & Zajicek JP 2012 'Δ9-tetrahydrocannabinol (Δ9-THC) exerts a direct neuroprotective effect in a human cell culture model of Parkinson's disease' Neuropathology and Applied Neurobiology 38, (6) 535-547 , DOI
Carroll CB, Zeissler ML, Chadborn N, Gibson K, William G, Zajicek JP, Morrison KE & Hanemann CO 2011 'Changes in iron-regulatory gene expression occur in human cell culture models of Parkinson's disease' Neurochem Int 59, 73-80