Dr Louise Alldridge
Profiles

Dr Louise Alldridge

Associate Professor in Biomedical Sciences (Education)

Peninsula Medical School (Faculty of Health)

Widening Participation Lead

Programme Lead BMBS with Foundation (Year 0)

Qualifications

B

BSc (Hons) Biology, MA Learning and Teaching, PhD Cell biology

Dr Louise Alldridge joined Peninsula Medical School in 2013. She is currently Lead for Widening Participation and Programme Lead for BMBS with Foundation Year. On arrival at Peninsula, Louise led the development and implementation of a new holistic strategy to widen participation of the most underrepresented groups in Medicine. The strategy was based on a ‘primary to practice’ vision, starting by building aspirations in primary school children, sustaining them and breaking down barriers (including academic, information access but also social and cultural) throughout secondary school and finally providing alternative entry routes into Medicine.

Prior to this Louise was employed at Griffith University School of Medicine, in Australia, where she was Academic Lead for Equity and Selection, Assessment and Indigenous Health. Here Louise led a strategy with local Indigenous Elders to widen participation of Aboriginal and Torres Strait Islander Students in Medicine. She also worked closely with Refugees, providing ways for them to study medicine.

She has been involved in undergraduate Medical, Veterinary and Nursing education since 1987 at Essex University, Cambridge University and Anglia Ruskin University.

She obtained her PhD in Cell Biology from The University of Essex in 1992. Her research record of accomplishment is mainly based in translational research into Endotoxaemia, Leukaemia and more recently Breast Cancer with over 30 peer-reviewed publications. Louise is an External examiner both in UK and overseas and is on peer review committees for several international journals. She is now developing a research portfolio in medical education and Widening Participation.

 

Professional membership

·       British Society for Immunology

·       Biochemical Society

·       Higher Education Academy

·       Board of Directors of PMCQ

·       GAMSAT Memberof Policy Committee

·       UMAT andGAMSAT Member of Research Sub-Committee

·       UMAT Memberof Test Management Committee

  •    ANZAPHE

Roles on external bodies

Chair:

National Widening Participation Access Group

External Examiner:

Essex University

Queensland University of Technology

Member:

Medical Schools Council Selection Alliance

National Widening Participation in Medicine Group

National Gateway Group

Medical Schools Council MMI writing Group

Teaching interests

Oncology

Small Interactive Groups

Staff serving as external examiners

Essex University Thesis Examiner

Griffith University Thesis Examiner
Queensland University of Technology Thesis Examiner

Research interests

Louise obtained her PhD in Cell Biology from The University of Essex in 1992. Her research record of accomplishment is mainly based in translational research into Endotoxaemia, Leukaemia and more recently Breast Cancer with over 30 peer-reviewed publications. Louise is an External examiner both in UK and overseas and is on peer review committees for several international journals. She is now developing a research portfolio in medical education and Widening Participation.

 


Key publications

Key publications are highlighted

Journals

Louise Alldridge and Teleah Lindenberg AspireRealise Achieve 2012. LIME Good Practice Case Studies, p8-11

Christina Greenwood, Gergana Metodieva, KhalidAl-Janabi, Berthold Lausen, Louise Alldridge, Lin Leng, Richard Bucala,Nelson Fernandez, Metodi Metodiev 2012. Stat1 and CD74 overexpression isco-dependent and linked to increased invasion and lymph node metastasis intriple-negative breast cancer. J. Proteomics, 75(6) 3031-40

Olena Zakharchenko, Louise Alldridge, Christina Greenwood and Serhiy Souchelnytskyi2011 Optimized protocol for protein extraction from the breast tissue that iscompatible with two-dimensional gel electrophoresis . Breast cancer: Basic andClinical Research:5 37-42

Olena Zakharchenko, Christina Greenwood, AnnaLewandowska, Ulf Hellman, Louise Alldridge  and Serhiy Souchelnytskyi2011 Meta-data analysis as a strategy to evaluate individual and commonfeatures of proteome changes in breast cancer. Cancer Genomics and Proteomics Volume 8:1-14

CR Greenwood, LC Alldridge, S Chandra Sekharan, KAl-Janabi, P Sauven, and S Souchelnytskyi Identificationof proteins and signalling pathways involved in neoadjuvant chemotherapyresponsiveness of breast tumours using proteomics Breast Cancer Res. 2010;12 (Suppl 1): P40.

France Docquier, Georgia-Xanthi Kita, Dawn Farrar, ParmjitJat, Michael O’Hare, Igor Cherukhin, Svetlana Gretton, Adhip Mandal, Louise Alldridge and Elena Klenova.2009. Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, isassociated with breast cancer phenotype and cell proliferation. Clinical Cancer Research., 15, 5762-577

Metodieva,G., Greenwood,C., Alldridge, L and Metodiev M. 2009. A peptide-centric approach to breast cancerbiomarker discovery utilizing label-free multiple reactions monitoring massspectrometry. ProteomicsClin. Appl. 3, 78–82

Alldridge, L ., Metodieva, G., Greenwood, C., Al-janabi, K., Thwaites, L.,and Metodiev, M. 2008. Proteome profiling of breast tumours by gelelectrophoresis and nano-scale electrospray ionization mass spectrometry. Journal of Proteome Research, 7 (4),1458-1469

Souchelnytskyi,S and Alldridge, L. 2008. BreastCancer Proteomics. The inaugural Mammary Gland Proteome Initiative Workshop. Proteomics-Clinical Applications, 2,8-10

Metodiev M and Alldridge L. 2008. Phosphoproteomicsa possible route to novel biomarkers of breast cancer. Proteomics-Clinical Applications, 2, 182-194

A.J Mc Vicar PhD a, C.R.Greenwood PhD b,, F. Fewell BA a, V. D’Arcy PhD b , S. ChandrasekharanFRCS b , and L.C. AlldridgePhD b*2007. Evaluation of anxiety, salivary cortisol and melatoninsecretion following reflexology treatment: A pilot study in healthy individuals.Complementary Therapies in Clinical Practice. 13, 137-145

MatthewC. J. Royle, Sabine Totemeyer, Duncan J. Maskell, Louise Alldridge and Clare E. Bryant, 2003.Stimulation of TLR4 bylipopolysaccharide during cellular invasion by live Salmonella typhimurium is a critical but not exclusive eventleading to macrophage responses. Journal of Immunology , 170(11), 5445-54.  

Alldridge L. C. and Bryant CE. 2003. Annexin1 regulates cell proliferation by disruption of cell morphology and inhibitionof cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Exp Cell Res. 290 (1), 93-107.

Dornan S, Sebestyen Z, Gamble J, Nagy P, Bodnar A, Alldridge L, Doe S, Holmes N, Goff LK,Beverley P, Szollosi J, Alexander DR. (2002) Differential association of CD45isoforms with CD4 and CD8 regulates the actions of specific pools of p56lcktyrosine kinase in T cell antigen receptor signal transduction. Journalof Biological Chemistry . 277, 1912-8.

AlldridgeL. C., Harris, H.J., Plevin,R.J., Hannon, R. and Bryant,C.E.(1999)Regulation of the mitogen activated protein kinase ERK pathway by theannexin lipocortin 1 in RAW macrophages.Journal of Biological Chemistry 274, 37620-37626

Shivnan,E.,Clayton, L., Alldridge, L.C.,Keating, K., Gullberg, M. and Alexander, D.R.(1996) CD45 monoclonal antibodies inhibit TCR-mediatedcalcium signals, CaM kinase IV GR activation and oncoprotein 18phosphorylation. Journal of Immunology157, 101-109.

Alldridge L.C., O’Farrell,M.K and Dealtry, G.B.(1991)Down-regulationof Lamins A and C by murine interferon beta. Exp. Cell.Res .195,546-550.

Alldridge, L. C., O’Farrell, M.K and Dealtry, G.B. (1989) Interferon beta increases the expression of Vimentin mRNAand protein levels in differentiated embryonal carcinoma cells. Exp. Cell. Res. 185,387-393

H Moor, K Al-Janabi, S ChandraSekharan, L Alldridge, S Souchelnytski

Identification and validation of tyrosine phosphorylated proteins that may be used to predict response to neoadjuvant chemotherapy treatment. 

European Journal of Surgical Oncology 38 (5), 432 

The influence of interferon on cytoskeletal regulation in murine embryonal carcinoma cells, L. C. Alldridge

LC Alldridge

Ph. D.], University of Essex

Effects of lipocortin-1 on mitogen-activated protein kinases

BRITISH JOURNAL OF PHARMACOLOGY 127, U12-U12 

H Dobbs, LC Alldridge, GB Dealtry

The influence of interferons on gene expression in murine embryonal carcinoma cells

Cell Differentiation and Development 27, 29 


Articles
Broad J, Matheson M, Verrall F, Taylor AK, Zahra D, Alldridge L & Feder G 2018 'Discrimination, harassment and non-reporting in UK medical education' Medical Education 52, (4) 414-426 , DOI PEARL
Mercer A, Crotty B, Alldridge L, Le L & Vele V 2015 'GAMSAT: A 10-year retrospective overview, with detailed analysis of candidates' performance in 2014' BMC MEDICAL EDUCATION 15, Author Site , DOI
Smyth T, Harris HJ, Brown A, Totemeyer S, Farnfield BA, Maskell DJ, Matsumoto M, Plevin R, Alldridge LC & Bryant CE 2006 'Differential modulatory effects of Annexin 1 on nitric oxide synthase induction by lipopolysaccharide in macrophages' Immunology 117, (3) 340-349 , DOI

Reports & invited lectures

  • Invited speaker, BBSRC Stem Cell Research conference at Oxford University 1994
    • Invited speaker Griffith University/Gold Coast Hospital Medical research Conference, Surfers Paradise 2010
    • Invited speaker LIME conference Auckland, NZ 2011
    • Invited speaker International Immunohistochemistry Conference, Gold Coast, Australia, 2012
    • Invited Speaker ANZAPHE 2014
    • Invited Speaker Widening Participation Conference Manchester University 2016

    Other academic activities

    Conference presentations

    • Invited speaker, BBSRC Stem Cell Research conference at Oxford University 1994
    • British Society for Immunology in 1994, 1996, 2000, 2002

    ·       International Endotoxin Society, Santa Fe, New Mexico, 1998. and in Paris 2000.

    ·       The Annexin Conference, Banff, Canada2003

    ·       The Gordon Cancer research conferenceRhode Island 2004

    • RCN Annual Conference, Birmingham. 2005
    • San Antonio Breast Cancer Conference, San Antonio Texas. 2006
    • Invited to be a founder member of the Mammary Gland Proteomic Initiative 2006
    • HUPO Amsterdam 2008
    • HUPO Sydney 2010
    • Invited speaker Griffith University/Gold Coast Hospital Medical research Conference, Surfers Paradise 2010
    • Invited speaker LIME conference Auckland, NZ 2011
    • Invited speaker International Immunohistochemistry Conference, Gold Coast, Australia, 2012
    • Medical selection as the first assessment in Professionalism ANZAPHE Conference Gold Coast, Australia, 2014
    • Invited Speaker Widening Participation Manchester University 2016