Dr Louise Alldridge
Profiles

Dr Louise Alldridge

Associate Professor (Senior Lecturer) in Biomedical Sciences

Peninsula Medical School (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

Academic Lead Cell and Molecular Biology

Widening Participation Lead
Senior Academic Tutor

Qualifications

BSc (hons) Biology MA Learning and Teaching PhD Cell biology

Dr Louise Alldridge joined PUPSMD in 2013 where she is the Senior Academic Tutor, lead for Widening Participation and discipline lead for cell and molecular biology. Prior to this she was employed at Griffith University School of Medicine, Gold Coast, Queensland, Australia , from April 2008, where she was Academic Lead for Equity and Selection, Assessment and Indigenous Health. She obtained her PhD in Cell Biology from The University of Essex in 1992. Her research track record is firmly based in translational research into medical conditions such as Endotoxaemia, Leukaemia and more recently Breast Cancer with over 20 peer reviewed publications and is on peer review committees for several international journals. She has been involved in undergraduate Medical, Veterinary and Nursing education since 1987 at Essex University, Cambridge University and Anglia Ruskin University. She recently completed a Masters in Learning and Teaching and is now developing a research portfolio in medical education. 


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Professional membership

·        British Society for Immunology

·        Biochemical Society

·        Higher Education Academy

·        Board of Directors of PMCQ

·        GAMSAT Memberof Policy Committee

·        UMAT andGAMSAT Member of Research Sub-Committee

·        UMAT Memberof Test Management Committee

  •      ANZAPHE

Staff serving as external examiners

Essex University Thesis Examiner

Griffith University Thesis Examiner
Queensland University of Technology Thesis Examiner

  1. Annette Mercer, Brendan Crotty, Louise Alldridge, Luc Le and Veronica Vele 2015. GAMSAT: A 10 year retrospective analysis, with detailed analysis of candidates performance in 2014. BMC Medical Education 15.31
  2.      Louise Alldridge and Teleah Lindenberg AspireRealise Achieve 2012. LIME Good Practice Case Studies, p8-11
  3. Christina Greenwood, Gergana Metodieva, KhalidAl-Janabi, Berthold Lausen, Louise Alldridge, Lin Leng, Richard Bucala,Nelson Fernandez, Metodi Metodiev 2012. Stat1 and CD74 overexpression isco-dependent and linked to increased invasion and lymph node metastasis intriple-negative breast cancer. J. Proteomics, 75(6) 3031-40
  4. Olena Zakharchenko, Louise Alldridge, Christina Greenwood and Serhiy Souchelnytskyi2011 Optimized protocol for protein extraction from the breast tissue that iscompatible with two-dimensional gel electrophoresis . Breast cancer: Basic andClinical Research:5 37-42
  5. Olena Zakharchenko, Christina Greenwood, AnnaLewandowska, Ulf Hellman, LouiseAlldridge  and Serhiy Souchelnytskyi2011 Meta-data analysis as a strategy to evaluate individual and commonfeatures of proteome changes in breast cancer. Cancer Genomics and Proteomics  Volume 8:1-14
  6.  CR Greenwood, LC Alldridge, S Chandra Sekharan, KAl-Janabi, P Sauven, and S Souchelnytskyi Identificationof proteins and signalling pathways involved in neoadjuvant chemotherapyresponsiveness of breast tumours using proteomics Breast Cancer Res. 2010;12 (Suppl 1): P40.
  7. France Docquier, Georgia-Xanthi Kita, Dawn Farrar, ParmjitJat, Michael O’Hare, Igor Cherukhin, Svetlana Gretton, Adhip Mandal, Louise Alldridge and Elena Klenova.2009. Decreased poly(ADP-ribosyl)ation of CTCF, a transcription factor, isassociated with breast cancer phenotype and cell proliferation. Clinical Cancer Research., 15, 5762-577
  8.   Metodieva,G., Greenwood,C., Alldridge, L and Metodiev M. 2009.  A peptide-centric approach to breast cancerbiomarker discovery utilizing label-free multiple reactions monitoring massspectrometry. ProteomicsClin. Appl. 3, 78–82
  9. Alldridge, L ., Metodieva, G., Greenwood, C., Al-janabi, K., Thwaites, L.,and Metodiev, M. 2008. Proteome profiling of breast tumours by gelelectrophoresis and nano-scale electrospray ionization mass spectrometry. Journal of Proteome Research, 7 (4),1458-1469
  10. Souchelnytskyi,S and Alldridge, L. 2008. BreastCancer Proteomics. The inaugural Mammary Gland Proteome Initiative Workshop. Proteomics-Clinical Applications, 2,8-10
  11.  Metodiev M and Alldridge L. 2008. Phosphoproteomicsa possible route to novel biomarkers of breast cancer. Proteomics-Clinical Applications, 2, 182-194
  12.  A.J Mc Vicar PhD a, C.R.Greenwood PhD b,, F. Fewell BA a, V. D’Arcy PhD b , S. ChandrasekharanFRCS b , and L.C. AlldridgePhD b*2007. Evaluation of anxiety, salivary cortisol and melatoninsecretion following reflexology treatment: A pilot study in healthy individuals.Complementary Therapies in Clinical Practice. 13, 137-145
  13. TomokoSmyth, Hayley Harris, Andrew Brown, Sabine Tötemeyer, Belinda Farnfield, DuncanMaskell, Makato Matsumoto, Robin Plevin, LouiseAlldridge, Clare Bryant: 2006 Differentialmodulatory effects of annexin 1 on nitric oxide synthase induction bylipopolysaccharide in macrophages,  Immunology 117, 340-349
  14.    MatthewC. J. Royle, Sabine Totemeyer, Duncan J. Maskell, Louise Alldridge and Clare E. Bryant, 2003.Stimulation of TLR4 bylipopolysaccharide during cellular invasion by live Salmonella typhimurium is a critical but not exclusive eventleading to macrophage responses. Journal of Immunology , 170(11), 5445-54.  
  15. Alldridge L. C. and Bryant CE. 2003. Annexin1 regulates cell proliferation by disruption of cell morphology and inhibitionof cyclin D1 expression through sustained activation of the ERK1/2 MAPK signal. Exp Cell Res. 290 (1), 93-107.
  16.  Dornan S, Sebestyen Z, Gamble J, Nagy P, Bodnar A, Alldridge L, Doe S, Holmes N, Goff LK,Beverley P, Szollosi J, Alexander DR. (2002) Differential association of CD45isoforms with CD4 and CD8 regulates the actions of specific pools of p56lcktyrosine kinase in T cell antigen receptor signal transduction. Journalof Biological Chemistry . 277, 1912-8.
  17. AlldridgeL. C., Harris, H.J., Plevin,R.J., Hannon, R. and Bryant,C.E.(1999)Regulation of the mitogen activated protein kinase ERK pathway by theannexin lipocortin 1 in RAW macrophages.Journal of Biological Chemistry 274, 37620-37626
  18. Shivnan,E.,Clayton, L., Alldridge, L.C.,Keating, K., Gullberg, M. and Alexander, D.R.(1996) CD45  monoclonal antibodies inhibit TCR-mediatedcalcium signals, CaM kinase IV GR activation and oncoprotein 18phosphorylation. Journal of Immunology157, 101-109.
  19. Alldridge L.C., O’Farrell,M.K and Dealtry, G.B.(1991)Down-regulationof Lamins A and C by murine interferon beta. Exp. Cell.Res .195,546-550.
  20.  Alldridge, L. C., O’Farrell, M.K andDealtry, G.B. (1989) Interferon beta increases the expression of Vimentin mRNAand protein levels in differentiated embryonal carcinoma cells. Exp. Cell. Res. 185,387-393.

Reports & invited lectures

  • Invited speaker, BBSRC Stem Cell Research conference at Oxford University 1994
    • Invited speaker Griffith University/Gold Coast Hospital Medical research Conference, Surfers Paradise 2010
    • Invited speaker LIME conference Auckland, NZ 2011
    • Invited speaker International Immunohistochemistry Conference, Gold Coast, Australia, 2012
    • Invited Speaker ANZAPHE 2014
    • Invited Speaker Widening Participation Conference Manchester University 2016

    Other academic activities

    Conference presentations

    • Invited speaker, BBSRC Stem Cell Research conference at Oxford University 1994
    • British Society for Immunology in 1994, 1996, 2000, 2002

    ·       International Endotoxin Society, Santa Fe, New Mexico, 1998. and in Paris 2000.

    ·       The Annexin Conference, Banff, Canada2003

    ·       The Gordon Cancer research conferenceRhode Island 2004

    • RCN Annual Conference, Birmingham. 2005
    • San Antonio Breast Cancer Conference,  San Antonio Texas. 2006
    • Invited to be a founder member of the Mammary Gland Proteomic Initiative 2006
    • HUPO Amsterdam 2008
    • HUPO Sydney 2010
    • Invited speaker Griffith University/Gold Coast Hospital Medical research Conference, Surfers Paradise 2010
    • Invited speaker LIME conference Auckland, NZ 2011
    • Invited speaker International Immunohistochemistry Conference, Gold Coast, Australia, 2012
    • Medical selection as the first assessment in Professionalism ANZAPHE Conference Gold Coast, Australia, 2014
    • Invited Speaker Widening Participation Manchester University 2016