Professor David Bristow
Profiles

Professor David Bristow

Head of Peninsula School of Medicine

Peninsula Medical School (Faculty of Medicine and Dentistry)

Role

As Head of Peninsula School of Medicine, I provide strategic leadership to the undergraduate and postgraduate medical programmes to ensure the delivery of the highest quality of educational provision.  Throughout my career in higher education I have been interested in the processes of teaching and learning, and am especially motivated to develop  evidence-based curricula  that produce excellent doctors and scientists. I am committed to support students and staff to achieve their full potential.  My research is investigating  the reliability and validity of medical student selection ,   faculty and staffing structure and professional identity ,  the best ways of teaching safe and effective prescribing,  and the effectiveness of integrated medical sciences curricula.

Key publications are highlighted

Journals
Articles
Lambe P, Kay E & Bristow D 2016 'Exploring uses of the UK Clinical Aptitude Test-situational judgement test in a dental student selection process' European Journal of Dental Education , DOI PEARL
Lambe P, Waters C & Bristow D 2013 'Do differentials in the support and advice available at UK schools and colleges influence candidate performance in the medical school admissions interview? A survey of direct school leaver applicants to a UK medical school' Med Teach 35, (9) 731-739 Author Site , DOI
Lambe P, Waters C & Bristow D 2012 'The UK Clinical Aptitude Test: is it a fair test for selecting medical students?' Med Teach 34, (8) e557-e565 Author Site , DOI
Lambe P & Bristow D 2011 'Predicting medical student performance from attributes at entry: a latent class analysis' MEDICAL EDUCATION 45, (3) 308-316 Author Site , DOI
Harding S, Britten N & Bristow D 2010 'The performance of junior doctors in applying clinical pharmacology knowledge and prescribing skills to standardized clinical cases' Br J Clin Pharmacol 69, (6) 598-606 Author Site , DOI
Lambe P & Bristow D 2010 'What are the most important non-academic attributes of good doctors? A Delphi survey of clinicians' MEDICAL TEACHER 32, (8) E347-E354 Author Site , DOI
Hudson JN & Bristow DR 2006 'Formative assessment can be fun as well as educational' ADVANCES IN PHYSIOLOGY EDUCATION 30, (1) 33-37 Author Site , DOI
Hudson JN & Bristow DR 2006 'Formative assessment can be fun as well as educational' Advances in Physiology Education 30, (1) 33-37
Zamani MR, Leeson AH, Nash J & Bristow DR 2002 'Histamine induces the phosphorylation of a 58 kDa protein in GT1-7 neuronal cells' NEUROSCIENCE RESEARCH COMMUNICATIONS 31, (1) 11-18 Author Site , DOI
Leeson AH, Zamani MR & Bristow DR 1999 'Acute histamine exposure induced the phosphorylation of a 58 KDa protein in mouse hypothalamic GT1-7 neuronal cells' BRITISH JOURNAL OF PHARMACOLOGY 127, U32-U32 Author Site
Savidge JR, Sturgess NC, Bristow DR & Lock EA 1999 'Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells' Neuropharmacology 38, (3) 375-382 Author Site
Brown MJ, Wood MD, Coldwell MC & Bristow DR 1998 'Gamma-aminobutyric acidA receptor function is desensitised in rat cultured cerebellar granule cells following chronic flunitrazepam treatment' J Neurochem 71, (3) 1232-1240 Author Site
Staton PC & Bristow DR 1998 'Role of group III metabotropic glutamate receptors in excitotoxin-induced cerebellar granule cell death' J Neurochem 71, (3) 1280-1288 Author Site
Brown MJ, Wood MD, Coldwell MC & Bristow DR 1998 'γ-Aminobutyric AcidA Receptor Function Is Desensitised in Rat Cultured Cerebellar Granule Cells Following Chronic Flunitrazepam Treatment' Journal of Neurochemistry 71, (3) 1232-1240 , DOI
Johnston JD, Price SA & Bristow DR 1998 'Flunitrazepam rapidly reduces GABA(A) receptor subunit protein expression via a protein kinase C-dependent mechanism' Br J Pharmacol 124, (7) 1338-1340 Author Site , DOI
Savidge JR, Sturgess NC, Bristow DR & Lock EA 1998 'Discrimination of whole-cell currents mediated by AMPA- and kainate-type glutamate receptors in rat cultured cerebellar granule cells' BRITISH JOURNAL OF PHARMACOLOGY 124, U70-U70 Author Site
Savidge JR & Bristow DR 1998 'Ca2+ permeability and joro spider toxin sensitivity of AMPA and kainate receptors on cerebellar granule cells' Eur J Pharmacol 351, (1) 131-138 Author Site
Johnston JD & Bristow DR 1998 'Regulation of GABAA receptor α1 protein is a sensitive indicator of benzodiazepine agonist efficacy' European Journal of Pharmacology 348, (2-3) 321-324 , DOI
Wood AM & Bristow DR 1998 'N-methyl-D-aspartate receptor desensitisation is neuroprotective by inhibiting glutamate-induced apoptotic-like death' J Neurochem 70, (2) 677-687 Author Site
Savidge JR, Bleakman D & Bristow DR 1997 'Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells' J Neurochem 69, (4) 1763-1766 Author Site
Staton PC & Bristow DR 1997 'The Dietary Excitotoxins β-N-Methylamino-l-Alanine and β-N-Oxalylamino-l-Alanine Induce Necrotic- and Apoptotic-Like Death of Rat Cerebellar Granule Cells' Journal of Neurochemistry 69, (4) 1508-1518 , DOI
Wood AM, Tiwari P & Bristow DR 1997 'Media composition modulates excitatory amino acid-induced death of rat cerebellar granule cells' Hum Exp Toxicol 16, (7) 350-355 Author Site , DOI
Savidge JR & Bristow DR 1997 'Routes of NMDA- and K+-stimulated calcium entry in rat cerebellar granule cells' Neuroscience Letters 229, (2) 109-112 , DOI
Savidge JR & Bristow DR 1997 'Distribution of Ca2+-permeable AMPA receptors among cultured rat cerebellar granule cells' NeuroReport 8, (8) 1877-1882 , DOI
Brown MJ, Wood MD, Coldwell MC & Bristow DR 1997 'Measurement of GABAA receptor function in rat cultured cerebellar granule cells by the Cytosensor microphysiometer' Br J Pharmacol 121, (1) 71-76 Author Site , DOI
Platt KP, Zwartjes RE & Bristow DR 1996 'The effect of GABA stimulation on GABAA receptor subunit protein and mRNA expression in rat cultured cerebellar granule cells' Br J Pharmacol 119, (7) 1393-1400 Author Site
Savidge JR & Bristow DR 1996 'Agonist regulation of N-methyl-D-aspartate (NMDA)-induced intracellular calcium elevations in rat cerebellar granule cells' BRITISH JOURNAL OF PHARMACOLOGY 119, P251-P251 Author Site
Brown MJ & Bristow DR 1996 'Molecular mechanisms of benzodiazepine-induced down-regulation of GABAA receptor α1 subunit protein in rat cerebellar granule cells' British Journal of Pharmacology 118, (5) 1103-1110 , DOI
Zamani MR & Bristow DR 1996 'The histamine H1 receptor in GT1-7 neuronal cells is regulated by calcium influx and KN-62, a putative inhibitor of calcium/calmodulin protein kinase II' Br J Pharmacol 118, (5) 1119-1126 Author Site
Staton PC & Bristow DR 1996 'Mechanisms of beta-methylamino-L-alanine (BMAA)- and beta-oxalylamino-L-alanine (BOAA)-induced death in rat cerebellar granule cells' BRITISH JOURNAL OF PHARMACOLOGY 117, P189-P189 Author Site
Platt KP & Bristow DR 1995 'Excitatory amino acid-induced neuronal cell death in rat cerebellar granule cell cultures' Biochem Soc Trans 23, (4) Author Site
Wood AM & Bristow DR 1995 'Media composition modulates glutamate-induced cell death in rat cerebellar granule cells' Biochem Soc Trans 23, (4) Author Site
Zamani MR, Dupere JR & Bristow DR 1995 'Receptor-mediated desensitisation of histamine H1 receptor-stimulated inositol phosphate production and calcium mobilisation in GT1-7 neuronal cells is independent of protein kinase C' J Neurochem 65, (1) 160-169 Author Site
Spencer DC & Bristow DR 1995 'Effect of chronic agonist treatment on the expression of the GABAA receptor in rat cerebellar granule cells' Behavioural Pharmacology 6, (SUPPLEMENT 1) 113-113 , DOI
Brown MJ & Bristow DR 1995 'The effect of chronic benzodiazepine on GABAA receptor subunit protein expression in rat cerebellar granule cells' Behavioural Pharmacology 6, (SUPPLEMENT 1) 104-104 , DOI
SPENCER DC & BRISTOW DR 1995 'THE EFFECT OF CHRONIC AGONIST STIMULATION ON THE EXPRESSION OF GABA(A) RECEPTORS IN RAT CEREBELLAR GRANULE CELLS' BRITISH JOURNAL OF PHARMACOLOGY 114, P297-P297 Author Site
BROWN MJ & BRISTOW DR 1995 'THE EFFECT OF CHRONIC BENZODIAZEPINE TREATMENT ON GABA(A) RECEPTOR SUBUNIT PROTEIN EXPRESSION IN RAT CEREBELLAR GRANULE CELLS' BRITISH JOURNAL OF PHARMACOLOGY 114, P298-P298 Author Site
Zamani MR, Dupere JR & Bristow DR 1994 'An immortalised murine hypothalamic neuronal cell, GT1-7, expresses functional histamine H1 receptors' Neurosci Lett 178, (1) 159-162 Author Site
Zamani R & Bristow DR 1993 'Desensitisation of histamine H1 receptor-mediated calcium mobilisation in HeLa cells: the role of protein kinase C' Biochem Soc Trans 21, (4) Author Site
Bristow DR, Banford PC, Bajusz I, Vedat A & Young JM 1993 'Desensitization of histamine H1 receptor-mediated inositol phosphate accumulation in guinea pig cerebral cortex slices' Br J Pharmacol 110, (1) 269-274 Author Site
Bristow DR & Zamani MR 1993 'Desensitization of histamine H1 receptor-mediated inositol phosphate production in HeLa cells' Br J Pharmacol 109, (2) 353-359 Author Site
Bristow DR, Arias-Montaño JA & Young JM 1991 'Histamine-induced inositol phosphate accumulation in HeLa cells: lithium sensitivity' British Journal of Pharmacology 104, (3) 677-684 , DOI
Bristow DR & Young JM 1991 'Characteristics of histamine-induced inositol phospholipid hydrolysis in HeLa cells' Agents Actions Suppl 33, 387-392 Author Site
Bristow DR, Moratalla R & Martin IL 1990 'Flunitrazepam increases the affinity of the GABAA receptor in cryostat-cut rat brain sections' European Journal of Pharmacology 184, (2-3) 339-340 , DOI
Bristow DR & Martin IL 1990 'Biochemical Characterization of an Isolated and Functionally Reconstituted ?-Aminobutyric Acid/Benzodiazepine Receptor' Journal of Neurochemistry 54, (3) 751-761 , DOI
Bristow DR & Martin IL 1989 'GABA preincubation of rat brain sections increases [3H]GABA binding to the GABAA receptor and compromises the modulatory interactions' European Journal of Pharmacology 173, (1) 65-73 , DOI
Bristow DR & Martin IL 1988 'Light microscopic autoradiographic localisation in rat brain of the binding sites for the GABAA receptor antagonist [3H]SR 95531: Comparison with the [3H]GABAA receptor distribution' European Journal of Pharmacology 148, (2) 283-288 , DOI
Bristow DR & Martin IL 1987 'Solubilisation of the ?-Aminobutyric Acid/Benzodiazepine Receptor from Rat Cerebellum: Optimal Preservation of the Modulatory Responses by Natural Brain Lipids' Journal of Neurochemistry 49, (5) 1386-1393 , DOI
Bristow DR & Martin IL 1987 'Solubilisation of the Benzodiazepine Receptor from Rat Cerebellum by the Detergent n-Octylpentaoxyethylene' Journal of Neurochemistry 48, (5) 1537-1540 , DOI
Bristow DR, Curtis NR, Suman-Chauhan N, Watling KJ & Williams BJ 1987 'Effects of tachykinins on inositol phospholipid hydrolysis in slices of hamster urinary bladder' British Journal of Pharmacology 90, (1) 211-217 , DOI
Bristow DR, Bowery NG & Woodruff GN 1986 'Light microscopic autoradiographic localisation of [3H]glycine and [3H]strychnine binding sites in rat brain' European Journal of Pharmacology 126, (3) 303-307 , DOI
Watling KJ & Bristow DR 1986 'GABAB Receptor-Mediated Enhancement of Vasoactive Intestinal Peptide-Stimulated Cyclic AMP Production in Slices of Rat Cerebral Cortex' Journal of Neurochemistry 46, (6) 1755-1762 , DOI
Conference Papers
Platt KP & Bristow DR 1995 'Excitatory amino acid-induced neuronal cell death in rat cerebellar granule cell cultures' S599-S599 , DOI
Wood AM & Bristow DR 1995 'Media composition modulates glutamate-induced cell death in rat cerebellar granule cells' S596-S596 , DOI