Professor Awadhesh Jha
Professor in Genetic Toxicology and Ecotoxicology
School of Biological and Marine Sciences (Faculty of Science and Engineering)
- Environmental monitoring
- Environmental toxicology
- Molecular toxicology
- Environmental radioactivity
- Cancer genetics
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Awadhesh N. Jha, Fellow Royal Society of Biology (FRSB)
Professor of Genetic Toxicology & Ecotoxicology
Environmental and Applied Biology Research Group: Lead
Research Excellence Framework (REF): UoA6 Coordinator
Ecotoxicology (Undergraduate programme) Member, University Graduate Committee
Member, University Equality and Diversity Committee
1989:PhD – “Ionising radiations and chromosome aberrations: a study using peripheral blood lymphocyte culture system in human” sponsored by International Atomic Energy Agency, Vienna (Austria) and Dept. of Atomic Energy, Bombay (India), Banaras Hindu University, Varanasi, India
1998:Accreditation as a Teacher in Higher Education following successful completion of the Staff and Educational Development Association (SEDA), UK recognised programme at the University of Plymouth, UK 1997:Certificate in Teaching and Learning in Higher Education, Academic Services, University of Plymouth, UK 1993:Home Office (UK) Training Course for Animals (Scientific Procedure Act, 1986), Brixham Environmental Laboratory, AstraZeneca, Brixham, Devon, UK (personal licence holder)
1983:Certificate following course on “Safety aspects in the research applications of ionising radiations” Bhabha Atomic Research Centre, Bombay, India
APPOINTMENTS / PROFESSIONAL EXPERIENCE:
2010-till date: Professor, School of Biomedical & Biological Sciences, University of Plymouth, UK
2005-2010: Reader, School Biological Sciences,University of Plymouth, Plymouth, UK
2001- 2005: Principal Lecturer, School Biological Sciences, University of Plymouth, Plymouth, UK
1998-2001: Senior Lecturer, Dept. of Biological Sciences, University of Plymouth, Plymouth, UK
1996-1998:ZENECA Lectureship in Marine Genotoxicity, University of Plymouth, UK
1993-1996: Marine Genetic Toxicologist, Brixham Environmental Laboratory, AstraZeneca (formerly Zeneca and ICI, UK), Brixham, Devon, UK
1990-1993:Post-doctoral Research Fellow, Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, The Netherlands
1989-1990:Research Associate (post-doctoral) supported by University Grants Commission, New Delhi, at Banaras Hindu University, India
1981-1989:Junior and Senior Research Fellows, Research Assistant, Centre of Advanced Study in Zoology, Banaras Hindu University, India
Member,Scientific / Organising Committee (10 membered):European Environmental Mutagen Society 2002-2003
Chair, Scientific Committee, United Kingdom Environmental Mutagen Society (UKEMS): 2001-2002; 2014-2015; Member, Executive Committee, UKEMS (2010-2013; Co-opted 2014-2015))
Member, United Kingdom (UK) and European Environmental Mutagen Society (UKEMS, EEMS) Member, Industrial Genotoxicology Group (IGG), UK
Founding Member, International Network on the Research in Eco-genotoxicology (INREG) (based in Roskilde, University, Denmark)
Member, Coordinating Group on Environmental Radioactivity (COGER), UK
Life Member and Member, Executive Committee (2009-2011), Indian Society of Cell Biology
Roles on external bodies
Journal Editing and Editorial Board Membership (since 2000):
Associate Editor, Ecotoxicology (Springer Science)
Member, Editorial Board of the International Journal- Mutation Research (Fundamental & Molecular Mechanisms of Mutagenesis): 1997-2002 (Elsevier Science)
Member, Editorial Board of the International Journal- the Science of the Total Environment: 2002-2006 (Elsevier Science)
Member, Editorial Board of the International Journal-Ecotoxicology (Springer Science)
Member, Editorial Board of the International Journal- Mutation Research (Genetic Toxicology & Environmental Mutagenesis) (Elsevier Science)
Co-Edited Special Issue of Marine Pollution Bulletin (Elsevier), The English Channel and its catchments: Status and Responses to Contaminants, Vol. 95, July 2015.
Managed and Co-Edited Special Issue of Journal of Environmental Radioactivity (Elsevier): Environmental Radioactivity: Implications for Human and Environmental Health, Vol. 133, July 2014.
Edited, Special Issue of Mutation Research (Fundamental and Molecular Mechanisms of the Mutagenesis): 'Use of Aquatic Organisms in Genotoxicological Studies' Vol. 552, August, 2004
Co-edited, Special Issue of Marine Environmental Research: Pollutant Response in Marine Organisms
PRIMO 11 Symposium) (Vol. 54, 2002)
Reviewer for the International Journals:
(* Regular reviewer)
Analytica Chimica Acta, Aquatic Toxicology, Biochimica Et Biophysica Acta, Biomarkers, Chemical Biological Interactions, Chemosphere, *Ecotoxicology, Environment International, Environmental Pollution, Environmental Toxicology, Environmental Toxicology and Chemistry, Estuarine Coastal and Shelf Sciences, Journal of Sea Research, Journal of Fish Biology, Journal of Marine Biological Association of the UK *Marine Environmental Research, Marine Biology, *The Science of the Total Environment, Marine Pollution Bulletin, *Mutagenesis, *Mutation Research, etc.
Reviewer for Research Grant Proposal:
Member, NERC Peer-Review College (2006-2010; 2012-2015), UK
Biotechnology & Biological Sciences Reserach Council (BBSRC), UK
Engineering & Physical Sciences Research Council (EPSRC), UK
Medical Research Council (MRC), UK
The Royal Society, UK
National Science Foundation (NSF), USA
Natural Sciences and Engineering Research Council (NSERC), Canada
Italian Ministry for Education University and Research (MIUR), Italy
Portuguese Ministry of Science & Technology, Lisbon, Portugal
British Council, UK
Wellcome Trust, UK
Molecular & Cellular Response to the Environment
Aspects of Genetics and Toxicology including Genetic Toxicology and Carcinogenesis
Aspects of Mutagenesis and Carcinogenesis (also for Medical Students under Special Study Unit Programme of Medical School)
Research Methods & Techniques for under- and post-graduates
Staff serving as external examiners
MSc, Environmental Technology, Imperial College London
Post-Graduate (PhD) Examinership:
University of Plymouth (Internal Examiner)
Peninsula College of Medicine & Dentistry (PCMD), UK
Glasgow Caledonian University, UK
University of Birmingham, UK
University of East Anglia, UK
University of Hull
University of Newcastle, UK
University of Portsmouth, UK
University of Southampton, UK
University of Sussex, UK
University of Ulster, UK
Universite Aix-Marseille, France
University of Nantes, Ifremer, France
University of Metz/ Lyon, France
Aligarh Muslim University, India
(Declined several examinership offers from overseas)
Group Leader: Environmental and Applied Biology Research Group
Group Leader: Genetic Toxicology and Ecotoxicology Research Group
My background with respect to research interest and experience is reflected in academic / professional qualificationss and the publication list. These reflect my interest and experience in classical, molecular and clinical cytogenetics, radiation cytogenetics, molecular genetics, chemical mutagenesis, environmental biomonitoring, eco-genotoxicology and ecotoxicology.
Member: Ecotoxicology & Stress Biology Research Group
Key Research Accomplishments:
• Contribution to fundamental and molecular mechanisms of mutagenesis with respect to human and ecosystem health
• Development and applications of assays to evaluate genotoxicity, cytotoxicity and ecotoxicity (at different levels of biological organisation) in the aquatic organisms/ environment
•Ecological hazard and risk assessment
•Contribution to applied and promotion of multidisciplinary research
Scientific Exchange Programme (since 2000):
British Council Sponsored (funded)Exchange Programme with University of Vienna, Austria, 2004-2005 Sponsored by DTI, UK; member of official 4 membered-UK team Radioecology of Chornobyl Zone, International Conference in Slavutych, Ukraine, September 17-19, 2002
British Council Sponsored Exchange Programme with University of Malaya, Malaysia, March-April 2002. Association of Commonwealth Universities Exchange Programme with Jamia Hamdard University, Delhi, India, January 2003-July 2003. (grant sanctioned to host visiting scientist)
Sponsored by DTI, UK; member of official 6 membered-UK team, Technical and Social Aspects of Chernobyl NPP Closure, Slavutych, Ukraine, September 26-29, 2000
- Organised 38th Annual Conference of United Kingdom Environmental Mutagen Society (UKEMS), July 2015. (www.ukems.org)
· Pollution andthe Marine Environment: An English Channel Perspective. Scientific and PublicEngagement Event, September 2014. (Convenor, Chair of the Scientific andOrganising Committee).
· Organised andco-chaired session on Eco-genotoxicology, 44th Annual Conference ofEuropean Environmental Mutagen Society, Lancaster University, July 2014.
· Organised,International Symposium on Environmental Radioactivity, Plymouth University,3-5 September 2012. (Main Organiser/ Convenor)
Scientific Sessions Chaired in InternationalConferences / Symposiums / Workshops (since 2008)
11th International Conference onEnvironmental Mutagens (ICEM; organised every 4 years on different continents),Foz do Iguassu, Brazil, November, 2013.
· 10thInternational Comet Assay Workshop, Porto, Portugal, September, 2013
· 9thInternational Comet Assay Workshop, Kusadasi, Turkey, September, 2011
· Internationalworkshop on Eco-genotoxicology, Norwegian Institute for Air Research,Lillestrom, Norway, April 2011
IntInternational Symposium on Alternate AnimalModels in Biological Research, Indian Institute of Toxicological Research,Lucknow, India, October 2010
40th Annual Conference of European Environmental MutagenSociety (EEMS), Oslo, Norway,September 2010
NanoImpact Technical Workshop- Hazard Assessmentof Nanomaterials in Biota-Dublin, Ireland, September 2010
Invited/ Keynote Lectures Delivered in International Conferences (since 2008)
- 38th Annual Conference of United Kingdom Environmental Mutagen Society (UKEMS), July 2015
Water Quality Monitoring and Management: International Symposium sponsored by INTERREG IV, Le Harve, France, September 2014
· International conference on plastics in the environment, Universita delPiemonte Orientale, Alessandria, Italy, February, 2014.
· 42ndAnnual Conference of European Environmental Mutagen Society (EEMS), Warsaw, Poland,September 2012
Emerging Risks from Ballast WaterTreatment, Berlin, Germany, October 2011
· InternationalSymposium on Alternate Animal Models in Biological Research, Lucknow, India, October 2010. (UK-India Research Initiative Sponsored by British Counciland Govt. of India).
· 40thAnnual Conference of European Environmental Mutagen Society (EEMS), Oslo, Norway, September 2010
· NanoImpactTechnical Workshop- Hazard Assessment of Nanomaterials in Biota-Dublin, Ireland, September 2010
10t10th International Conference on Environmental Mutagens (ICEM; organised every 4 years on different continents), and 39th Annual Conference of European Environmental Mutagen Society (EEMS), Florence, Italy, August 2009
International meeting, Replacement of mammalian models: the role of in vitro techniques with fish and invertebrates, Society of Experimental Biology (SEB), Glasgow, UK June 2009
2nd International Symposium on Genotoxicity in Aquatic Environment, Dessau, Germany, April 2008
International Conference on Nanomaterial Toxicology, Indian Nanoscience Society, Lucknow, India, February 2008
International Atomic EnergyAgency (IAEA) Marine Laboratory, Principalityof Monaco, Invited Talk. January 2008
Paarticipations/ Presentations in National & International Conferences / Workshops(since 2008)
24thAnnual Meeting of Society of Environmental Chemistry and Toxicology- Europe(SETAC-Europe), Basel, Switzerland, May 2014, (Oral and PosterPresentations)
· 33rdAnnual Meeting of Co-Ordinating Group on Environmental Radioactivity, LancasterUniversity, UK, April, 2014
· SETACK UKAnnual Meeting, Plymouth University, UK, September 2013 (Oral and PosterPresentations, Session Chair)
· Analytical& Environmental Sciences Seminar Series, Kings College London, UK, February,2013
· EnvironmentalRadioactivity Network (Env-Rad-Net)- Launch Meeting. Diamond Light Source Ltd.,Diamond House, Harwell Science and Innovation campus, Oxfordshire, UK, January,2013
· NaturalEnvironment Research Council radioactivity & the Environment BrokerageEvent, Bristol, October, 2012
· 35thAnnual Conference of the United Kingdom Environmental Mutagen Society (UKEMS),Swansea University, UK, July, 2012
· Invited Lecture at Indian Institute of Chemical Biology, Kolkata, India, August 2011
· Invited lecture at PG Department of Zoology, LN Mithila University, Darbhanga, Bihar, India, July,2011
34th Annual Conference of the United Kingdom Environmental Mutagen Society (UKEMS),University of Nottingham, UK, June, 2011
International workshop on Eco-genotoxicology, Norwegian Institute for Air Research,Lillestrom, Norway, April, 2011
Mini-symposium: A systems approach to predicting stress (Ocean acidification) using model species. University of Hull, UK, February 2011.
· NanoImpactTechnical Workshop- Hazard Assessment of Nanomaterials in Biota-Dublin, R Ireland, September 2010
· Workshopon Chemical Induced Carcinogenesis (Roberts Fund by and for PhD researchers),University of Birmingham, UK, April,2010
· Marine Environment and Human Health (MEHH), Natural Environment Research CouncilStrategic Ocean Funding Initiative (SOFI), Weymouth, UK, February, 201
SSSETACK UK, Human and Environmental Health, (invited lecture), London, UK, September 2009
15th Pollutant Response in Marine Organisms Primo, Bordeaux, France, May 2009
Research degrees awarded to supervised students
1. Current Post Doctoral Research Fellows:
Dr. Matt Baron
Dr. Lorna Dallas
Dr. Rich Maunder
Dr. Deepu Oommen
Dr Yann Aminot (Funding: NERC, UK)
Dr. Awantha Dissanayake
Dr. Nick Dodd (Senior Research Fellow)
Previous Post-Doctoral fellows/ Visiting Fellow:
Dr. Ildiko Gyory (2012-2014)
Dr Alessia D'Agata
Dr Damien Tran
Prof Sheikh Raisuddin
2. PhD Completion as Director of Studies (first supervisor): 13
Franck Atienzar (2000): Development of the random amplified polymorphic DNA (RAPD) technique to measure the effects of genotoxins in aquatic organisms (Funded by EU Marie Curie Grant)
Philip Pascoe (2002):Chromosomal variation in Nucella lapillus (L.) and other muricid gastropods (Funded by Plymouth Marine Laboratory)
Josephine Hagger (2003):Evaluation of radionuclide-induced damage in marine invertebrates (Funded by NERC, EA and Devonport Royal Dockyard Ltd., Special CASE Award)
Victoria Cheung (2003):Detection of genetic toxicity in marine invertebrates (Funded by DETR and Univ. of Plymouth)
Claire Cailes (2007):Impact of ionising radiations in freshwater invertebrates (in collaboration with CEH Dorset; Drs. Jim Smith & John Murphy) (Funded by NERC)
Zoë Lyle (2008):Interactive toxic effects of UV radiation and PAHs (in collaboration with PMS and Cornwall College : Drs. Alison Curnow and Leo Salter) (Funded by the Duchy Health Charity & Penninsula Medical School)
Martin Canty (2010): Echinoderms and marine pollution: Development of non-destructive biomarkers (Other Supervisors: Prof. MB Jones; Dr. R Brown; Dr. T Hutchinson; Funding: NERC CASE Award with AstraZeneca)
Sherain Al-Subiai (2007-10): Impact of PAHs on aquatic invertebrates (with Dr. A. John Moody) (Funded by State of Kuwait)
Sanna Abdul Mustafa (2007-11): Impact of pollutnats on frshwater fish (with Dr. Simon Davies) (Funded by Republic of Iraq Govt.)
Helena Reinardy (2008-11) Impact of ionising radiations on aquatic organisms (with Drs. Ted Henry-UoP; Bill Langsdon-MBA and Ross Jeffree-IAEA, MEL, Monaco). (Funded by Marine Institute and IAEA, Vienna).
Yanan Di (2008-12) Invertebrate ecotoxicology (with Drs. Declan Schroeder-MBA and Murray Brown-UoP) (Funded by ORS).
Matthew Baron (2010-13) Mechanistic Application of Spheroids Cell Culture to 3Rs in Fish Ecotoxicology(Co-Supervisors: Profs. W Purcell, S Jackson and Dr. S Owen; Funding: BBSRC CASE award with AstraZeneca)
Lorna Dallas (2010-13) Consequences of chronic exposure of marine species to low concentrations of pollutants; (Co-supervisors: Drs. Miranda Keith-Roach and Brett Lyons, CEFAS, Weymouth; Funding: European Commission; INTERREG)
3. PhD Completion as Co Supervisor: 6
Saravuth Rattanachongkiat (2000-2004): Distribution and speciation of arsenic in the Pale Pa-Nang estuary (With Dr. Mike Foulkes and Prof. Geoff Millward, School of Earth, Ocean and Environmental Sciences, University of Plymouth) (Funded by the Govt. of Thailand)
Catherine Money (2003-2006) Metal speciation and Toxicity (in Collaboartion with Drs. Charlotte Braungardt, Eric eictenberg and Prof. Paul Worsford) (Funded by NERC; CASE Award)
James Reeves (2004-2007): Role of micronutrients and environmental agents for the induction of oxidative damage in relation to fish health (with Dr. Simon Davies) (Funded by Waltham Pet Care, Mars)
Sebastien Rider (2005-2008): Role of dietary selenium and zinc in promotion of fish nutrition and health (with Dr. Simon Davies) (Funded by BBSRC and Alltech)
Arafat Ahmed (2007-2011) Food, nutrion and toxicity in larvae of marine fish species (with Dr. Simon Davies) (Govt. of Republic of Iraq)
Samad Omar (2008-2011) Development of sustainable diets for carp based on novel industrial by-products (with Dr. Simon Davies)
Alexandros Samartzis (2007-2013): Trace element nutrition and toxicity in sea brim (with Dr. Simon Davies) (Govt. of Greece)
4. PhD In Progress as Director of Studies: 4
Laura Langan (2012-2015) (Co-Supervisors: Profs. WPurcell, S Jackson and Dr. S Owen; Funding: AstraZeneca & PlymouthUniversity)
Rajan Mynard (2013-2016) canengineered nanoparticles induce potential neurological health effects? : an invitro study adopting molecular approaches. (Co-Supervisors: Profs: DavidParkinson, Simon Jackson and Andrei Khlobystov)
Hanan AlSarawi (2013-2016) Developingan integrated strategy for the assessment of hazardous substances in Kuwaiti’smarine environment (Co-Supervisors: Dr. Brett P Lyon, CEFAS, Weymouth; Prof.Mohammed Al-Sarawi, Kuwait).
Emily Vernon (2014-2017) AssessingImpact Ionising Radiations on Molluscs (Co-Supervisors: Prof Jim Smith and DrAlex Ford, Portsmouth University)
5. PhD In Progress as Co-Supervisor: 1
Ruwaidah Musstaf (2014-2017): Interaction of laser with cellular system (DoS: Dr. David Jenkins)
Nick Fueller (2014-2017) Radiation effects on invertebrates (Dr. Alex Ford and Prof Jim Smith, Portsmouth University)
Current / Previous Post-Graduate Visiting Students:
· Ms Elena Papis, University of Insubria, Italy, January-December, 2007
· Ms Teresa Balbi, University of Genoa, Italy; June-July 2014
· Ms Taynah Vicari, University of Parana, Brazil; 2014-2015
· Ms Marianne Faure, ESITPA in Rouen, France; 2013-14
· Mr Erik Ferrara, University of Messina, Italy; May- July 2015
· Ms Silvia Arossa, University of Ancona, Italy; May -November 2015
Grants & contracts
Recent Research Grants (since 2000):
Short Title- Sponsor- Year
1. Development of the strategies to assess the impact of radioactive effluent discharge on the marine invertebrates (special CASE award)-NERC, EA, DML-1998-2001
2. Impact of ionising radiation on aquatic invertebrates in the Chernobyl zone(in collaboration with CEH, Dorset) -NERC-2002-2005
3. In Vitro investigation of the interactive toxic effects of UV radiation (in collaboration with Cornwall College, Cornwall Dermatology Unit, Peninsula Medical School)Duchy Health Charity-2003-2006
4. Ecotoxicological impact of chemical contaminants on aquatic organisms- Assoc. CW Uni.-2003-2003 5. Development of Biomarkers using Echinoderms (with Prof. Malcolm Jones)- Industrial CASE Award (in collaboration with AstraZeneca)- NERC-2004-2007
6. Trace element enhancement of ornamental fish diets to minimise oxidative stress and genomic instability (with Dr. Simon Davies)- Waltham Centre for Pet nutrition, Mars; 2004-2007
7. Role of dietary selenium and zinc in promotion of fish nutrition and health (with Dr.Simon Davies)- BBSRC-ALLTECH CASE Studentship; 2005-2008
8. Assessing the impact of polyaromatic hydrocarbons in marine invertebrates. Govt. of Kuwait, Research Studentship; 2007-2010
9. Impact of contaminants on fish: toxicological and pathological approach. Republic of Iraq, Research Studentship. 2007-2011
10. Impact of Ionising raditions on aquatic organisms; UoP and IAEA, Vienna; 2008-2011.
11. Consequences of chronic exposure of marine species to low concentrations of pollutants; European Commission (INTERREG IV A). 2009-14. (PI)
12. Mechanistic Application of Spheroids Cell Culture to 3Rs in Fish Ecotoxicology; BBSRC-CASE Award with AstraZeneca; 2010-2013 (PI).
13. Influence of membrane fludity on the maliganant potential of tumour cells. Plymouth Hospitals NHS Trust; 2011-2013 (PI)
14. Prevalidation of molecular and genetic biomarkers in therapeutic managment of cancer. Plymouth Hospitals NHS Trust; 2012-2014. (PI).
15.Moving up adimension: 3D in vitro models as effective alternatives to live fish studies; Biotechnology and Biological Sciences Research Council (BBSRC: 70%contribution); Natural Environment Research Council (NERC: 30% contribution);2014-17
16. Elucidating the potential interactionof manufactured nanoparticles with polycyclic aromatic hydrocarbons: Anintegrated toxicogenomics approach; Natural Environment Research Council(NERC); 2014-18; Multidisciplinary Collaborative Project (PI)
17. TRansfer - Exposure – Effects (TREE):integrating the science needed to underpin radioactivity assessments for humansand wildlife; Natural Environment Research Council (NERC); 2014-18 (Co-PI;Consortium led by: CEH, Lancaster; PI- Dr Brenda Howard, MBE)
18. ChannelCatchment Cluster (3C): Recent developments in tools and techniques for waterquality management in the France (channel) England region; European Commission(INTERREG IV A); 2013-2015 (PI)
Creative practice & artistic projects
Contribution to the Public Understanding of Science; Wider Dissemination of Activities:
Newspaper articles and interviews
Articles in relation to research activities and for the interest of general public and colleagues
Participation and listed for BBC Radio (e.g. 5 Live, BBC World Service, Ulster, West Country, Scotland etc.) and local TV channels on current issues
Key publications are highlightedJournals
- Book Chapter (since 2014)
Farre M and AN Jha (2020) Metabolomics effects of nanomaterials: an ecotoxicological perspective. In Environmental Metabolomics: Applications in the field and laboratory studies from the exposure to the metabolome (Chapter 9). (Eds. Diana Alvarez-Munoz and Marinella Farre). Elsevier. ISBN: 97801281966.
- Review Articles (since 2014)
1. Beresford NA et al. (2019) Towards solving a scientific controversy – The effects of ionising radiation on the environment. Journal of Environmental Radioactivity https://doi.org/10.1016/j.jenvrad.2019.106033.
2. Mussttaf RA, DF Jenkins, AN Jha (2019) Assessing the Impact of Low Level Laser Therapy (LLLT) on Biological Systems: A Review. International Journal of Radiation Biology 95, 2, 120-143.
3. Jha AN (2018) Professor Adayapalam Tyagarajan Natarajan (1928-2017): a tribute (obituary). Mutagenesis 32, 545-546.
4. Al-Sarawi, HA, AN Jha, MA Al-Sarawi, BP Lyons (2015) Historic and contemporary contamination in the marine environment of Kuwait: an overview. Marine Pollution Bulletin 100, 621–628.
5. Millward GE, AN Jha, C Minier, N. Pope, WJ Langston (2015) The English Channel and its catchments: Status and responses to contaminants. Marine Pollution Bulletin 95, 523-528.
6. Dallas LJ and AN Jha (2015) Applications of biological tools or biomarkers in aquatic biota: a case study of the Tamar estuary, South West England. Marine Pollution Bulletin 95, 618-633.
7. Wang Q, AN Jha, X Chen, J-f Dong, X-min Wang (2015) The future of nuclear safety: vital role of geoscientists? Renewable and Sustainable Energy Review 43, 239-243.
8. Jha AN, WH Blake, GE Millward (2014) Environmental Radioactivity: implications for human and environmental health. Journal of Environmental Radioactivity 133, 1-4.
9. Werschkun B, S Banerji, OC Basurko, M David, F Fuhr, S Gollasch, T Grummt, M Haarich, AN Jha, S Kacan, A Kehrer, J Linders, E Mesbahi, D Pughiuc, SD Richardson, B Schwarz-Schulzj, A Shah, N Theobald, U von Gunten, S Wieck, T Höfer, (2014) Emerging risks from ballast water treatment: The run-up to the International Ballast Water Management Convention. Chemosphere 112, 256-266.
10. Wang Q, Xi Chen, AN Jha, H Rogers (2014) Natural Gas from Shale Formation – The Evolution, Evidences and Challenges of Shale Gas Revolution in United States. Renewable and Sustainable Energy Review 30, 1-28.
- Original Scientific Papers (since 2014):
1. Sforzini S, C Oliveri, A Barranger, AN Jha, M Banni, MN Moore, A Viarengo (2020) Effects of fullerene C60 in blue mussels: Role of mTOR in autophagy related cellular/tissue alterations. Chemosphere 246, 125707. https://doi.org/10.1016/j.chemosphere.2019.125707.
2. Vernon EL, TP Bean, AN Jha (2019) Assessing relative biomarker responses in marine and freshwater bivalve molluscs following exposure to phosphorus 32 (32P): Application of genotoxicological and molecular biomarkers. Journal of Environmental Radioactivity. doi.org/10.1016/j.jenvrad.2019.106120.
3. Barranger A, GA Rance, Y Aminot, LJ Dallas, S Sforzini, NJ Weston, RW Lodge, M Banni, VM Arlt, MN Moore, JW Readman, A Viarengo, AN Khlobystov, AN Jha (2019) An integrated approach to determine interactive genotoxic and global gene expression effects of multiwalled carbon nanotubes (MWCNTs) and Benzo[a]pyrene (BaP) on marine mussels: Evidence of reverse ‘Trojan Horse’ effects. Nanotoxicology 13, 1324-1343. https://doi.org/10.1080/17435390.2019.1654003.
4. Barranger A, LM Langan, V Sharma, GA Rance, Y Aminot, NJ Weston, F Akcha, MN Moore, VM Arlt, AN Khlobystov, JW Readman, AN Jha (2019) Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels. Nanomaterials 9, 987; doi:10.3390/nano9070987.
6. Vernon EL, AN Jha (2019) Assessing relative sensitivities of marine and freshwater bivalves following exposure to copper: Application of classical and novel genotoxicological biomarkers. Mutation Research 842, 60-71.
7. Langan LM,, SF Owen, M Trznadel, NJF Dodd, SK Jackson,WM. Purcell, AN Jha (2018) Spheroid size does not impact metabolism of the β-blocker propranolol in 3D intestinal fish model. Frontiers in Pharmacology 9, Article 947; doi:103389/phar2018.00947.
8. Vernon EL, JT Smith, AN Jha (2018) Relative comparison of tissue specific bioaccumulation and radiation dose estimation in marine and freshwater bivalve molluscs following exposure to phosphorus 32. Journal of Environmental Radioactivity 192, 312-320.
9. Langan LM, SF Owen, AN Jha (2018b) Establishment and long term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss. BIOLOGY OPEN, bio032870. doi:10.1242/bio.032870.(Open access; Cover Page Article).
10. Langan LM, S Arossa, SF Owen, AN Jha (2018a) Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies. Mutation Research (Genetic Toxicology & Environmental Mutagenesis), 826, 53–64.
11. Pearson HBC, LJ Dallas, SDW Comber, CB Braungardt, PJ Worsfold, AN Jha (2018) Mixtures of tritiated water, zinc and dissolved organic carbon: Assessing interactive bioaccumulation and genotoxic effects in marine mussels, Mytilus Galloprovincialis. Journal of Environmental Radioactivity 187, 133-143.
12. Mussttaf RA, D Jenkins, A Jha (2018) Photo-stimulatory effect of LLLT on the proliferation rate of human monocytic leukaemia cells. IET-Nanobiotechnology 12, 175-181 Doi: 10.1049/iet-nbt.2017.0035.
13. Sforzini S, C Oliveri, A Orrù, G Chessa, B Pacchioni, C Millino, AN Jha, A Viarengo, M Banni (2018b) Application of a new targeted low density microarray and conventional biomarkers to evaluate the health status of marine mussels: A field study in Sardinian coast, Italy. The Science of the Total Environment 628–629, 319–328.
14. Sforzini S, MN Moore, C Oliveri, A Volta, A Jha, M Banni, A Viarengo (2018a) Role of mTOR in autophagic and lysosomal reactions to environmental stressors in molluscs. Aquatic Toxicology 195, 114–128.
15. Dallas LJ, A Turner, TP Bean, BP Lyons, AN Jha (2018) An integrated approach to assess the impacts of zinc pyrithione at different levels of biological organization in marine mussels. Chemosphere 196, 531-539.
16. Sanchis J, Y Aminot, E Abad, AN Jha, JW Readman, M Farre (2018) Transformation of C60 fullerenes aggregates suspended and weathered under realistic environmental conditions. Carbon 128, 54-62.
17. Al-Sarawi HA, AN Jha, C Baker-Austin, MA Al-Sarawi, BP Lyons (2018) Baseline screening for the presence of antimicrobial resistance in E. coli isolated from Kuwait’s marine environment. Marine Pollution Bulletin 129, 893-898.
18. Maunder RJ, MG Baron, SF Owen, AN Jha (2017) Investigations to extend viability of a rainbow trout primary gill cell culture. Ecotoxicology 26, 1314-1326.
19. Langan LM, GM Harper, SF Owen, WM Purcell, SK Jackson, AN Jha (2017) Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper. Ecotoxicology 26, 1117-1133 (Open Access).
20. Banni M, S Sforzini, VM Arlt, A Barranger, LJ Dallas, C Oliveri, Y Aminot, B Pacchioni, C Millino, G Lanfranchi, JW Readman, MN Moore, A Viarengo, AN Jha (2017) Assessing the impact of Benzo[a]pyrene on Marine Mussels: application of a novel targeted low density microarray complementing classical biomarker responses. PLoS ONE 12 (6): e0178460doi.org/10.1371/journl.pone.0178460.
21. Baron MG, KS Mintram, SF Owen, MJ Hetheridge, A John Moody, WM Purcell, SK Jackson, AN Jha (2017) Pharmaceutical metabolism in fish: using a 3-D hepatic in vitro model to assess clearance. PLoS ONE 12(1): e0168837.doi:10.1371/journal.pone.0168837.
22. Di Y, Y Aminot, DC Schroeder, JW Readman, AN Jha (2017) Integrated biological responses and tissue-specific expression of p53 and ras genes in marine mussels following exposure to benzo(α)pyrene and C60 fullerenes, either alone or in combination. Mutagenesis 32, 77-90.
23. Oommen D, NJF Dodd, D Yiannakis, R Moyeed, AN Jha (2016b) Linking genotoxicity and cytotoxicity with membrane fluidity: a comparative study in ovarian cancer cell lines following exposure to auranofin. Mutation Research- Genetic Toxicology and Environmental Mutagenesis 809, 43-49.
24. Oommen D, D Yiannakis, AN Jha (2016a) BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin. Mutation Research 784 (Fundamental Mol. Mech. of Mutagenesis), 8–15.
25. Dallas LJ, TP Bean, A Turner, BP Lyons, AN Jha (2016b) Exposure to tritiated water at an elevated temperature: genotoxic and transcriptomic effects in marine mussels (M. galloprovincialis). Journal of Environmental Radioactivity 164, 325-336.
26. Dallas LJ, A Devos, B Fievet, A Turner, BP Lyons, AN Jha (2016a) Radiation dose estimation for marine mussels following exposure to tritium: best practice for use of the ERICA tool in ecotoxicological studies. Journal of Environmental Radioactivity 155-156, 1-6.
27. Dissanayake A, AG Scarlett, AN Jha (2016) Diamondoid naphthenic acids cause in vivo genetic damage in gills and haemocytes of marine mussels. Environmental Science and Pollution Research 23, 7060-7066.
28. Langan LM, NJF Dodd, SF Owen, WM Purcell, SK Jackson, AN Jha (2016) Direct measurements of oxygen in the middle of 3D tissue cultures using electron paramagnetic resonance spectroscopy. PLoS ONE DOI:10.1371/journal.pone.0149492.
29. Barón E, A Dissanayake, V Judit, C Crowther, J Readman, A Jha, E Eljarrat, D Barcelo (2016) Evaluation of the genotoxic and physiological effects of decabromodiphenyl ether (BDE-209) and dechlorane plus (DP) flame retardants in marine mussels (Mytilus galloprovincialis). Environmental Science and Technology 50, 2700-2708.
30. Devos A, LJ Dallas, C Voiseux, C Lecomte-Pradines, AN Jha, B Fievet (2015) Assessment of growth, genotoxic responses and expression of stress related genes in the Pacific oyster Crassostrea gigas following chronic exposure to ionizing radiation. Marine Pollution Bulletin 95, 688-698.
31. Mustafa SA, SS Karieb, SJ Davies, AN Jha (2015) Assessment of oxidative damage to DNA, transcriptional expression of key genes, lipid peroxidation and histopathological changes in carp Cyprinus carpio L. following exposure to chronic hypoxic and subsequent recovery in normoxic conditions. Mutagenesis 30, 107-116.
32. D’Agata A, S Fasulo, LJ Dallas, AS Fisher, M Maisano, JW Readman, AN Jha (2014) Enhanced toxicity of ‘bulk’ titanium dioxide compared to ‘fresh’ and ‘aged’ nano-TiO2 in marine mussels (Mytilus galloprovincialis). Nanotoxicology 8, 549-558.
Reports & invited lectures
Technical / Project Reports (since 2000):
1. Handy RD, D Maycock, AN Jha (2009) An evaluation of the UK skills base for toxicologists and ecotoxicologists. Final report to DEFRA, UK. Contract No. RR102321.Available on line: (http://randd.defra.gov.uk/Document.aspx?Document=CB0419_8185_FRP.pdf)
2. Hagger JA, AN Jha (2003) Evaluation of radionuclide induced genetic damage in marine invertebrates. PhD thesis as a final report to the Environment Agency, UK for National R & D Project P3-S1 and Devonport Royal Dockyard (DML), Plymouth.
3. Lowe David et al. (2000) Assessment of Impact of Ozone Depletion on Aquatic Ecosystems. Final Report to the Department of Environment, Transport and the Regions (DETR). Contract Reference EPG 1/1/49
Scientific Sessions Chaired in International Conferences (since 2000):
9th International Comet Assay Workshop, Kusadasi, Turkey, September, 2011
International workshop on Eco-genotoxicology, Norwegian Institute for Air Research, Lillestrom, Norway, April 2011
40th Annual Conference of European Environmental Mutagen Society (EEMS), Oslo, Norway, September 2010
NanoImpact Technical Workshop- Hazard Assessment of Nanomaterials in Biota- Dublin, Ireland, September 2010
International Symposium on Alternate Animal Models in Biological Research, Indian Institute of Toxicological Research, Lucknow, India, October 2010
40th Annual Conference of European Environmental Mutagen Society (EEMS), Oslo, Norway, September 2010
NanoImpact Technical Workshop- Hazard Assessment of Nanomaterials in Biota- Dublin, R. of Ireland, September 2010
Genetic-Ecotoxicology session, 7th International Conference on Mutagenesis, Carcinogenesis and Teratogenesis, Organised by Brazilan Society of Environmental Mutagenesis, Carcinogenesis and Teratogenesis. Club Med, Brazil, October 2007
Ecotoxicology Session, VII International Comet Assay Workshop, University of Ulster, Coleraine, Northern Ireland, UK, June 2007
III International Conference & VI Cuban Mutageneis, Teratogeneis & Carcinogeneis Workshop, Havana, Cuba, September 2006.
Chair, Session on Genotoxicity, 13th Pollutant Response in Marine Organisms (PRIMO 13) Symposium,Alessandria, Italy, June 2005
Session on Eco-genotoxicology, 33rd Annual Conference of the European Environmental Mutagen Society (EEMS), Aberdeen, Scotland, UK, August, 2003
Session on Eco-genotoxicology, 25th Anniversary Conference of United Kingdom Environmental Mutagen Society (UKEMS), Plymouth, UK, June- July 2002
Session on Eco-genotoxicology, International Symposium on Environmental Genomics and Health Sciences; XXVII Annual Conference of the Environmental Mutagen Society of India (EMSI), Lucknow, India, March 2002
Sessions on Genotoxicity, 11th Symposium on Pollutant Response in Marine Organisms (PRIMO), Plymouth, UK, July 2001
Invited Speaker in International Conferences (since 2000):
(** Fully /* Partially Sponsored)
*44th Annual Conference of European Environmental Mutagen Society (EEMS), Lancaster, UK.
*42nd Annual Conference of European Environmental Mutagen Society (EEMS), Warsaw, Poland, September 2012
**Emerging Risks from Ballast Water Treatment, Berlin, Germany, October 2011
*10th International Conference on Environmental Mutagens (ICEM), Florence, Italy, August 2009
**International meeting, Replacement of mammalian models: the role of in vitro techniques with fish and invertebrates, Society of Experimental Biology (SEB), Glasgow, UK June 2009
*2nd International Symposium on Genotoxicity in aquatic environment, Dessau, Germany, April 2008
*International Conference on Nanomaterial Toxicology, Indian Nanoscience Society, Lucknow, India, February 2008.
*7th International Conference on Mutagenesis, Carcinogenesis and Teratogenesis, Organised by Brazilan Society of Environmental Mutagenesis, Carcinogenesis and Teratogenesis. Club Med, Brazil, October 2007
*11th International Society of Invertebrate Reproduction and Development (ICRID), Smithsonain Tropical Research Institute (STRI), Panama City, Panama, August 2007
VII International Comet Assay Workshop, University of Ulster, Coleraine, Northern Ireland, UK, June 2007
* 30th Annual Conferene of Indian Society of Cell Biology (30th AICBC), University of Delhi, Delhi, India, February 2007
III International Conference & VI Cuban Mutageneis, Teratogeneis & Carcinogeneis Workshop, Havana, Cuba, September 2006
*3rd Internationa Conference on Metals & radionuclides in the Environment, Vilnius, Lithuania, April 2006.
*35th Annual Conference of the European Environmental Mutagen Society (EEMS), Kos, Greece, July 2005
* *20th Anniversary Low Level Radiation & Health Conference, Heriot-Watt University, Edinburgh, UK, July 2004 **International Symposium on Genotoxicity & Immunotoxicity: Unwelcome effects in aquatic systems, Koblenz, Germany, April 2004
** International Meeting on Protecting Biota from Ionising Radiation, Society of Radiological Protection (SRP), Royal College of Physicians, Edinburgh, UK, January 2004
*33rd Annual Conference of the European Environmental Mutagen Society (EEMS), Aberdeen, Scotland, UK, August 2003
*3rd International Symposium on the Protection of the Environment from ionising radiation, Darwin, Australia, July 2002 (could not participate)
**Asia-Pacific Conference on Marine Science and Technology, Kuala Lumpur, Malaysia, May 2002 *International Symposium on Environmental Genomics and Health Sciences; XXVII Annual Conference of the Environmental Mutagen Society of India (EMSI); Lucknow, India, March 2002
*International Symposium on Environmental Health Sciences in the 21st Century and 26th annual Conference of Environmental Mutagen Society of India, Jawaharlal Nehru University (JNU), New Delhi, India, March 2001 **Metals in Eastern and Central Europe: Health Effects, Sources of Contamination and Methods of Remediation, Prague, Czech Republic, November 2000 (organised by National Institute of Environmental Health and Sciences, USA)
30th Annual Meeting of the European Environmental Mutagen Society, Budapest, Hungary, August 2000
Awadhesh N. Jha
Fax: +44 (0) 1752 584605
School of Biomedical & Biological Sciences
University of Plymouth
Plymouth, PL4 8AA, UK