- DCL level 7, Derriford Hospital, Derriford Rd
- adrian.copplestone@plymouth.ac.uk
Profiles
Professor Adrian Copplestone
Emeritus Professor
Peninsula Medical School (Faculty of Health)
Role
Associate Dean (Plymouth Locality) Peninsula College of Medicine and Dentistry
Honorary Professor in Haematology
Consultant Haematologist, Derriford Hospital
Key publications are highlighted
Journals
Articles
2016
'Type C TP53-CDKN1A pathway dysfunction occurs independently of CDKN1A
gene polymorphisms in chronic lymphocytic leukaemia and is associated with TP53
abnormalities'
British Journal of Haematology
178,
(5)
824-826
, DOI
2014
'The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units'
BLOOD TRANSFUSION
12,
(2)
210-219
, DOI
2013
'The implementation of NICE guidance on venous thromboembolism risk
assessment and prophylaxis: A before- after observational study to assess the
impact on patient safety across four hospitals in England'
BMC Health Services Research
1-18
Publisher Site
PEARL
2013
'A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers'
New England Journal of Medicine
368,
(19)
1771-1780
, DOI
2013
'Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma'
Journal of Clinical Oncology
31,
(3)
301-307
, DOI
2012
'The effect of maximum storage on iron status, oxidative stress and antioxidant protection in paediatric packed cell units'
Blood Transfus
N/a,
1-9
, DOI
2010
'Do All Patients With Hematologic Malignancies and Severe Thrombocytopenia Need Prophylactic Platelet Transfusions?'
Transfusion Medicine Reviews
24,
(3)
163-171
, DOI
2008
'Teaching transfusion in UK medical schools: a survey by the National Blood Transfusion Committee'
Medical Education
42,
(4)
439-439
, DOI
2006
'ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)'
Blood
107,
(9)
3584-3592
, DOI
2005
'Changes in blood supplies, regulations, and transfusion practice'
BMJ
330,
(7486)
268-269
, DOI
2004
'Prospective randomized controlled trial of acute normovolaemic haemodilution in major gastrointestinal surgery'
British Journal of Anaesthesia
93,
(6)
775-781
, DOI
2004
'Activation of coagulation occurs after electrical cardioversion in patients with chronic atrial fibrillation despite optimal anticoagulation with warfarin'
International Journal of Cardiology
95,
(1)
83-88
, DOI
2004
'Anticoagulation in pregnancy: a survey of current practice'
British Journal of Haematology
124,
(1)
124-125
, DOI
2003
'Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation'
HAEMATOLOGICA
88,
(11)
1272-1278
2003
'Ethics of large clinical trials in rapidly lethal diseases'
The Lancet
361,
(9365)
1297-1297
, DOI
2003
'Ethics of large clinical trials in rapidly lethal diseases'
The Lancet
361,
(9365)
1296-1296
, DOI
2003
'A study of the proteins responsible for stimulating B-CLL-specific T-cell responses by autologous dendritic cells pulsed with tumour cell lysate'
The Hematology Journal
4,
(4)
271-276
, DOI
2003
'In vitro dendritic cell-induced T cell responses to B cell chronic lymphocytic leukaemia enhanced by IL-15 and dendritic cell-B-CLL electrofusion hybrids'
Clinical and Experimental Immunology
131,
(1)
82-89
, DOI
2002
'Allelic Discrimination of Factor V Leiden Using the GeneAmp® 5700 Sequence Detection System'
Thrombosis and Haemostasis
88,
(12)
1071-1072
, DOI
2001
'Generation in vitro of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate'
Clinical and Experimental Immunology
126,
(1)
16-28
, DOI
2001
'Thymic Enlargement in an Adult Following a Severe Infection'
Clinical Radiology
56,
(4)
331-333
, DOI
2001
'Vigam-S, a solvent/detergent-treated intravenous immunoglobulin, in idiopathic thrombocytopenic purpura'
Transfusion Medicine
11,
(1)
37-44
, DOI
2001
'Nomograms for the Administration of Unfractionated Heparin'
Thrombosis and Haemostasis
85,
(03)
565-565
, DOI
2000
'An external quality assurance scheme for haematological cell morphology - A pilot cpa scheme which assesses individual performance'
Blood
96,
(11 PART II)
2000
'Composition of b cell lysates from patients with b cell chronic lymphocytic leukaemia which when pulsed onto autologous dendritic cells have stimulated autologous and allogeneic t cell responses'
Blood
96,
(11 PART II)
1999
'Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by ex vivo assessment of drug sensitivity by DiSC assay'
British Journal of Haematology
106,
(2)
474-476
, DOI
1998
'Dyskeratosis Congenita (DC) Registry: identification of new features of DC'
British Journal of Haematology
103,
(4)
990-996
, DOI
1998
'Autoimmune Haemolysis in Patients with B-CLL Treated with Chlorodeoxyadenosine (CDA)'
Leukemia & Lymphoma
29,
(3-4)
391-398
, DOI
1997
'Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12'
British Journal of Haematology
98,
(4)
934-939
, DOI
1997
'A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions'
Transfusion Medicine
7,
(1)
33-39
, DOI
1997
'The distribution of leukaemia in association with domestic water quality in South West England'
European Journal of Cancer Prevention
6,
(1)
11-19
, DOI
1997
'Thromboprophylaxis with Low Molecular Weight Heparin (Fragmin) in High Risk Pregnancies'
Thrombosis and Haemostasis
77,
(01)
039-043
, DOI
1996
'Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion'
Immunohematology
12,
(2)
80-83
1996
'A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group'
Blood
88,
(7)
2480-2487
, DOI
1996
'Guidelines on gamma irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease'
Transfusion Medicine
6,
(3)
261-271
, DOI
1996
'Delayed reactivation of hepatitis B infection after cladribine'
The Lancet
348,
(9020)
129-129
, DOI
1996
'Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients'
British Journal of Haematology
92,
(2)
382-388
, DOI
1995
'Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells'
Journal of Clinical Pathology
48,
(5)
482-487
, DOI
1995
'A rapid and reliable PCR method for detecting clonal T cell populations'
Journal of Clinical Pathology - Clinical Molecular Pathology
48,
(2)
1995
'Effect of anti-APO1 on Spontaneous Apotosis of B Cells in Chronic Lymphocytic Leukaemia: The Role of bel-2 and Interleukin 4'
Leukemia & Lymphoma
19,
(3-4)
301-308
, DOI
1994
'Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4'
Blood
84,
(7)
2297-2304
1994
'Necrosis of the female breast: a complication of oral anticoagulation in patients with protein S deficiency'
The Breast
3,
(2)
116-118
, DOI
1994
'Bedside filtration of blood products in the prevention of HLA alloimmunization--a prospective randomized study. Alloimmunisation Study Group'
Blood
83,
(10)
3028-3035
1993
'Acute non-lymphocytic leukemia with t(16;21)'
Cancer Genetics and Cytogenetics
70,
(2)
144-145
, DOI
1992
'Acute myeloid leukemia with T-lymphoid expression and distinct chromosomal abnormalities [letter; comment]'
Blood
80,
(5)
1368-1369
, DOI
1992
'Acquired factor XI inhibitor in chronic lymphocytic leukaemia'
Journal of Clinical Pathology
45,
(4)
352-353
, DOI
1991
'Haematological toxicity compromises MOPP/ABVD chemotherapy in Hodgkin's disease'
Clinical Oncology
3,
(3)
151-154
, DOI
1990
'Control of haemostasis'
Br J Hosp Med
43,
(5)
385-389
1990
'Radon and leukaemia (IV)'
Lancet
335,
(8701)
1987
'An 8;14 translocation in a case of plasma cell leukemia'
Leukemia Research
11,
(7)
655-659
, DOI
1985
'Successful Treatment of Post-Transfusion Purpura with High Dose Immunoglobulins after Lack of Response to Plasma Exchange'
Vox Sanguinis
49,
(2)
164-167
, DOI
1984
'Assessment of Therapeutic Control of Anticoagulation'
Acta Haematologica
71,
(6)
376-380
, DOI
1982
'Neutropenic enterocolitis during mianserin-induced agranulocytosis'
BMJ
285,
(6348)
1117-1117
, DOI