Professor Adrian Copplestone

Professor Adrian Copplestone

Emeritus Professor

Peninsula Medical School (Faculty of Health)

Associate Dean (Plymouth Locality) Peninsula College of Medicine and Dentistry
Honorary Professor in Haematology
Consultant Haematologist, Derriford Hospital

Key publications

Key publications are highlighted

Tracy I, Tapper W, Parker A, Gardiner A, Sadullah S, Pratt G, Copplestone A, Oscier D & Best OG 2016 'Type C TP53-CDKN1A pathway dysfunction occurs independently of CDKN1A gene polymorphisms in chronic lymphocytic leukaemia and is associated with TP53 abnormalities' British Journal of Haematology 178, (5) 824-826 , DOI
Collard K, White D & Copplestone A 2014 'The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' BLOOD TRANSFUSION 12, (2) 210-219 Author Site , DOI
Bateman A, Sheaff WR, Child S, Boiko O, Ukoumunne OC, Nokes T, Copplestone A & Gericke C 2013 'The implementation of NICE guidance on venous thromboembolism risk assessment and prophylaxis: A before- after observational study to assess the impact on patient safety across four hospitals in England' BMC Health Services Research 1-18 Publisher Site Open access
Stanworth SJ, Estcourt LJ, Powter G, Kahan BC, Dyer C, Choo L, Bakrania L, Llewelyn C, Littlewood T & Soutar R 2013 'A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers' New England Journal of Medicine 368, (19) 1771-1780 , DOI
Leblond V, Johnson S, Chevret S, Copplestone A, Rule S, Tournilhac O, Seymour JF, Patmore RD, Wright D & Morel P 2013 'Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma' Journal of Clinical Oncology 31, (3) 301-307 , DOI
Collard K, White D & Copplestone A 2012 'The effect of maximum storage on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' Blood Transfus N/a, 1-9 Author Site , DOI
Stanworth SJ, Dyer C, Choo L, Bakrania L, Copplestone A, Llewelyn C, Norfolk D, Powter G, Littlewood T & Wood EM 2010 'Do All Patients With Hematologic Malignancies and Severe Thrombocytopenia Need Prophylactic Platelet Transfusions?' Transfusion Medicine Reviews 24, (3) 163-171 , DOI
Duguid J & Copplestone JA 2008 'Teaching transfusion in UK medical schools: a survey by the National Blood Transfusion Committee' Medical Education 42, (4) 439-439 , DOI
Richardson SJ, Matthews C, Catherwood MA, Alexander HD, Carey BS, Farrugia J, Gardiner A, Mould S, Oscier D & Copplestone JA 2006 'ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)' Blood 107, (9) 3584-3592 , DOI
Copplestone JA 2005 'Changes in blood supplies, regulations, and transfusion practice' BMJ 330, (7486) 268-269 , DOI
Sanders G, Mellor N, Rickards K, Rushton A, Christie I, Nicholl J, Copplestone A & Hosie K 2004 'Prospective randomized controlled trial of acute normovolaemic haemodilution in major gastrointestinal surgery' British Journal of Anaesthesia 93, (6) 775-781 , DOI
Jacob K, Talwar S, Copplestone A, Gilbert TJ & Haywood GA 2004 'Activation of coagulation occurs after electrical cardioversion in patients with chronic atrial fibrillation despite optimal anticoagulation with warfarin' International Journal of Cardiology 95, (1) 83-88 , DOI
Copplestone JA, Pavord S & Hunt BJ 2003 'Anticoagulation in pregnancy: a survey of current practice' British Journal of Haematology 124, (1) 124-125 , DOI
Schetelig J, Fetscher S, Reichle A, Berdel WE, Beguin Y, Brunet S, Caballero D, Majolino I, Hagberg H & Johnsen HE 2003 'Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation' HAEMATOLOGICA 88, (11) 1272-1278 Author Site
Rule S & Copplestone A 2003 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1297-1297 , DOI
Mawson AR 2003 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1296-1296 , DOI
Goddard R, Prentice A, Copplestone A & Kaminski E 2003 'A study of the proteins responsible for stimulating B-CLL-specific T-cell responses by autologous dendritic cells pulsed with tumour cell lysate' The Hematology Journal 4, (4) 271-276 , DOI
GODDARD RV, PRENTICE AG, COPPLESTONE JA & KAMINSKI ER 2003 'In vitro dendritic cell-induced T cell responses to B cell chronic lymphocytic leukaemia enhanced by IL-15 and dendritic cell-B-CLL electrofusion hybrids' Clinical & Experimental Immunology 131, (1) 82-89 , DOI
Monk SE, Duckworth AW, Farrugia J, Copplestone JA & Rule SAJ 2002 'Allelic Discrimination of Factor V Leiden Using the GeneAmp® 5700 Sequence Detection System' Thrombosis and Haemostasis 88, (12) 1071-1072 , DOI
Goddard RV, Prentice AG, Copplestone JA & Kaminski ER 2001 'Generation in vitro of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate' Clinical & Experimental Immunology 126, (1) 16-28 , DOI
DeFRIEND DE, COOTE JM, WILLIAMS MP & COPPLESTONE JA 2001 'Thymic Enlargement in an Adult Following a Severe Infection' Clinical Radiology 56, (4) 331-333 , DOI
Newland AC, Burton I, Cavenagh JD, Copplestone A, Dolan G, Houghton J & Reilly T 2001 'Vigam-S, a solvent/detergent-treated intravenous immunoglobulin, in idiopathic thrombocytopenic purpura' Transfusion Medicine 11, (1) 37-44 , DOI
Lovett J, Kingman HM, Copplestone JA, Prentice AG & Grubb H 2001 'Nomograms for the Administration of Unfractionated Heparin' Thrombosis and Haemostasis 85, (03) 565-565 , DOI
Copplestone A, Green S, Pocock M & Prentice A 2000 'An external quality assurance scheme for haematological cell morphology - A pilot cpa scheme which assesses individual performance' Blood 96, (11 PART II)
Goddard RV, Prentice AG, Copplestone JA & Kaminski ER 2000 'Composition of b cell lysates from patients with b cell chronic lymphocytic leukaemia which when pulsed onto autologous dendritic cells have stimulated autologous and allogeneic t cell responses' Blood 96, (11 PART II)
Bosanquet AG, Copplestone JA, Johnson SAN, Smith AG, Povey SJ, Orchard JA & Oscier DG 1999 'Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by ex vivo assessment of drug sensitivity by DiSC assay' British Journal of Haematology 106, (2) 474-476 , DOI
Knight S, Vulliamy T, Copplestone A, Gluckman E, Mason P & Dokal I 1998 'Dyskeratosis Congenita (DC) Registry: identification of new features of DC' British Journal of Haematology 103, (4) 990-996 , DOI
Chasty RC, Myint H, Oscier DG, Orchard JA, Bussutil DP, Hamon MD, Prentice AG & Copplestone JA 1998 'Autoimmune Haemolysis in Patients with B-CLL Treated with Chlorodeoxyadenosine (CDA)' Leukemia & Lymphoma 29, (3-4) 391-398 , DOI
Oscier DG, Matutes E, Copplestone A, Pickering RM, Chapman R, Gillingham R, Catovsky D & Hamblin TJ 1997 'Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12' British Journal of Haematology 98, (4) 934-939 , DOI
Anderson NA, Gray S, Copplestone JA, Chan DC, Hamon M, Prentice AG, Johnson SAN, Phillips M, Van Waeg G & Oakhill A 1997 'A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions' Transfusion Medicine 7, (1) 33-39 , DOI
Foster AM, Prentice AG, Copplestone JA, Cartwright RA & Ricketts C 1997 'The distribution of leukaemia in association with domestic water quality in South West England' European Journal of Cancer Prevention 6, (1) 11-19 , DOI
Hunt BJ, Doughty H-A, Majumdar G, Copplestone A, Kerslake S, Buchanan N, Hughes G & Khamashta M 1997 'Thromboprophylaxis with Low Molecular Weight Heparin (Fragmin) in High Risk Pregnancies' Thrombosis and Haemostasis 77, (01) 039-043 , DOI
Chan D, Poole GD, Binney M, Hamon MD, Copplestone JA & Prentice AG 1996 'Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion' Immunohematology 12, (2) 80-83
Wattel E, Guerci A, Hecquet B, Economopoulos T, Copplestone A, Mahe B, Couteaux ME, Resegotti L, Voglova V & Foussard C 1996 'A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group' Blood 88, (7) 2480-2487 , DOI
Chapman J, Finney RD, Forman K, Kelsey P, Knowles SM, Napier JAF, Phillips P, Mitchell R, Murphy MF & Waters AH 1996 'Guidelines on gamma irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease' Transfusion Medicine 6, (3) 261-271 , DOI
Busuttil DP, Chasty RC, Fraser M, Copplestone JA & Prentice AG 1996 'Delayed reactivation of hepatitis B infection after cladribine' The Lancet 348, (9020) 129-129 , DOI
Matutes E, Oscier D, Garcia-Marco J, Ellis J, Copplestone A, Gillingham R, Hamblin T, Lens D, Swansbury GJ & Catovsky D 1996 'Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients' British Journal of Haematology 92, (2) 382-388 , DOI
Busuttil D & Copplestone A 1995 'Management of blood loss in Jehovah's Witnesses' BMJ 311, (7013) 1115-1116 , DOI
Busuttil D & Copplestone A 1995 'Management of blood loss in Jehovah's Witnesses' BMJ 311, (7013) 1115-1116 Author Site , DOI
Copplestone JA, Williamson P, Norfolk DR, Morgenstern GR, Wimperis JZ & Williamson LM 1995 'Wider benefits of leukodepletion of blood products [letter]' Blood 86, (1) 409-410 , DOI
Mainou-Fowler T, Copplestone JA & Prentice AG 1995 'Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells' Journal of Clinical Pathology 48, (5) 482-487 , DOI
Lynas C, Howe D, Copplestone JA, Johnson SAN & Phillips MJ 1995 'A rapid and reliable PCR method for detecting clonal T cell populations' Molecular Pathology 48, (2) M101-M104 , DOI
Mainou-Flower T, Craig VA, Copplestone AJ, Hamon MD & Prentice AG 1995 'Effect of anti-APO1 on Spontaneous Apotosis of B Cells in Chronic Lymphocytic Leukaemia: The Role of bel-2 and Interleukin 4' Leukemia & Lymphoma 19, (3-4) 301-308 , DOI
Mainou-Fowler T, Craig VA, Copplestone JA, Hamon MD & Prentice AG 1994 'Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4' Blood 84, (7) 2297-2304 , DOI
Cham CW, Chan D, Copplestone JA, Prentice AG, Lyons CB, Jones PA & Watkins RM 1994 'Necrosis of the female breast: a complication of oral anticoagulation in patients with protein S deficiency' The Breast 3, (2) 116-118 , DOI
Williamson LM, Wimperis JZ, Williamson P, Copplestone JA, Gooi HC, Morgenstern GR & Norfolk DR 1994 'Bedside filtration of blood products in the prevention of HLA alloimmunization--a prospective randomized study. Alloimmunisation Study Group' Blood 83, (10) 3028-3035 , DOI
Copplestone JA, Prentice AG, Hamon MD, Gawler J & Anderson N 1994 'HTLV-I infection is crippling' BMJ 308, (6923) 273-273 , DOI
Nobbs MC, Chan-Lam D, Howell RT, Kitchen C & Copplestone JA 1993 'Acute non-lymphocytic leukemia with t(16;21)' Cancer Genetics and Cytogenetics 70, (2) 144-145 , DOI
Copplestone JA & Prentice AG 1992 'Definition of relapse in acute myeloid leukaemia' Leukemia Research 16, (12) 1139-1140 , DOI
Chan-Lam D, Copplestone JA, Prentice AG, Smith A, Lane AC, Hodges E & Smith JL 1992 'Acute myeloid leukemia with T-lymphoid expression and distinct chromosomal abnormalities [letter; comment]' Blood 80, (5) 1368-1369 , DOI
Goodrick MJ, Prentice AG, Copplestone JA, Pamphilon DH & Boon RJ 1992 'Acquired factor XI inhibitor in chronic lymphocytic leukaemia' Journal of Clinical Pathology 45, (4) 352-353 , DOI
Thomas EA, Copplestone JA, Dubbins PA & Friend JR 1991 'The radiologist cries “HELLP”!' The British Journal of Radiology 64, (766) 964-966 , DOI
Goodrick MJ, Daniel F, Prentice AG, Copplestone JA & Tyrrell CJ 1991 'Haematological toxicity compromises MOPP/ABVD chemotherapy in Hodgkin's disease' Clinical Oncology 3, (3) 151-154 , DOI
Prentice AG, Bradford CR & Copplestone JA 1990 'Control of haemostasis' Br J Hosp Med 43, (5) 385-389 Author Site
Prentice AG & Copplestone JA 1990 'Radon and leukaemia (IV)' Lancet 335, (8701)
Copplestone JA & Prentice AG 1988 'Acute myeloblastic leukaemia in the elderly' Leukemia Research 12, (8) 617-625 , DOI
Copplestone A & Oscier DG 1987 'Heparin-induced thrombocytopenia in pregnancy' Br J Haematol 65, (2) Author Site , DOI
Copplestone JA, Oscier DG & Johnson S 1987 'An 8;14 translocation in a case of plasma cell leukemia' Leukemia Research 11, (7) 655-659 , DOI
Hamblin TJ, Abidi SMN, Nee PA, Copplestone A, Mufti GJ & Oscier DG 1985 'Successful Treatment of Post-Transfusion Purpura with High Dose Immunoglobulins after Lack of Response to Plasma Exchange' Vox Sanguinis 49, (2) 164-167 , DOI
Mufti GT, Oscier DG, Hamblin TJ, Copplestone A & Abidi SMN 1984 'CYTARABINE IN PRE-LEUKAEMIA' The Lancet 323, (8387) 1187-1187 , DOI
Gartell P, Braye SG & Copplestone JA 1984 'Neutropenic typhlitis' Diseases of the Colon & Rectum 27, (4) 274-275 , DOI
Copplestone A & Roath S 1984 'Assessment of Therapeutic Control of Anticoagulation' Acta Haematologica 71, (6) 376-380 , DOI
Braye SG, Copplestone JA & Gartell PC 1982 'Neutropenic enterocolitis during mianserin-induced agranulocytosis' BMJ 285, (6348) 1117-1117 , DOI
Copplestone A 2010 'Transfusion' Practical Hemostasis and Thrombosis Wiley-Blackwell 287-296 , DOI
Jones J & Copplestone A 'Regulatory Aspects of Blood Transfusion' Practical Transfusion Medicine Wiley-Blackwell 169-180 , DOI