- DCL level 7, Derriford Hospital, Derriford Rd, Plymouth, PL6 8DH
- adrian.copplestone@plymouth.ac.uk
Profiles
Professor Adrian Copplestone
Emeritus Professor
Peninsula Medical School (Faculty of Health)
Biography
Biography
Associate Dean (Plymouth Locality) Peninsula College of Medicine and Dentistry
Honorary Professor in Haematology
Consultant Haematologist, Derriford Hospital
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2016) 'Type C TP53-CDKN1A pathway dysfunction occurs independently of <i>CDKN1A</i>
gene polymorphisms in chronic lymphocytic leukaemia and is associated with <i>TP53</i>
abnormalities' British Journal of Haematology 178, (5) 824-826 , DOI
(2014) 'The influence of storage age on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' Blood Transfus 12, (2) 210-219 , DOI
(2013) 'The implementation of NICE guidance on venous thromboembolism risk
assessment and prophylaxis: A before- after observational study to assess the
impact on patient safety across four hospitals in England' BMC Health Services Research 1-18 Publisher Site Open access
(2013) 'A No-Prophylaxis Platelet-Transfusion Strategy for Hematologic Cancers' New England Journal of Medicine 368, (19) 1771-1780 , DOI
(2013) 'Results of a Randomized Trial of Chlorambucil Versus Fludarabine for Patients With Untreated Waldenström Macroglobulinemia, Marginal Zone Lymphoma, or Lymphoplasmacytic Lymphoma' Journal of Clinical Oncology 31, (3) 301-307 , DOI
(2012) 'The effect of maximum storage on iron status, oxidative stress and antioxidant protection in paediatric packed cell units' Blood Transfus N/a, 1-9 , DOI
(2010) 'Do All Patients With Hematologic Malignancies and Severe Thrombocytopenia Need Prophylactic Platelet Transfusions?' Transfusion Medicine Reviews 24, (3) 163-171 , DOI
(2008) 'Generation <i>in vitro</i> of B-cell chronic lymphocytic leukaemia-proliferative and specific HLA class-II-restricted cytotoxic T-cell responses using autologous dendritic cells pulsed with tumour cell lysate' Clinical and Experimental Immunology 126, (1) 16-28 , DOI
(2008) 'Teaching transfusion in UK medical schools: a survey by the National Blood Transfusion Committee' Medical Education 42, (4) 439-439 , DOI
(2006) 'ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL)' Blood 107, (9) 3584-3592 , DOI
(2005) 'Changes in blood supplies, regulations, and transfusion practice' BMJ 330, (7486) 268-269 , DOI
(2004) 'Prospective randomized controlled trial of acute normovolaemic haemodilution in major gastrointestinal surgery' British Journal of Anaesthesia 93, (6) 775-781 , DOI
(2004) 'Activation of coagulation occurs after electrical cardioversion in patients with chronic atrial fibrillation despite optimal anticoagulation with warfarin' International Journal of Cardiology 95, (1) 83-88 , DOI
(2003) 'Anticoagulation in pregnancy: a survey of current practice' British Journal of Haematology 124, (1) 124-125 , DOI
(2003) 'Long-term disease-free survival in patients with angioimmunoblastic T-cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation' HAEMATOLOGICA 88, (11) 1272-1278
(2003) 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1297-1297 , DOI
(2003) 'Ethics of large clinical trials in rapidly lethal diseases' The Lancet 361, (9365) 1296-1296 , DOI
(2003) '<i>In vitro</i> dendritic cell-induced T cell responses to B cell chronic lymphocytic leukaemia enhanced by IL-15 and dendritic cell–B-CLL electrofusion hybrids' Clinical and Experimental Immunology 131, (1) 82-89 , DOI
(2003) 'A study of the proteins responsible for stimulating B-CLL-specific T-cell responses by autologous dendritic cells pulsed with tumour cell lysate' The Hematology Journal 4, (4) 271-276 , DOI
(2002) 'Allelic Discrimination of Factor V Leiden Using the GeneAmp® 5700 Sequence Detection System' Thrombosis and Haemostasis 88, (12) 1071-1072 , DOI
(2001) 'Thymic Enlargement in an Adult Following a Severe Infection' Clinical Radiology 56, (4) 331-333 , DOI
(2001) 'Vigam-S, a solvent/detergent-treated intravenous immunoglobulin, in idiopathic thrombocytopenic purpura' Transfusion Medicine 11, (1) 37-44 , DOI
(2001) 'Nomograms for the Administration of Unfractionated Heparin' Thrombosis and Haemostasis 85, (03) 565-565 , DOI
(2000) 'An external quality assurance scheme for haematological cell morphology - A pilot cpa scheme which assesses individual performance' Blood 96, (11 PART II)
(2000) 'Composition of b cell lysates from patients with b cell chronic lymphocytic leukaemia which when pulsed onto autologous dendritic cells have stimulated autologous and allogeneic t cell responses' Blood 96, (11 PART II)
(1999) 'Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by <i>ex vivo</i>
assessment of drug sensitivity by DiSC assay' British Journal of Haematology 106, (2) 474-476 , DOI
(1998) 'Dyskeratosis Congenita (DC) Registry: identification of new features of DC' British Journal of Haematology 103, (4) 990-996 , DOI
(1998) 'Autoimmune Haemolysis in Patients with B-CLL Treated with Chlorodeoxyadenosine (CDA)' Leukemia & Lymphoma 29, (3-4) 391-398 , DOI
(1997) 'Atypical lymphocyte morphology: an adverse prognostic factor for disease progression in stage A CLL independent of trisomy 12' British Journal of Haematology 98, (4) 934-939 , DOI
(1997) 'A prospective randomized study of three types of platelet concentrates in patients with haematological malignancy: corrected platelet count increments and frequency of nonhaemolytic febrile transfusion reactions' Transfusion Medicine 7, (1) 33-39 , DOI
(1997) 'The distribution of leukaemia in association with domestic water quality in South West England' European Journal of Cancer Prevention 6, (1) 11-19 , DOI
(1997) 'Thromboprophylaxis with Low Molecular Weight Heparin (Fragmin) in High Risk Pregnancies' Thrombosis and Haemostasis 77, (01) 039-043 , DOI
(1996) 'A randomized trial of hydroxyurea versus VP16 in adult chronic myelomonocytic leukemia. Groupe Francais des Myelodysplasies and European CMML Group' Blood 88, (7) 2480-2487 , DOI
(1996) 'Guidelines on gamma irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease' Transfusion Medicine 6, (3) 261-271 , DOI
(1996) 'Delayed reactivation of hepatitis B infection after cladribine' The Lancet 348, (9020) 129-129 , DOI
(1996) 'Severe intravascular hemolysis due to autoantibodies stimulated by blood transfusion' Immunohematology 12, (2) 80-83 , DOI
(1996) 'Trisomy 12 defines a group of CLL with atypical morphology: correlation between cytogenetic, clinical and laboratory features in 544 patients' British Journal of Haematology 92, (2) 382-388 , DOI
(1995) 'Effect of interleukins on the proliferation and survival of B cell chronic lymphocytic leukaemia cells' Journal of Clinical Pathology 48, (5) 482-487 , DOI
(1995) 'A rapid and reliable PCR method for detecting clonal T cell populations' Molecular Pathology 48, (2) M101-M104 , DOI
(1995) 'Effect of anti-APO1 on Spontaneous Apotosis of B Cells in Chronic Lymphocytic Leukaemia: The Role of bel-2 and Interleukin 4' Leukemia & Lymphoma 19, (3-4) 301-308 , DOI
(1994) 'Interleukin-5 (IL-5) increases spontaneous apoptosis of B-cell chronic lymphocytic leukemia cells in vitro independently of bcl-2 expression and is inhibited by IL-4' Blood 84, (7) 2297-2304 , DOI
(1994) 'Necrosis of the female breast: a complication of oral anticoagulation in patients with protein S deficiency' The Breast 3, (2) 116-118 , DOI
(1994) 'Bedside filtration of blood products in the prevention of HLA alloimmunization--a prospective randomized study. Alloimmunisation Study Group' Blood 83, (10) 3028-3035 , DOI
(1993) 'Acute non-lymphocytic leukemia with t(16;21)' Cancer Genetics and Cytogenetics 70, (2) 144-145 , DOI
(1992) 'Definition of relapse in acute myeloid leukaemia' Leukemia Research 16, (12) 1139-1140 , DOI
(1992) 'Acute myeloid leukemia with T-lymphoid expression and distinct chromosomal abnormalities [letter; comment]' Blood 80, (5) 1368-1369 , DOI
(1992) 'Acquired factor XI inhibitor in chronic lymphocytic leukaemia' Journal of Clinical Pathology 45, (4) 352-353 , DOI
(1991) 'Haematological toxicity compromises MOPP/ABVD chemotherapy in Hodgkin's disease' Clinical Oncology 3, (3) 151-154 , DOI
(1990) 'Control of haemostasis' Br J Hosp Med 43, (5) 385-389
(1990) 'Radon and leukaemia (IV)' Lancet 335, (8701)
(1987) 'An 8;14 translocation in a case of plasma cell leukemia' Leukemia Research 11, (7) 655-659 , DOI
(1985) 'Successful Treatment of Post-Transfusion Purpura with High Dose Immunoglobulins after Lack of Response to Plasma Exchange' Vox Sanguinis 49, (2) 164-167 , DOI
(1984) 'Assessment of Therapeutic Control of Anticoagulation' Acta Haematologica 71, (6) 376-380 , DOI
(1983) 'FALSE NEGATIVE RESULTS WITH LATEX-BASED TEST FOR FIBRINOGEN DEGRADATION PRODUCTS' The Lancet 322, (8359) 1144-1144 , DOI
(1982) 'Neutropenic enterocolitis during mianserin-induced agranulocytosis' BMJ 285, (6348) 1117-1117 , DOI