Trojan horses logo

Book chapter

Farre M and AN Jha (2020) Metabolomics effects of nanomaterials: an ecotoxicological perspective. In Environmental Metabolomics: Applications in the field and laboratory studies from the exposure to the metabolome (Chapter 9; pp 259-81). (Eds. Diana Alvarez-Munoz and Marinella Farre). Elsevier. ISBN: 97801281966.


Peer-reviewed publications

Moore MN, S Sforzini, A Viarengo, A Barranger, Y Aminot, JW Readman, AN Khlobystov, VM Arlt, M Banni, AN Jha (2021) Antagonistic cytoprotective effects of C60 fullerene nanoparticles in simultaneous exposure to benzo[a]pyrene in a molluscan animal model. The Science of the Total Environment 755, 142355.

Sforzini S, C Oliveri, A Barranger, AN Jha, M Banni, MN Moore, A Viarengo (2020) Effects of fullerene C60 in blue mussels: Role of mTOR in autophagy related cellular/tissue alterations. Chemosphere 246, 125707.

Barranger A, GA Rance, Y Aminot, LJ Dallas, S Sforzini, NJ Weston, RW Lodge, M Banni, VM Arlt, MN Moore, JW Readman, A Viarengo, AN Khlobystov, AN Jha (2019) An integrated approach to determine interactive genotoxic and global gene expression effects of multiwalled carbon nanotubes (MWCNTs) and Benzo[a]pyrene (BaP) on marine mussels: Evidence of reverse ‘Trojan Horse’ effects. Nanotoxicology 13, 1324-1343;

Barranger A, LM Langan, V Sharma, GA Rance, Y Aminot, NJ Weston, F Akcha, MN Moore, VM Arlt, AN Khlobystov, JW Readman, AN Jha (2019) Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels. Nanomaterials 9, 987; doi:10.3390/nano9070987.

Sforzini S, C Oliveri, A Orrù, G Chessa, B Pacchioni, C Millino, AN Jha, A Viarengo, M Banni (2018b) Application of a new targeted low density microarray and conventional biomarkers to evaluate the health status of marine mussels: A field study in Sardinian coast, Italy. The Science of the Total Environment 628–629, 319–328.


Sforzini S, MN Moore, C Oliveri, A Volta, A Jha, M Banni, A Viarengo (2018a) Role of mTOR in autophagic and lysosomal reactions to environmental stressors in molluscs. Aquatic Toxicology 195, 114–128.

Sanchis J, Y Aminot, E Abad, AN Jha, JW Readman, M Farre (2018) Transformation of C60 fullerenes aggregates suspended and weathered under realistic environmental conditions. Carbon 128, 54-62.

Banni M, S Sforzini, VM Arlt, A Barranger, LJ Dallas, C Oliveri, Y Aminot, B Pacchioni, C Millino, G Lanfranchi, JW Readman, MN Moore, A Viarengo, AN Jha (2017) Assessing the impact of Benzo[a]pyrene on Marine Mussels: application of a novel targeted low density microarray complementing classical biomarker responses. PLoS ONE 12 (6):

Di Y, Y Aminot, DC Schroeder, JW Readman, AN Jha (2017) Integrated biological responses and tissue-specific expression of p53 and ras genes in marine mussels following exposure to benzo(α)pyrene and C60 fullerenes, either alone or in combination. Mutagenesis 32, 77-90.

La Torre A., Rance GA, Miners SA, Lucas CH, Smith EF, Fay MW, Zoberbier T, Giménez-López MC, Kaiser U, Brown PD, Khlobystov, A.N. (2016) Ag-catalysed cutting of multi-walled carbon nanotubes. Nanotechnology 27, 1–8. doi:10.1088/0957-4484/27/17/175604

Other related publications

D’Agata A, S Fasulo, LJ Dallas, AS Fisher, M Maisano, JW Readman, AN Jha (2014) Enhanced toxicity of ‘bulk’ titanium dioxide compared to ‘fresh’ and ‘aged’ nano-TiO2 in marine mussels (Mytilus galloprovincialis). Nanotoxicology 8, 549-558.

Al-Subiai SN, VM Arlt, PE Frickers, JW Readman, B Stolpe, JR Lead, AJ Moody, AN Jha (2012) Merging nano-genotoxicology with eco-genotoxicology: An integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C60 fullerenes and fluoranthene in marine mussels, Mytilus sp. Mutation Research (Genetic Toxicology and Environmental Mutagenesis) 745, 92-103.

Zoberbier T, Chamberlain TW, Biskupek J, Kugnathan N, Eyhusen S, Bichoutskaia E, Kaiser U, Khlobystov AN (2012) Interactions and reactions of transition metal clusters with the interior of single-walled carbon nanotubes imaged at the atomic scale. Journal of the American Chemical Society 134(6), 3073–3079.

La Torre A, MW Fay, GA Rance, MC Giménez-López, WA Solomonsz, PD Brown, AN Khlobystov (2012) Interaction of Gold Nanoparticles with the interiors of Hollow Graphitised Carbon Nanofibers. Small 1, 1222-1228.

Di Y, DC Schroeder, A Highfield, JW Readman, AN Jha (2011) Tissue specific expression of p53 and ras genes in response to the environmental genotoxicants Benzo(a)pyrene in marine mussels. Environmental Science and Technology 45, 8974-8981.

Kadar E, GA Tarran, AN Jha, SN Al-Subiai (2011) Stabilisation of engineered zerovalent nanoiron with Na-acrylic copolymer enhances spermiotoxicity. Environmental Science and Technology 45, 3245-3251.

Dodd NJF, AN Jha (2011) The photoexcitation of aqueous suspensions of titanium dioxide nanoparticles: an electron spin resonance (ESR) spin trapping study of potentially oxidative reactions. Photochemistry & Photobiology 87, 632-640.


A. La Torre, M. C. Giménez-López, M. W. Fay, G. A. Rance, W. A. Solomonsz, T. W. Chamberlain, P. D. Brown, A. N. Khlobystov (2010). Assembly, Growth, and Catalytic Activity of Gold Nanoparticles in Hollow Carbon Nanofibres. ACS Nano, 6, 2000-2007.

Kadar E, D Lowe, M Sole, AS Fisher, AN Jha, JW Readman, TH Hutchinson (2010) Uptake and biological responses to nano-Fe versus soluble FeCl3 in excised mussel gills. Analytical and Bioanalytical Chemistry 396, 657-66.

A. La Torre, G. A. Rance, J. El Harfi, J. Li, D. J. Irvine, P. D. Brown, A. N. Khlobystov (2010) Transport and encapsulation of Gold Nanoparticles in Carbon Nanotubes. Nanoscale 2, 1006-1010.

Dodd NJF, AN Jha (2009) Titanium dioxide induced cell damage: A proposed role of the carbonyl radical. Mutation Research (Fundamental and Molecular Mechanisms of Mutagenesis), 660, 79-82.

Banni, M., A. Negri, M. Rebelo, F. Rapallo, H. Boussetta, A. Viarengo and F. Dondero (2009) Expression analysis of the molluscan p53 protein family mRNA in mussels (Mytilus spp.) exposed to organic contaminants. Comp Biochem Physiol C Toxicol Pharmacol 149(3): 414-418.

Moore, M. N., J. A. J. Readman, J. W. Readman, D. M. Lowe, P. E. Frickers and A. Beesley (2009) Lysosomal cytotoxicity of carbon nanoparticles in cells of the molluscan immune system: An in vitro study. Nanotoxicology 3(1): 40-45.

Vevers WF, AN Jha (2008) Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro. Ecotoxicology 17, 410-420.

Reeves JF, SJ Davies, NJF Dodd, AN Jha (2008) Hydroxyl radicals (·OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells. Mutation Research (Fundamental and Molecular Mechanisms of Mutagenesis), 640, 113-122.

Refereed conference proceedings

Dallas LJ, VM Arlt , S Sforzini , M Banni , Y Animot , JW Readman , A Viarengo, AN Jha (2016) Tissue-specific differences in transcriptomic and genotoxic responses of marine mussels exposed to benzo[a] pyrene. Mutagenesis 31, 732.

Jha AN (2015) Modified comet assay to determine oxidative damage to DNA in aquatic organisms: role of confounding factors influencing the results. Front. Genet. ICAW 2015 - 11th International Comet Assay Workshop. doi: 10.3389/conf.fgene.2015.01.00022.

Dallas L, C Oliveri, M Banni, Y Aminot, V Arlt, S Sforzini, JW Readman, A Viarengo, AN Jha (2015) Novel insights into benzo(a)pyrene toxicity in marine mussels: an integrated approach incorporating a new targeted low density microarray. Mutagenesis 30, 852.

Di Y, SN Al-Subiai, LJ Dallas, VM Arlt, JW Readman, B Stolpe, JR Lead, D Schorder, AJ Moody, AN Jha (2015) Interaction of engineered nanoparticles with PAHs: could they act as “Trojan-horses” to induce biological responses in marine species? Mutagenesis 30, 865-866.


Vicari T, M Baron, R Maunder,A La Torre, G Rance, A Khlobystov, A Jha (2015) Uptake, distribution and toxicological effects of two different silver nanomaterials in 3-D in vitro fish cultures. Mutagenesis 30, 875.

Di Y, D Schroeder, A Highfield, J Readman, A Jha (2012) Integrated biological responses and tissue-specific expression of p53 and ras genes in marine mussels following exposure to C60 fullerenes and/or benzo(α)pyrene. Mutagenesis 27, 811.

Reeves JF, NJ F Dodd, SJ Davies, AN Jha (2008) Hydroxyl radicals (·OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells under in vitro conditions Nanotoxicology 2, S1, S57.