Dr Zoe Brookes
Profiles

Dr Zoe Brookes

Associate Professor of Dental Education and Research

Peninsula Dental School (Faculty of Health)

Biography

Biography

Associate Head of School - Teaching and Learning 
Associate Professor in Dental Education and Research 
Clinical Lead of Oral Microbiome Research Group 

Zoe is currently employed at the University of Plymouth as an Associate Professor in Dental Education and Research with a variety of educational roles, including overseeing the Year 1-5 curriculum of the BDS Programme (Bachelor of Dental Surgery) course, Acquired Dental Knowledge assessment lead, Enquiry Based Learning lead and Intercalating MSc Dental lead.

Her research interests involve undertaking clinical research in a primary care dental setting, investigating the mechanisms linking oral health and systemic disease, having established and now leading the the Plymouth Oral Microbiome Research Group (OMRG). She also leads blood pressure case finding clinics with Peninsula Dental Social Enterprise. The Plymouth OMRG investiugates links between the oral microbiome and blood pressure control (hypertension and pre-eclampsia), as well as the effects of anti-microbial mouth washes on the oral microbiome, where Zoe is working with the FDI task team on recommendations for their use. She is involved in a national initiatives to develop health screening services at the dentist. She has also previously published extensively in the field of sepsis, identifying microvascular endothelial cell mechanisms and pharmacological agents that improved blood flow and reduced inflammation during sepsis.  

Zoe originally graduated with a BSc in Physiology and Pharmacology, after which she gained a PhD investigating the role of anaesthetics within the microcirculation, both from the University of Sheffield, ultimately becoming a Non-Clinical Lecturer and Principal Investigator there. Before this she also worked at the University of Alberta in the Department of Physiology as a Postdoctoral Research Fellow, funded by the National Institute for Health and Care Research. Since graduating in dentistry from Plymouth University Zoe has practised in clinics in the city and still works part-time as Dental Associate within the NHS, with an interest in anxious patients and periodontal disease.

Qualifications

PhD, PCHE, SFHEA, MJDF (RCS, Eng), BDS, BSc (Hons)

2021 - present: Associate Professor, BDS Year 2 Programme Lead, Peninsula Dental School, Faculty of Medicine and Dentistry, University of Plymouth, UK (0.8FTE)
2016 - 2021 Clinical Lecturer
2015 - present: General Dentist, Plymouth, UK (0.2FTE) 
2009 - 2010: Honorary Lecturer, Department of Cardiovascular Sciences, University of Sheffield, UK   
2002 - 2009: Lecturer/Principal Investigator for Microcirculation, Sepsis and Anaesthesia Research Group, University of Sheffield, UK 
2000 - 2002: Postdoctoral Fellow (NIHR/CIHR), Department of Physiology, HMRC, University of Alberta, Canada
1999 - 2000: Postdoctoral Research Associate, Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK 

Education 

2014 - 2015: DF1 training, Plymouth Scheme
2010 - 2014: BDS Peninsula School of Medicine and Dentistry, Universites of Plymouth and Exeter, UK 
1995 - 1999: PhD Effects of intravenous anaesthesia on the microcirculation in vivo. University of Sheffield, UK 
1996 - 1998: Postgraduate Certificate in Higher Education, University of Sheffield, UK 
1992 - 1995: BSc Hons Physiology and Pharmacology, University of Sheffield, UK

Professional membership

GDC 252112

Senior Fellow of Advance HE (SFHEA)

Membership of the Faculty of Dental Surgery (Royal College of Surgeons, England)

British Dental Association 

International Association for Dental Research / British Society Oral and Dental Research

British Vascular Biology and Microcirculation Society

Roles on external bodies

Lead for the FDI International task team for mouthwashes in oral care https://www.fdiworlddental.org/task-teams

Assistant Treasurer and committee member, British Society Oral and Dental Research 

CDO CVD advisory board committee member

External Programme Examiner for BMedSci (intercalated research degree), School of Medicine, University of Sheffield

CRN NIHR Oral and Dental sub Specialty Lead, South West and Wales  

CRN Primary Care Dental Champion, South West and Wales 

BHF grant reviewer

Teaching

Teaching

Teaching interests

Undergraduate small and large group teaching, plenaries and curriculum design for BDS and BSc DTH courses


Postgraduate teaching and supervision, including PhD students, in areas of research interest and expertise 

Interested in research relating to inter-professional education and enquiry based learning (EBL)

Areas of interest for teaching: cardiovascular physiology and pharmacology, systemic inflammatory diseases, oral microbiology and immunology
 

Research

Research

Research interests

Plymouth Oral Microbiome research Group (Bescos, Brookes): effects of oral health systemic disease, focussing on the oral microbiome

See latest publication invesitigating the effects of chlorhexidine mouthwash on the oral microbiome

Effects of sepsis on endothelial cells and the microcirculation 

Publications

Publications

Key publications

Key publications are highlighted

Journals

Doble A, Bescos R, Witton R, Shivji S, Ayres R, Brookes Z. A Case-Finding Protocol for High Cardiovascular Risk in a Primary Care Dental School-Model with Integrated Care. Int J Environ Res Public Health. 2023;20(6):4959.

Ali K, Alhaija ESA, Raja M, Zahra D, Brookes ZL, McColl E, Zafar S, Kirnbauer B, Al Wahadni AM, Al-Fodeh RS, Bani-Hani TG, Daher SO, Daher HO. Blended learning in undergraduate dental education: a global pilot study. Med Educ Online. 2023 Dec;28(1):2171700.

Roy H, Bescos R, McColl E, Rehman U, Cray E, Belfield LA, Nweze KD, Tsang K, Singleton W, Whitfield P, Brookes Z. Oral microbes and the formation of cerebral abscesses: A single-centre retrospective study. J Dent. 2023 Jan;128:104366.

Brookes Z, Mills I, Witton R, McColl E Top tips for incorporating research Br Dent J. 2022;232(7):427-429.

Ali K, Gupta P, Turay E, Burns L, Brookes Z, Raja M. Dentistry in a multicultural society: the impact of animal-based products on person-centred care. Br Dent J. 2022;232(4):269-272.

Ali K, Venkatasami N, Zahra D, Brookes Z, Kisielewska J. Evaluation of sepsis teaching for medical and dental students at a British University. Eur J Dent Educ. 2021 Jun 15. doi: 10.1111/eje.12702.

Brookes ZLS, Bescos R, Belfield LA, Ali K, Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020;103:103497. doi: 10.1016/j.jdent.2020.103497

Bescos, R., Ashworth, A., Cutler, C., Brookes, Z. L., Belfield, L., Rodiles, A., . . . Hickson, M. (2020). Effects of Chlorhexidine mouthwash on the oral microbiome. Scientific Reports, 10(1). doi:10.1038/s41598-020-61912-4

Bescos R, Brookes Z, Belfield L, Fenandez-Sanjuro M, Casas-Agustench P. Modulation of oral microbiota: A new frontier in exercise supplementation. PharmaNutrition 14 2020: 100230.

Bescos, R., Casas-Agustench, P., Belfield, L., Brookes, Z., & Gabaldón, T. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 002203452093214. doi:10.1177/0022034520932149

Zahra, D., Bennett, J., Belfield, L., Ali, K., McIlwaine, C., Bruce, M., . . . Zaric, S. (2019). Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum. European Journal of Dental Education. doi:10.1111/eje.12451

McIlwaine, C., Brookes, Z. L. S., Zahra, D., Ali, K., Zaric, S., Jones, G., & Belfield, L. A. (2019). A novel, integrated curriculum for dental hygiene-therapists and dentists. British Dental Journal, 226, 67. Retrieved from https://doi.org/10.1038/sj.bdj.2019.10

McGown, C. C., Brookes, Z. L. S., Hellewell, P. G., Ross, J. J., & Brown, N. J. (2015). Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(5), 557-564. doi:10.1007/s00210-015-1100-y

Alfieri, A., Ong, A. C. M., Kammerer, R. A., Solanky, T., Bate, S., Tasab, M., . . . Brookes, Z. L. (2014). Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin. Pharmacological Research, 80, 43-51. doi:10.1016/j.phrs.2013.12.008

Brookes, Z. L. S., Stedman, E. N., Brown, N. J., Hebbes, C. P., Guerrini, R., Calo, G., . . . Lambert, D. G. (2013). The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo. PLoS ONE, 8(9), e74943. doi:10.1371/journal.pone.0074943

Brookes, Z. L. S., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., . . . Ong, A. C. M. (2013). Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. American Journal of Physiology-Heart and Circulatory Physiology, 304(1), H33-H41. doi:10.1152/ajpheart.01102.2011

Brookes, Z. L. S. (2013). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 14(1), 27-31. doi:10.1016/j.mpaic.2012.11.002

Lawton, B. K., Brown, N. J., Reilly, C. S., & Brookes, Z. L. S. (2012). Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. British Journal of Anaesthesia, 108(6), 929-935. doi:10.1093/bja/aes069

Reeves, K. J., Brookes, Z. L. S., Reed, M. W. R., & Brown, N. J. (2012). Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation. Journal of Vascular Research, 49(2), 132-143. doi:10.1159/000331281

Alfieri, A., Watson, J. J., Kammerer, R. A., Tasab, M., Progias, P., Reeves, K., . . . Brookes, Z. L. (2012). Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Critical Care, 16(5), R182. doi:10.1186/cc11666

McGown, C. C., Brown, N. J., Hellewell, P. G., & Brookes, Z. L. S. (2011). ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. Microvascular Research, 81(3), 281-288. doi:10.1016/j.mvr.2011.02.003

Debono, M., Sheppard, L., Irving, S., Jackson, P., Butterworth, J., Brookes, Z. L. S., . . . Ross, R. J. (2011). Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery. European Journal of Endocrinology, 164(3), 413-419. doi:10.1530/eje-10-0996

Mansart, A., Ruff, L. J., Ariaans, M. P., Ross, J. J., Reilly, C. S., Brown, N. J., . . . Brookes, Z. L. S. (2010). Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(6), 555-562. doi:10.1007/s00210-010-0514-9

Brookes, Z. L. S. (2010). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 11(2), 78-82. doi:10.1016/j.mpaic.2009.10.018

McGown, C. C., Brown, N. J., Hellewell, P. G., Reilly, C. S., & Brookes, Z. L. S. (2010). Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. British Journal of Anaesthesia, 104(2), 183-190. doi:10.1093/bja/aep361

Scicluna, J. K., Mansart, A., Ross, J. J., Reilly, C. S., Brown, N. J., & Brookes, Z. L. S. (2009). Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects. European Journal of Pharmacology, 621(1-3), 67-70. doi:10.1016/j.ejphar.2009.08.029

Brookes, Z. L. S., Mansart, A., McGown, C. C., Ross, J. J., Reilly, C. S., & Brown, N. J. (2009). Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia. Lymphatic Research and Biology, 7(3), 131-137. doi:10.1089/lrb.2008.1019

Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073

Brookes, Z. L. S., McGown, C. C., & Reilly, C. S. (2009). Statins for all: the new premed?. British Journal of Anaesthesia, 103(1), 99-107. doi:10.1093/bja/aep149

Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccahride abolishes extra-splenic vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin-1. Shock 2008; 29(6):675-80. 10.1097/shk.0b013e31815811a3

Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Diminished contraction of rat peripheral arteries to phenylephrine,during exposure to lipopolysaccharide in vitro, involves nitric oxide and endothelin-1. Shock 2008; 29(3):417-21.10.1097/shk.0b013e318142c5df

Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009.). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073

Brookes, Z. L. S., Stedman, E. N., Guerrini, R., Lawton, B. K., Calo, G., & Lambert, D. G. (2007). Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), H2977-H2985. doi:10.1152/ajpheart.00448.2007

McGown, C. C., & Brookes, Z. L. S. (2007). Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. British Journal of Anaesthesia, 98(2), 163-175. doi:10.1093/bja/ael358

Brookes, Z. L. S., Reilly, C. S., Lawton, B. K., & Brown, N. J. (2006). Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of cd11b after hemorrhage. Shock, 25(5), 492-499. doi:10.1097/01.shk.0000209541.76305.8e

Li, Y., Brookes, Z. L. S., & Kaufman, S. (2005). Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regulatory Peptides, 132(1-3), 41-46. doi:10.1016/j.regpep.2005.09.009

Hall, E., & Brookes, Z. L. S. (2005). Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regulatory Peptides, 131(1-3), 34-37. doi:10.1016/j.regpep.2005.06.006

Dhawan, V., Brookes, Z. L. S., & Kaufman, S. (2005). Repeated pregnancies (multiparity) increases venous tone and reduces compliance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289(1), R23-R28. doi:10.1152/ajpregu.00034.2005

Brookes, Z. L. S., & Kaufman, S. (2005). Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. The Journal of Physiology, 565(1), 269-277. doi:10.1113/jphysiol.2005.083147

Dhawan, V., Brookes, Z., & Kaufman, S. (2004). Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation. Cardiovascular Research, 64(1), 179-186. doi:10.1016/j.cardiores.2004.06.018

Brookes, Z. L., Reilly, C. S., & Brown, N. J. (2004). Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo. British Journal of Anaesthesia, 93(2), 249-256. doi:10.1093/bja/aeh190

Brookes, Z. L. S., & Kaufman, S. (2003). Myogenic responses and compliance of mesenteric and splenic vasculature in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284(6), R1604-R1610. doi:10.1152/ajpregu.00411.2002

Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2003). The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo. Anesthesia & Analgesia, 96(2), 456-462. doi:10.1097/00000539-200302000-00030

Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents. Shock, 18(6), 542-548. doi:10.1097/00024382-200212000-00010

Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. British Journal of Anaesthesia, 88(2), 255-263. doi:10.1093/bja/88.2.255

Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2000). Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber. British Journal of Anaesthesia, 85(6), 901-903. doi:10.1093/bja/85.6.901


Articles
Brookes ZLS, McCullough M, Kumar P & McGrath C (2023) 'Mouthwashes: Implications for Practice' International Dental Journal 73, (Supplement 2) S98-S101 , DOI Open access
Duane B, Yap T, Neelakantan P, Anthonappa R, Bescos R, McGrath C, McCullough M & Brookes Z (2023) 'Mouthwashes: Alternatives and Future Directions' International Dental Journal 73, S89-S97 , DOI Open access
Brookes Z, McGrath C & McCullough M (2023) 'Antimicrobial Mouthwashes: An Overview of Mechanisms—What Do We Still Need to Know?' International Dental Journal , DOI Open access
Brookes Z, Teoh L, Cieplik F & Kumar P (2023) 'Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?' International Dental Journal 73, (Supplement 2) S74-S81 , DOI Open access
McColl E & Brookes Z (2023) 'Shared care learning' British Dental Journal 235, (4) 233-234 , DOI
Doble A, Bescos R, Witton R, Shivji S, Ayres R & Brookes Z (2023) 'A Case-Finding Protocol for High Cardiovascular Risk in a Primary Care Dental School—Model with Integrated Care' International Journal of Environmental Research and Public Health 20, (6) 4959-4959 , DOI Open access
Ali K, Alhaija ESA, Raja M, Zahra D, Brookes ZL, McColl E, Zafar S, Kirnbauer B, Al Wahadni AM & Al-Fodeh RS (2023) 'Blended learning in undergraduate dental education: a global pilot study' Medical Education Online 28, (1) , DOI Open access
Roy H, Bescos R, McColl E, Rehman U, Cray E, Belfield LA, Nweze K-D, Tsang K, Singleton W & Whitfield P (2022) 'Oral microbes and the formation of cerebral abscesses: a single-centre retrospective study' Journal of Dentistry , DOI Open access
Brookes Z, Mills I, Witton R & McColl E (2022) 'Top tips for incorporating research' British Dental Journal 232, (7) 427-429 , DOI Open access
Ali K, Gupta P, Turay E, Burns L, Brookes Z & Raja M (2022) 'Dentistry in a multicultural society: the impact of animal-based products on person-centred care' British Dental Journal 232, (4) 269-272 Author Site , DOI Open access
Brookes ZLS, Belfield LA, Ashworth A, Casas-Agustench P, Raja M, Pollard AJ & Bescos R (2021) 'Effects of chlorhexidine mouthwash on the oral microbiome' Journal of Dentistry 113, Publisher Site , DOI Open access
Ali K, Venkatasami N, Zahra D, Brookes Z & Kisielewska J (2021) 'Evaluation of Sepsis Teaching for Medical and Dental Students at a British University' European Journal of Dental Education , DOI Open access
Brookes ZLS, Bescos R, Belfield LA, Ali K & Roberts A (2020) 'Current uses of chlorhexidine for management of oral disease: a narrative review' Journal of Dentistry 103, 103497-103497 Publisher Site , DOI Open access
Bescos R, Brookes ZLS, Belfield LA, Fernandez-Sanjurjo M & Casas-Agustench P (2020) 'Modulation of oral microbiota: A new frontier in exercise supplementation' PharmaNutrition 14, 100230-100230 , DOI Open access
Bescos R, Casas-Agustench P, Belfield L, Brookes Z & Gabaldón T (2020) 'Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine' Journal of Dental Research 99, (9) 1113-1113 , DOI Open access
Bescos R, Ashworth A, Cutler C, Brookes ZL, Belfield L, Rodiles A, Casas-Agustench P, Farnham G, Liddle L & Burleigh M (2020) 'Effects of Chlorhexidine mouthwash on the oral microbiome' Scientific Reports 10, (1) 0-0 , DOI Open access
Zahra D, Bennett J, Belfield L, Ali K, McIlwaine C, Bruce M, Jones G, Brookes ZL, Coelho C & Zaric S (2019) 'Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum' European Journal of Dental Education 0, (ja) Author Site , DOI Open access
McIlwaine C, Brookes ZLS, Zahra D, Ali K, Zaric S, Jones G & Belfield LA (2019) 'A novel, integrated curriculum for dental hygiene-therapists and dentists' British Dental Journal 226, 67-67 Author Site Open access
McGown CC, Brookes ZLS, Hellewell PG, Ross JJ & Brown NJ (2015) 'Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII' Naunyn-Schmiedeberg's Archives of Pharmacology 388, (5) 557-564 , DOI
Alfieri A, Ong ACM, Kammerer RA, Solanky T, Bate S, Tasab M, Brown NJ & Brookes ZL (2014) 'Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin' Pharmacological Research 80, 43-51 , DOI
Brookes ZLS, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, Reilly CS & Lambert DG (2013) 'The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo' PLoS ONE 8, (9) e74943-e74943 , DOI
Brookes ZLS (2013) 'Pharmacological modulation of cardiac function and blood vessel calibre' Anaesthesia & Intensive Care Medicine 14, (1) 27-31 , DOI
Brookes ZLS, Ruff L, Upadhyay VS, Huang L, Prasad S, Solanky T, Nauli SM & Ong ACM (2013) 'Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone' American Journal of Physiology-Heart and Circulatory Physiology 304, (1) H33-H41 , DOI
Lawton BK, Brown NJ, Reilly CS & Brookes ZLS (2012) 'Role of L-type calcium channels in altered microvascular responses to propofol in hypertension' British Journal of Anaesthesia 108, (6) 929-935 , DOI
Alfieri A, Watson JJ, Kammerer RA, Tasab M, Progias P, Reeves K, Brown NJ & Brookes ZL (2012) 'Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis' Critical Care 16, (5) R182-R182 , DOI
Reeves KJ, Brookes ZLS, Reed MWR & Brown NJ (2012) 'Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation' Journal of Vascular Research 49, (2) 132-143 , DOI
McGown CC, Brown NJ, Hellewell PG & Brookes ZLS (2011) 'ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase' Microvascular Research 81, (3) 281-288 , DOI
Debono M, Sheppard L, Irving S, Jackson P, Butterworth J, Brookes ZLS, Newell-Price J, Ross JJ & Ross RJ (2011) 'Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery' European Journal of Endocrinology 164, (3) 413-419 , DOI
Brookes ZLS (2010) 'The effects of haemorrhage on the microcirculation during intravenous anaesthesia'
Mansart A, Ruff LJ, Ariaans MP, Ross JJ, Reilly CS, Brown NJ, Kaufman S & Brookes ZLS (2010) 'Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1' Naunyn-Schmiedeberg's Archives of Pharmacology 381, (6) 555-562 , DOI
McGown CC, Brown NJ, Hellewell PG, Reilly CS & Brookes ZLS (2010) 'Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III' British Journal of Anaesthesia 104, (2) 183-190 , DOI
Brookes ZLS (2010) 'Pharmacological modulation of cardiac function and blood vessel calibre' Anaesthesia & Intensive Care Medicine 11, (2) 78-82 , DOI
Scicluna JK, Mansart A, Ross JJ, Reilly CS, Brown NJ & Brookes ZLS (2009) 'Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects' European Journal of Pharmacology 621, (1-3) 67-70 , DOI
Brookes ZLS, Mansart A, McGown CC, Ross JJ, Reilly CS & Brown NJ (2009) 'Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia' Lymphatic Research and Biology 7, (3) 131-137 , DOI
Brookes ZLS, McGown CC & Reilly CS (2009) 'Statins for all: the new premed?' British Journal of Anaesthesia 103, (1) 99-107 , DOI
Chamberlain J, Francis S, Brookes Z, Shaw G, Graham D, Alp NJ, Dower S & Crossman DC (2009) 'Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding' PLoS ONE 4, (4) e5073-e5073 , DOI
Mansart A, Ross JJ, Reilly CS, Brown NJ & Brookes ZLS (2008) 'LPS ABOLISHES EXTRASPLENIC VASOCONSTRICTION TO ATRIAL NATRIURETIC PEPTIDE' Shock 29, (6) 675-680 , DOI
Scicluna JK, Mansart A, Ross JJ, Reilly CS, Brown NJ & Brookes ZLS (2008) 'REDUCED VASCULAR RESPONSE TO PHENYLEPHRINE DURING EXPOSURE TO LIPOPOLYSACCHARIDE IN VITRO INVOLVES NITRIC OXIDE AND ENDOTHELIN 1' Shock 29, (3) 417-421 , DOI
Brookes ZLS, Stedman EN, Guerrini R, Lawton BK, Calo G & Lambert DG (2007) 'Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine' American Journal of Physiology-Heart and Circulatory Physiology 293, (5) H2977-H2985 , DOI
McGown CC & Brookes ZLS (2007) 'Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide' British Journal of Anaesthesia 98, (2) 163-175 , DOI
Brookes ZLS, Reilly CS, Lawton BK & Brown NJ (2006) 'INTRAVENOUS ANESTHESIA INHIBITS LEUKOCYTE-ENDOTHELIAL INTERACTIONS AND EXPRESSION OF CD11B AFTER HEMORRHAGE' Shock 25, (5) 492-499 , DOI
Li Y, Brookes ZLS & Kaufman S (2005) 'Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature' Regulatory Peptides 132, (1-3) 41-46 , DOI
Hall E & Brookes ZLS (2005) 'Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis' Regulatory Peptides 131, (1-3) 34-37 , DOI
Dhawan V, Brookes ZLS & Kaufman S (2005) 'Repeated pregnancies (multiparity) increases venous tone and reduces compliance' American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289, (1) R23-R28 , DOI
Brookes ZLS & Kaufman S (2005) 'Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat <i>in vivo</i>' The Journal of Physiology 565, (1) 269-277 , DOI
DHAWAN V, BROOKES Z & KAUFMAN S (2004) 'Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation' Cardiovascular Research 64, (1) 179-186 , DOI
Brookes ZL, Reilly CS & Brown NJ (2004) 'Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo' British Journal of Anaesthesia 93, (2) 249-256 , DOI
Brookes ZLS & Kaufman S (2003) 'Myogenic responses and compliance of mesenteric and splenic vasculature in the rat' American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284, (6) R1604-R1610 , DOI
Brookes ZLS & Jacobs-Kaufman S (2003) 'Myogenic responses and compliance of mesenteric and splenic vasculature in the rat' American Journal of Physiology - Regulatory Integrative and Comparative Physiology 284, (6 53-6) , DOI
Brookes ZLS, Brown NJ & Reilly CS (2003) 'The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo' Anesthesia &amp; Analgesia 96, (2) 456-462 , DOI
Brookes ZLS, Brown NJ & Reilly CS (2003) 'The dose-dependent effects of fentanyl on rat skeletal muscle microcirculation <i>in vivo</i>' ANESTHESIA AND ANALGESIA 96, (2) 456-462 Author Site , DOI
Brookes ZLS, Brown NJ & Reilly CS (2002) 'Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents' Shock 18, (6) 542-548 , DOI
Brookes ZLS, Brown NJ & Reilly CS (2002) 'Response of the rat cremaster microcirculation to hemorrhage <i>in vivo</i>:: Differential effects of intravenous anesthetic agents' SHOCK 18, (6) 542-548 Author Site , DOI
Brookes ZLS, Brown NJ & Reilly CS (2002) 'Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage' British Journal of Anaesthesia 88, (2) 255-263 , DOI
Brookes ZLS, Brown NJ & Reilly CS (2000) 'Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber †' British Journal of Anaesthesia 85, (6) 901-903 , DOI
Chapters

Brookes ZL (2015). Pharmacological modulation of blood vessel calibre: Basic and advanced sciences for anaesthetic practice: prepare for the FRCA: Key articles from the Medicine and Intensive Care Journal. Elsevier, Ed. Nicholas Page

Conference Papers
Brookes ZLS, Brown NJ & Reilly CS (1998) 'Effects of controlled haemorrhage on the microcirculation during ketamine anaesthesia'