Dr Zoe Brookes
Profiles

Dr Zoe Brookes

Clinical Lecturer in Undergraduate Dental Studies

Peninsula Dental School (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

Clinical Lecturer in Dental Undergraduate Studies
DTH Year 2 Lead
EBL small group Facilitator

Zoe is currently employed at the University of Plymouth as Clinical Lecturer in Undergraduate Dental Studies and is also Year 2 Lead for the dental therapy and hygiene course. She also has a strong research background and is currently working with Dr Bing Hu investigating the role of endothelial cells in salivary gland disease. She has also previously published extensively in the field of sepsis, identifying microvascular endothelial cell mechanisms and pharmacological agents that improved blood flow and reduced inflammation during sepsis.  

Zoe originally graduated with a BSc in physiology and pharmacology, after which she gained a PhD investigating the role of anaesthetics within the microcirculation, both from the University of Sheffield, ultimately becoming a non-clinical lecturer and principal investigator there. Before this she also worked at the University of Alberta in the Department of Physiology as a postdoctoral research fellow, funded by the National Institute for Health Research. Since graduating in dentistry from Plymouth University Zoe has practised in clinics in the city and still works part-time as dental associate within the NHS.

Qualifications

PhD, PCHE, BDS, BSc (Hons)

2016 - present Clinical Lecturer of Dental Undergraduate Studies and EBL facilitator, Peninsula School of Medicine and Dentistry, Plymouth, UK

2015 - present Dental Associate, Plymouth, UK  

2009 - 2010: Honorary Lecturer, Department of Cardiovascular Sciences, University of Sheffield, UK    
2002 - 2009: Lecturer/Principal Investigator for Microcirculation and Anaesthesia Research Group, University of Sheffield, UK 
2000 - 2002: Postdoctoral Fellow (NIHR/CIHR), Department of Physiology, HMRC, University of Alberta, Canada
1999 - 2000: Postdoctoral Research Associate, Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK 

Education 

2014 - 2015: DF1 training, Plymouth Scheme
2010 - 2014: BDS Peninsula School of Medicine and Dentistry, Universites of Plymouth and Exeter, UK 
1995 - 1999: PhD Effects of intravenous anaesthesia on the microcirculation in vivo. University of Sheffield, UK 
1996 - 1998: Postgraduate Certificate in Higher Education, University of Sheffield, UK 
1992 - 1995: BSc Hons Physiology and Pharmacology, University of Sheffield, UK

Teaching interests

Undergraduate small and large group teaching, plenaries and curriculum design for BDS and DTH courses

Postgraduate teaching and supervision, including PhD students, in areas of research interest and expertise 
Areas of interest for teaching: cardiovascular physiology and pharmacology, systemic inflammatory diseases
 

Research interests

Endothelial cells dysfunction and regeneration during salivary gland disease
Effects of sepsis on the microvasculature and the link between oral health and systemic inflammatory disease

1. McGown CC, Brookes ZLS, Hellewell PG, Ross JJ, Brown NJ. Atorvastatin reduces endotoxin-induced  microvascular inflammation via NOS II. Naunyn Schmiedebergs Arch Pharmacol 2015; 388:557-64.

2. Alfieri A, Ong AC, Kammerer RA, Solanky T, BateS, Tasab M, Brown NJ, Brookes ZLS. Angiopoietin-1  regulates microvascular reactivity and protects the microcirculation during acute endothelialdysfunction: role of eNOS and VE-cadherin. Pharmacol Res 2014; 80:43-51

3. Brookes ZLS, Stedman EN, Brown NJ, Hebbes CP, Guerrini R, Calo G, Reilly CS, Lambert DG. The Nociceptin/OrphaninFQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo . PLoS One 2013; 8(9):e74943.

4. Brookes ZLS, Ruff L, Upadhyay VS, Huang L, Prasad S, Solanky T, Nauli SM, Ong AC. Pkd2 mesenteric  vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. Am J Physiol Heart Circ Physiol . 2013; 304(1):H33-41.

5. Alfieri A, Watson JJ, Kammerer RA, Tasab M, Progias P, Reeves K, Brown NJ, Brookes ZLS. Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Crit Care . 2012; 16(5):R182.

6. Lawton BK, Brown NJ, Reilly CS, Brookes ZLS. Role of L-type calcium channels in altered microvascular  responses to propofol in hypertension . Br J Anaesth. 2012;108(6):929-35.

7. Reeves KJ, Brookes ZLS,Reed MW, Brown NJ. Evaluation of fluorescent plasma markers for in vivo  microscopy of the microcirculation. J Vasc Res . 2012; 49(2):132-43.

8. McGown CC, Brown NJ, Hellewell PG, Brookes ZLS. ROCK induced inflammation of the microcirculation  during endotoxemia mediated by nitric oxide synthase. Microvasc Res . 2011; 81(3):281-8.  

9. Debono M, Sheppard L, Irving S, Jackson P, Butterworth J, Brookes ZLS, Newell-Price J, Ross JJ, Ross  RJ. Assessing adrenal status in patients before and immediately after coronary artery  graft surgery. Eur J Endocrinol . 2011; 164(3):413-9.  

10. Mansart A, Ruff LJ, Ariaans MP, Ross JJ, Reilly CS, Brown NJ, Kaufman S, Brookes ZLS. Constriction of  rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn Schmiedebergs Arch Pharmacol 2010;381(6):555-62.

11. McGown CC, Brown NJ, Hellewell PG, Reilly CS,  Brookes ZLS. Beneficial microvascular and anti  inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. Br J Anaesth 2010; 104(2):183-90.

12. Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccharide alters  vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: time dependent effects. Eur J Pharmacol 2009; 621(1-3):67-70

13. Brookes ZLS, Mansart A, McGown CC,Ross JJ, Reilly CS, Brown NJ. Macromolecular leak from  extrasplenic lymphatics during endotoxemia. Lymph Biol Res 2009; 7(3):131-7.

14.Chamberlain J, Francis SE, Brookes Z, Alp NJ, Arnold ND, Shaw G,King K, Graham D, Rogus J,  Huttner K, Kornman K, Dower S, Crossman DC. Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS One 2009; 4(4):e5073.

15. Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccahride abolishes extra-splenic vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin-1. Shock 2008; 29(6):675-80

16. Scicluna J, Mansart A, Ross JJ, ReillyCS, Brown NJ, Brookes ZLS. Diminished contraction of rat  peripheral arteries to phenylephrine,during  exposure to lipopolysaccharide in vitro, involves nitric oxide and endothelin-1. Shock 2008; 29(3):417-21. 

17. Brookes ZLS, Stedman EN, Calo G, Guerrini R, Lambert DG. Proinflammatory and vasodilator effects of  nociceptin/orphaninFQ in the rat mesenteric microcirculation are mediated by histamine. Am J Physiol Heart Circ Physiol. 2007; 293(5):H2977-85.

18. Brookes ZLS, Reilly CS, Lawton BK, Brown NJ. Intravenous anesthesia inhibits leukocyte-endothelial  interactions and expression of CD11b following hemorrhage. Shock. 2006; 25(5):492-9.

19. Li Y, Brookes ZLS, Kaufman S. Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity  and compliance of the rat mesenteric arterial and venous vasculature. Regul Pept.  2005;132(13):41-6.

20. Hall E, Brookes ZL. Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regul Pept. 2005;131(1-3):34-7.

21. Dhawan V, Brookes ZLS, Kaufman S. Repeated pregnancies (multiparity) increases venous tone and  reduces compliance. Am J Physiol Regul Integr Comp Physiol . 2005; 289(1):R23-8.

22. Brookes ZLS, Kaufman S. Effects of atrial natriuretic peptide on the extrasplenic microvasculature and  lymphatics in the rat in vivo. J Physiol. 2005; 565(Pt 1):269-77.

23. Dhawan V, Brookes ZLS, Kaufman S. Long-term effects of repeated pregnancies (multiparity) on blood  pressure regulation. Cardiovasc Res. 2004; 64(1):179-86.

24. Brookes ZLS       ,Reilly CS, Brown NJ. Differential effects of propofol, ketamine and thiopental anaesthesia  on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo . Br J Anaesth 2004;93:249-56.

25. Brookes ZLS   , Kaufman SE. Myogenic responses andcompliance of mesenteric and splenic vasculature  in the rat. 2003; Am J Physiol Regul Integr Comp Physiol. 284: R1604-10.

26. Brookes ZLS , Brown NJ, Reilly CS. The dose-dependent effects of fentanyl in the dorsal microcirculatory  chamber. Anesth Analges 2003; 96:456-62.

27. Brookes ZLS , Brown NJ, Reilly CS. Effects of hemorrhage on the rat cremaster muscle microcirculation  in vivo during intravenous anesthesia. Shock 2002; 18: 542-548.

28. Brookes ZLS , Brown NJ, Reilly CS. Effects of haemorrhage on the rat mesenteric microcirculation in vivo  during intravenous anaesthesia. Br J Anaesth 2002; 88: 255-63.

29.  Brookes ZLS , Brown NJ, Reilly CS. Intravenous anaesthesia and the rat microcirculation: the dorsal microcirculatory chamber. Br J Anaesth 2000; 85(6): 901-3.

Review articles 

30. Brookes ZLS. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia &  Intensive Care Medicine 2013;14(1): 27-31. Updated.

31. Brookes ZLS. Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia &  Intensive Care Medicine 2010; 11(2): 78-82.

32. Brookes ZLS, McGown CC, Reilly CS. Statins for all: the new premed? Br J Anaesth 2009;103(1): 99- 107.

33. McGown CC, Brookes ZLS. Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br J Anaesth. 2007; 98(2):163-75.

Book chapters

Brookes ZL (2015). Pharmacological modulation of blood vessel calibre: Basic and advanced sciences for anaesthetic practice: prepare for the FRCA: Key articles from the Medicine and Intensive Care Journal. Elsevier, Ed. Nicholas Page