
Profiles
Dr Zoe Brookes
Associate Professor of Dental Education and Research
Peninsula Dental School (Faculty of Health)
Biography
Biography
Qualifications
Professional membership
GDC 252112
Senior Fellow of Advance HE (SFHEA)
Membership of the Faculty of Dental Surgery (Royal College of Surgeons, England)
British Dental Association
International Association for Dental Research / British Society Oral and Dental Research
British Vascular Biology and Microcirculation Society
Roles on external bodies
Assistant Treasurer and committee member, British Society Oral and Dental Research
CDO CVD advisory board committee member
External Programme Examiner for BMedSci (intercalated research degree), School of Medicine, University of Sheffield
CRN NIHR Oral and Dental sub Specialty Lead, South West and Wales
CRN Primary Care Dental Champion, South West and Wales
BHF grant reviewer
Teaching
Teaching
Teaching interests
Undergraduate small and large group teaching, plenaries and curriculum design for BDS and BSc DTH courses
Research
Research
Research interests
Publications
Publications
Key publications
Key publications are highlighted
Journals
Ali K, Gupta P, Turay E, Burns L, Brookes Z, Raja M. Dentistry in a multi-cultural society: Impact of animal-based products on person-centred care. British Dental Journal 2021 In Press.
Ali K, Venkatasami N, Zahra D, Brookes Z, Kisielewska J. Evaluation of sepsis teaching for medical and dental students at a British University. Eur J Dent Educ. 2021 Jun 15. doi: 10.1111/eje.12702.
Brookes ZLS, Bescos R, Belfield LA, Ali K, Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020;103:103497. doi: 10.1016/j.jdent.2020.103497
Bescos R, Brookes Z, Belfield L, Fenandez-Sanjuro M, Casas-Agustench P. Modulation of oral microbiota: A new frontier in exercise supplementation. PharmaNutrition 14 2020: 100230.
Bescos, R., Casas-Agustench, P., Belfield, L., Brookes, Z., & Gabaldón, T. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 002203452093214. doi:10.1177/0022034520932149
Zahra, D., Bennett, J., Belfield, L., Ali, K., McIlwaine, C., Bruce, M., . . . Zaric, S. (2019). Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum. European Journal of Dental Education. doi:10.1111/eje.12451
McIlwaine, C., Brookes, Z. L. S., Zahra, D., Ali, K., Zaric, S., Jones, G., & Belfield, L. A. (2019). A novel, integrated curriculum for dental hygiene-therapists and dentists. British Dental Journal, 226, 67. Retrieved from https://doi.org/10.1038/sj.bdj.2019.10
McGown, C. C., Brookes, Z. L. S., Hellewell, P. G., Ross, J. J., & Brown, N. J. (2015). Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(5), 557-564. doi:10.1007/s00210-015-1100-y
Alfieri, A., Ong, A. C. M., Kammerer, R. A., Solanky, T., Bate, S., Tasab, M., . . . Brookes, Z. L. (2014). Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin. Pharmacological Research, 80, 43-51. doi:10.1016/j.phrs.2013.12.008
Brookes, Z. L. S., Stedman, E. N., Brown, N. J., Hebbes, C. P., Guerrini, R., Calo, G., . . . Lambert, D. G. (2013). The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo. PLoS ONE, 8(9), e74943. doi:10.1371/journal.pone.0074943
Brookes, Z. L. S., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., . . . Ong, A. C. M. (2013). Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. American Journal of Physiology-Heart and Circulatory Physiology, 304(1), H33-H41. doi:10.1152/ajpheart.01102.2011
Brookes, Z. L. S. (2013). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 14(1), 27-31. doi:10.1016/j.mpaic.2012.11.002
Lawton, B. K., Brown, N. J., Reilly, C. S., & Brookes, Z. L. S. (2012). Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. British Journal of Anaesthesia, 108(6), 929-935. doi:10.1093/bja/aes069
Reeves, K. J., Brookes, Z. L. S., Reed, M. W. R., & Brown, N. J. (2012). Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation. Journal of Vascular Research, 49(2), 132-143. doi:10.1159/000331281
Alfieri, A., Watson, J. J., Kammerer, R. A., Tasab, M., Progias, P., Reeves, K., . . . Brookes, Z. L. (2012). Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Critical Care, 16(5), R182. doi:10.1186/cc11666
McGown, C. C., Brown, N. J., Hellewell, P. G., & Brookes, Z. L. S. (2011). ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. Microvascular Research, 81(3), 281-288. doi:10.1016/j.mvr.2011.02.003
Debono, M., Sheppard, L., Irving, S., Jackson, P., Butterworth, J., Brookes, Z. L. S., . . . Ross, R. J. (2011). Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery. European Journal of Endocrinology, 164(3), 413-419. doi:10.1530/eje-10-0996
Mansart, A., Ruff, L. J., Ariaans, M. P., Ross, J. J., Reilly, C. S., Brown, N. J., . . . Brookes, Z. L. S. (2010). Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(6), 555-562. doi:10.1007/s00210-010-0514-9
Brookes, Z. L. S. (2010). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 11(2), 78-82. doi:10.1016/j.mpaic.2009.10.018
McGown, C. C., Brown, N. J., Hellewell, P. G., Reilly, C. S., & Brookes, Z. L. S. (2010). Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. British Journal of Anaesthesia, 104(2), 183-190. doi:10.1093/bja/aep361
Scicluna, J. K., Mansart, A., Ross, J. J., Reilly, C. S., Brown, N. J., & Brookes, Z. L. S. (2009). Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects. European Journal of Pharmacology, 621(1-3), 67-70. doi:10.1016/j.ejphar.2009.08.029
Brookes, Z. L. S., Mansart, A., McGown, C. C., Ross, J. J., Reilly, C. S., & Brown, N. J. (2009). Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia. Lymphatic Research and Biology, 7(3), 131-137. doi:10.1089/lrb.2008.1019
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., McGown, C. C., & Reilly, C. S. (2009). Statins for all: the new premed?. British Journal of Anaesthesia, 103(1), 99-107. doi:10.1093/bja/aep149
Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccahride abolishes extra-splenic vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin-1. Shock 2008; 29(6):675-80. 10.1097/shk.0b013e31815811a3
Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Diminished contraction of rat peripheral arteries to phenylephrine,during exposure to lipopolysaccharide in vitro, involves nitric oxide and endothelin-1. Shock 2008; 29(3):417-21.10.1097/shk.0b013e318142c5df
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009.). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., Stedman, E. N., Guerrini, R., Lawton, B. K., Calo, G., & Lambert, D. G. (2007). Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), H2977-H2985. doi:10.1152/ajpheart.00448.2007
McGown, C. C., & Brookes, Z. L. S. (2007). Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. British Journal of Anaesthesia, 98(2), 163-175. doi:10.1093/bja/ael358
Brookes, Z. L. S., Reilly, C. S., Lawton, B. K., & Brown, N. J. (2006). Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of cd11b after hemorrhage. Shock, 25(5), 492-499. doi:10.1097/01.shk.0000209541.76305.8e
Li, Y., Brookes, Z. L. S., & Kaufman, S. (2005). Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regulatory Peptides, 132(1-3), 41-46. doi:10.1016/j.regpep.2005.09.009
Hall, E., & Brookes, Z. L. S. (2005). Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regulatory Peptides, 131(1-3), 34-37. doi:10.1016/j.regpep.2005.06.006
Dhawan, V., Brookes, Z. L. S., & Kaufman, S. (2005). Repeated pregnancies (multiparity) increases venous tone and reduces compliance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289(1), R23-R28. doi:10.1152/ajpregu.00034.2005
Brookes, Z. L. S., & Kaufman, S. (2005). Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. The Journal of Physiology, 565(1), 269-277. doi:10.1113/jphysiol.2005.083147
Dhawan, V., Brookes, Z., & Kaufman, S. (2004). Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation. Cardiovascular Research, 64(1), 179-186. doi:10.1016/j.cardiores.2004.06.018
Brookes, Z. L., Reilly, C. S., & Brown, N. J. (2004). Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo. British Journal of Anaesthesia, 93(2), 249-256. doi:10.1093/bja/aeh190
Brookes, Z. L. S., & Kaufman, S. (2003). Myogenic responses and compliance of mesenteric and splenic vasculature in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284(6), R1604-R1610. doi:10.1152/ajpregu.00411.2002
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2003). The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo. Anesthesia & Analgesia, 96(2), 456-462. doi:10.1097/00000539-200302000-00030
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents. Shock, 18(6), 542-548. doi:10.1097/00024382-200212000-00010
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. British Journal of Anaesthesia, 88(2), 255-263. doi:10.1093/bja/88.2.255
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2000). Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber. British Journal of Anaesthesia, 85(6), 901-903. doi:10.1093/bja/85.6.901
Brookes ZL (2015). Pharmacological modulation of blood vessel calibre: Basic and advanced sciences for anaesthetic practice: prepare for the FRCA: Key articles from the Medicine and Intensive Care Journal. Elsevier, Ed. Nicholas Page