Dr Vikram Sharma
Lecturer in Biomedical Sciences
School of Biomedical Sciences (Faculty of Health)
Lecturer in Biomedical Sciences & Head of Proteomics Core Laboratory
BSc (Hons) Biochemistry, 2001
MSc (Hons) Biochemistry (Research Masters), 2003
PhD (CSIR Fellow), Pharmacology and Toxicology, 2008
PgCert in Academic Practice, 2016
BBTS Red Cell SIG
Fellow of the HigherEducation Academy, UK
Roles on external bodies
I regularly review research articles from PLOS ONE, Proteomics-Clinical Applications (Wiley), Canadian Journal of Physiology and Pharmacology, Drug Design, Development and Therapy, Current Biomarkers Findings, Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Journal of Blood Medicine (Dovepress). Besides this, I review/assess fellowship applications for The Royal College of Surgeons of England.
I am also an Editorial Board Member in Journal of Natural Science, Biology and Medicine, BEMS Reports and EC Pharmacology & Toxicology Journal.
Seminars on Proteomics and Bioinformatics based Data Analysis. Teaching and training sessions in Mass Spectrometry based Proteomics for undergraduates and postgraduates.
Lecturing in the following modules:
Personal tutor: BHCS1001, BHCS1002
Staff serving as external examiners
External reviewer for PhD thesis.
I am running the Proteomics Core Laboratory located within the Derriford Research Facility. We collaborate on various projects employing LC-MS based Proteomics and Bioinformatic workflows to address challenging research questions. Besides this, I also provide specialist advice on experimental designs for a wide range of research projects.
My research primarily focusses on development of customised LC-MS based Proteomic Workflows for a wide range of applications. I have keen interest in epigenetic post translational modifications and their role in disease pathology, cancer and toxic responses.
1. Mr Raed Garout: New methods for detection of Down's syndrome pregnancies. (Co-Supervisor)
2. Ms Yeasmin Akhter: Proteomics based profiling of meningiomas. (Co-Supervisor)
3. Ms Eugene Passaro: Anti Cancer Drug Design and Discovery ( International Exchange PhD Student with University of Naples, Italy)
Placement Students on Drug Discovery Projects:
Ms Karen Doyle
Ms Lizzie Clark
Past PhD students:
Dr Nizar Saeedi: Investigating Virulence of ST127 Uropathogenic Escherichia coli.
Ms Charlotte Crowther: Analytical, toxicogenomics and modelling approaches to determine the impacts of radionuclides and metals.
Current masters student:
Mr Jake Pennels Dovey : Deciphering the mode of action of new generation Epigenetic modifiers in Cancer.
There are 8 current undergraduate students on projects investigating novel drug targets in Non-Small Cell Lung Carcinoma (NSCLC) and B-ALL.
Previous UK and EU Research exchange trainees:
Research Assistant: Ms Avinisha Lal (Role of New generation of Epi-Drugs in Cancer)
Erasmus Exchange Student: Ms Aurore Hebras (University of Poitiers, France)
Previous undergraduate, placement and masters students:
Mr Jake Serle: Role of Epigenetic inhibitors in non small cell lung carcinoma.
Ms Lucinda Burt: Deciphering the mode of action of new generation Epigenetic modifiers in Non Small Cell Lung Carcinoma
Mr Daniel Machin; Novel Epidrugs in NSCLC
Ms Maisie Fox: Epigenetic mechanisms underlying Acute Lymphoid Leukemia.
Mr Jordan Martin: Role of Hybrid Histone Deacetylase Inhibitors in Acute Lymphoid Leukemia
Mr Adam North: Proteomic profiling to reveal mode of action of UVI5008 in B-ALL
Ms Abena Yeboah: Proteomic based screen to investigate mode of action of NCE's in B-ALL
Ms Jasmin Mirzayan: Role of Hybrid Epi-Drugs in B-ALL.
Mr Ojieriakhi Ede-Ehizode
Mr Toby Huxtable
Potential new positions:
Self funded PhD/ResM applicants are encouraged to apply.
Grants & contracts
Key publications are highlightedJournals
IBMS accredited CPD event: Workshop on "Hands On Proteomics and Data Analysis" (2014)
Other academic activities
Supervision of undergraduate, postgraduate and PhD students. I also offer summer placement, masters and undergraduate research projects. External reviewer for PhD dissertations.