Dr Torsten Bossing
Profiles

Dr Torsten Bossing

Visiting Research Fellow

Plymouth University Peninsula Schools of Medicine and Dentistry (NC)

Role

Senior Research Fellow, Head of Imaging Suite at John Bull

Qualifications

1991 Diploma, Johannes Gutenberg University Mainz, Germany

1996 Dr.rer.nat., Johannes Gutenberg University, Germany

Teaching interests

Since2013               Teaching and Lecturing at Plymouth University

                                 Personal Research Project (3001-X),     

                                Methods in Human Biosciences (BHCS2019)

                                Evidence-Based Practice in Biomedical Sciences(BHCS2002)

                                Current Issues in Neurobiology (BHCS3007)

                                Master Research Project (BIOM5006) 

                                Teaching and Supervision of undergraduates, postgraduates and staff in advanced microscopy    

2012- 2013              Lecturer and Convener of ‘Neurobiology of CNS Disorders’, Bangor University

2011-2013              Lecturer in ‘Biosciences,Enterprise and Employability’, Bangor University

2010- 2013              Convener of the modules ‘CurrentTopics in Life Sciences’; ‘Experimental Projects’ and ‘Literature Projects’;Lecturer in Human Physiology – Brain Physiology; Head of the Third Year students, Personal Tutor at the School of Biological Sciences at Bangor University

since 2007                Supervision of postgraduate and undergraduate students during their research projects

Research interests

Understanding the workings of the human central nervous system (CNS) with its millions of neurons generating trillions of connections is a formidable challenge. Fortunately, to uncover the basic rules, we can turn to simpler organisms. I am making use of the simple fruit fly Drosophila to study evolutionary conserved mechanisms in CNS development and disease. Using classical genetics, molecular biology, transgenics and micromanipulation I study the embryonic development of the CNS to understand how damage in the CNS can be repaired. I also investigate the transcriptional program ensuring the correct formation of neural networks

Research degrees awarded to supervised students

primary supervisor: 


current: 1 PhD student, 1MSc student;      

completed: 1PhD (2014), 1 completed MRes (2013), 1 completed MSc (2015)

Grants & contracts

2015                         PhDstipend awarded by Medical Faculty, Plymouth University (GBP 52k/ 3 years         

2014                           collaborator in BBSRCGrant (Responsive Mode), Principal Investigator Dr. Claudia Barros (GBP 390k/ 3years)

2012                         Royal Society Research Grant (GBP14,8k/ 1 year)

2010                         Tenovus Cancer Charity UK(co-supervisor, GBP 115k/ 4 years)

2009                          ResearchLectureship sponsored by Bioscience, Environment and Agriculture Alliance (GBP220k/ 4 years)

2008                          GeraldKerkut PhD Studentship (GBP 57k/ 3 years)

1998- 2007                WellcomeResearch Associate

1996- 1998               European Fellowship (Human Capital and Mobility)

1996                         Prize forthe best Ph.D. Thesis at the Johannes Gutenberg University, Faculty of Biology

Sealey, M.A., Vourkou, E., Cowan, C.M., Bossing,T., Quraishe S., Grammenoudi, S., Skoulakis, E.M.C and Mudher, A. (2017): Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy. Neurobiology of Disease, doi: 10.1016/j.nbd.2017.05.003

 

Liu, B and Bossing, T. (2016): Single neuron transcriptomics identify SRSF/ SRprotein B52 as a regulator of axon growth and Choline acetyltransferase synthesis. SciRep. 11;6:34952. doi: 10.1038/srep34952.

 

Ding, R., Weynans K., Bossing, T.,Barros, C. and Berger, C (2016): The Hippo signaling pathway maintains quiescence in Drosophila neural stem cells.  Nat Commun29;7: 10510. doi: 10.1038/ncomms10510 

 

Liu, B., Campos, E. M. and Bossing, T.(2014): Drosophila Embryos as Model to AssessCellular and Developmental Toxicity of Multi-Walled Carbon Nanotubes (MWCNT) in Living Organisms. PLoS One18;9(2):e88681. doi:10.1371/journal.pone.0088681 

 

Bossing, T (corresponding author).,Barros, C.S., Fischer B., Russell, S. and Shepherd, D. (2012): Disruption of microtubules integrity initiates mitosis during CNS repair. Dev Cell 23, 433-440 

Cowan, C, Bossing, T., Page A.,Shepherd, D. and Mudher, A. (2010): Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta Neuropathologica 120, 593-604

Choksi, S.P., Southall, T., Bossing, T.,Edoff, K., de Wit, E., van Steensel, B., Micklem, G., Brand, A.H. (2006): Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev Cell 11, 775-789. 


Bossing, T.and Brand, A. H. (2006): Determination of cell fate along the antero-posterior axis of the Drosophila ventral midline. Development 133, 1001-1012 

Bossing, T.and Brand, A. H. (2002a): Dephrin, a transmembrane Ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophila embryonic CNS. Development 129, 4205-4218. 

Bossing, T.,Barros, C. S. and Brand A.H. (2002b): Rapid tissue-specific expression assay in living embryos. Genesis 34(1-2),123-126. 

 

Dittrich, R, Bossing, T., Gould, A.P.,Technau, G.M. and Urban, J. (1997): The differentiation of the serotonergic neurons in the Drosophila ventral nerve cord depends on the combined function of the zinc finger proteins eagle and huckebein. Development  124, 2515-2525.

 

Landgraf, M., Bate, C.M, Bossing, T. andTechnau, G.M. (1997): The origin, location and projection of the embryonic abdominal motoneurons of Drosophila., J. Neurosci. 17, 9642-9655. 

 

Schmidt, H., Rickert, C., Bossing, T.,Vef, O., Urban, J. and Technau, G.M. (1997): The embryonic CNS lineages of Drosophila melanogaster: II. The lineages derived from the dorsal part of the neuroectoderm. Dev. Biol.189,186-204. 

 

Bossing, T.,Udolph, G., Doe, C.Q. and Technau, G.M. (1996): The embryonic CNS lineages of Drosophila melanogaster: I. The lineages derived from the ventral half of the truncal neuroectoderm. Dev. Biol.179, 41-61. 

Bossing, T.,Technau, G.M. and Doe, C.Q. (1996): huckebein  is required for glial specification and axon pathfinding in the NB1-1 and NB2-2 lineages in the Drosophila CNS. Mech.Dev. 55, 53-64. 

Broadus, J., Skeath, J.B., Spana, E., Bossing,T., Technau, G.M. and Doe, C.Q. (1995): New neuroblast markers and the origin of the aCC/ pCC neurons in the Drosophila CNS. Mech. Dev.  54, 1-10. 

 

Udolph, G., Lüer, K., Bossing, T. andTechnau, G.M. (1995): Commitment of CNS progenitors along the dorsoventral axis of Drosophila neuroectoderm. Science  269, 1278-1281. 

 

Bossing, T.and Technau, G.M. (1994): The fate of the CNS midline progenitors in Drosophila as revealed by a new method for single cell labelling. Development  120, 1895-1906. 

Udolph, G., Prokop, A., Bossing, T. andTechnau, G.M. (1993): A common precursor for glia and neurons in the embryonic CNS of Drosophila gives rise to segment-specific lineage variants. Development 118, 765-775.