- R2RL26, John Bull, Drake Circus, Plymouth, PL4 8AA
- +44 1752 437414
- torsten.bossing@plymouth.ac.uk

Profiles
Dr Torsten Bossing
Senior Research Fellow
Peninsula Medical School (Faculty of Health)
- Neuroscience
- Light microscopy
- Alzheimer's disease
- Nervous system damage
- Experimental methods
- Laboratory methods
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
Senior Research Fellow, Head of Plymouth Light Microscopy (PLiMS, https://www.plymouth.ac.uk/research/plymouth-light-microscopy-service)
Qualifications
1991 Diploma, Johannes Gutenberg University Mainz, Germany
Professional membership
member of British Society of Developmental Biology (BSDB)
Fellow of the Royal Microscopical Society (RMS)
Fellow of Advance Higher Education (Advance HE)
Key publications
Teaching
Teaching
Teaching interests
Since 2013
Teaching and Lecturing at Plymouth University
Personal Research Project (3001-X),
Methods in Human Biosciences (BHCS2019)
Medicine in Society (SSC2)
Current Issues in Neurobiology (BHCS3007)
Master Research Project (BIOM5006)
Teaching and Supervision of undergraduates, postgraduates and staff in advanced microscopy
2012- 2013
Lecturer and Convener of ‘Neurobiology of CNS Disorders’, Bangor University
2011-2013 Lecturer in ‘Biosciences, Enterprise and Employability’, Bangor University
2010-2013 Convener of the modules ‘Current Topics in Life Sciences’; ‘Experimental Projects’ and ‘Literature Projects’; Lecturer in Human Physiology – Brain Physiology; Head of the Third Year students, Personal Tutor at the School of Biological Sciences at Bangor University
Since 2007
Supervision of postgraduate and undergraduate students during their research projects.
Research
Research
Research interests
Understanding the workings of the human central nervous system (CNS) with its millions of neurons generating trillions of connections is a formidable challenge. Fortunately, to uncover the basic rules, we can turn to simpler organisms. I am making use of the simple fruit fly Drosophila to study evolutionary conserved mechanisms in CNS development and disease. #
Using classical genetics, molecular biology, transgenics and micromanipulation I study the embryonic development of the CNS to understand how damage in the CNS can be repaired. I also investigate the transcriptional program ensuring the correct formation of neural networks.
Research degrees awarded to supervised students
Primary supervisor:
Grants & contracts
2015: PhDstipend awarded by Medical Faculty, Plymouth University (GBP 52k/ 3 years
2014: Collaborator in BBSRCGrant (Responsive Mode), Principal Investigator Dr. Claudia Barros (GBP 390k/ 3years)
2012: Royal Society Research Grant (GBP14,8k/ 1 year)
2010: Tenovus Cancer Charity UK(co-supervisor, GBP 115k/ 4 years)
2009: Research Lectureship sponsored by Bioscience, Environment and Agriculture Alliance (GBP220k/ 4 years)
2008: GeraldKerkut PhD Studentship (GBP 57k/ 3 years)
1998- 2007: WellcomeResearch Associate
1996- 1998: European Fellowship (Human Capital and Mobility)
1996: Prize forthe best Ph.D. Thesis at the Johannes Gutenberg University, Faculty of Biology
Publications
Publications
Key publications
Key publications are highlighted
JournalsPersonal
Personal
Other academic activities
Publications
Gil-Ranedo J, Gonzaga E, Jaworek KJ, Berger C, Bossing T, Barros CS. (2019).STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.Cell Rep.10, 2921-2933.e5. doi: 10.1016/j.celrep.2019.05.023.
Sealey,M.A., Vorkou, E., Cowan, C.M., Bossing, T., QuraisheS., Grammenoudi, s., Skoulakis, E.M.C and Mudher, A.(2017).Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy. Neurobiol Dis. 11; 105, 74-83. Doi: 10.1016/j.nbd.2017.05.003
Liu, B and Bossing, T (2016).Single neuron transcriptomics identify SRSF/ SR protein B52 as a regulator of axon growth and Choline acetyltransferase synthesis. Scientific Reports6, 34952, 10.1038/srep34952
Ding, R., Weynans K., Bossing, T.,Barros, C. and Berger, C (2016). The Hippo signaling pathway maintains quiescence in Drosophila neural stem cells. Nat Commun29;7: 10510. doi: 10.1038/ncomms10510 (2 citations)
Liu, B., Campos, E. M. and Bossing, T. (2014):Drosophila Embryos as Model to Assess Cellular and Developmental Toxicity of Multi-Walled Carbon Nanotubes (MWCNT) in Living Organisms.PLoS One 9 (5 citations)
Bossing, T (corresponding author)., Barros, C.S., Fischer B., Russell, S. and Shepherd, D. (2012): Disruption of microtubules integrity initiates mitosis during CNS repair. Dev Cell23, 433-440 (4 citations)
Cowan, C, Bossing, T., Page A., Shepherd, D. and Mudher, A. (2010): Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo. Acta Neuropathologica120, 593-604 (54 citations)
Choksi, S.P., Southall, T., Bossing, T., Edoff, K., de Wit, E., van Steensel, B., Micklem, G., Brand, A.H. (2006):Prospero acts as a binary switch between self-renewal and differentiation in Drosophilaneural stem cells. Developmental Cell11, 775-789. (256 citations)
Bossing, T. and Brand, A. H. (2006): Determination of cell fate along the antero-posterior axis of the Drosophilaventral midline.Development133, 1001-1012 (25 citations)
Bossing, T.and Brand, A. H.(2002a): Dephrin, a transmembrane ephrin with a unique structure, prevents interneuronal axons from exiting the Drosophilaembryonic CNS. Development129, 4205-4218. (51 citations)
Bossing, T., Barros, C. S. and Brand A.H.(2002b): Rapid tissue-specific expression assay in living embryos. Genesis34(1-2), 123-126. (12 citations)
Dittrich, R, Bossing, T., Gould, A.P., Technau, G.M. and Urban, J.(1997): The differentiation of the serotonergic neurons in the Drosophilaventral nerve cord depends on the combined function of the zinc finger proteins eagleand huckebein. Development 124, 2515-2525. (98 citations)
Landgraf, M., Bate, C.M, Bossing, T.and Technau, G.M.(1997): The origin, location and projection of the embryonic abdominal motoneurons of Drosophila., J. Neurosci. 17, 9642-9655. (209 citations)
Schmidt, H., Rickert, C., Bossing, T., Vef, O., Urban, J. and Technau, G.M. (1997): The embryonic CNS lineages of Drosophila melanogaster: II. The lineages derived from the dorsal part of the neuroectoderm.Dev. Biol.189, 186-204. (342 citations)
Bossing, T., Udolph, G., Doe, C.Q. and Technau, G.M.(1996a): The embryonic CNS lineages ofDrosophila melanogaster: I. The lineages derived from the ventral half of the truncal neuroectoderm. Dev. Biol.179, 41-61.(378 citations)
Bossing, T., Technau, G.M. and Doe, C.Q.(1996b): huckebein is required for glial specification and axon pathfinding in the NB1-1 and NB2-2 lineages in the DrosophilaCNS. Mech. Dev. 55, 53-64. (28 citations)
Broadus, J., Skeath, J.B., Spana, E., Bossing, T., Technau, G.M. and Doe, C.Q. (1995): New neuroblast markers and the origin of the aCC/ pCC neurons in the DrosophilaCNS. Mech. Dev. 54, 1-10. (196 citations)
Udolph, G., Lüer, K., Bossing, T.and Technau, G.M.(1995): Commitment of CNS progenitors along the dorsoventral axis of Drosophilaneuroectoderm. Science 269, 1278-1281. (41 citations)
Bossing, T.and Technau, G.M.(1994): The fate of the CNS midline progenitors in Drosophilaas revealed by a new method for single cell labelling. Development 120, 1895-1906. (176 citations)
Udolph, G., Prokop, A., Bossing, T.and Technau, G.M.(1993): A common precursor for glia and neurons in the embryonic CNS of Drosophilagives rise to segment-specific lineage variants. Development118, 765-775. (125 citation)