Dr Nicola King
Profiles

Dr Nicola King

Lecturer in Cardiac Physiology (Education)

School of Biomedical Sciences (Faculty of Health)

Biography

Biography

Lecturer in Cardiac Physiology

Qualifications

  • BSc Hons - Napier University, Edinburgh
  • PhD - Newcastle University, Newcastle Upon Tyne
  • PgCAP - University of Plymouth

Professional membership

British Society for Cardiovascular Research

The Physiological Society

Roles on external bodies

Chair - Association of Clinical Physiology Educators
Former elected member of the executive board of the British Society for Cardiovascular Research

Teaching

Teaching

Teaching interests

I largely teach all aspects of cardiovascular science including physiology, pathophysiology and pharmacotherapy. However, you will also find me teaching other aspects of physiology to Foundation year and first year students 


I am module leader for:
  • BHCS1008: Cardiovascular and respiratory physiology
  • BHCS2018 (Z): Systems physiology: function and dysfunction
  • BHCS3018: Specialist cardiovascular investigations.
I am the programme lead for:
BSc Hons Biomedical Science with Integrated Foundation Year


Staff serving as external examiners

University of Ulster 2021-2024

Research

Research

Research interests

The major thrust of my research is to explore different approaches to improving the outcomes of patients undergoing cardiac surgery or cardiology interventions. The method used is systematic review and meta-analysis.  

Other research

Classically a major focus of my research is the role of amino acids and small peptides in the heart. In particular I concentrate on membrane transport, hypertrophy, and myocardal protection against ischaemia reperfusion. Membrane transport has been a mainstay of my research going right back to my PhD days. Most recent publications have investigated dipeptide transport in the kidney under various conditions.

Research degrees awarded to supervised students

PhD Helen Williams

Grants & contracts

2009-2012 - The Brunei healthy heart projects: sourcing strategic Halal antioxidants. Brunei Government 1,440,000 BND


2007 - Can nurses and biomedical scientists learn and work interprofessionally? A pilot in Brunei for a comparative regional study. 1837.5 BND

2005-2007 - An investigation into the expression and activity of cysteine transporters in heart: relationship to glutathione synthesis and cardioprotection. British Heart Foundation (BHF) £126,200

2002-2004 - Amino acids and myocardial hypertrophy: expression, transport and protection. BHF Intermediate Fellowship £131,732

2002-2004 - An investigation into the expression and activity of the cystine-glutamate exchanger in relation to glutathione's role in myocardial protection. BHF £84,270

1999-2001 - An investigation into the cardioprotective action of glutamate and expression and regulation of its transporters in the heart. BHF Junior research fellowship. £66,410

1999-2001 - An investigation of the expression and regulation of glutamate and aspartate transporters in heart and their implications to myocardial protection. BHF £66,112 

Publications

Publications

Key publications

Key publications are highlighted

Journals

Articles
Reynolds AC, Asopa S, Modi A & King N (2021) 'HTK versus multidose cardioplegias for myocardial protection in adult cardiac surgery: A meta‐analysis' Journal of Cardiac Surgery 36, (4) 1334-1343 , DOI Open access
Demerchi SA, King N, McFarlane JR & Moens PDJ (2021) 'Effect of methionine feeding on oxidative stress, intracellular calcium and contractility in cardiomyocytes isolated from male and female rats' Molecular and Cellular Biochemistry 476, (5) 2039-2045 , DOI
Alghamdi O, King N, Jones GL & Moens PDJ (2021) 'Effect of ageing and hypertension on the expression and activity of PEPT2 in normal and hypertrophic hearts' Amino Acids 53, (2) 183-193 , DOI
King N (2020) 'Pandemic Struggles of the Mad Professor' Schizophrenia Bulletin 47, (2) 271-272 , DOI
Owen CM, Asopa S, Smart NA & King N (2020) 'Microplegia in cardiac surgery: Systematic review and meta‐analysis' Journal of Cardiac Surgery 35, (10) 2737-2746 , DOI Open access
Ahmad Demerchi S, Robert McFarlane J, Dominique Jean Moens P & King N (2020) 'Effect of L-Methionine Feeding on Serum Homocysteine and Glutathione Levels in Male and Female Wistar Rats' Advances in Biochemistry 8, (1) 21-21 , DOI Open access
Mauldon H, Dieberg G, Smart N & King N (2020) 'Effect of Age on Clinical Outcomes Following On-/Off-Pump Coronary Artery Bypass: MetaAnalysis and Meta-Regression' Brazilian Journal of Cardiovascular Surgery 35, (5) , DOI
Ameen HMH, Alwan MH & King N (2019) 'Relationship between Initial High-Sensitivity Cardiac Troponin-T Morbidity and Mortality in Patients after ST-Elevation Myocardial Infarction in Erbil City, Iraq' Journal of heart and cardiology , DOI Open access
Pincombe NL, Pearson MJ, Smart NA, King N & Dieberg G (2019) 'Effect of vitamin D supplementation on endothelial function – An updated systematic review with meta-analysis and meta-regression' Nutrition, Metabolism and Cardiovascular Diseases , DOI Open access
King N (2019) 'The Mad Professor' Schizophrenia Bulletin , DOI Open access
Smart NA, King N, Lambert JD, Pearson MJ, Campbell JL, Risom SS & Taylor RS (2018) 'Exercise-based cardiac rehabilitation improves exercise capacity and health-related quality of life in people with atrial fibrillation: a systematic review and meta-analysis of randomised and non-randomised trials' Open Heart Open access
King N & Mann V (2018) 'Why do on-pump patients live longer?' Aging 10, (10) 2553-2554 Author Site , DOI Open access
Reynolds AC & King N (2018) 'Hybrid coronary revascularization versus conventional coronary artery bypass grafting: Systematic review and meta-analysis' Medicine 97, (33) Author Site , DOI Open access
Alghamdi OA, King N, Andronicos NM, Jones GL, Chami B, Witting PK & Moens PDJ (2018) 'Molecular changes to the rat renal cotransporters PEPT1 and PEPT2 due to ageing' Molecular and Cellular Biochemistry 452, (1-2) 71-82 , DOI Open access
Pearson MJ, King N & Smart NA (2018) 'Effect of exercise therapy on established and emerging circulating biomarkers in patients with heart failure: a systematic review and meta-analysis' Open Heart 5, (2) e000819-e000819 , DOI Open access
Smart NA, Dieberg G & King N (2018) 'Reply' Journal of the American College of Cardiology 72, (3) 347-347 , DOI Open access
Smart N, Dieberg G & King N (2018) 'Long-term outcomes of on vs. off pump coronary artery bypass grafting' Journal of the American College of Cardiology , DOI Open access
Alghamdi OA, King N, Jones GL & Moens PDJ (2017) 'A new use of β-Ala-Lys (AMCA) as a transport reporter for PEPT1 and PEPT2 in renal brush border membrane vesicles from the outer cortex and outer medulla' Biochimica et Biophysica Acta - Biomembranes 1860, (5) 960-964 Author Site , DOI Open access
Jewiss D, Ostman C, King N & Smart NA (2017) 'Clinical Outcomes to Exercise Training in Type 1 Diabetes: A Systematic Review and Meta-Analysis' Diabetes Research and Clinical Practice Author Site , DOI Open access
King N (2017) 'Is there a long-term survival benefit with on pump coronary artery bypass grafting?' Annals of Translational Medicine 498-498 , DOI Open access
Alghamdi OA, King N, Jones GL & Moens PDJ (2017) 'Kinetic Measurements of Di- and Tripeptide and Peptidomimetic Drug Transport in Different Kidney Regions Using the Fluorescent Membrane Potential-Sensitive Dye, DiS-C3-(3)' Journal of Membrane Biology 250, (6) 641-649 Author Site , DOI Open access
King N, Daham AN & Al-Meshhadani MH (2017) 'Cardiac auscultation versus two-dimensional transthoracic echocardiography in the detection of native aortic and mitral valve disease in Erbil city' Journal of Heart and Cardiology , DOI Open access
King N (2017) 'On vs. off pump coronary artery bypass grafting: the next chapter' Annals of Translational medicine 5, (5) 116-116 , DOI Open access
Dieberg G, Smart NA & King N (2016) 'Minimally invasive cardiac surgery: A systematic review and meta-analysis' INTERNATIONAL JOURNAL OF CARDIOLOGY 223, 554-560 Author Site , DOI Open access
Dieberg G, Smart NA & King N (2016) 'On- vs. off-pump coronary artery bypass grafting: A systematic review and meta-analysis' International Journal of Cardiology , DOI Open access
King N, Dieberg G & Smart NA (2016) 'Effects of pre-procedural remote ischaemic pre-conditioning on the outcomes of elective percutaneous coronary intervention. A systematic review and meta-analysis' Clinical Trials and Regulatory Science in Cardiology 21, 1-6 , DOI Open access
King N, Van der Touw T, Spowart L & Lawlor C (2016) 'A scoping study investigating student perceptions towards inquiry based learning in the laboratory' European Journal of Science and Mathematics Education Publisher Site Open access
Smart NA, King N, McFarlane JR, Graham PL & Dieberg G (2016) 'Effect of exercise training on liver function in adults who are overweight or exhibit fatty liver disease: a systematic review and meta-analysis' British Journal of Sports Medicine bjsports-2016-096197-bjsports-2016-096197 , DOI Open access
King N, Dieberg G & Smart NA (2016) 'Remote ischaemic pre-conditioning does not affect clinical outcomes following coronary Artery bypass grafting. A systematic review and meta-analysis' Clinical Trials and Regulatory Science in Cardiology 17, 1-8 , DOI Open access
Riyadh Thiab N, King N, McMillan M, Almashhadany A & L Jones G (2016) 'Age-related protein and mRNA expression of glutathione peroxidases (GPx) and Hsp-70 in different regions of rat kidney with and without stressor' AIMS Molecular Science 3, (2) 125-137 , DOI
Thiab NR, King N & Jones GL (2015) 'Effect of ageing and oxidative stress on antioxidant enzyme activity in different regions of the rat kidney' Molecular and Cellular Biochemistry 408, (1-2) 253-260 , DOI
Thiab NR, King N & Jones GL (2015) 'Effects of ageing on metabolite and oxidant concentrations in different regions of rat kidney under normal and stress conditions' Molecular and Cellular Biochemistry 408, (1-2) 55-61 , DOI
Almashhadany A, Alghamdi OA, Van der Touw T, Jones GL & King N (2015) 'l-Glycyl-l-glutamine provides the isolated and perfused young and middle-aged rat heart protection against ischaemia–reperfusion injury' Amino Acids 47, (8) 1559-1565 , DOI
Almashhadany A, Shackebaei D, Van der Touw T, Jones GL, Suleiman M-S & King N (2015) 'Homocysteine Exposure Impairs Myocardial Resistance to Ischaemia Reperfusion and Oxidative Stress' Cellular Physiology and Biochemistry 37, (6) 2265-2274 , DOI
King N, Al Shaama M & Suleiman M-S (2012) 'Propofol improves recovery of the isolated working hypertrophic heart from ischaemia–reperfusion' Pflügers Archiv - European Journal of Physiology 464, (5) 513-522 , DOI
King N, Lin H & Suleiman M-S (2010) 'Oxidative stress increases SNAT1 expression and stimulates cysteine uptake in freshly isolated rat cardiomyocytes' Amino Acids 40, (2) 517-526 , DOI
King N, Lin H & Suleiman M-S (2010) 'Cysteine protects freshly isolated cardiomyocytes against oxidative stress by stimulating glutathione peroxidase' Molecular and Cellular Biochemistry 343, (1-2) 125-132 , DOI
(2010) 'RT-PCR Protocols' , DOI
King N (2010) 'The Use of Comparative Quantitative RT-PCR to Investigate the Effect of Cysteine Incubation on GPx1 Expression in Freshly Isolated Cardiomyocytes' 215-232 , DOI
King N (2007) 'Measurement of cardiac gene expression by reverse transcription polymerase chain reaction (RT-PCR)' Methods Mol Biol 366, 109-119 Author Site , DOI
Lin H & King N (2006) 'Demonstration of functional dipeptide transport with expression of PEPT2 in guinea pig cardiomyocytes' Pflügers Archiv - European Journal of Physiology 453, (6) 915-922 , DOI
King N, Lin H, McGivan JD & Saadeh Suleiman M (2006) 'Expression and activity of the glutamate transporter EAAT2 in cardiac hypertrophy: implications for ischaemia reperfusion injury' Pflügers Archiv - European Journal of Physiology 452, (6) 674-682 , DOI
Shackebaei D, King N, Shukla B & Suleiman M-S (2005) 'Mechanisms underlying the cardioprotective effect of l-cysteine' Molecular and Cellular Biochemistry 277, (1-2) 27-31 , DOI
King N, Korolchuk S, McGivan JD & Suleiman M-S (2004) 'A new method of quantifying glutathione levels in freshly isolated single superfused rat cardiomyocytes' Journal of Pharmacological and Toxicological Methods 50, (3) 215-222 , DOI
King N, Lin H, McGivan JD & Suleiman M-S (2004) 'Aspartate transporter expression and activity in hypertrophic rat heart and ischaemia-reperfusion injury' The Journal of Physiology 556, (3) 849-858 , DOI
King N (2003) 'Glutamate loading protects freshly isolated and perfused adult cardiomyocytes against intracellular ROS generation' Journal of Molecular and Cellular Cardiology 35, (8) 975-984 , DOI
Williams H, King N, Griffiths EJ & Suleiman M-S (2001) 'Glutamate-loading Stimulates Metabolic Flux and Improves Cell Recovery Following Chemical Hypoxia in Isolated Cardiomyocyte' Journal of Molecular and Cellular Cardiology 33, (12) 2109-2119 , DOI
Williams H, King N, Griffiths EJ & Suleiman MS (2001) 'Glutamate-loading stimulates metabolic flux and improves cell recovery following chemical hypoxia in isolated cardiomyocytes' JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY 33, (12) 2109-2119 Author Site , DOI
King N (2001) 'Characteristics of ?-aspartate transport and expression of EAAC-1 in sarcolemmal vesicles and isolated cells from rat heart' Cardiovascular Research 52, (1) 84-94 , DOI
King N & Suleiman M-S (1998) 'Effect of regular training on the myocardial and plasma concentrations of taurine and?-amino acids in thoroughbred horses' Amino Acids 15, (3) 241-251 , DOI
King N & Suleiman MS (1998) 'Characteristics of l -alanine transport in cardiac sarcolemmal vesicles and into isolated cardiac myocytes' Pfl�gers Archiv European Journal of Physiology 436, (3) 384-390 , DOI
Brown CDA, King N & Simmons NL (1993) 'Co-expression of an anion conductance pathway with Na+-glucose cotransport in rat renal brush-border membrane vesicles' Pfl�gers Archiv European Journal of Physiology 423, (5-6) 406-410 , DOI
Books

Editor:

RT-PCR Protocols: 2nd Ed (2010). For the series Methods in Molecular Biology. Springer Protocols, Humana Press, New Jersey, USA. ISBN: 978-1-60761-628.3

Chapters

King N. (2012) "The human body: a nutrition perspective" in Wardlaw's Nutrition. 1st Australia/New Zealand Edition. Ed GM Wardlaw and AM Smith. McGrawHill, Sydney, Australia. ISBN: 9781743071465

King N. (2007). "Amino acids and mitochondria" in Mitochondria: the dynamic organelle for the series Avances in Biochemistry in Health and Disease. Ed S Schaffer and M-S Suleiman. Springer, New York, USA. ISBN: 9780387699448

Conference Papers
King N, Wood C & Smart NA (2017) 'META-ANALYSIS COMPARING BIORESORBABLE VS. DRUG-ELUTING STENTS' 276-276 Open access
King N, Lin H, McGivan JD & Suleiman MS (2005) 'Mechanisms underlying the upregulation of cysteine uptake by oxidative stress in isolated cardiac myocytes' 189-189
King N, McGivan JD, Griffiths EJ & Suleiman MS (2001) 'Source of the reactive oxygen species released during reperfusion of single rat ventricular myocytes following a simulated hypoxia' 83P-83P
King N, Williams H, Griffiths EJ & Suleiman MS (2001) 'Isolation of rat ventricular myocytes in the presence of glutamate protects against free radical production during simulated hypoxia and reoxgenation' 23P-23P
King N, McGivan JD & Suleiman MS (2000) 'Expression and characterisation of the aspartate transporter EAAC1 in isolated rat cardiac myocytes' 35P-36P
King N & Suleiman MS (2000) 'Characteristics of L-aspartate uptake into sarcolemmal vesicles prepared from rat hearts' 84P-85P
King N & Suleiman MS (1997) 'Characteristics of L-leucine transport into sarcolemmal vesicles and isolated cardiac myocytes prepared from rat heart' P73-P73
King N, Colledge WH & Simmons NL (1996) 'Co-expression of a chloride conductance with sodium-glucose co-transport in brush-border membrane vesicles (BBMV) isolated from mouse kidneys in which the CFTR gene has been disrupted' P87-P87
King N & Chapman RA (1996) 'Sodium-dependent transport of L-alanine into sarcolemmal vesicles isolated from sheep left ventricle' P24-P25
BROWN CDA, KING N & SIMMONS NL (1993) 'COEXISTENCE OF AN ANION CONDUCTANCE AND NA-GLUCOSE COTRANSPORT IN RAT RENAL BRUSH-BORDER MEMBRANE-VESICLES INVITRO' P369-P369
Other Publications

King N., & Smart N (2008) Report on joint British Cardiac and British Society for Cardiovascular Research (BSCR) Conference. The Bulletin (BSCR) 21:16-20.

King N (2007) Postcard from Brunei. The Bulletin (BSCR) 20:19-22