Dr Michael Jarvis
Profiles

Dr Michael Jarvis

Associate Professor (Reader) in Virology and Immunology

School of Biomedical Sciences (Faculty of Health)

Michael can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Clinical trials
  • Immunology
  • Virology
  • Herpesvirus
  • Viral hemorrhagic disease
  • Molecular biology
  • Ebola
  • Vaccines
Biography

Biography

http://www.thejarvislab.com Please visit laboratory website for more information. 

Qualifications

University of California at Davis, CA

PhD

1996

Biochemistry & Molecular Biology

University of California at Davis, CA

MA

1995

Biochemistry & Molecular Biology

Trinity Hall, University of Cambridge, UK

 

 1987-1988

Biochemistry

Sonoma State University,   Rohnert Park, CA

BA Cum Laude

  1987

Biology

Professional membership

Professional Positions:

2012-present  Associate Professor, School of Biomedical& Biological Sciences, University of Plymouth,                        Plymouth, Devon, UK

2010-2012     Member of Graduate Faculty,Department of Molecular Microbiology and Immunology (MMI), OHSU, Portland, OR

2002-2012     Assistant Professor, VGTI, OHSU,Beaverton, OR

1996-2002     Postdoctoral Fellow,MMI, OHSU, Portland, OR

 

Other Experience and Professional Memberships:

2013–present  Member of Society for Applied Microbiology

2013-present Director of Graduate Studies, SoBHS

2013-present Plymouth School of Medicine and Dentistry (PSMD) Research Governance Committee

2013-present  PSMD Research Degrees Committee

2013-present  SoBHS Executive Group

Roles on external bodies




2003–2016      Journal of Virology Editorial Board

2012–present  Vaccine Editorial Board

2013–present  Virology Editorial Board

2014–2017      Journal of General Virology Editorial Board

2015–present  Wellcome Review Board

2009–present    International AIDS Vaccine Initiative (IAVI) External Scientific Advisory Committee for Development of a CMV-based HIV vaccine

2013–present    National Institutes of Health (NIH), USA Grant Review Board

2013–present   Austrian Research Promotion Agency (FFG) Grant Review Board

2012–present   Swedish Research Council Grant Review Board

Research

Research

Research interests

http://www.thejarvislab.com/research/

A native Californian, Ireceived my PhD in Biochemistry and Molecular Biology from the University ofCalifornia at Davis in 1996. With >16 years experience in cytomegalovirus(CMV) biology and the use of state-of-the-art bacterial artificial chromosome (BAC)technology, I am regarded as a leading expert in the construction andcharacterization of recombinant viral vectors for prophylactic and therapeuticvaccination against infectious disease and cancer. Until 2012, I was a memberof a large multi-laboratory effort at Oregon Health & Sciences University focusedon development of a CMV-based HIV vaccine using the simian immunodeficiencyvirus (SIV) rhesus macaque model of AIDS. These studies addressing an importantsocietal problem resulted in a number of high-profile publications in Nature,Nature Medicine and Science. I moved to the University of Plymouth in Spring of2012, where I am currently an Associate Professor (Reader) in Virology &Immunology. I regard myself as a virologist who utilizes immunology, and overthe years have enjoyed acquiring the immunological expertise necessary toexamine and understand the immunology behind the vectors. I find the innovativeaspect of science particularly exciting, and development of imaginativestrategies for the use of these vectors underpins my research. My move toPlymouth has given me the necessary intellectual freedom to focus on projectsthat I initiated at OHSU, as well as to pursue new paths of interest. 

Publications

Publications

Key publications

Key publications are highlighted

Journals
Articles
Tang-Huau T-L, Rosenke K, Meade-White K, Carmody A, Smith BJ, Bosio CM, Jarvis MA & Feldmann H (2021) 'Mastomys natalensis Has a Cellular Immune Response Profile Distinct from Laboratory Mice' Viruses 13, (5) 729-729 , DOI
Rosenke K, Hansen F, Schwarz B, Feldmann F, Haddock E, Rosenke R, Barbian K, Meade-White K, Okumura A & Leventhal S (2021) 'Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model' Nature Communications 12, (1) , DOI
Hansen F, Jarvis MA, Feldmann H & Rosenke K (2021) 'Lassa Virus Treatment Options' Microorganisms 9, (4) 772-772 , DOI
Hansen F, Feldmann H & Jarvis MA (2021) 'Targeting Ebola virus replication through pharmaceutical intervention' Expert Opinion on Investigational Drugs 30, (3) 201-226 , DOI
Basinski AJ, Fichet-Calvet E, Sjodin AR, Varrelman TJ, Remien CH, Layman NC, Bird BH, Wolking DJ, Monagin C & Ghersi BM (2021) 'Bridging the gap: Using reservoir ecology and human serosurveys to estimate Lassa virus spillover in West Africa' PLOS Computational Biology 17, (3) e1008811-e1008811 , DOI
Maremagae SR, Bezuidenhout CC, Murphy AM, Jarvis MA, Naicker P & Lebea PJ (2020) 'A rapid response vaccine development strategy for newcastle disease in poultry' African Journal of Food, Agriculture, Nutrition and Development 20, (07) 16941-16956 , DOI
Rosenke K, Jarvis MA, Feldmann F, Schwarz B, Okumura A, Lovaglio J, Saturday G, Hanley PW, Meade-White K & Williamson BN (2020) 'Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models' JCI Insight , DOI
Nuismer SL, Remien CH, Basinski AJ, Varrelman T, Layman N, Rosenke K, Bird B, Jarvis M, Barry P & Hanley PW (2020) 'Bayesian estimation of Lassa virus epidemiological parameters: Implications for spillover prevention using wildlife vaccination' PLOS Neglected Tropical Diseases 14, (9) e0007920-e0007920 , DOI Open access
Calvignac-Spencer S, Kouadio L, Couacy-Hymann E, Sogoba N, Rosenke K, Davison AJ, Leendertz F, Jarvis MA, Feldmann H & Ehlers B (2020) 'Multiple DNA viruses identified in multimammate mouse (Mastomys natalensis) populations from across regions of sub-Saharan Africa' Archives of Virology 165, (10) 2291-2299 , DOI Open access
Alkutbe R, Redfern K, Jarvis M & Rees G (2020) 'Nutrient Extraction Lowers Postprandial Glucose Response of Fruit in Adults with Obesity as well as Healthy Weight Adults' Nutrients 12, (3) 766-766 , DOI Open access
Rosenke K, Meade-White K, Letko M, Clancy C, Hansen F, Liu Y, Okumura A, Tang-Huau T-L, Li R & Saturday G (2020) 'Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection' Emerging Microbes & Infections 9, (1) 2673-2684 , DOI
Jarvis MA, Hansen FA, Rosenke K, Haddock E, Rollinson C, Rule S, Sewell G, Hughes A & Feldmann H (2020) 'Evaluation of drugs for potential repurposing against COVID-19 using a tier-based scoring system' Antiviral Therapy , DOI Open access
Schoenborn P, Osborne R, Toms N, Johnstone K, Milsom C, Muneer R, Jarvis MA & Belshaw R (2019) 'OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics' BMC Medical Education 19, (1) , DOI Open access
Atcheson E, Li W, Bliss CM, Chinnakannan S, Heim K, Sharpe H, Hutchings C, Dietrich I, Nguyen D & Kapoor A (2019) 'Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus' Hepatology 71, (3) 794-807 , DOI Open access
Murthy S, O’Brien K, Agbor A, Angedakin S, Arandjelovic M, Ayimisin EA, Bailey E, Bergl RA, Brazzola G & Dieguez P (2019) 'Cytomegalovirus distribution and evolution in hominines' Virus Evolution 5, (2) , DOI Open access
Kolb P, Sijmons S, McArdle MR, Taher H, Womack J, Hughes C, Ventura A, Jarvis MA, Stahl-Hennig C & Hansen S (2018) 'Identification and functional characterization of a novel Fc gamma-binding glycoprotein in Rhesus Cytomegalovirus' Journal of Virology Author Site , DOI Open access
Hansen SG, Zak DE, Xu G, Ford JC, Marshall EE, Malouli D, Gilbride RM, Hughes CM, Ventura AB & Ainslie E (2018) 'Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine' Nature Medicine 24, (2) 130-+ Author Site , DOI Open access
Redfern KM, Cammack VM, Sweet N, Preston, SoBHCS Student Team, Jarvis M & Rees G (2017) 'Nutrient-extraction blender preparation reduces postprandial glucose responses from fruit juice consumption' Nutrition and Diabetes 7, Publisher Site , DOI Open access
Marzi A, Murphy AA, Feldmann F, Parkins CJ, Haddock E, Hanley PW, Emery MJ, Engelmann F, Messaoudi I & Feldmann H (2016) 'Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection' Scientific Reports 6, (1) , DOI Open access
Murphy AA, Redwood AJ & Jarvis MA (2015) 'Self-disseminating vaccines for emerging infectious diseases' Expert Review of Vaccines 15, (1) 31-39 , DOI Open access
Anoh AE, Akoua-Koffi C, Couacy-Hymann E, Pauly M, Schubert G, Mossoun A, Weiss S, Leendertz SAJ, Jarvis MA & Leendertz FH (2015) 'Genetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire' Virology Journal 12, (1) , DOI Open access
Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS & Jarvis MA (2015) 'Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo' Proceedings of the National Academy of Sciences 112, (27) 8427-8432 , DOI
Hill SC, Murphy AA, Cotten M, Palser AL, Benson P, Lesellier S, Gormley E, Richomme C, Grierson S & Bhuachalla DN (2015) 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' Journal of General Virology 96, (6) 1411-1422 , DOI Open access
Hill SC, Murphy AA, Cotten M, Palser AL, Benson P, Lesellier S, Gormley E, Richomme C, Grierson S & Bhuachalla DN (2015) 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' J Gen Virol 96, (6) 1411-1422 Author Site , DOI
Tsuda Y, Parkins CJ, Caposio P, Feldmann F, Botto S, Ball S, Messaoudi I, Cicin-Sain L, Feldmann H & Jarvis MA (2015) 'A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose' Vaccine 33, (19) 2261-2266 Author Site , DOI
Spiess K, Fares S, Sparre-Ulrich AH, Hilgenberg E, Jarvis MA, Ehlers B & Rosenkilde MM (2015) 'Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses' J Virol 89, (4) 2253-2267 Author Site , DOI
Hansen SG, Piatek M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y & Lewis MS (2014) 'Corrigendum: Immune clearance of highly pathogenic SIV infection' Nature 514, (7524) 654-654 , DOI
MacManiman JD, Meuser A, Botto S, Smith PP, Liu F, Jarvis MA, Nelson JA & Caposio P (2014) 'Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis' mBio 5, (6) Author Site , DOI Open access
Macmaniman JD, Meuser A, Botto S, Smith PP, Liu F, Jarvis MA, Nelson JA & Caposio P (2014) 'Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis' mBio 5, (6) , DOI
Murthy S, Couacy-Hymann E, Metzger S, Nowak K, De Nys H, Boesch C, Wittig R, Jarvis MA, Leendertz FH & Ehlers B (2013) 'Absence of Frequent Herpesvirus Transmission in a Nonhuman Primate Predator-Prey System in the Wild' JOURNAL OF VIROLOGY 87, (19) 10651-10659 Author Site , DOI
Scuda N, Madinda NF, Akoua-Koffi C, Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendertz SAJ, Couacy-Hymann E & Robbins M (2013) 'Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population' PLOS PATHOGENS 9, (6) Author Site , DOI Open access
Dekhtiarenko I, Jarvis MA, Ruzsics Z & Cicin-Sain L (2013) 'The Context of Gene Expression Defines the Immunodominance Hierarchy of Cytomegalovirus Antigens' Journal of Immunology 190, 3399-3409 , DOI
Tierney R, Nakai T, Parkins CJ, Caposio P, Fairweather NF, Sesardic D & Jarvis MA (2012) 'A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice' VACCINE 30, (20) 3047-3052 Author Site , DOI
Klyushnenkova EN, Kouiavskaia DV, Parkins CJ, Caposio P, Botto S, Alexander RB & Jarvis MA (2012) 'A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8(+) T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer' Journal of Immunotherapy 35, 390-399 , DOI
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R & Swanson T (2011) 'Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine' Nature 473, (7348) 523-527 Author Site , DOI Open access
Tsuda Y, Caposio P, Parkins CJ, Botto S, Messaoudi I, Cicin-Sain L, Feldmann H & Jarvis MA (2011) 'A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus' Plos Neglected Tropical Diseases 5, , DOI Open access
Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA & Picker LJ (2010) 'Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus' Science 328, (5974) 102-106 Author Site , DOI
Wille PT, Knoche AJ, Nelson JA, Jarvis MA & Johnson DC (2010) 'A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells' J Virol 84, (5) 2585-2596 Author Site , DOI
Dutia BM, Reid SJ, Drummond DD, Ligertwood Y, Bennet I, Rietberg W, Silvia O, Jarvis MA & Nash AA (2009) 'A Novel Cre Recombinase Imaging System for Tracking Lymphotropic Virus Infection In Vivo' PLoS ONE 4, (8) e6492-e6492 , DOI Open access
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K & Trubey CM (2009) 'Correction: Corrigendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nature Medicine 15, (4) 462-462 , DOI
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K & Trubey CM (2009) 'Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nat Med 15, (3) 293-299 Author Site , DOI Open access
Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson JA, Jarvis MA & Johnson DC (2008) 'Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells' J Virol 82, (1) 60-70 Author Site , DOI
Jarvis MA & Nelson JA (2007) 'Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal' J Virol 81, (5) 2095-2101 Author Site , DOI
Jarvis MA, Borton JA, Keech AM, Wong J, Britt WJ, Magun BE & Nelson JA (2006) 'Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation' J Virol 80, (11) 5588-5598 Author Site , DOI
Ryckman BJ, Jarvis MA, Drummond DD, Nelson JA & Johnson DC (2006) 'Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion' J Virol 80, (2) 710-722 Author Site , DOI
Hegde NR, Dunn C, Lewinsohn DM, Jarvis MA, Nelson JA & Johnson DC (2005) 'Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL' J Exp Med 202, (8) 1109-1119 Author Site , DOI Open access
Britt WJ, Jarvis MA, Drummond DD & Mach M (2005) 'Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B' Journal of Virology 79, 4066-4079 , DOI
Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG & Wong SW (2004) 'A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism' J Virol 78, (22) 12529-12536 Author Site , DOI
Jarvis MA, Jones TR, Drummond DD, Smith PP, Britt WJ, Nelson JA & Baldick CJ (2004) 'Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication' J Virol 78, (1) 285-293 Author Site , DOI
Britt WJ, Jarvis M, Seo J-Y, Drummond D & Nelson J (2004) 'Rapid Genetic Engineering of Human Cytomegalovirus by Using a Lambda Phage Linear Recombination System: Demonstration that pp28 (UL99) Is Essential for Production of Infectious Virus' Journal of Virology 78, (1) 539-543 , DOI
Murphy E, Yu D, Grimwood J, Schmutz J, Dickson M, Jarvis MA, Hahn G, Nelson JA, Myers RM & Shenk TE (2003) 'Coding potential of laboratory and clinical strains of human cytomegalovirus' Proceedings of the National Academy of Sciences of the United States of America 100, 14976-14981 , DOI
Jarvis MA & Nelson JA (2002) 'Human cytomegalovirus persistence and latency in endothelial cells and macrophages' Curr Opin Microbiol 5, (4) 403-407 Author Site , DOI
Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BGM, Griffith DJ, Wait CL, Druker BJ & Heinrich MC (2002) 'Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells' J Virol 76, (16) 8383-8399 Author Site , DOI
Jarvis MA & Nelson JA (2002) 'Mechanisms of human cytomegalovirus persistence and latency' Front Biosci 7, d1575-d1582 Author Site , DOI
Jarvis MA, Fish KN, Söderberg-Naucler C, Streblow DN, Meyers HL, Thomas G & Nelson JA (2002) 'Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells' J Virol 76, (10) 5147-5155 Author Site , DOI
Jean F, Thomas L, Molloy SS, Liu G, Jarvis MA, Nelson JA & Thomas G (2000) 'A protein-based therapeutic for human cytomegalovirus infection' Proc Natl Acad Sci U S A 97, (6) 2864-2869 Author Site , DOI
Leung NJ, Aldovini A, Young R, Jarvis MA, Smith JM, Meyer D, Anderson DE, Carlos MP, Gardner MB & Torres JV (2000) 'The Kinetics of Specific Immune Responses in Rhesus Monkeys Inoculated with Live Recombinant BCG Expressing SIV Gag, Pol, Env, and Nef Proteins' Virology 268, (1) 94-103 , DOI
Jarvis MA, Wang CE, Meyers HL, Smith PP, Corless CL, Henderson GJ, Vieira J, Britt WJ & Nelson JA (1999) 'Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent' J Virol 73, (6) 4552-4560 Author Site , DOI
Jarvis MA, Wang CE, Michalik D, Peffer NJ & Nelson JA (1997) 'The human cytomegalovirus genome is assembled into chromatin during infection of human fibroblasts' Molecular Biology of the Cell 8, 1866-1866
Levin LG, Jarvis M, Powell J, Harrison JA & Reisner HM (1996) 'Induction of Human Factor VIII Inhibitors in Rats 2: Fine Mapping of Rat anti-Human rFVIII Antibodies' Thrombosis and Haemostasis 76, (06) 0998-1003 , DOI
Jarvis MA, Levin LG, Harrison JA, DePianto DJ, Suzuki CM, Ziaja CL, Brown JE, Jolly KW, Reisner HM & Abidgaard CF (1996) 'Induction of Human Factor VIII Inhibitors in Rats by Immunization with Human Recombinant Factor VIII: a Small Animal Model for Humans with High Responder Inhibitor Phenotype' Thrombosis and Haemostasis 75, (02) 318-325 , DOI
Rosenke K, Jarvis MA, Feldmann F, Schwarz B, Okumura A, Lovaglio J, Saturday G, Hanley PW, Meade-White K & Williamson BN 'Hydroxychloroquine Proves Ineffective in Hamsters and Macaques Infected with SARS-CoV-2' , DOI
Books
Arvin A; CampadelliFiume G; Mocarski E; Moore PS; Roizman B; Whitley R; Yamanishi K (2007) Molecular basis of persistence and latency.
Chapters
Jarvis MA, Hansen SG, Nelson JA, Picker LJ & Frueh K (2013) 'Vaccine vectors using the unique biology and immunology of cytomegalovirus' in Reddehase MJ Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BGM, Griffith DJ, Wait CL, Druker BJ & Heinrich MC (2002) 'A functional genomics approach to Kaposi's sarcoma' 180-191 Author Site , DOI
Jarvis MA & Nelson JA 'HCMV: molecular basis of persistence and latency' Human Herpesviruses Cambridge University Press 765-779 , DOI