- B401, Portland Square, Drake Circus, Plymouth, PL4 8AA
- +44 1752 584456
- michael.jarvis@plymouth.ac.uk
Profiles
Dr Michael Jarvis
Associate Professor in Virology and Immunology
School of Biomedical Sciences (Faculty of Health)
Dr Michael Jarvis can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Clinical trials
- Immunology
- Virology
- Herpesvirus
- Viral hemorrhagic disease
- Molecular biology
- Ebola
- Vaccines
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
http://www.thejarvislab.com Please visit laboratory website for more information.
Qualifications
| University of California at Davis, CA | PhD | 1996 | Biochemistry & Molecular Biology |
| University of California at Davis, CA | MA | 1995 | Biochemistry & Molecular Biology |
| Trinity Hall, University of Cambridge, UK |
| 1987-1988 | Biochemistry |
| Sonoma State University, Rohnert Park, CA | BA Cum Laude | 1987 | Biology |
Professional membership
Professional Positions:
2012-present Associate Professor, School of Biomedical& Biological Sciences, University of Plymouth, Plymouth, Devon, UK
2010-2012 Member of Graduate Faculty,Department of Molecular Microbiology and Immunology (MMI), OHSU, Portland, OR
2002-2012 Assistant Professor, VGTI, OHSU,Beaverton, OR
1996-2002 Postdoctoral Fellow,MMI, OHSU, Portland, OR
Other Experience and Professional Memberships:
2013–present Member of Society for Applied Microbiology
2013-present Director of Graduate Studies, SoBHS
2013-present Plymouth School of Medicine and Dentistry (PSMD) Research Governance Committee
2013-present PSMD Research Degrees Committee
2013-present SoBHS Executive Group
Roles on external bodies
2003–2016 Journal of Virology Editorial Board
2012–present Vaccine Editorial Board
2013–present Virology Editorial Board
2014–2017 Journal of General Virology Editorial Board
2015–present Wellcome Review Board
2009–present International AIDS Vaccine Initiative (IAVI) External Scientific Advisory Committee for Development of a CMV-based HIV vaccine
2013–present National Institutes of Health (NIH), USA Grant Review Board
2013–present Austrian Research Promotion Agency (FFG) Grant Review Board
2012–present Swedish Research Council Grant Review Board
Research
Research
Research interests
http://www.thejarvislab.com/research/
A native Californian, Ireceived my PhD in Biochemistry and Molecular Biology from the University ofCalifornia at Davis in 1996. With >16 years experience in cytomegalovirus(CMV) biology and the use of state-of-the-art bacterial artificial chromosome (BAC)technology, I am regarded as a leading expert in the construction andcharacterization of recombinant viral vectors for prophylactic and therapeuticvaccination against infectious disease and cancer. Until 2012, I was a memberof a large multi-laboratory effort at Oregon Health & Sciences University focusedon development of a CMV-based HIV vaccine using the simian immunodeficiencyvirus (SIV) rhesus macaque model of AIDS. These studies addressing an importantsocietal problem resulted in a number of high-profile publications in Nature,Nature Medicine and Science. I moved to the University of Plymouth in Spring of2012, where I am currently an Associate Professor (Reader) in Virology &Immunology. I regard myself as a virologist who utilizes immunology, and overthe years have enjoyed acquiring the immunological expertise necessary toexamine and understand the immunology behind the vectors. I find the innovativeaspect of science particularly exciting, and development of imaginativestrategies for the use of these vectors underpins my research. My move toPlymouth has given me the necessary intellectual freedom to focus on projectsthat I initiated at OHSU, as well as to pursue new paths of interest.
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2023) 'Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Streptococcus suis Serotype 2, 7, and 9 in Mice' Veterinary Sciences 10, (1) 48-48 , DOI Open access
(2023) 'Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Streptococcus suis Serotype 2, 7, and 9 in Mice' Veterinary Sciences 10, (1) 48-48 , DOI
(2022) 'Molnupiravir inhibits SARS-CoV-2 variants including Omicron in the hamster model' JCI Insight 7, (13) , DOI Open access
(2022) 'Epstein-Barr Virus-Encoded BILF1 Orthologues From Porcine Lymphotropic Herpesviruses Display Common Molecular Functionality' Frontiers in Endocrinology 13, , DOI Open access
(2022) 'SARS-CoV-2 reinfection prevents acute respiratory disease in Syrian hamsters but not replication in the upper respiratory tract' Cell Reports 38, (11) , DOI Open access
(2022) 'Three-Week Old Pigs Are Not Susceptible to Productive Infection with SARS-COV-2' Microorganisms 10, (2) , DOI Open access
(2021) 'UK B.1.1.7 (Alpha) variant exhibits increased respiratory replication and shedding in nonhuman primates' Emerging Microbes and Infections 10, (1) 2173-2182 , DOI Open access
(2021) 'Mastomys natalensis Has a Cellular Immune Response Profile Distinct from Laboratory Mice' Viruses 13, (5) 729-729 , DOI Open access
(2021) 'Orally delivered MK-4482 inhibits SARS-CoV-2 replication in the Syrian hamster model' Nature Communications 12, (1) , DOI Open access
(2021) 'Targeting Ebola virus replication through pharmaceutical intervention' Expert Opinion on Investigational Drugs 30, (3) 201-226 , DOI Open access
(2021) 'Bridging the gap: Using reservoir ecology and human serosurveys to estimate Lassa virus spillover in West Africa' PLoS Computational Biology 17, (3) e1008811-e1008811 , DOI Open access
(2020) 'Defining the Syrian hamster as a highly susceptible preclinical model for SARS-CoV-2 infection' Emerging Microbes & Infections 9, (1) 2673-2684 , DOI Open access
(2020) 'A rapid response vaccine development strategy for newcastle disease in poultry' African Journal of Food, Agriculture, Nutrition and Development 20, (07) 16941-16956 , DOI Open access
(2020) 'Hydroxychloroquine prophylaxis and treatment is ineffective in macaque and hamster SARS-CoV-2 disease models' JCI Insight , DOI Open access
(2020) 'Bayesian estimation of Lassa virus epidemiological parameters: Implications for spillover prevention using wildlife vaccination' PLOS Neglected Tropical Diseases 14, (9) e0007920-e0007920 , DOI Open access
(2020) 'Multiple DNA viruses identified in multimammate mouse (Mastomys natalensis) populations from across regions of sub-Saharan Africa' Archives of Virology 165, (10) 2291-2299 , DOI Open access
(2020) 'Nutrient Extraction Lowers Postprandial Glucose Response of Fruit in Adults with Obesity as well as Healthy Weight Adults' Nutrients 12, (3) 766-766 , DOI Open access
(2019) 'OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics' BMC Medical Education 19, (1) , DOI Open access
(2019) 'Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus' Hepatology 71, (3) 794-807 , DOI Open access
(2019) 'Cytomegalovirus distribution and evolution in hominines' Virus Evolution 5, (2) , DOI Open access
(2019) 'Evaluation of drugs for potential repurposing against COVID-19 using a tier-based scoring system' Antiviral Therapy , DOI Open access
(2018) 'Identification and functional characterization of a novel Fc gamma-binding glycoprotein in Rhesus Cytomegalovirus' Journal of Virology , DOI Open access
(2018) 'Prevention of tuberculosis in rhesus macaques by a cytomegalovirus-based vaccine' Nature Medicine 24, (2) 130-+ , DOI Open access
(2017) 'Nutrient-extraction blender preparation reduces postprandial glucose responses from fruit juice consumption' Nutrition and Diabetes 7, Publisher Site , DOI Open access
(2016) 'Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection' Scientific Reports 6, (1) , DOI Open access
(2015) 'Self-disseminating vaccines for emerging infectious diseases' Expert Review of Vaccines 15, (1) 31-39 , DOI Open access
(2015) 'Genetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire' Virology Journal 12, (1) , DOI Open access
(2015) 'Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo' Proceedings of the National Academy of Sciences 112, (27) 8427-8432 , DOI
(2015) 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' Journal of General Virology 96, (6) 1411-1422 , DOI Open access
(2015) 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' J Gen Virol 96, (6) 1411-1422 , DOI
(2015) 'A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose' Vaccine 33, (19) 2261-2266 , DOI
(2015) 'Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses' J Virol 89, (4) 2253-2267 , DOI
(2014) 'Corrigendum: Immune clearance of highly pathogenic SIV infection' Nature 514, (7524) 654-654 , DOI
(2014) 'Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis' mBio 5, (6) , DOI Open access
(2014) 'Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis' mBio 5, (6) , DOI
(2013) 'Absence of Frequent Herpesvirus Transmission in a Nonhuman Primate Predator-Prey System in the Wild' JOURNAL OF VIROLOGY 87, (19) 10651-10659 , DOI
(2013) 'Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population' PLOS PATHOGENS 9, (6) , DOI Open access
(2013) 'The Context of Gene Expression Defines the Immunodominance Hierarchy of Cytomegalovirus Antigens' Journal of Immunology 190, 3399-3409 , DOI
(2012) 'A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice' VACCINE 30, (20) 3047-3052 , DOI
(2012) 'A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8(+) T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer' Journal of Immunotherapy 35, 390-399 , DOI
(2011) 'Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine' Nature 473, (7348) 523-527 , DOI Open access
(2011) 'A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus' Plos Neglected Tropical Diseases 5, , DOI Open access
(2010) 'Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus' Science 328, (5974) 102-106 , DOI
(2010) 'A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells' J Virol 84, (5) 2585-2596 , DOI
(2009) 'A Novel Cre Recombinase Imaging System for Tracking Lymphotropic Virus Infection In Vivo' PLoS ONE 4, (8) e6492-e6492 , DOI Open access
(2009) 'Correction: Corrigendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nature Medicine 15, (4) 462-462 , DOI
(2009) 'Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nat Med 15, (3) 293-299 , DOI Open access
(2008) 'Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells' J Virol 82, (1) 60-70 , DOI
(2007) 'Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal' J Virol 81, (5) 2095-2101 , DOI
(2006) 'Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation' J Virol 80, (11) 5588-5598 , DOI
(2006) 'Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion' J Virol 80, (2) 710-722 , DOI
(2005) 'Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL' J Exp Med 202, (8) 1109-1119 , DOI Open access
(2005) 'Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B' Journal of Virology 79, 4066-4079 , DOI
(2004) 'A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism' J Virol 78, (22) 12529-12536 , DOI
(2004) 'Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication' J Virol 78, (1) 285-293 , DOI
(2004) 'Rapid Genetic Engineering of Human Cytomegalovirus by Using a Lambda Phage Linear Recombination System: Demonstration that pp28 (UL99) Is Essential for Production of Infectious Virus' Journal of Virology 78, (1) 539-543 , DOI
(2003) 'Coding potential of laboratory and clinical strains of human cytomegalovirus' Proceedings of the National Academy of Sciences of the United States of America 100, 14976-14981 , DOI
(2002) 'Human cytomegalovirus persistence and latency in endothelial cells and macrophages' Curr Opin Microbiol 5, (4) 403-407 , DOI
(2002) 'Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells' J Virol 76, (16) 8383-8399 , DOI
(2002) 'Mechanisms of human cytomegalovirus persistence and latency' Front Biosci 7, d1575-d1582 , DOI
(2002) 'Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells' J Virol 76, (10) 5147-5155 , DOI
(2000) 'A protein-based therapeutic for human cytomegalovirus infection' Proc Natl Acad Sci U S A 97, (6) 2864-2869 , DOI
(2000) 'The Kinetics of Specific Immune Responses in Rhesus Monkeys Inoculated with Live Recombinant BCG Expressing SIV Gag, Pol, Env, and Nef Proteins' Virology 268, (1) 94-103 , DOI
(1999) 'Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent' J Virol 73, (6) 4552-4560 , DOI
(1997) 'The human cytomegalovirus genome is assembled into chromatin during infection of human fibroblasts' Molecular Biology of the Cell 8, 1866-1866
(1996) 'Induction of Human Factor VIII Inhibitors in Rats 2: Fine Mapping of Rat anti-Human rFVIII Antibodies' Thrombosis and Haemostasis 76, (06) 0998-1003 , DOI
(1996) 'Induction of Human Factor VIII Inhibitors in Rats by Immunization with Human Recombinant Factor VIII: a Small Animal Model for Humans with High Responder Inhibitor Phenotype' Thrombosis and Haemostasis 75, (02) 318-325 , DOI
Books
Arvin A; CampadelliFiume G; Mocarski E; Moore PS; Roizman B; Whitley R; Yamanishi K (2007) Molecular basis of persistence and latency.
Chapters
(2013) 'Vaccine vectors using the unique biology and immunology of cytomegalovirus' in Reddehase MJ Cytomegaloviruses: From Molecular Pathogenesis to Intervention
(2007) 'HCMV: molecular basis of persistence and latency' Human Herpesviruses Cambridge University Press 765-779 , DOI