Dr Michael Jarvis
Profiles

Dr Michael Jarvis

Associate Professor (Reader) in Virology and Immunology

School of Biomedical & Healthcare Sciences (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

http://www.thejarvislab.com Please visit laboratory website for more information. 

Qualifications

University of California at Davis, CA

PhD

1996

Biochemistry & Molecular Biology

University of California at Davis, CA

MA

1995

Biochemistry & Molecular Biology

Trinity Hall, University of Cambridge, UK

 

 1987-1988

Biochemistry

Sonoma State University,      Rohnert Park, CA

BA Cum Laude

   1987

Biology

Professional membership

Professional Positions:

2012-present   Associate Professor, School of Biomedical& Biological Sciences, University of Plymouth,                         Plymouth, Devon, UK

2010-2012       Member of Graduate Faculty,Department of Molecular Microbiology and Immunology (MMI), OHSU, Portland, OR

2002-2012       Assistant Professor, VGTI, OHSU,Beaverton, OR

1996-2002       Postdoctoral Fellow,MMI, OHSU, Portland, OR

 

Other Experience and Professional Memberships:

2013–present   Member of Society for Applied Microbiology

2013-present  Director of Graduate Studies, SoBHS

2013-present  Plymouth School of Medicine and Dentistry (PSMD) Research Governance Committee

2013-present   PSMD Research Degrees Committee

2013-present   SoBHS Executive Group

Roles on external bodies




2003–2016       Journal of Virology Editorial Board

2012–present   Vaccine Editorial Board

2013–present   Virology Editorial Board

2014–2017       Journal of General Virology Editorial Board

2015–present    Wellcome Review Board

2009–present    International AIDS Vaccine Initiative (IAVI) External Scientific Advisory Committee for Development of a CMV-based HIV vaccine

2013–present    National Institutes of Health (NIH), USA Grant Review Board

2013–present   Austrian Research Promotion Agency (FFG) Grant Review Board

2012–present   Swedish Research Council Grant Review Board

Research interests

http://www.thejarvislab.com/research/

A native Californian, Ireceived my PhD in Biochemistry and Molecular Biology from the University ofCalifornia at Davis in 1996. With >16 years experience in cytomegalovirus(CMV) biology and the use of state-of-the-art bacterial artificial chromosome (BAC)technology, I am regarded as a leading expert in the construction andcharacterization of recombinant viral vectors for prophylactic and therapeuticvaccination against infectious disease and cancer. Until 2012, I was a memberof a large multi-laboratory effort at Oregon Health & Sciences University focusedon development of a CMV-based HIV vaccine using the simian immunodeficiencyvirus (SIV) rhesus macaque model of AIDS. These studies addressing an importantsocietal problem resulted in a number of high-profile publications in Nature,Nature Medicine and Science. I moved to the University of Plymouth in Spring of2012, where I am currently an Associate Professor (Reader) in Virology &Immunology. I regard myself as a virologist who utilizes immunology, and overthe years have enjoyed acquiring the immunological expertise necessary toexamine and understand the immunology behind the vectors. I find the innovativeaspect of science particularly exciting, and development of imaginativestrategies for the use of these vectors underpins my research. My move toPlymouth has given me the necessary intellectual freedom to focus on projectsthat I initiated at OHSU, as well as to pursue new paths of interest. 

Key publications are highlighted

Journals
Articles
Marzi A, Murphy AA, Feldmann F, Parkins CJ, Haddock E, Hanley PW, Emery MJ, Engelmann F, Messaoudi I & Feldmann H 2016 'Cytomegalovirus-based vaccine expressing Ebola virus glycoprotein protects nonhuman primates from Ebola virus infection' Scientific Reports 6, (1) , DOI PEARL
Murphy AA, Redwood AJ & Jarvis MA 2016 'Self-disseminating vaccines for emerging infectious diseases' Expert Review of Vaccines 15, (1) 31-39 , DOI PEARL
Tsuda Y, Parkins CJ, Caposio P, Feldmann F, Botto S, Ball S, Messaoudi I, Cicin-Sain L, Feldmann H & Jarvis MA 2015 'A cytomegalovirus-based vaccine provides long-lasting protection against lethal Ebola virus challenge after a single dose' Vaccine 33, (19) 2261-2266 Author Site , DOI
Chambers M, Murphy AA, Palser AL, Grierson S, Hill SC, Boschiroli M-L, Bhuachalla DN, Pybus OG, Cotten M & Lesellier S 2015 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' Journal of General Virology 96, (6) 1411-1422 , DOI
Anoh AE, Akoua-Koffi C, Couacy-Hymann E, Pauly M, Schubert G, Mossoun A, Weiss S, Leendertz SAJ, Jarvis MA & Leendertz FH 2015 'Genetic identification of cytomegaloviruses in a rural population of Côte d’Ivoire' Virology Journal 12, (1) , DOI PEARL
Spiess K, Fares S, Sparre-Ulrich AH, Hilgenberg E, Jarvis MA, Ehlers B & Rosenkilde MM 2015 'Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses' J Virol 89, (4) 2253-2267 Author Site , DOI
Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T, Hjortø GM, Larsen O, Burg JS & Jarvis MA 2015 'Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo' Proceedings of the National Academy of Sciences 112, (27) 8427-8432 , DOI
MacManiman JD, Meuser A, Botto S, Smith PP, Liu F, Jarvis MA, Nelson JA & Caposio P 2014 'Human cytomegalovirus-encoded pUL7 is a novel CEACAM1-like molecule responsible for promotion of angiogenesis' MBio 5, (6) Author Site , DOI PEARL
Murthy S, Couacy-Hymann E, Metzger S, Nowak K, De Nys H, Boesch C, Wittig R, Jarvis MA, Leendertz FH & Ehlers B 2013 'Absence of Frequent Herpesvirus Transmission in a Nonhuman Primate Predator-Prey System in the Wild' JOURNAL OF VIROLOGY 87, (19) 10651-10659 Author Site , DOI
Scuda N, Madinda NF, Akoua-Koffi C, Adjogoua EV, Wevers D, Hofmann J, Cameron KN, Leendertz SAJ, Couacy-Hymann E & Robbins M 2013 'Novel Polyomaviruses of Nonhuman Primates: Genetic and Serological Predictors for the Existence of Multiple Unknown Polyomaviruses within the Human Population' PLOS PATHOGENS 9, (6) Author Site , DOI PEARL
Dekhtiarenko I, Jarvis MA, Ruzsics Z & Cicin-Sain L 2013 'The Context of Gene Expression Defines the Immunodominance Hierarchy of Cytomegalovirus Antigens' Journal of Immunology 190, 3399-3409 , DOI
Klyushnenkova EN, Kouiavskaia DV, Parkins CJ, Caposio P, Botto S, Alexander RB & Jarvis MA 2012 'A Cytomegalovirus-based Vaccine Expressing a Single Tumor-specific CD8(+) T-cell Epitope Delays Tumor Growth in a Murine Model of Prostate Cancer' Journal of Immunotherapy 35, 390-399 , DOI
Tierney R, Nakai T, Parkins CJ, Caposio P, Fairweather NF, Sesardic D & Jarvis MA 2012 'A single-dose cytomegalovirus-based vaccine encoding tetanus toxin fragment C induces sustained levels of protective tetanus toxin antibodies in mice' VACCINE 30, (20) 3047-3052 Author Site , DOI
Tsuda Y, Caposio P, Parkins CJ, Botto S, Messaoudi I, Cicin-Sain L, Feldmann H & Jarvis MA 2011 'A Replicating Cytomegalovirus-Based Vaccine Encoding a Single Ebola Virus Nucleoprotein CTL Epitope Confers Protection against Ebola Virus' Plos Neglected Tropical Diseases 5, , DOI PEARL
Hansen SG, Ford JC, Lewis MS, Ventura AB, Hughes CM, Coyne-Johnson L, Whizin N, Oswald K, Shoemaker R & Swanson T 2011 'Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine' Nature 473, (7348) 523-527 Author Site , DOI PEARL
Wille PT, Knoche AJ, Nelson JA, Jarvis MA & Johnson DC 2010 'A human cytomegalovirus gO-null mutant fails to incorporate gH/gL into the virion envelope and is unable to enter fibroblasts and epithelial and endothelial cells' J Virol 84, (5) 2585-2596 Author Site , DOI
Hansen SG, Powers CJ, Richards R, Ventura AB, Ford JC, Siess D, Axthelm MK, Nelson JA, Jarvis MA & Picker LJ 2010 'Evasion of CD8+ T cells is critical for superinfection by cytomegalovirus' Science 328, (5974) 102-106 Author Site , DOI
Dutia BM, Reid SJ, Drummond DD, Ligertwood Y, Bennet I, Rietberg W, Silvia O, Jarvis MA & Nash AA 2009 'A Novel Cre Recombinase Imaging System for Tracking Lymphotropic Virus Infection In Vivo' PLoS ONE 4, (8) e6492-e6492 , DOI
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K & Trubey CM 2009 'Corrigendum: Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nature Medicine 15, (4) 462-462 , DOI
Hansen SG, Vieville C, Whizin N, Coyne-Johnson L, Siess DC, Drummond DD, Legasse AW, Axthelm MK, Oswald K & Trubey CM 2009 'Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge' Nat Med 15, (3) 293-299 Author Site , DOI PEARL
Ryckman BJ, Rainish BL, Chase MC, Borton JA, Nelson JA, Jarvis MA & Johnson DC 2008 'Characterization of the human cytomegalovirus gH/gL/UL128-131 complex that mediates entry into epithelial and endothelial cells' J Virol 82, (1) 60-70 Author Site , DOI
Jarvis MA & Nelson JA 2007 'Human cytomegalovirus tropism for endothelial cells: not all endothelial cells are created equal' J Virol 81, (5) 2095-2101 Author Site , DOI
Jarvis MA, Borton JA, Keech AM, Wong J, Britt WJ, Magun BE & Nelson JA 2006 'Human cytomegalovirus attenuates interleukin-1beta and tumor necrosis factor alpha proinflammatory signaling by inhibition of NF-kappaB activation' J Virol 80, (11) 5588-5598 Author Site , DOI
Ryckman BJ, Jarvis MA, Drummond DD, Nelson JA & Johnson DC 2006 'Human cytomegalovirus entry into epithelial and endothelial cells depends on genes UL128 to UL150 and occurs by endocytosis and low-pH fusion' J Virol 80, (2) 710-722 Author Site , DOI
Britt WJ, Jarvis MA, Drummond DD & Mach M 2005 'Antigenic domain 1 is required for oligomerization of human cytomegalovirus glycoprotein B' Journal of Virology 79, 4066-4079 , DOI
Hegde NR, Dunn C, Lewinsohn DM, Jarvis MA, Nelson JA & Johnson DC 2005 'Endogenous human cytomegalovirus gB is presented efficiently by MHC class II molecules to CD4+ CTL' J Exp Med 202, (8) 1109-1119 Author Site , DOI PEARL
Rue CA, Jarvis MA, Knoche AJ, Meyers HL, DeFilippis VR, Hansen SG, Wagner M, Früh K, Anders DG & Wong SW 2004 'A cyclooxygenase-2 homologue encoded by rhesus cytomegalovirus is a determinant for endothelial cell tropism' J Virol 78, (22) 12529-12536 Author Site , DOI
Jarvis MA, Jones TR, Drummond DD, Smith PP, Britt WJ, Nelson JA & Baldick CJ 2004 'Phosphorylation of human cytomegalovirus glycoprotein B (gB) at the acidic cluster casein kinase 2 site (Ser900) is required for localization of gB to the trans-Golgi network and efficient virus replication' J Virol 78, (1) 285-293 Author Site
Britt WJ, Jarvis M, Seo J-Y, Drummond D & Nelson J 2004 'Rapid Genetic Engineering of Human Cytomegalovirus by Using a Lambda Phage Linear Recombination System: Demonstration that pp28 (UL99) Is Essential for Production of Infectious Virus' Journal of Virology 78, (1) 539-543 , DOI
Murphy E, Yu D, Grimwood J, Schmutz J, Dickson M, Jarvis MA, Hahn G, Nelson JA, Myers RM & Shenk TE 2003 'Coding potential of laboratory and clinical strains of human cytomegalovirus' Proceedings of the National Academy of Sciences of the United States of America 100, 14976-14981 , DOI
Jarvis MA & Nelson JA 2002 'Human cytomegalovirus persistence and latency in endothelial cells and macrophages' Curr Opin Microbiol 5, (4) 403-407 Author Site
Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BGM, Griffith DJ, Wait CL, Druker BJ & Heinrich MC 2002 'Kaposi's sarcoma-associated herpesvirus-induced upregulation of the c-kit proto-oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells' J Virol 76, (16) 8383-8399 Author Site
Jarvis MA & Nelson JA 2002 'Mechanisms of human cytomegalovirus persistence and latency' Front Biosci 7, d1575-d1582 Author Site
Jarvis MA, Fish KN, Söderberg-Naucler C, Streblow DN, Meyers HL, Thomas G & Nelson JA 2002 'Retrieval of human cytomegalovirus glycoprotein B from cell surface is not required for virus envelopment in astrocytoma cells' J Virol 76, (10) 5147-5155 Author Site
Jean F, Thomas L, Molloy SS, Liu G, Jarvis MA, Nelson JA & Thomas G 2000 'A protein-based therapeutic for human cytomegalovirus infection' Proc Natl Acad Sci U S A 97, (6) 2864-2869 Author Site , DOI
Leung NJ, Aldovini A, Young R, Jarvis MA, Smith JM, Meyer D, Anderson DE, Carlos MP, Gardner MB & Torres JV 2000 'The Kinetics of Specific Immune Responses in Rhesus Monkeys Inoculated with Live Recombinant BCG Expressing SIV Gag, Pol, Env, and Nef Proteins' Virology 268, (1) 94-103 , DOI
Jarvis MA, Wang CE, Meyers HL, Smith PP, Corless CL, Henderson GJ, Vieira J, Britt WJ & Nelson JA 1999 'Human cytomegalovirus infection of caco-2 cells occurs at the basolateral membrane and is differentiation state dependent' J Virol 73, (6) 4552-4560 Author Site
Jarvis MA, Wang CE, Michalik D, Peffer NJ & Nelson JA 1997 'The human cytomegalovirus genome is assembled into chromatin during infection of human fibroblasts' Molecular Biology of the Cell 8, 1866-1866
Levin LG, Jarvis M, Powell J, Harrison JA & Reisner HM 1996 'Induction of human factor VIII inhibitors in rats .2. Fine mapping of rat anti-human rFVIII antibodies' THROMBOSIS AND HAEMOSTASIS 76, (6) 998-1003 Author Site
Jarvis MA, Levin LG, Harrison JA, DePianto DJ, Suzuki CM, Ziaja CL, Brown JE, Jolly KW, Reisner HM & Abildgaard CF 1996 'Induction of human factor VIII inhibitors in rats by immunization with human recombinant factor VIII: A small animal model for humans with high responder inhibitor phenotype' THROMBOSIS AND HAEMOSTASIS 75, (2) 318-325 Author Site
Hill SC, Murphy AA, Cotten M, Palser AL, Benson P, Lesellier S, Gormley E, Richomme C, Grierson S & Bhuachalla DN 0 'Discovery of a polyomavirus in European badgers (Meles meles) and the evolution of host range in the family Polyomaviridae' J Gen Virol 96, (6) 1411-1422 Author Site , DOI
Corrigenda
Hansen SG, Piatek M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y & Lewis MS 2014 'Corrigendum: Immune clearance of highly pathogenic SIV infection' Nature 514, (7524) 654-654 , DOI
Books
Arvin A; CampadelliFiume G; Mocarski E; Moore PS; Roizman B; Whitley R; Yamanishi K 2007 Molecular basis of persistence and latency.
Chapters
Jarvis MA, Hansen SG, Nelson JA, Picker LJ & Frueh K 2013 'Vaccine vectors using the unique biology and immunology of cytomegalovirus' in Reddehase MJ Cytomegaloviruses: From Molecular Pathogenesis to Intervention
Jarvis MA & Nelson JA 2007 'HCMV: Molecular basis of persistence and latency' Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis 765-779 , DOI
Moses AV, Jarvis MA, Raggo C, Bell YC, Ruhl R, Luukkonen BGM, Griffith DJ, Wait CL, Druker BJ & Heinrich MC 2002 'A functional genomics approach to Kaposi's sarcoma' 180-191 Author Site