Dr Matt Jones
Profiles

Dr Matt Jones

Research Fellowship of Excellence

Peninsula Medical School (Faculty of Health)

Biography

Biography

2021 Research Excellence Fellow, Peninsula Medical School

Qualifications

Academic qualifications:

2002-2008   Ph.D. Biochemistry, University of Leicester

2001-2002   M.Sc. Oncology, University of Nottingham

1998-2001   B.Sc. (Hons.) Biochemistry and Genetics, Class 2:1, University of Nottingham

Previous posts:

2012-2021  Postdoctoral Research Associate, Wellcome Centre for Cell-Matrix Research, Faculty of Biology Medicine & Health, University of Manchester

2010-2012  Postdoctoral Research Associate, Department of Cell and Developmental Biology, Upstate Medical University, Syracuse, NY, USA

2008-2010  Postdoctoral Research Associate, Department of Pharmacology, Yale University, New Haven, CT, USA

Professional membership

Member of the British Society for Cell Biology

Key publications

Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD & Jørgensen C (2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
Lock JG, Jones MC, Askari JA, Gong X, Oddone A, Olofsson H, Göransson S, Lakadamyali M, Humphries MJ & Strömblad S (2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
Jones MC, Askari JA, Humphries JD & Humphries MJ (2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access
View all publications
Teaching

Teaching

Teaching interests

Cell Biology

Extracellular Matrix

Integrins

Tumour Microenvironment

Cell Signalling

Cell Migration

Cell Cycle

Research

Research

Research interests

One of the key events in the evolution of multicellular organisms was the acquisition of the ability of cells to attach to their surroundings, including the network of proteins that support and surround them in tissues called the extracellular matrix (ECM). This adhesion maintains the cells in the correct place in tissues and provides signals that the cells rely on to maintain their function.

Cells adhere to the ECM via a family of cell surface proteins called integrins. Integrins then act as point for a number of other proteins to accumulate and these complexes of proteins can form a physical link with the cell skeleton, both anchoring the cell in a specific location and facilitating cell movement. Integrin complexes also act as signalling hubs that provide information to the cell about its surroundings. In any given tissue in the human body there are hundreds of proteins that make up the ECM and 24 different integrins that all recognise specific proteins and function in different ways. Understanding how these different integrins work and control cell behaviour is therefore critical to understanding how cells function in tissues.

My main research interest is determining how different ECM proteins and Integrins influence cell biology, with a particular focus on the cross-talk between adhesion signalling and cell-cycle progression. To achieve this we use imaging, proteomics, flow cytometry, and biochemical approaches in a range of normal and cancer cells cultured in 2D and 3D environments.  

Grants & contracts

2022 Academy of Medical Sciences, Springboard Award; Extracellular matrix regulation of cell quiescence and proliferation, £99,098

2022 Northcott Devon Medical Foundation; Defining changes in prostate stromal extracellular matrix during cancer progression and in response to androgen-deprivation therapy, £9726.

2021 Peninsula Medical School Research Excellence Fellowship; £30,000

2021 Peninsula Medical School Pump Prime Funding; £5000


Publications

Publications

Key publications

Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD & Jørgensen C (2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
Lock JG, Jones MC, Askari JA, Gong X, Oddone A, Olofsson H, Göransson S, Lakadamyali M, Humphries MJ & Strömblad S (2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
Jones MC, Askari JA, Humphries JD & Humphries MJ (2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access

Key publications are highlighted

Journals
Articles
Humphries JD, Zha J, Burns J, Askari JA, Below CR, Chastney MR, Jones MC, Mironov A, Knight D & O'Reilly DA (2022) 'Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation' Matrix Biology 110, 16-39 , DOI
Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD & Jørgensen C (2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
Hetmanski JHR, Jones MC, Chunara F, Schwartz J-M & Caswell PT (2021) 'Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration' PLOS Computational Biology 17, (3) , DOI Open access
Chastney MR, Lawless C, Humphries JD, Warwood S, Jones MC, Knight D, Jorgensen C & Humphries MJ (2020) 'Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation' Journal of Cell Biology 219, (8) , DOI Open access
Jones MC, Zha J & Humphries MJ (2019) 'Connections between the cell cycle, cell adhesion and the cytoskeleton' Philosophical Transactions of the Royal Society B: Biological Sciences 374, (1779) 20180227-20180227 , DOI
Lock JG, Baschieri F, Jones MC, Humphries JD, Montagnac G, Strömblad S & Humphries MJ (2019) 'Clathrin-containing adhesion complexes' Journal of Cell Biology 218, (7) 2086-2095 , DOI Open access
Lock JG, Jones MC, Askari JA, Gong X, Oddone A, Olofsson H, Göransson S, Lakadamyali M, Humphries MJ & Strömblad S (2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
Jones MC, Askari JA, Humphries JD & Humphries MJ (2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access
Horton ER, Humphries JD, James J, Jones MC, Askari JA & Humphries MJ (2016) 'The integrin adhesome network at a glance' Journal of Cell Science , DOI
Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DHJ, Askari JA & Humphries MJ (2015) 'Isolation of Integrin‐Based Adhesion Complexes' Current Protocols in Cell Biology 66, (1) , DOI
Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD & Humphries MJ (2015) 'Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling' Nature Communications 6, (1) , DOI
Jones MC, Machida K, Mayer BJ & Turner CE (2013) 'Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration' Molecular Biology of the Cell 24, (12) 1882-1894 , DOI
Pignatelli J, Jones MC, LaLonde DP & Turner CE (2012) 'Beta2-Adaptin Binds Actopaxin and Regulates Cell Spreading, Migration and Matrix Degradation' PLoS ONE 7, (10) e46228-e46228 , DOI
Rajasekaran D, Keeler C, Syed MA, Jones MC, Harrison JK, Wu D, Bhandari V, Hodsdon ME & Lolis EJ (2012) 'A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional Effects' Biochemistry 51, (28) 5642-5654 , DOI
Zhang Y, Tang W, Jones MC, Xu W, Halene S & Wu D (2010) 'Different Roles of G Protein Subunits β1 and β2 in Neutrophil Function Revealed by Gene Expression Silencing in Primary Mouse Neutrophils' Journal of Biological Chemistry 285, (32) 24805-24814 , DOI
Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H & Norman JC (2009) 'VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching' Traffic 10, (6) 754-766 , DOI
Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M & Jones MC (2009) 'Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors' Nature Medicine 15, (4) 392-400 , DOI
Gampel A, Moss L, Jones MC, Brunton V, Norman JC & Mellor H (2006) 'VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment' Blood 108, (8) 2624-2631 , DOI
Jones MC, Caswell PT & Norman JC (2006) 'Endocytic recycling pathways: emerging regulators of cell migration' Current Opinion in Cell Biology 18, (5) 549-557 , DOI
Personal

Personal

Reports & invited lectures

2021 ARUK South West Regional Meeting, Plymouth

2020 CSUN Interdisciplinary Cancer Meeting, Los Angeles, CA, USA (Online)

2020 University of Groningen, Netherlands

2018 North of England Cell Biology Meeting, Huddersfield

2018 CRUK Beatson Institute International Conference, Glasgow

2014 Signalling by Adhesion Receptors Gordon Research Seminar and selected talk for main Gordon Research Conference, Lewiston, ME, USA


Conferences organised

As a postdoc, I co-chaired the 2015 Gordon Research Seminar: Fibronectin, Integrins and Related Molecules in Il Ciocco, Italy