Profiles
Dr Matt Jones
Lecturer in Cancer Biology
Peninsula Medical School (Faculty of Health)
Biography
Biography
2021 Research Excellence Fellow, Peninsula Medical School
Qualifications
Academic qualifications:
2002-2008Ph.D. Biochemistry, University of Leicester
2001-2002 M.Sc. Oncology, University of Nottingham
1998-2001 B.Sc. (Hons.) Biochemistry and Genetics, Class 2:1, University of Nottingham
Previous posts:
2012-2021 Postdoctoral Research Associate, Wellcome Centre for Cell-Matrix Research, Faculty of Biology Medicine & Health, University of Manchester
2010-2012 Postdoctoral Research Associate, Department of Cell and Developmental Biology, Upstate Medical University, Syracuse, NY, USA
2008-2010 Postdoctoral Research Associate, Department of Pharmacology, Yale University, New Haven, CT, USA
2002-2008Ph.D. Biochemistry, University of Leicester
2001-2002 M.Sc. Oncology, University of Nottingham
1998-2001 B.Sc. (Hons.) Biochemistry and Genetics, Class 2:1, University of Nottingham
Previous posts:
2012-2021 Postdoctoral Research Associate, Wellcome Centre for Cell-Matrix Research, Faculty of Biology Medicine & Health, University of Manchester
2010-2012 Postdoctoral Research Associate, Department of Cell and Developmental Biology, Upstate Medical University, Syracuse, NY, USA
2008-2010 Postdoctoral Research Associate, Department of Pharmacology, Yale University, New Haven, CT, USA
Professional membership
Member of the British Society for Cell Biology
Key publications
(2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
(2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
(2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access
Teaching
Teaching
Teaching interests
Cell BiologyExtracellular Matrix
Integrins
Tumour Microenvironment
Cell Signalling
Cell Migration
Cell Cycle
Integrins
Tumour Microenvironment
Cell Signalling
Cell Migration
Cell Cycle
Research
Research
Research interests
One of the key events in the evolution of multicellular organisms was the acquisition of the ability of cells to attach to their surroundings, including the network of proteins that support and surround them in tissues called the extracellular matrix (ECM). This adhesion maintains the cells in the correct place in tissues and provides signals that the cells rely on to maintain their function.
Cells adhere to the ECM via a family of cell surface proteins called integrins. Integrins then act as point for a number of other proteins to accumulate and these complexes of proteins can form a physical link with the cell skeleton, both anchoring the cell in a specific location and facilitating cell movement. Integrin complexes also act as signalling hubs that provide information to the cell about its surroundings. In any given tissue in the human body there are hundreds of proteins that make up the ECM and 24 different integrins that all recognise specific proteins and function in different ways. Understanding how these different integrins work and control cell behaviour is therefore critical to understanding how cells function in tissues.
My main research interest is determining how different ECM proteins and Integrins influence cell biology, with a particular focus on the cross-talk between adhesion signalling and cell-cycle progression. To achieve this we use imaging, proteomics, flow cytometry, and biochemical approaches in a range of normal and cancer cells cultured in 2D and 3D environments.
Cells adhere to the ECM via a family of cell surface proteins called integrins. Integrins then act as point for a number of other proteins to accumulate and these complexes of proteins can form a physical link with the cell skeleton, both anchoring the cell in a specific location and facilitating cell movement. Integrin complexes also act as signalling hubs that provide information to the cell about its surroundings. In any given tissue in the human body there are hundreds of proteins that make up the ECM and 24 different integrins that all recognise specific proteins and function in different ways. Understanding how these different integrins work and control cell behaviour is therefore critical to understanding how cells function in tissues.
My main research interest is determining how different ECM proteins and Integrins influence cell biology, with a particular focus on the cross-talk between adhesion signalling and cell-cycle progression. To achieve this we use imaging, proteomics, flow cytometry, and biochemical approaches in a range of normal and cancer cells cultured in 2D and 3D environments.
Grants & contracts
2022 Academy of Medical Sciences, Springboard Award; Extracellular matrix regulation of cell quiescence and proliferation, £99,098
2022 Northcott Devon Medical Foundation; Defining changes in prostate stromal extracellular matrix during cancer progression and in response to androgen-deprivation therapy, £9726.
2021 Peninsula Medical School Research Excellence Fellowship; £30,000
2021 Peninsula Medical School Pump Prime Funding; £5000
2022 Northcott Devon Medical Foundation; Defining changes in prostate stromal extracellular matrix during cancer progression and in response to androgen-deprivation therapy, £9726.
2021 Peninsula Medical School Research Excellence Fellowship; £30,000
2021 Peninsula Medical School Pump Prime Funding; £5000
Publications
Publications
Key publications
(2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
(2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
(2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access
Key publications are highlighted
Journals
Articles
(2023) 'Cell cycle control by cell-matrix interactions' Current Opinion in Cell Biology 86, 102288-102288 , DOI Open access
(2023) 'Giant worm-shaped ESCRT scaffolds surround actin-independent integrin clusters' Journal of Cell Biology 222, (7) , DOI Open access
(2022) 'Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation' Matrix Biology 110, 16-39 , DOI
(2021) 'Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1' Journal of Biological Chemistry 297, (1) , DOI Open access
(2021) 'Combinatorial mathematical modelling approaches to interrogate rear retraction dynamics in 3D cell migration' PLOS Computational Biology 17, (3) , DOI Open access
(2020) 'Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation' Journal of Cell Biology 219, (8) , DOI Open access
(2019) 'Connections between the cell cycle, cell adhesion and the cytoskeleton' Philosophical Transactions of the Royal Society B: Biological Sciences 374, (1779) 20180227-20180227 , DOI
(2019) 'Clathrin-containing adhesion complexes' Journal of Cell Biology 218, (7) 2086-2095 , DOI Open access
(2018) 'Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis' Nature Cell Biology 20, (11) 1290-1302 , DOI
(2018) 'Cell adhesion is regulated by CDK1 during the cell cycle' Journal of Cell Biology 217, (9) 3203-3218 , DOI Open access
(2015) 'Isolation of Integrin‐Based Adhesion Complexes' Current Protocols in Cell Biology 66, (1) , DOI
(2015) 'Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling' Nature Communications 6, (1) , DOI
(2013) 'Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration' Molecular Biology of the Cell 24, (12) 1882-1894 , DOI
(2012) 'Beta2-Adaptin Binds Actopaxin and Regulates Cell Spreading, Migration and Matrix Degradation' PLoS ONE 7, (10) e46228-e46228 , DOI
(2012) 'A Model of GAG/MIP-2/CXCR2 Interfaces and Its Functional Effects' Biochemistry 51, (28) 5642-5654 , DOI
(2010) 'Different Roles of G Protein Subunits β1 and β2 in Neutrophil Function Revealed by Gene Expression Silencing in Primary Mouse Neutrophils' Journal of Biological Chemistry 285, (32) 24805-24814 , DOI
(2009) 'VEGFR1 (Flt1) Regulates Rab4 Recycling to Control Fibronectin Polymerization and Endothelial Vessel Branching' Traffic 10, (6) 754-766 , DOI
(2009) 'Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors' Nature Medicine 15, (4) 392-400 , DOI
(2006) 'Endocytic recycling pathways: emerging regulators of cell migration' Current Opinion in Cell Biology 18, (5) 549-557 , DOI
(2006) 'VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment' Blood 108, (8) 2624-2631 , DOI
Personal
Personal
Reports & invited lectures
2021 ARUK South West Regional Meeting, Plymouth
2020 CSUN Interdisciplinary Cancer Meeting, Los Angeles, CA, USA (Online)
2020 University of Groningen, Netherlands
2018 North of England Cell Biology Meeting, Huddersfield
2018 CRUK Beatson Institute International Conference, Glasgow
2014 Signalling by Adhesion Receptors Gordon Research Seminar and selected talk for main Gordon Research Conference, Lewiston, ME, USA
2020 CSUN Interdisciplinary Cancer Meeting, Los Angeles, CA, USA (Online)
2020 University of Groningen, Netherlands
2018 North of England Cell Biology Meeting, Huddersfield
2018 CRUK Beatson Institute International Conference, Glasgow
2014 Signalling by Adhesion Receptors Gordon Research Seminar and selected talk for main Gordon Research Conference, Lewiston, ME, USA
Conferences organised
As a postdoc, I co-chaired the 2015 Gordon Research Seminar: Fibronectin, Integrins and Related Molecules in Il Ciocco, Italy