Dr Lynn McCallum
Associate Professor of Haematology (Education)
School of Biomedical Sciences (Faculty of Health)
- Prostate cancer
- Cell signalling
- Stem cell renewal
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Associate Professor in Haematology (Education)
Programme Lead Healthcare Sciences
PhD University of Edinburgh
BSc (Hons) Queen's University Belfast
PGCAP Plymouth University 2012
American Society for Hematology
British Society for Haematology
International CCN Society
Fellow of the Higher Education Academy
Roles on external bodies
South West Lead Scientist Network representative for Plymouth University
Member of Association for Clinical Physiology Education
Stem cell signalling
Staff serving as external examiners
External Examiner Bradford University
Investigation of CCN matricellular proteins in normal and malignant haematopoesis and solid tumour metastasis to bone. CCN proteins modulate stem cell signalling pathways including that of transforming growth factor beta, bone morphogenic protein, Notch and Wnt-beta-catenin. Abberations in CCN expression have been associated with a number of haematological malignancies including leukaemia and also in prostate cancer. CCN overexpression and knockdown systems have been created to identify the associated signalling pathways involved in tumourigenesis, advanced and resistant disease using gene array profiling. Identification of novel targeting strategies directed toward CCN associated stem cell signalling will allow development of novel therapeutics to more effectively target cancer.
Research degrees awarded to supervised students
Sukanya Suresh PhD (QUB, 2011)
Afak Zaidi PhD (UoP, 2019)
Grants & contracts
Research and Innovation, Plymouth University R&I (2012, £37,250). Seedcorn investment to investigate ‘Targeting Prostate Cancer Progression’.
British Society for Haematology (2010, £6900). Start-up grant ‘Profiling CCN expression in Haematological malignancy’
Key publications are highlightedJournals
Reports & invited lectures
South West Lead Scientist hosting Healthcare Science Conference, 1st July 2019, UWE Frenchay Campus.