- A420, Portland Square, Drake Circus, Plymouth, PL4 8AA
- +44 1752 585990
- lynn.mccallum@plymouth.ac.uk

Profiles
Dr Lynn McCallum
Associate Professor of Haematology (Education)
School of Biomedical Sciences (Faculty of Health)
- Haematology
- Leukaemia
- Prostate cancer
- Cell signalling
- Stem cell renewal
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
Associate Professor in Haematology (Education)
Programme Lead Healthcare Sciences
Qualifications
PhD University of Edinburgh
BSc (Hons) Queen's University Belfast
PGCAP Plymouth University 2012
Professional membership
American Society for Hematology
British Society for Haematology
International CCN Society
Fellow of the Higher Education Academy
Roles on external bodies
South West Lead Scientist Network representative for Plymouth University
Member of Association for Clinical Physiology Education
Teaching
Teaching
Teaching interests
Haematology
Oncology
Stem cell signalling
Targeted therapeutics
Professional practice
Staff serving as external examiners
External Examiner Bradford University, BSc Hons Healthcare Science (2017-2021)
External Examiner University of Ulster, MSc Biomedical Science (2021-2025)
Research
Research
Research interests
Investigation of CCN matricellular proteins in normal and malignant haematopoesis and solid tumour metastasis to bone. CCN proteins modulate stem cell signalling pathways including that of transforming growth factor beta, bone morphogenic protein, Notch and Wnt-beta-catenin. Abberations in CCN expression have been associated with a number of haematological malignancies including leukaemia and also in prostate cancer. CCN overexpression and knockdown systems have been created to identify the associated signalling pathways involved in tumourigenesis, advanced and resistant disease using gene array profiling. Identification of novel targeting strategies directed toward CCN associated stem cell signalling will allow development of novel therapeutics to more effectively target cancer.
Research degrees awarded to supervised students
Sukanya Suresh PhD (QUB, 2011)
Afak Zaidi PhD (UoP, 2019)
Grants & contracts
Research and Innovation, Plymouth University R&I (2012, £37,250). Seedcorn investment to investigate ‘Targeting Prostate Cancer Progression’.
British Society for Haematology (2010, £6900). Start-up grant ‘Profiling CCN expression in Haematological malignancy’
Publications
Publications
Key publications
Key publications are highlighted
JournalsPersonal
Personal
Conferences organised
South West Lead Scientist hosting Healthcare Science Conference, 1st July 2019, UWE Frenchay Campus.
Links
International CCN Society: http://ccnsociety.com/index.html
British Society for Haematology: http://www.b-s-h.org.uk/
Society for Endocrinology: http://www.endocrinology.org