Dr Liyam Laraba
Profiles

Dr Liyam Laraba

Research Fellow

Peninsula Medical School (Faculty of Health)

Biography

Biography

I am an early-career researcher in neuro-oncology with a focus on NF2-deficient tumours of the nervous system. 

Since completing my undergraduate and master's degree in biochemistry at the University of Birmingham, I came to the lab of Prof David Parkinson at the University of Plymouth for my PhD.

I am now developing as an independent researcher within NF2-related tumour biology whilst developing broader interests such as teaching.

Qualifications

MSc Biochemistry - University of Birmingham, 2016.

PhD Neuro-oncology - University of Plymouth, 2021.

Research

Research

Research interests

I am interested in the role of dysregulated Hippo signalling in NF2-null tumours of the nervous system. 

We use both primary human meningioma and schwannoma cell cultures as well as relevant mouse models to test drugs which target aberrant tumour cell activity.

Grants & contracts

Children's Tumor Foundation Young Investigator Award - 2020-2022

Publications

Publications

Key publications

Key publications are highlighted

Journals

·   Marta Palomo-Irigoyen,1 Encarni Pérez-Andrés,1 Marta Iruarrizaga-Lejarreta,1 Adrián Barreira-Manrique,1 Miguel Tamayo-Caro,1 Laura Vila-Vecilla,1 Leire Moreno-Cugnon,1 Nagore Beitia,1 Daniela Medrano,1 David Fernández-Ramos,1,2 Juan José Lozano,3 Satoshi Okawa,4,5 José L. Lavín,1 Natalia Martín-Martín,1,6 James D. Sutherland,1 Virginia Guitiérez de Juan,1,2 Monika Gonzalez-Lopez,1 Nuria Macías-Cámara,1,2 David Mosén-Ansorena,1 Liyam Laraba,7 C. Oliver Hanemann,7 Emanuela Ercolano,7 David B. Parkinson,7 Christopher W. Schultz,8 Marcos J. Araúzo-Bravo,9,10 Alex M. Ascensión,9 Daniela Gerovska,9 Haizea Iribar,11 Ander Izeta,11 Peter Pytel,12 Philipp Krastel,13 Alessandro Provenzani,14 Pierfausto Seneci,15 Ruben D. Carrasco,16 Antonio Del Sol,1,4,10,17 María Luz Martinez-Chantar,1,2 Rosa Barrio,1 Eduard Serra,6,18 Conxi Lazaro,6,19,20 Adrienne M. Flanagan,21,22 Myriam Gorospe,23 Nancy Ratner,24 Ana M. Aransay,1,2 Arkaitz Carracedo,1,6,10,25 Marta Varela-Rey,1,2 and Ashwin Woodhoo1,10. (2020) HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis. J Clin Invest. 2020;130(7): 3848-3864. https://doi.org/10.1172/JCI130379.

 

·  Emmanuel A. Maze2†, Bora Agit1†, Shona Reeves1, David A. Hilton1, David B. Parkinson1, Liyam Laraba1, Emanuela Ercolano1, Kathreena M. Kurian4, C. Oliver Hanemann1+, Robert Belshaw 2,3+* and Sylwia Ammoun1+* Human Endogenous Retrovirus Type K promotes proliferation of Merlin-negative schwannoma and meningioma which can be inhibited by anti-retroviral and anti-TEAD drugs. Cancer Res. 2021; accepted, online ahead of print. https://doi.org/10.1158/0008-5472.CAN-20-3857

Articles
Maze EA, Agit B, Reeves S, Hilton DA, Parkinson DB, Laraba L, Ercolano E, Kurian KM, Hanemann CO & Belshaw RD (2021) 'Human endogenous retrovirus type K promotes proliferation and confers sensitivity to anti-retroviral drugs in Merlin-negative schwannoma and meningioma' Cancer Research , DOI Open access
Palomo-Irigoyen M, Pérez-Andrés E, Iruarrizaga-Lejarreta M, Barreira-Manrique A, Tamayo-Caro M, Vila-Vecilla L, Moreno-Cugnon L, Beitia N, Medrano D & Fernández-Ramos D (2020) 'HuR/ELAVL1 drives malignant peripheral nerve sheath tumor growth and metastasis' Journal of Clinical Investigation 130, (7) 3848-3864 , DOI Open access
Personal

Personal

Other academic activities

·   Children’s Tumour Foundation Meeting – November 2018

Poster Presentation.

·   British Neuropathological Society – March 2019

Oral presentation.

·   Berlin Brain Tumour Meeting – May 2019

Poster Presentation.

 ·   AACR Virtual meeting – March 2020

Poster Presentation.

·   Children’s Tumour Foundation Virtual Meeting – June 2021

Oral Presentation.