Dr Lee Hutt
Profiles

Dr Lee Hutt

Lecturer in Biomedical Sciences

School of Biomedical Sciences (Faculty of Health)

Biography

Biography

Lecturer in Biomedical Sciences

Qualifications

2018 Professional Development in Academic Practice (PDAP)

2016 Ph.D. Microbiology, University of Plymouth, 2016 (Taxonomy, physiology and biochemistry of the sulfur Bacteria)

2012 B.Sc. (1st class Hons) Biological Sciences, University of Plymouth, 2012

Teaching

Teaching

Teaching interests

Module Leader:

BHCS002 Current Developments in Human Biology and Biomedical Sciences

Teaching Involvement:

FMD001 Molecules to Cells 

BHCS001 Infection, Immunity and Therapeutics

BHCS1003 Human Metabolism

BHCS1004 Introduction to Human Pathology

BHCS1005 Human Disease 

BHCS1006 Infection and Immunity

BHCS2004 Cell Biology in Health and Disease

BHCS2006 Infection, Immunity and Disease

BHCS3003 Clinical Microbiology

BIOM5003 Contemporary Science of Infection and Immunity

BIOM5005 Project Design and Development

BHCS5010 Contemporary Applications in Cancer Biology and Therapeutics

Research

Research

Research interests

Biodiversity and anti-microbial potential of the Roman Baths, Bath

It is estimated that as many as 10 million people a year will die due to anti-microbial resistance (AMR) and cost the global economy 100 trillion US dollars per year by 2050. In order to tackle this threat scientists have started looking into novel compounds with anti-microbial activity from more "unusual" environments. The Roman Baths (Bath) is the only ‘warm’ hot spring in the UK and is rich in microbiological diversity, several species of which I worked on during my Ph.D. I am conducting research into both the microbial diversity of the Roman Baths and attempting to isolate bacterial strains producing novel compounds with anti-microbial activity.

Biology and Novel Treatments for eukaryotic parasites

Intestinal parasites, such as Giardia intestinalis, infect millions of people globally every year. The World Health Organisation (WHO) considers Giardiasis (the disease caused be Giardia) as one of the World's most neglected diseases, with approximately 1 billion people in developing parts of the world at risk of infection every year. The disease is relatively easy to treat with common types of antibiotics; however, there is increasing evidence of anti-microbial resistance (AMR) in this parasite. I am interested in identifying novel therapeutics/prophylactic treatments for Giardiasis and mechanisms by which Giardia becomes resistant to anti-microbials. Understanding the biology of this unusual Eukaryote organism is key to our treatment of the disease it causes.

Please contact me if you wish to discuss my areas of research further.

Publications

Publications

Journals

Hutt, L. P., Harper, G. M., Moody, A. J. & Boden, R. (2020) Insights into growth kinetics and roles of enzymes of Krebs’ cycle and sulfur oxidation during exochemolithoheterotrophic growth of Achromobacter aegrifaciens NCCB 38021 on succinate with thiosulfate as the auxiliary electron donor. Archives of Microbiology, https://doi.org/10.1007/s00203-020-02028-1.

Dyer, C., Hutt, L. P., Burky, R. & Joshi, L. T. (2019) Biocide resistance and transmission of Clostridium difficile spores spiked onto clinical surfaces from an American healthcare facility. Applied and Environmental Microbiology, 85 (17) doi: 10.1128/AEM.01090-19.

Boden, R., Scott, K. M., Rae, A. & Hutt, L. P. (2017) Reclassification of Thiomicrospira hydrogeniphila (Watsuji et al. 2016) to Thiomicrorhabdue hydrogeniphila comb. nov., with emended description of Thiomicrorhabdus (Boden et al. 2017). International Journal of Systematic and Evolutionary Microbiology, 67 (10) pp 4205-4209.

Boden, R., Scott, K. M., Williams, J., Russel, S., Antonen, K., Rae, A. & Hutt, L. P. (2017) An evaluation of Thiomicrospira, Hydrogenovibrio and Thioalkalimicrobium: reclassification of four species of Thiomicrospira to each Thiomicrorhabdus gen. nov. and Hydrogenovibrio, and reclassification of all four species of Thioalkalimicrobium to Thiomicrospira. International Journal of Systematic and Evolutionary Microbiology, 67 (5) pp 1140-1151.

Boden, R., Hutt, L. P. & Rae, A. W. (2017) Reclassification of Thiobacillus aquaesulis (Wood & Kelly, 1995) as Annwoodia aquaesulis gen. nov., comb. nov. transfer of Thiobacillus (Beijernck, 1904) from Hydrogenophilales to the Nitrosomonadales class. nov. within the 'Proteobacteria', and 4 new families within the orders Nitrosomonadales and Rhodocyclales. International Journal of Systematic and Evolutionary Microbiology, 67 (5) pp 1191-1205.

Hutt, L. P., Huntemann, M., Clum, A., Pillay, M., Palaniappan, K., Varghese, N., Mikhailova, N., Stamatis, D., Reddy, T., Daum, C., Shapiro, N., Ivanova, N.,Kyrpides, N., Woyke, T. & Boden, R. (2017) Permanent draft genome of Thiobacillus thioparus DSM 505T, an obligately chemolithoautotrophic member of the Betaproteobacteria. Standards in Genomic Sciences. 12 (10).

Boden, R., Hutt, L. P., Huntemann, M., Clum, A., Pillay, M., Palaniappan, K., Varghese, N., Mikhailova, N., Stamatis, D. & Reddy, T., Ngan, C. Y., Daum, C., Shapiro, N., Markowitz, V., Ivanova, T., Woyke, T. & Kyrpides, N. (2016) Permanent draft genome of Thermithiobacillus tepidarius DSM 3134T, a moderately thermophilic, obligately chemolithoautotrophic member of the Acidithiobacillia. Standards in Genomic Sciences, 11 (74).

Chapters

Boden, R. & Hutt, L. P. (2019) Acidithiobacillus. In: Bergey’s Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Inc.

Boden, R. & Hutt, L. P. (2019) Annwoodia. In: Bergey’s Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Inc.

Boden, R. & Hutt, L. P. (2019) Hydrogenophilalia. In: Bergey’s Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Inc.

Boden, R. & Hutt, L. P. (2019) Thermithiobacillus. In: Bergey’s Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Inc.

Boden, R. & Hutt, L. P. (2019) Thiobacillus. In: Bergey’s Manual of Systematics of Archaea and Bacteria. John Wiley & Sons, Inc.

Boden, R. & Hutt, L. P. (2018) Aerobic Bacterial Catabolism of Dimethylsulfoniopropionate. In: Rojo F (Ed) Aerobic utilization of hydrocarbon and lipid microbiology. Cham, Switzerland: Springer. 1-27.

Boden, R. & Hutt, L. P. (2018) Bacterial Metabolism of C1 Sulfur Compounds. In: Rojo F (Ed) Aerobic utilization of hydrocarbon and lipid microbiology. Cham, Switzerland: Springer. 1-43.

Boden, R. & Hutt, L. P. (2018) Determination of kinetic parameters and metabolic modes using the chemostat. In: Consequences of microbial interactions with hydrocarbons, oils, and lipids: Biodegradation and bioremediation. Cham, Switzerland: Springer. 1-42.

Boden, R. & Hutt, L. P. (2018) Chemolithoheterotrophy: Means to higher growth yields from this widespread metabolic trait. In: Rojo F (Ed) Aerobic utilization of hydrocarbon and lipid microbiology. Cham, Switzerland: Springer. 1-25.