The Global Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. Leandro Jose's work contributes towards the following SDG(s):
About Leandro Jose
Cancer metabolism is based on alterations of metabolic activities compared to normal cells. One of the most observed metabolic alterations in several cancers is the increased uptake of glucose to support growth by energy production and the formation of precursors such as nucleotides, amino acids, and lipids. The primary experience of the researcher is in biochemistry, genetics, and metabolism, more specifically, in the characterisation of carbon source metabolism.
Tumour progression requires a metabolic rewiring of cancer cells, providing enough energy for metabolism and cellular growth and increasing cancer cells fitness for proliferation and survival. The Researcher is working on carbohydrate metabolism supporting brain tumour growth and signalling pathways responsible for meningioma progression. Meningioma is the most common primary brain tumour and can be classified according to distinct DNA methylation classes, which provide a more accurate prediction of tumour behaviour than histopathological grading alone. DNA methylation profiling stratifies meningiomas into molecular groups associated with favourable, intermediate, and adverse clinical outcomes, reflecting differences in recurrence risk and overall prognosis.
Contact Leandro Jose
+44 1752 583434
leandro.deassis@plymouth.ac.uk
