Dr Kris Jeremy

Biography

Deputy Head of School, School of Biomedical Sciences

Associate Professor of Biochemistry (Education)

Programme Lead - BSc (Hons) Biomedical Science (August 2015 - May 2021)

Blood pathway lead - HCS LS/BSc (Hons) Applied Biomedical Science

Lecturer in Biomedical Science (Biochemistry) (August 2014 - August 2021)

Qualifications

Background

Royal Air Force

GlaxoSmithKline

IdentiGEN UK

Qualifications

BSc (Hons) Biochemistry

PhD Biomedical Science

Postgraduate Certificate in Teaching and Learning in Higher Education (PGCHE)

PgDIP CMI Strategic Management and Leadership

Professional membership

Chartered Manager (CMgr)

Chartered Biologist (CBiol)

Fellow of the Higher Education Academy (FHEA)

Fellow of the Institute of Biomedical Science (FIBMS)

Fellow of the Royal Society of Biology (FRSB)

Roles on external bodies

Education Officer - Institute of Biomedical Science (South Western Region)

Teaching

Teaching interests

Module lead

FMD001 Molecules to Cells
BHCS3004 Specialist Biochemistry and Screening

Teaching

FdSc

FMD001 Molecules to Cells

BSc

BHCS1001 Biomedical Investigation and Experimentation

BHCS1002 Human Anatomy and Physiology: Cells to Systems

BHCS1003 Human Metabolism

DIET403 Nutritional Biochemistry

BHCS1005 Human Disease

BHCS1011 Study skills and personal development

BHCS2001 Biology of Disease

BHCS2002 Evidence-Based Practice in Biomedical Science

BHCS2005 Clinical Haematology and Biochemistry

BHCS2027 Placements and Employability

BHCS2020 Human Metabolism

DIET509 Diet, Metabolism and Health

BHCS2025 Nutritional Science 2

BHCS3001 Personal Research Project

BHCS3004 Specialist Biochemistry and Screening

BHCS3024 Diet, Exercise and Chronic Disease

BHCS3031 Personal development and employability

MSc

BIOM5002 Contemporary Applications of Cell Biology

BIOM5006 Research Project

BHCS5009 Cancer Biology and Therapeutics

BHCS5010 Contemporary Applications in Cancer Biology and Therapeutics

HNUT702 Applied Nutrition

Programme Lead

BSc (Hons) Biomedical Science (2015-2021)

Staff serving as external examiners

Bangor University - External examiner - BSc (Hons) Biomedical Science (2016 - 2020)

Cardiff Metropolitan University - External validation - BSc (Hons) Biomedical Science top-up - ICBT, Sri Lanka (2017)

UWE, Bristol - Programme Enhancement Review External Panel Member - MSci Biological Sciences and BSc (Hons) Biological Sciences (2019)

External examiner - BSc (Hons) Biomedical Science - Sri Lanka ICBT, Singapore Dimensions and Cardiff Metropolitan programmes (2021 - 2025)

Research

Research interests

CD47 signalling in erythrocytes and AML cell lines

CD47 is a five transmembrane cell surface protein of the immunoglobulin (Ig) superfamily, which is heavily glycosylated and expressed by virtually all cells in the body. Ligation of CD47 with a monoclonal antibody (BRIC 126) and a synthetic peptide (4N1K) based on the C terminal binding domain of Thromobospondin-1 (TSP-1) leads to phosphatidylserine (PS) exposure and cell death in erythrocytes. Recent research has shown that CD47 is upregulated on solid tumours and is overexpressed on acute myeloid leukaemia (AML) cell lines. Overexpression of CD47 indicates poor prognosis in AML hence blockade of CD47 has improved cancer therapy. CD47 is also prognostic for breast cancer.

Recent research has shown measurable amounts of PS exposure and cell death in several AML cell lines in response to BRIC126. It is hoped that research into this pathway will help to elucidate the underlying molecular mechanisms responsible for CD47 mediated phosphatidylserine exposure in AML cell lines. Several targets within this proposed pathway have already been identified for further study.

Grants & contracts

External grants:

Co-investigator: Northcott Devon Medical Foundation: “Understanding the role of CD47 in colorectal cancer and the use of anti-CD47 monoclonal antibodies for potential cancer immunotherapy” - Awarded December 2019.

Publications

Jeremy, K. P., Plummer, Z. E., Head, D. J., Madgett, T. E., Sanders, K. L., Wallington, A., Storry, J. R., Gilsanz, F., Delaunay, J. & Avent, N. D. (2009) 4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins. Haematologica, 94, 1354-61.

Jeremy K, Delaunay J, Gilsanz F, Avent N Opposing effects of protein kinase A and C causes differential phosphatidylserine exposure in a CD47 receptor mediated erythrocyte apoptotic pathway (2008) Haematologica 93, S1:188

Jeremy K, Plummer Z, Head D, Delaunay J, Gilsanz F, Avent N Proteomic and Biochemical Profiling of 4.1R deficient red blood cells (2007) Haematologica; 92, S1:342-343

Personal

Reports & invited lectures

25th British Blood Transfusion Society Annual Scientific Meeting, Glasgow SECC, Glasgow, September 13th-15th 2007 - Special Interest Group

Profiles

Deputy Head of School

School of Biomedical Sciences (Faculty of Health)