Konstantin Glebov

Konstantin Glebov

Honorary Professor

Peninsula Medical School (Faculty of Health)



Passionate about research into mechanisms and potential treatments of rare diseases as well as researching policies that support local communities of patients with rare diseases and improve research into rare diseases.https://rarediseasessouthwest.org.uk


2002 - Diploma in Biology with honors2007 - PhD in Neuroscience (summa cum laude)


Research interests

My main research interest is molecular basis of neuron-glia communication. Glia cells are the most abundant cell type in human brain. Communication between neuron and glia cells is one of the most intriguing processes that happen in the brain. It is mediated through different classes of receptors and release of small double membrane vesicles called exosomes. Study of these mechanisms can help us to understand molecular basis underlying pathomechanisms of brain disorders like Alexander disease, Alzheimer’s, and Parkinson.


Key publications

Key publications are highlighted

Karsak M, Glebov K, Scheffold M, Bajaj T, Kawalia A, Karaca I, Rading S, Kornhuber J, Peters O & Diez-Fairen M (2019) 'A rare heterozygous TREM2 coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2' Human Mutation , DOI Open access
Walter J, Kemmerling N, Wunderlich P & Glebov K (2017) 'γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation' Journal of Neurochemistry 143, (4) 445-454 , DOI Open access
Messéant J, Ezan J, Delers P, Glebov K, Marchiol C, Lager F, Renault G, Tissir F, Montcouquiol M & Sans N (2017) 'Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways' Development 144, (9) 1712-1724 , DOI Open access
Mitroi DN, Deutschmann AU, Raucamp M, Karunakaran I, Glebov K, Hans M, Walter J, Saba J, Gräler M & Ehninger D (2016) 'Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism' Scientific Reports 6, (1) , DOI Open access
Beckmann A-M, Glebov K, Walter J, Merkel O, Mangold M, Schmidt F, Becker-Pauly C, Gütschow M & Stirnberg M (2016) 'The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2' Biological Chemistry 397, (8) , DOI Open access
Glebov K, Wunderlich P, Karaca I & Walter J (2016) 'Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)' Journal of Neuroinflammation 13, (1) , DOI Open access
LaPash Daniels CM, Paffenroth E, Austin EV, Glebov K, Lewis D, Walter J & Messing A (2015) 'Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease' PLOS ONE 10, (9) e0138132-e0138132 , DOI Open access
Ramirez A, Karsak M, Thelen M, Glebov K, Nagler M, Rading S, Thiele H, Lernnarz M, Jessen F & Maier W (2015) 'P2‐049: Functional characterization of a novel <i>TREM2</i> coding variant linked to familial Alzheimer's disease' Alzheimer's &amp; Dementia 11, (7S_Part_10) , DOI
Glebov K, Löchner M, Jabs R, Lau T, Merkel O, Schloss P, Steinhäuser C & Walter J (2014) 'Serotonin stimulates secretion of exosomes from microglia cells' Glia 63, (4) 626-634 , DOI Open access
Gauthier-Kemper A, Igaev M, Sündermann F, Janning D, Brühmann J, Moschner K, Reyher H-J, Junge W, Glebov K & Walter J (2014) 'Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43' Molecular Biology of the Cell 25, (21) 3284-3299 , DOI Open access
Karaca I, Tamboli IY, Glebov K, Richter J, Fell LH, Grimm MO, Haupenthal VJ, Hartmann T, Gräler MH & van Echten-Deckert G (2014) 'Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein' Journal of Biological Chemistry 289, (24) 16761-16772 , DOI Open access
Glebov K, Voronezhskaya EE, Khabarova MY, Ivashkin E, Nezlin LP & Ponimaskin EG (2014) 'Mechanisms underlying dual effects of serotonin during development of Helisoma trivolvis(Mollusca)' BMC Developmental Biology 14, (1) , DOI Open access
Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H & Walter J (2013) 'Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage' Journal of Biological Chemistry 288, (46) 33027-33036 , DOI Open access
Glebov K & Walter J (2011) 'Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-β Peptide' Neurodegenerative Diseases 10, (1-4) 309-312 , DOI Open access
Glebov K, Schütze S & Walter J (2011) 'Functional Relevance of a Novel SlyX Motif in Non-conventional Secretion of Insulin-degrading Enzyme' Journal of Biological Chemistry 286, (26) 22711-22715 , DOI
Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M, Hoch M, Mc Donald JM, Wüllner U, Glebov K & Heneka MT (2011) 'Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease' The EMBO Journal 30, (11) 2255-2265 , DOI
Voronezhskaya E, Glebov K, Khabarova M, Ponimaskin E & Nezlin L (2008) 'Adult-to-embryo chemical signaling in the regulation of larval development in trochophore animals: Cellular and molecular mechanisms' Acta Biologica Hungarica 59, (Supplement 2) 117-122 , DOI
Renner U, Glebov K, Lang T, Papusheva E, Balakrishnan S, Keller B, Richter DW, Jahn R & Ponimaskin E (2007) 'Localization of the Mouse 5-Hydroxytryptamine<sub>1A</sub>Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling' Molecular Pharmacology 72, (3) 502-513 , DOI
Ponimaskin E, Dumuis A, Gaven F, Barthet G, Heine M, Glebov K, Richter DW & Oppermann M (2005) 'Palmitoylation of the 5-Hydroxytryptamine<sub>4a</sub>Receptor Regulates Receptor Phosphorylation, Desensitization, and β-Arrestin-Mediated Endocytosis' Molecular Pharmacology 67, (5) 1434-1443 , DOI
Conference Papers
Schuele R, Ferbert A, Oteyza AC, Synofzik M, Glebov K, Gonzalez M, Walter J, Stevanin G, Zuechner S & Schoels L (2013) 'Defective synthesis of complex gangliosides is involved in hereditary spastic paraplegia' S405-S405