- Room 124, Derriford Research Facility, 16 Research Way, Plymouth, PL6 8BU
- +44 1752 583220
- konstantin.glebov@plymouth.ac.uk

Profiles
Dr Konstantin Glebov
Lecturer in Clinical Neurobiology
Peninsula Medical School (Faculty of Health)
Qualifications
2002 - Diploma in Biology with honors
2007 - PhD in Neuroscience (summa cum laude)
Research interests
My main research interest is molecular basis of neuron-glia communication. Glia cells are the most abundant cell type in human brain. Communication between neuron and glia cells is one of the most intriguing processes that happen in the brain. It is mediated through different classes of receptors and release of small double membrane vesicles called exosomes. Study of these mechanisms can help us to understand molecular basis underlying pathomechanisms of brain disorders like Alexander disease, Alzheimer’s, and Parkinson.
Key publications
Key publications are highlighted
Journals
Articles
2019 'A rare heterozygous
TREM2
coding variant identified in familial clustering of dementia affects an intrinsically disordered protein region and function of TREM2' Human Mutation , DOI Open access
2017 'γ-Secretase in microglia - implications for neurodegeneration and neuroinflammation' Journal of Neurochemistry 143, (4) 445-454 , DOI Open access
2017 'Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways' Development 144, (9) 1712-1724 , DOI Open access
2016 'Sphingosine 1-phosphate lyase ablation disrupts presynaptic architecture and function via an ubiquitin- proteasome mediated mechanism' Scientific Reports 6, (1) , DOI Open access
2016 'The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2' Biological Chemistry 397, (8) , DOI Open access
2016 'Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2)' Journal of Neuroinflammation 13, (1) , DOI Open access
2015 'Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease' PLOS ONE 10, (9) e0138132-e0138132 , DOI Open access
2014 'Serotonin stimulates secretion of exosomes from microglia cells' Glia 63, (4) 626-634 , DOI Open access
2014 'Interplay between phosphorylation and palmitoylation mediates plasma membrane targeting and sorting of GAP43' Molecular Biology of the Cell 25, (21) 3284-3299 , DOI Open access
2014 'Deficiency of Sphingosine-1-phosphate Lyase Impairs Lysosomal Metabolism of the Amyloid Precursor Protein' Journal of Biological Chemistry 289, (24) 16761-16772 , DOI Open access
2014 'Mechanisms underlying dual effects of serotonin during development of Helisoma trivolvis (Mollusca)' BMC Developmental Biology 14, (1) 14-14 , DOI Open access
2013 'Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage' Journal of Biological Chemistry 288, (46) 33027-33036 , DOI Open access
2012 'Statins in Unconventional Secretion of Insulin-Degrading Enzyme and Degradation of the Amyloid-ß Peptide' Neurodegenerative Diseases 10, (1-4) 309-312 , DOI Open access
2011 'Functional Relevance of a Novel SlyX Motif in Non-conventional Secretion of Insulin-degrading Enzyme' Journal of Biological Chemistry 286, (26) 22711-22715 , DOI
2011 'Extracellular phosphorylation of the amyloid β-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease' The EMBO Journal 30, (11) 2255-2265 , DOI
2008 'Adult-to-embryo chemical signaling in the regulation of larval development in trochophore animals: Cellular and molecular mechanisms' Acta Biologica Hungarica 59, (Supplement 2) 117-122 , DOI
2007 'Localization of the Mouse 5-Hydroxytryptamine1A Receptor in Lipid Microdomains Depends on Its Palmitoylation and Is Involved in Receptor-Mediated Signaling' Molecular Pharmacology 72, (3) 502-513 , DOI
2005 'Palmitoylation of the 5-Hydroxytryptamine4a Receptor Regulates Receptor Phosphorylation, Desensitization, and β-Arrestin-Mediated Endocytosis' Molecular Pharmacology 67, (5) 1434-1443 , DOI
Conference Papers
2013 'Defective synthesis of complex gangliosides is involved in hereditary spastic paraplegia' S405-S405