Dr Karen Piper
Profiles

Dr Karen Piper

PenCTU Trial Manager

Peninsula Medical School (Faculty of Health)

Biography

Biography

Commenced at Pen CTU as a Trial Manager in October 2022.

Over 12 years experience in professional services working across NHS/ HEI sector supporting pre- and post-award clinical research grants (NIHR/ charities); this included programme management of a £20 million DHSC/MoD grant over 10 years in trauma, with clinical trials embedded. Previously an academic researcher (immunologist) working in the HEI sector.


Qualifications

2 (i) BSc (Hons) Biological Sciences (Portsmouth Polytechnic)

PhD Immunoparasitology (National Institute for Medical Research (NIMR), Mill Hill, London)

Prince2 (Foundation)


Publications

Publications

Journals

1.   Eldershaw SA, Pearce H, Inman CF, Piper KP, Abbotts B, Stephens C, Nicol S, Croft W, Powell R, Begum J, Taylor G, Nunnick J, Walsh D, Sirovica M, Saddique S, Nagra S, Ferguson P, Moss P, Malladi R. (2021). DNA and modified vaccinia Ankara prime-boost vaccination generates strong CD8 + T cell responses against minor histocompatibility antigen HA-1. Br. J. Haematol. 195(3):433-446.

2.   Lissauer D, Piper K, Goodyear O, Kilby MD, Moss PAH. (2012). Fetal-specific CD8+ cytotoxic T cell responses develop during normal pregnancy and exhibit broad functional capacity. (2012). J. Immunol. 189(2):1072-80. 

3.   Piper K.P., Karanth, M., McLarnon, A., Kalk, E., Murray, J., Pratt, G., Moss P.A. (2011). Chronic lymphocytic leukaemia cells drive the global CD4+ T cell repertoire towards a regulatory phenotype and leads to the accumulation of CD4+ forkhead box P3+ T cells. Clin. Exp. Immunol. 166: 154 – 63.

4.   McLarnon, A., Piper K.P., Goodyear, O.C., Arrazi, J.M., Mahendra, P., Cook, M., Clark, F., Pratt, G., Craddock, C., Moss, P.A. (2010). CD8(+) T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect. Haematologica 95:1572-8.

5.   Morgan, M.D., Day, C.J., Piper, K.P., Khan, N., Harper, L., Moss, P.A., Savage, C.O. (2010). Patients with Wegener's granulomatosis demonstrate a relative deficiency and functional impairment of T-regulatory cells. Immunology 130:64-73.

6.   Lissauer, D.M., Piper, K.P., Moss, P.A., Kilby, M.D. (2009). Fetal microchimerism: the cellular and immunological legacy of pregnancy. Expert Rev Mol Med.11:e33

7.   Nicholls, S., Piper, K.P., Mohammed, F., Dafforn, T.R., Tenzer, S., Salim, M., Mahendra, P., Craddock, C., van Endert, P., Schild, H., Mark Cobbold, M., Engelhard V.H., Moss, P.A. and Willcox, B.E. (2009) Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition. PNAS 106: 3889-94.

8.   Pourgheysari, B., Piper, K.P., McLarnon, A., Arrazi, J., Bruton, R., Clark, F., Cook, M., Mahendra, P., Craddock, C. Moss, P.A.H. (2009). Early reconstitution of effector memory CD4+ CMV-specific T cells protects against CMV reactivation following allogeneic stem cell transplantation. Bone Marrow Transplant 43: 853-61.

9.   Goodyear, O.C., Pratt, G., McLarnon, A., Cook, M., Piper, K. & Moss, P. (2008). Differential pattern of CD4+ and CD8+ T cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. Blood 112: 3362-3372.

10. Palendira, U., Chinn, R., Raza, R., Piper, K., Pratt, G., Machado, L., Bell, A., Khan, N., Hislop, A.D., Steyn, R., Rickinson, A.B., Buckley, C.D. and Moss, P. (2008) Selective accumulation of virus-specific CD8+ T cells with unique homing phenotype within the human bone marrow. Blood 112: 3293-3302.

11. Baumforth, K.R.N, Anna Birgersdotter, A., Gary M Reynolds, G.M., Wenbin Wei, W., Kapatai, G., Flavell, J.R., Kalk, E., Piper, K., Lee, S., Machad, L., Hadley, K., Sundbland, A., Sjoberg, J., Bjorkholm, M., Porwit, A.A., Yap L-F., Teo, S., Grundy, R., Young, L.S., Ernberg, I, Woodman, C.B.J. & Murray, P.G. (2008). Expression of the EBV-encoded EBNA1 in Hodgkin’s lymphoma cells mediates upregulation of CCL20 and the migration of regulatory T cells. Am J. Path 173: 195-204.

12.Olavarria, E., Siddique, S., Griffiths, M.J., Avery, D., Byrne, J.L., Piper, K.P., Lennard, A.L., Pallan, L., Arrazi, J.M., Perz J.B., O’Shea, D., Goldman, J.M., Apperley, J.F. & Craddock, C.F. (2007). Posttransplantation imatinib as a strategy to postpone the requirement for immunotherapy in patients undergoing reduced-intensity allografts for chronic myeloid leukemia. Blood 110: 4614-7.

13. Piper, K.P., Horlock, C., Curnow S.J., Arrazi J., Nicholls, S., Mahendra, P., Craddock, C. & Moss, P.A.H. (2007). CXCL10 - CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem cell transplantation. Blood 110: 3827-32.

14. Lissauer D, Piper K.P., Moss P.A.H. & Kilby M.D. (2007). Persistence of fetal cells in the mother: friend or foe? Br. J Obst. Gynae. 114: 1321-5.

15. Piper, K.P.., McLarnon, A., Arrazi, J., Horlock, C., Ainsworth, J., Kilby, M.D., Martin, W.L. & Moss, P.A. (2007). Functional HY-specific CD8+ T cells are found in a high proportion of women following pregnancy with a male fetus. Biol. Reprod. 76: 96-101.

16. Imrie, H., Fowkes, F.J., Michon, P., Hume, J.C., Piper, K.P., Reeder, J.C. & Day, K.P. (2006). Haptoglobin levels are associated with haptoglobin genotype and alpha+ -Thalassemia in a malaria-endemic area. Am. J. Trop. Med. Hyg. 74: 965-71.

17. Rice, J., Dunn, S., Piper, K., Buchan, S.L., Moss, P.A. & Stevenson, F.K. (2006). DNA fusion vaccines induce epitope-specific cytotoxic CD8+ T cells against human leukaemia-associated minor histocompatibility antigens. Cancer Res. 66: 5436-42.

18. Goodyear, O., Piper, K., Khan, N., Starczynski, J., Mahendra, P., Pratt, G. & Moss, P.A. (2005). CD8+ T cells specific for cancer-germline gene antigens are found in many patients with multiple myeloma and their frequency correlates with disease burden. Blood 106: 4217-24.

19. Clark, F.J, Gregg, R., Piper, K.P., Dunnion, D., Freeman, L., Griffiths, M., Begum, G., Mahendra, P., Craddock, C., Moss, P.A.H., & Chakraverty, R. (2004). Chronic Graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25+high regulatory T-cells. Blood 103: 2410-6.

20. Tebo, A.E., Kremsner, P.G., Piper, K.P. & Luty. A.J.F. (2002). Low antibody responses to variant surface antigens of Plasmodium falciparum are associated with severe malaria and increased susceptibility to malaria attacks in Gabonese children. American Journal of Tropical Medicine and Hygiene 67: 597-603.

21. Piper, K.P., Hayward, R.E., Cox, M.J. & Day, K.P.(1999). Malaria transmission and naturally acquired immunity to PfEMP-1. Infection & Immunity 67: 6369-74.

22. Rodrigues V. Jr., Piper K., Couissinier-Paris P., Bacelar, O. Dessein H. & Dessein  A.J. (1999) Genetic control of schistosome infections by the SM1 locus of the 5q31-q33 region is linked to differentiation of type 2 helper T lymphocytes. Infection & Immunity 67: 4689-92.

23. Hayward, R.E., Tiwari, B., Piper, K.P., Baruch, D.I. & Day, K.P. (1999) Virulence and transmission success of the malarial parasite Plasmodium falciparum. PNAS 96: 4563-8.

24. Piper K.P., Roberts D.J., Day K.P. (1999) Plasmodium falciparum: Analysis of the antibody specificity to the surface of the trophozoite-infected erythrocyte. Experimental Parasitology 91: 161-9.

25. Kohlstadt S., Couissinier-Paris P., Bourgois A., Bouchon B., Piper K., Kolbe H. & Dessein A.J. (1997). Characterization of a schistosome T cell-stimulating antigen (Sm10) associated with protective immunity in humans. Molecular and Biochemical Parasitology 84: 155-165.

26.  Dent L.A., Munro G.H., Piper K.P., Sanderson C.J., Finlay D.A., Dempster R.K., Bignold L.P., Harkin D.G. & Hagan P.(1997). Eosinophilic interleukin 5 (IL-5) transgenic mice: eosinophil activity and impaired clearance of Schistosoma mansoni. Parasite Immunology 119: 291-300.

27. Rodrigues V.Jr., Abel L., Piper K. & Dessein A.J. (1996). Segregation analysis indicates a major gene in the control of interleukine-5 production in humans infected with Schistosoma mansoni. American Journal of Human Genetics 59: 453-461.

28. Piper K.P. & McLaren D.J. (1993). The role of T cells in vaccine immunity in the murine model of schistosomiasis mansoni. International Journal of Parasitology 23: 245-56.

29. Piper K.P., Mott R.F., Hockley D.J. & McLaren D.J. (1991). Schistosoma mansoni: larval damage and role of effector cell(s) in the synergy between vaccine immunity and praziquantel treatment. Parasitology 103: 207-24.

30. Piper K.P, Mott R.F. & McLaren D.J. (1990). Schistosoma mansoni: histological analysis of the synergistic interaction between vaccine immunity and praziquantel therapy in the lungs of mice. Parasite Immunology 12: 367-87.