Dr Juri Na

Juri graduated from the Seoul National University, South Korea, in 2016 with a PhD in Molecular Imaging and Therapy, Biomedical Sciences. She commenced a PhD under the supervision of Professor June-Key Chung and Hyewon Youn. Her research focused on both molecular imaging and DNA damage repair using gene level modifications.

Juri had worked as a postdoctoral researcher in the Department of Oncology, University of Oxford from 2016 to 2021, working with Professor Anne Kiltie. Her research project is focusing on radiation-related DNA damage repair and function of MRE11 at both the molecular and in vivo level.

Juri has joined PMS within in the Brain Tumour Research Centre of Excellence at University of Plymouth in 2021, working in Professor Oliver Hanemann's group as a research fellow. Her research project is developing radiosensitiser in meningioma.

Research interests

PROFESSIONAL EXPERIENCE

Postdoctoral Researcher, Department of Oncology, University of Oxford                    Oxford, UK. 2016-2021

·    Investigating genes regulating DNA damage repair

·    Developing radiosensitiser (HDACi)

·    Cloning and functional characterisation of novel genes regulating radiosensitivity

·    Lenti-virus production to establish stable cell line over-expressing target gene

·    Analysis of gene and protein expression during development in mutant and wild-type (protein purification with AKTA, nuclease assay, cleavage assay, conventional immuno-blotting study)

·    Identification and assessment of different form of MRE11 protein function through molecular biology methods

·    Publishing of scientific papers in peer-reviewed journals to support the research programme

·    Regular attendance and presenting of results at national and international meetings to publicise and promote the research

EDUCATION

Seoul National University, Department of Biomedical Science                             Seoul, Korea. 2010-2016

Doctor of Philosophy in Biomedical Science

Enhanced efficacy of radiation therapy by the overexpression of chromatin remodelling factor BRG1-Bromodomain

·    Using molecular imaging and biology techniques to investigate the role of BRG1 bromodomain (developing radiosensitiser), a chromatin remodelling factor, especially after DNA damage by ionising radiation (PET/CT, Iodine-131, Iodine-125, Cesium-137, Flourine-18-FDG, Carbon-11, Luminescence, Florescence, GFP, MRI, SPECT for either therapy or imaging)

·    Gaining expertise in a broad range of molecular and biochemical techniques (Tissue culture including Colon, Brain, Thyroids, Bladder, Breast, Pancreas, Prostate, and Liver cancer cells, primary cell culture from both human and mouse tumour, macrophage, mesenchymal stem cell, transfection for both viral and transient, gene cloning, viral transduction, qPCR, clonogenic assay, comet assay, flow cytometry, senescence beta-gal staining, ELISA, Immunohistochemistry, Western blotting, Immunoprecipitation, cDNA microanalysis, Immunofluorescence, mouse experiment including glioblastoma and hepatocellular carcinoma orthotopic modelling)

·    Characterisation of competitive reaction of bromodomain through gene overexpression

·    Successful fulfilment of research objectives within grant timelines

·    Primary human glioblastoma cell line development (more than 50 cell lines, the name starts with GBM from SNUH)

·    Established glioblastoma, and hepatocarcinoma orthotopic model in mouse

·    Sodium Iodide symporter reporter modification and characterising to enhance therapeutic effect

·    Immunology based experiment for self-renewal and circulation test

Research degrees awarded to supervised students

Teaching Assistant, University of Oxford (2016-2021)

·    Delivering practical and tutorial sessions for courses in Molecular Biology and Oncology for 3 different FHS students (Medical Students from university of Oxford), and Erasmus Student

·    Responsible for prior-assessment of curriculum, development of suitable resources in collaboration with other presenters, organisation and delivery of sessions and coursework marking and feedback Co-Supervisor, University of Oxford

·    Training junior lab members in practical techniques to ensure competence and personal safety

Teaching Assistant, Seoul National University (2010-2016)

·    Managing Internship programmes for seniors at undergraduate school for every summer and winter holiday (3 months for each, 13 students in total for six and half years)

·    Assisting with the delivery of this pre-designed practical course, helping students to run their experiments and analyse the results

Grants & contracts

·    EACR25 Meeting Bursary, The 25th Biennial Congress of European Association for Cancer Research (2018)

·    Excellent Oral Presentation Award, The 22nd Annual Meeting of Korean Society of Radiation Bioscience (2016)

·    Young Investigator Award/Grants, The 10th Annual Meeting of the Japanese Society for Molecular imaging, Japan (2015)

·    Excellent Research Grants, Department of Biomedical Science, Seoul National University, Korea (2015)

·    Excellent Oral Presentation Award, Department of Biomedical Science, Seoul National University, Korea (2015)

·    Poster Award/Grants, Annual Symposium, Institute of Radiation Medicine, Seoul National University, Korea (2014)

·    Young Investigator Award/Grants, The 9th Annual Meeting, Japanese Society for Molecular imaging, Japan (2014)

·    Young Investigator’s Award/Grants, The 13th Annual Meeting, Korean Society of Molecular Imaging, Korea (2014)

·    Student Travel Stipend/Grants, 2011 Annual Meeting, World Molecular Imaging Congress, USA (2011)

·    Research Scholarship from Brain Korea 21 plus (2014, 2012, 2011)

·    Lecture & Research Scholarship (2013, 2010)

·    Superior Academic Performance (2012, 2010)