- Research office, John Bull Building, 16 Research Way
Dr Jon Gil-Ranedo
Research Fellow in Cancer Stem Cell Neurobiology
Peninsula Medical School (Faculty of Health: Medicine, Dentistry and Human Sciences)
Mymajor scientific interest is biomedicine, from basic to translational. My PhD focused on oncology, specifically in human glioblastoma-derived cancer stem cells (hGBM-CSC). In my previous postdoctoral research I was studying the infection mechanisms of the Minute Virus of Mice parvovirus in human cancer cells, and testing its use as selective oncolytic virotherpapy agent in hGBM-CSC models, in vitro and in vivo. I have also been working in the generation and characterization of iPS cells.
Currently I am working in the identification and characterization of novel molecular markers of specific neural stem cell types using the Drosophila larval brain as model.
Gil-Ranedo, J.*, Hernando, E.*, Valle, N., Riolobos, L., Maroto B.,and Almendral, J.M. Differential Phosphorylation and Configuration ofCapsid Subunits in Parvovirus Assembly and Maturation. Journal ofVirology (2015). (*Co-Authors). Submitted.
Gil-Ranedo, J.*, Hernando, E.*, Riolobos, L., Domínguez, C., Kann,M., and Almendral, J.M. The mammalian cell cycle regulates parvovirusnuclear capsid assembly. PLoS Pathogens (2015). (*Co-Authors).
Mendiburu-Eliçabe, M., and Gil-Ranedo, J. Combination therapy ofintraperitoneal rapamycin and convection-enhanced delivery ofnanoliposomal CPT-11 in rodent orthotopic brain tumor xenografts.Current Cancer Drug Targets (2015).
Mendiburu-Eliçabe, M.*, Gil-Ranedo, J*. and Izquierdo, M. Efficacy ofRapamycin against glioblastoma cancer stem cells. Clinical andTranslational Oncology (2013). (*Co-Authors).
Gil-Ranedo, J., Mendiburu-Eliçabe, M., García-Villanueva, M.,Medina D., del Álamo, M. and Izquierdo M. An Off-Target NucleosteminRNAi Inhibits Growth in Human Glioblastoma-Derived Cancer Stem Cells(2011). PloS one.