- Research office, John Bull Building, 16 Research Way
Dr Jon Gil-Ranedo
Research Fellow in Cancer Stem Cell Neurobiology
Peninsula Medical School (Faculty of Health)
Mymajor scientific interest is biomedicine, from basic to translational. My PhD focused on oncology, specifically in human glioblastoma-derived cancer stem cells (hGBM-CSC). In my previous postdoctoral research I was studying the infection mechanisms of the Minute Virus of Mice parvovirus in human cancer cells, and testing its use as selective oncolytic virotherpapy agent in hGBM-CSC models, in vitro and in vivo. I have also been working in the generation and characterization of iPS cells.
Currently I am working in the identification and characterization of novel molecular markers of specific neural stem cell types using the Drosophila larval brain as model.
Gil-Ranedo, J.*, Hernando, E.*, Valle, N., Riolobos, L., Maroto B.,and Almendral, J.M. Differential Phosphorylation and Configuration ofCapsid Subunits in Parvovirus Assembly and Maturation. Journal ofVirology (2015). (*Co-Authors). Submitted.
Gil-Ranedo, J.*, Hernando, E.*, Riolobos, L., Domínguez, C., Kann,M., and Almendral, J.M. The mammalian cell cycle regulates parvovirusnuclear capsid assembly. PLoS Pathogens (2015). (*Co-Authors).
Mendiburu-Eliçabe, M., and Gil-Ranedo, J. Combination therapy ofintraperitoneal rapamycin and convection-enhanced delivery ofnanoliposomal CPT-11 in rodent orthotopic brain tumor xenografts.Current Cancer Drug Targets (2015).
Mendiburu-Eliçabe, M.*, Gil-Ranedo, J*. and Izquierdo, M. Efficacy ofRapamycin against glioblastoma cancer stem cells. Clinical andTranslational Oncology (2013). (*Co-Authors).
Gil-Ranedo, J., Mendiburu-Eliçabe, M., García-Villanueva, M.,Medina D., del Álamo, M. and Izquierdo M. An Off-Target NucleosteminRNAi Inhibits Growth in Human Glioblastoma-Derived Cancer Stem Cells(2011). PloS one.