- B433, Portland Square, Drake Circus, Plymouth, PL4 8AA
- +44 1752 584640
- J.Moody@plymouth.ac.uk
Profiles
Dr John Moody
Visiting Research Fellow
School of Biological and Marine Sciences (Faculty of Science and Engineering)
Dr John Moody can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Biochemistry
- Enzymology
- Oxidative stress
- Carbon monoxide toxicity
- Oxygen toxicity
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
Qualifications
B.Sc. (1st class Hons) Biochemistry, Queen's University, Belfast, 1981
Ph.D. Biology, University of York, 1984
Research
Research
Research interests
Comparative biochemistry particularly in relation to responses to hypoxia
Environmental toxicology of metals and other pollutants
Oxidative stress in environmental toxicology, particularly the potential impact of selenium limitation
Mitochondrial, Bacterial and Archaeal electron transfer complexes/systems
Current PhD students
as Director of Studies
Agapery Pattinasarany
as other supervisor
Michael Collins
Alex Santillan Sarmiento
Completed PhD students as DoS
Rebekah Cioffi
Husam Aljwaid
Anwar Almzaiel
Hanady Al-Shmgani
Lindsey Glew
Marie Hannam
Ashvin Patel
Laura Biggs
Completed PhD students as other supervisor
Shirin Saleh
Mohd bin Hashim
Abbas Al-Shabany
Claudio Saez Avaria
Zainab Al-Shabany
Angela Cooper
Dokuboba Amachree
Raid Nisr
Paul Waines
Shalinee Singh
Jianfeng Yuan
Frances Shaw
Publications
Publications
Key publications
Key publications are highlighted
Journals
Articles
(2020) 'Insights into growth kinetics and roles of enzymes of Krebs’ cycle and sulfur oxidation during exochemolithoheterotrophic growth of Achromobacter aegrifaciens NCCB 38021 on succinate with thiosulfate as the auxiliary electron donor' Archives of Microbiology , DOI Open access
(2017) 'Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance' PLOS ONE 12, (1) e0168837-e0168837 , DOI Open access
(2016) 'DNA double-strand breaks in incubating female common eiders (Somateria mollissima): Comparison between a low and a high polluted area' Environmental Research 151, 297-303 , DOI
(2016) 'Physiological niche and geographical range in European diving beetles (Coleoptera: Dytiscidae)' Biology letters 12, (6) , DOI Open access
(2016) 'Antioxidant Responses in Relation to Persistent Organic Pollutants and Metals in a Low- and a High-Exposure Population of Seabirds' Environmental Science & Technology 50, (9) 4817-4825 , DOI
(2016) 'Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages' Bioscience Reports 36, (1) 0-0 , DOI Open access
(2015) 'Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes' Journal of Diabetes and its Complications 29, (7) 943-949 , DOI Open access
(2015) 'Hyperbaric oxygen enhances neutrophil apoptosis and their clearance by monocyte-derived macrophages' Biochemistry and Cell Biology 93, (4) 405-416 , DOI
(2015) 'A novel field transplantation technique reveals intra-specific metal-induced oxidative responses in strains of Ectocarpus siliculosus with different pollution histories' Environ Pollut 199, 130-138 , DOI Open access
(2015) 'Copper-induced intra-specific oxidative damage and antioxidant responses in strains of the brown alga Ectocarpus siliculosus with different pollution histories' Aquat Toxicol 159, 81-89 , DOI Open access
(2014) 'Comparison of intermittent and continuous exposures to inorganic mercury in the mussel, Mytilus edulis: accumulation and sub-lethal physiological effects' Ecotoxicol Environ Saf 109, 133-142 , DOI Open access
(2013) 'Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation' Biochem Biophys Res Commun 442, (1-2) 51-55 , DOI
(2013) 'Comparison of intermittent and continuous exposures to cadmium in the blue mussel, Mytilus edulis: accumulation and sub-lethal physiological effects' Ecotoxicol Environ Saf 95, 19-26 , DOI
(2013) 'Effects of hyperoxia on the permeability of 16HBE14o- cell monolayers--the protective role of antioxidant vitamins E and C' FEBS J 280, (18) 4512-4521 , DOI
(2013) 'Effects of hyperbaric oxygen treatment on antimicrobial function and apoptosis of differentiated HL-60 (neutrophil-like) cells' Life Sci 93, (2-3) 125-131 , DOI
(2013) 'Effects of ocean acidification and elevated temperature on shell plasticity and its energetic basis in an intertidal gastropod' MARINE ECOLOGY PROGRESS SERIES 472, 155-168 , DOI
(2013) 'Growth performance and starch utilization in common carp (Cyprinus carpio L.) in response to dietary chromium chloride supplementation' J Trace Elem Med Biol 27, (1) 45-51 , DOI
(2012) 'Hyperoxia-induced ciliary loss and oxidative damage in an in vitro bovine model: the protective role of antioxidant vitamins E and C' Biochem Biophys Res Commun 429, (3-4) 191-196 , DOI
(2012) 'CD38 expression regulates NAD(H) levels in human leukemia cells' Free Radical Biology and Medicine 53, S122-S123 , DOI
(2012) 'Merging nano-genotoxicology with eco-genotoxicology: an integrated approach to determine interactive genotoxic and sub-lethal toxic effects of C(60) fullerenes and fluoranthene in marine mussels, Mytilus sp' Mutat Res 745, (1-2) 92-103 , DOI
(2012) 'Screening microorganisms for insulin binding reveals binding by Burkholderia multivorans and Burkholderia cenocepacia and novel attachment of insulin to Aeromonas salmonicida via the A-layer' FEMS Microbiol Lett 328, (2) 93-99 , DOI
(2011) 'Effects of the microbial secondary metabolites pyrrolnitrin, phenazine and patulin on INS-1 rat pancreatic β-cells' FEMS Immunol Med Microbiol 63, (2) 217-227 , DOI
(2011) 'The effect of material choice on biofilm formation in a model warm water distribution system' Biofouling 27, (10) 1161-1174 , DOI
(2011) 'A multiple biomarker approach to investigate the effects of copper on the marine bivalve mollusc, Mytilus edulis' Ecotoxicol Environ Saf 74, (7) 1913-1920 , DOI
(2011) 'Comparative analysis of cholinesterase activities in food animals using modified Ellman and Michel assays' Can J Vet Res 75, (4) 261-270
(2011) 'Purification of soluble acetylcholinesterase from sheep liver by affinity chromatography' Appl Biochem Biotechnol 165, (1) 336-346 , DOI
(2011) 'Limited DNA damage in human endothelial cells after hyperbaric oxygen treatment and protection from subsequent hydrogen peroxide exposure' Biochim Biophys Acta 1810, (5) 526-531 , DOI
(2011) 'Spontaneous reactivation and aging kinetics of acetylcholinesterase inhibited by dichlorvos and diazinon' JOURNAL OF TOXICOLOGICAL SCIENCES 36, (2) 237-241
(2011) 'Comparison of two storage methods for the analysis of cholinesterase activities in food animals' Enzyme Res 2010, , DOI Open access
(2011) 'Selenium in water enhances antioxidant defenses and protects against copper-induced DNA damage in the blue mussel Mytilus edulis' Aquat Toxicol 101, (1) 64-71 , DOI
(2011) 'Exposure to elevated temperature and Pco(2) reduces respiration rate and energy status in the periwinkle Littorina littorea' Physiol Biochem Zool 84, (6) 583-594 , DOI
(2011) 'Tissue-specific incorporation and genotoxicity of different forms of tritium in the marine mussel, Mytilus edulis' Environ Pollut 159, (1) 274-280 , DOI
(2010) 'Chemical excretions of angled bonefish Albula vulpes and their potential use as predation cues by juvenile lemon sharks Negaprion brevirostris' J Fish Biol 77, (4) 947-962 , DOI
(2010) 'Immunotoxicity and oxidative stress in the Arctic scallop Chlamys islandica: effects of acute oil exposure' Ecotoxicol Environ Saf 73, (6) 1440-1448 , DOI
(2010) 'Effects of the model PAH phenanthrene on immune function and oxidative stress in the haemolymph of the temperate scallop Pecten maximus' Chemosphere 78, (7) 779-784 , DOI
(2010) 'Functional immune response in Pecten maximus: combined effects of a pathogen-associated molecular pattern and PAH exposure' Fish Shellfish Immunol 28, (1) 249-252 , DOI
(2009) 'Response of blood vessels in vitro to hyperbaric oxygen (HBO): modulation of VEGF and NO(x) release by external lactate or arginine' Biochim Biophys Acta 1787, (7) 828-834 , DOI
(2009) 'Immune function in the Arctic Scallop, Chlamys islandica, following dispersed oil exposure' Aquat Toxicol 92, (3) 187-194 , DOI
(2009) 'Contamination of bivalve haemolymph samples by adductor muscle components: implications for biomarker studies' Ecotoxicology 18, (3) 334-342 , DOI
(2009) 'Hyperbaric oxygen treatment induces platelet aggregation and protein release, without altering expression of activation molecules' Clin Biochem 42, (6) 467-476 , DOI
(2008) 'Defences against oxidative stress in vibrios associated with corals' FEMS Microbiol Lett 281, (1) 58-63 , DOI
(2007) 'Protective effects of selenium on mercury-induced DNA damage in mussel haemocytes' Aquat Toxicol 84, (1) 11-18 , DOI
(2007) 'Herbivore-induced infochemicals influence foraging behaviour in two intertidal predators (vol 151, pg 454, 2007)' OECOLOGIA 152, (4) 805-805 , DOI
(2007) 'Herbivore-induced infochemicals influence foraging behaviour in two intertidal predators' Oecologia 151, (3) 454-463 , DOI
(2007) 'An enzyme in snail saliva induces herbivore-resistance in a marine alga' FUNCTIONAL ECOLOGY 21, (1) 101-106 , DOI
(2007) 'Elevated oxygen fraction reduces cilial abundance in explanted human bronchial tissue' Ultrastruct Pathol 31, (5) 339-346 , DOI
(2006) 'Reevaluation of the Greiss reaction: How much of a problem is interference by nicotinamide nucleotides?' Analytical Biochemistry 356, (1) 154-156 , DOI
(2006) 'Organ culture of human bronchial explants' BRITISH JOURNAL OF ANAESTHESIA 96, (2) 281P-282P
(2006) 'Uneven cilial distribution in rat trachea' BRITISH JOURNAL OF ANAESTHESIA 96, (2) 281P-281P
(2006) 'Hyperbaric oxygen therapy does not stimulate production of detectable nitric oxide (NO), vascular endothelial growth factor (VEGF), or damage blood vessels in vitro' Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology 143, (4) S107-S107
(2005) 'A single exposure to hyperbaric oxygen does not cause oxidative stress in isolated platelets: no effect on superoxide dismutase, catalase, or cellular ATP' Clin Biochem 38, (8) 722-726 , DOI
(2005) 'Oxidative metabolism in platelets, platelet aggregation, and hematology in patients undergoing multiple hyperbaric oxygen exposures' Undersea Hyperb Med 32, (5) 327-340
(2004) 'Carbon monoxide exposure in rat heart: evidence for two modes of toxicity' Biochem Biophys Res Commun 321, (1) 241-246 , DOI
(2003) 'The degree of carotenoid esterification influences the absorption of astaxanthin in rainbow trout, Oncorhynchus mykiss (Walbaum)' AQUACULTURE NUTRITION 9, (4) 247-251 , DOI
(2003) 'Extreme UV-A sensitivity of the filamentous gliding bacterium Vitreoscilla stercoraria' FEMS Microbiol Lett 224, (1) 73-76 , DOI
(2003) 'Carbon monoxide exposure in rat heart: glutathione depletion is prevented by antioxidants' Biochem Biophys Res Commun 302, (2) 392-396 , DOI
(2002) 'Effect of esterification on the absorption of astaxanthin in rainbow trout, Oncorhynchus mykiss (Walbaum)' AQUACULTURE RESEARCH 33, (5) 343-350 , DOI
(2001) 'Carbon monoxide toxicity in the heart: evidence for ischaemia/reperfusion like injury. Joint meeting of the Biochemical Society and Physiological Society' Biochemical Society Transactions 30,
(2001) 'The effect of multiple hyperbaric oxygen treatments on blood function and redox status. Joint meeting of the Biochemical Society and Physiological Society' Biochemical Society Transactions 30,
(1998) 'The reaction of halides with pulsed cytochrome bo from Escherichia coli' Biochem J 331 ( Pt 2), (Pt 2) 459-464 , DOI
(1997) 'EPR spectroscopy of Escherichia coli cytochrome bo which lacks CuB' FEBS Lett 412, (1) 43-47 , DOI
(1997) 'Comparison of the ligand-binding properties of native and copper-less cytochromes bo from Escherichia coli' Biochem J 324 ( Pt 3), (Pt 3) 743-752 , DOI
(1997) 'The reaction of halides with cytochrome bo from Escherichia coli' Biochem Soc Trans 25, (1) , DOI
(1996) ''As prepared' forms of fully oxidised haem/Cu terminal oxidases' Biochim Biophys Acta 1276, (1) 6-20 , DOI
(1995) 'Cyanide and carbon monoxide binding to the reduced form of cytochrome bo from Escherichia coli' Biochemistry 34, (23) 7576-7585 , DOI
(1995) 'Interconversion of fast and slow forms of cytochrome bo from Escherichia coli' Biochemistry 34, (20) 6838-6846 , DOI
(1994) 'The reaction of hydrogen peroxide with pulsed cytochrome bo from Escherichia coli' Eur J Biochem 226, (2) 731-737 , DOI
(1994) ''CO2-ligated' cytochrome c oxidase: characterization and comparison with the Cl- -ligated enzyme' Biochem J 302 ( Pt 3), (Pt 3) 821-826 , DOI
(1994) 'Flash photolysis of the carbon monoxide compounds of wild-type and mutant variants of cytochrome bo from Escherichia coli' Biochim Biophys Acta 1183, (3) 521-532 , DOI
(1993) 'CO recombination as a probe of the Fe/Cu binuclear centre of terminal protonmotive oxidases' Biochem Soc Trans 21, (4) , DOI
(1993) 'The effects of bicarbonate/carbon dioxide on the near-UV/visible spectrum and ligand binding properties of fast bovine heart cytochrome c oxidase' Biochem Soc Trans 21, (4) , DOI
(1993) 'Cyanide binding to single-electron-reduced fast cytochrome-c oxidase' Biochem Soc Trans 21 ( Pt 3), (3) , DOI
(1993) 'Ligand-binding properties and heterogeneity of cytochrome bo from Escherichia coli' Biochim Biophys Acta 1141, (2-3) 321-329 , DOI
(1993) 'Binuclear centre structure of terminal protonmotive oxidases' FEBS Lett 316, (3) 216-223 , DOI
(1992) 'Ligand binding properties of bacterial oxidases in relation to cytochrome-c oxidase' Biochem Soc Trans 20, (3) , DOI
(1992) 'Detection of a near infra-red absorption band of ferrohaem a3 in cytochrome c oxidase' FEBS Lett 305, (3) 171-173 , DOI
(1991) 'Single electron reduction of 'slow' and 'fast' cytochrome-c oxidase' FEBS Lett 293, (1-2) 101-105 , DOI
(1991) 'Characterisation of 'fast' and 'slow' forms of bovine heart cytochrome-c oxidase' Biochim Biophys Acta 1059, (2) 189-207 , DOI
(1991) 'HETEROGENEITY IN FAST CYANIDE-BINDING PREPARATIONS OF CYTOCHROME-C-OXIDASE' BIOCHEMICAL SOCIETY TRANSACTIONS 19, (3) S262-S262 , DOI
(1991) 'THE CYTOCHROME-OXIDASE G = 12 EPR SIGNAL' BIOCHEMICAL SOCIETY TRANSACTIONS 19, (3) S259-S259 , DOI
(1990) 'Inhibitor effects on redox-linked protonations of the b haems of the mitochondrial bc1 complex' Biochim Biophys Acta 1018, (1) 29-40 , DOI
(1990) 'The effect of pH on redox titrations of haem a in cyanide-liganded cytochrome-c oxidase: experimental and modelling studies' Biochim Biophys Acta 1015, (2) 205-215 , DOI
(1989) 'MITOCHONDRIAL DAMAGE AND PROTONMOTIVE STOICHIOMETRY' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 893-894 , DOI
(1989) 'REDOX TITRATION OF HEME-A IN CYANIDE-LIGANDED CYTOCHROME-C OXIDASE - EFFECT OF PH' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 895-896 , DOI
(1989) 'REDOX TITRATION OF HEME-A IN CYANIDE-LIGANDED CYTOCHROME-C OXIDASE - SIMULATION STUDIES ON INTERACTING, PH-DEPENDENT, REDOX CENTERS' BIOCHEMICAL SOCIETY TRANSACTIONS 17, (5) 896-897 , DOI
(1989) 'The functional catalytic unit involved in proton pumping by rat liver cytochrome-c reductase and by cytochrome-c oxidase' Biochim Biophys Acta 973, (1) 29-34 , DOI
(1987) 'Protonmotive stoichiometry of rat liver cytochrome c oxidase: determination by a new rate/pulse method' Biochim Biophys Acta 894, (2) 209-227 , DOI
(1986) 'IDENTIFICATION OF THE NICOTINAMIDE NUCLEOTIDE TRANSHYDROGENASE OF RAT-LIVER MITOCHONDRIA' BIOCHEMICAL SOCIETY TRANSACTIONS 14, (6) 1210-1212 , DOI
(1986) 'Is there Ca2+(Sr2+)-3-hydroxybutyrate symport in rat-liver mitochondria? A reappraisal' Eur J Biochem 157, (2) 243-249 , DOI
(1986) 'Proton translocation by cytochrome oxidase in (antimycin + myxothiazol)-treated rat liver mitochondria using ferrocyanide or hexammineruthenium as electron donor' Biochem J 236, (1) 15-21 , DOI
(1986) 'Measurement of the proton-motive stoichiometry of the respiratory chain of rat liver mitochondria: the effect of N-ethylmaleimide' Biochim Biophys Acta 849, (2) 229-235 , DOI
(1985) 'Chemiosmotic coupling in cytochrome oxidase. Possible protonmotive O loop and O cycle mechanisms' FEBS Lett 188, (1) 1-7 , DOI
(1983) 'Inhibition of nicotinamide nucleotide transhydrogenase in rat liver submitochondrial particles by dicyclohexylcarbodi-imide and butanedione' Biochem J 209, (3) 889-892 , DOI
Chapters
(1997) 'Cytochrome c oxidase' in Gräber P; Milazzo G Bioenergetics Birkhauser 418-456
Conference Papers
(2014) 'Pharmacological modulation of NAD alters TNF-alpha responses in macrophage subsets' 180-180 Open access
(2011) 'Molecular mimicries of linear epitopes between pancreatic glutamic acid decarboxylase (GAD65) and proteins from Escherichia coli' 140-140
(2009) 'Does the stress associated with catch-and-release angling of bonefish (Albula vulpes) affect predation by juvenile lemon sharks (Negaprion brevirostris)?' S69-S69 , DOI
(2008) 'The effects of carbon monoxide and hyperbaric oxygen on the cardiovascular system' S126-S127 , DOI
(2006) 'The effect of hyperbaric oxygen on platelet S-nitrosothiol release and aggregation' S115-S115
(1995) 'Rapid-scan FTIR spectroscopic studies on the photolysis and recombination of the cyanide adduct of fully reduced bovine cytochrome c oxidase' S521-S521 , DOI
(1994) 'STORAGE EFFECTS ON THE LIGAND-BINDING PROPERTIES OF BOVINE HEART CYTOCHROME-C-OXIDASE' S286-S286 , DOI
(1993) 'Cyacide binding to single-electron-reduced fast cytochrome-c oxidase'
(1991) 'Ligation and electronation states of cytochrome-c oxidase in relation to other oxidases and peroxidases' England 617-622 , DOI
(1989) 'THE CHARGE TRANSLOCATING REACTIONS OF THE BC COMPLEXES AND CYTOCHROME-OXIDASE' 7-19