Dr Jane Carre
Profiles

Dr Jane Carre

Daphne Jackson Postdoctoral Research Fellow

School of Biomedical Sciences (Faculty of Health)

Positions

2019-present      Daphne Jackson Research Fellow (Kidney Research UK), School of Biomedical Sciences, University of Plymouth.

2015-2019         Career Break (Childcare).

2011-2015         Lecturer (Education) University of Exeter Medical School/Peninsula School of Medicine and Dentistry.

2005-2010         Senior Postdoctoral Research Associate, Wolfson Institute for Biomedical Research, University College London.

2001-2005         Postdoctoral Research Associate, Department of Biochemistry, University of Sussex.

Qualifications

2013-2015          Postgraduate Certificate in Academic Practice, University of Exeter.        

1996-2000          DPhil, Biochemistry, University of Sussex.                               

1992-1996          BSc Hons, Biochemistry with European Studies, University of Sussex (Université de Bordeaux II).

Professional membership

AdvanceHE (Higher Education Academy), Fellow

Biochemical Society

Mitochondrial Physiology Society

Key publications

Zolfaghari PS, Carré JE, Parker N, Curtin NA, Duchen MR & Singer M 2015 'Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis' American Journal of Physiology-Endocrinology and Metabolism 308, (9) E713-E725 , DOI
Carré JE, Orban J-C, Re L, Felsmann K, Iffert W, Bauer M, Suliman HB, Piantadosi CA, Mayhew TM & Breen P 2010 'Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis' American Journal of Respiratory and Critical Care Medicine 182, (6) 745-751 , DOI
Carré JE & Singer M 2008 'Cellular energetic metabolism in sepsis: The need for a systems approach' Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777, (7-8) 763-771 , DOI
View all publications

Teaching interests

Teaching has featured strongly throughout my research career, from supervising undergraduate project and placement students, to training clinicians and graduate students. I have enjoyed teaching undergraduate students in biochemistry and across the medical sciences, using a range of innovative and traditional learning approaches.

Research interests

All cells require energy to function. In most cell types, this energy is provided through the activity of mitochondria. My overall research interest is how mitochondrial (dys)function and adaptation contribute to health and disease, with a current focus on muscle. Muscle weakness and wasting (atrophy) contribute to frailty in metabolic and immunological disorders, malignancies, infectious diseases, as well as in ageing.

Alongside exercise and nutrition, interest in mitochondrially-targeted therapeutics for muscle wasting conditions is increasing. The underlying basis of observed mitochondrial changes in these myopathies however is unclear. It is therefore not known at what stage each of these therapeutic approaches may be appropriate - or indeed harmful.

Through my current research, funded by Kidney Research UK, I aim to determine whether muscle mitochondrial changes seen in chronic kidney disease reflect dysfunction, or a cellular adaptation to altered energetic demand. By building our understanding of healthy and uraemic muscle cell bioenergetics, this research will help rationalise mitochondria as therapeutic targets in chronic kidney disease and could inform research into therapeutic approaches for other clinically-relevant situations, including critical illness.

Key publications

Zolfaghari PS, Carré JE, Parker N, Curtin NA, Duchen MR & Singer M 2015 'Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis' American Journal of Physiology-Endocrinology and Metabolism 308, (9) E713-E725 , DOI
Carré JE, Orban J-C, Re L, Felsmann K, Iffert W, Bauer M, Suliman HB, Piantadosi CA, Mayhew TM & Breen P 2010 'Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis' American Journal of Respiratory and Critical Care Medicine 182, (6) 745-751 , DOI
Carré JE & Singer M 2008 'Cellular energetic metabolism in sepsis: The need for a systems approach' Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777, (7-8) 763-771 , DOI

Key publications are highlighted

Journals
Articles
Carré JE & Affourtit C 2019 'Mitochondrial Activity and Skeletal Muscle Insulin Resistance in Kidney Disease' International Journal of Molecular Sciences 20, (11) 2751-2751 , DOI Open access
Knight AR, Taylor EL, Lukaszewski R, Jensen KT, Jones HE, Carré JE, Isupov MN, Littlechild JA, Bailey SJ & Brewer E 2018 'A high-sensitivity electrochemiluminescence-based ELISA for the measurement of the oxidative stress biomarker, 3-nitrotyrosine, in human blood serum and cells' Free Radical Biology and Medicine 120, 246-254 , DOI
Affourtit C, Alberts B, Barlow J, Carré JE & Wynne AG 2018 'Control of pancreatic β-cell bioenergetics' Biochemical Society Transactions Author Site , DOI Open access
Pinto BB, Dyson A, Umbrello M, Carré JE, Ritter C, Clatworthy I, Duchen MR & Singer M 2017 'Improved Survival in a Long-Term Rat Model of Sepsis Is Associated With Reduced Mitochondrial Calcium Uptake Despite Increased Energetic Demand' Critical Care Medicine 45, (8) e840-e848 , DOI
Zolfaghari PS, Carré JE, Parker N, Curtin NA, Duchen MR & Singer M 2015 'Skeletal muscle dysfunction is associated with derangements in mitochondrial bioenergetics (but not UCP3) in a rodent model of sepsis' American Journal of Physiology-Endocrinology and Metabolism 308, (9) E713-E725 , DOI
Dyson A, Ekbal N, Stotz M, Barnes S, Carré J, Tully S, Henderson S, Barrett L & Singer M 2014 'Component reductions in oxygen delivery generate variable haemodynamic and stress hormone responses' British Journal of Anaesthesia 113, (4) 708-716 , DOI
Rudiger A, Dyson A, Felsmann K, Carré JE, Taylor V, Hughes S, Clatworthy I, Protti A, Pellerin D & Lemm J 2012 'Early functional and transcriptomic changes in the myocardium predict outcome in a long-term rat model of sepsis' Clinical Science 124, (6) 391-401 , DOI
Recknagel P, Gonnert FA, Westermann M, Lambeck S, Lupp A, Rudiger A, Dyson A, Carré JE, Kortgen A & Krafft C 2012 'Liver Dysfunction and Phosphatidylinositol-3-Kinase Signalling in Early Sepsis: Experimental Studies in Rodent Models of Peritonitis' PLoS Medicine 9, (11) e1001338-e1001338 , DOI Open access
Cochemé HM, Quin C, McQuaker SJ, Cabreiro F, Logan A, Prime TA, Abakumova I, Patel JV, Fearnley IM & James AM 2011 'Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix' Cell Metabolism 13, (3) 340-350 , DOI
Carré JE, Affourtit C & Moore AL 2010 'Interaction of purified alternative oxidase from thermogenic Arum maculatum with pyruvate' FEBS Lett 585, (2) 397-401 Author Site , DOI
Carré JE, Orban J-C, Re L, Felsmann K, Iffert W, Bauer M, Suliman HB, Piantadosi CA, Mayhew TM & Breen P 2010 'Survival in Critical Illness Is Associated with Early Activation of Mitochondrial Biogenesis' American Journal of Respiratory and Critical Care Medicine 182, (6) 745-751 , DOI
Carré JE & Singer M 2008 'Cellular energetic metabolism in sepsis: The need for a systems approach' Biochimica et Biophysica Acta (BBA) - Bioenergetics 1777, (7-8) 763-771 , DOI
Moore AL, Carré JE, Affourtit C, Albury MS, Crichton PG, Kita K & Heathcote P 2008 'Compelling EPR evidence that the alternative oxidase is a diiron carboxylate protein' Biochim Biophys Acta 1777, (4) 327-330 Author Site , DOI
Protti A, Carré J, Frost MT, Taylor V, Stidwill R, Rudiger A & Singer M 2007 'Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle' Critical Care Medicine 35, (9) 2150-2155 , DOI
Crichton PG, Affourtit C, Albury MS, Carré JE & Moore AL 2004 'Constitutive activity of Sauromatum guttatum alternative oxidase in Schizosaccharomyces pombe implicates residues in addition to conserved cysteines in alpha-keto acid activation' FEBS Lett 579, (2) 331-336 Author Site , DOI
Conference Papers
Dyson A, Stotz M, Barnes SJ, Carre JE, Barrett LK & Singer M 2011 'OXYGEN DELIVERY IS NOT CREATED EQUAL: CARDIORESPIRATORY AND STRESS RESPONSES IN DIFFERENT SHOCK STATES' S114-S114
Nash R, Carre JE, Dyson A & Singer M 2010 'TISSUE PGC-1A MRNA LEVELS IN A RODENT MODEL OF SEPSIS' S291-S291
Carre JE, Re L, Orban J-C, Felsmann K, Suliman H, Stotz M, Breen P, Bellingan G, Piantadosi C & Bauer M 2009 'MITOCHONDRIAL BIOGENESIS RESPONSE IS ASSOCIATED WITH POSITIVE OUTCOME IN CRITICALLY ILL PATIENTS' 165-165
Carré JE & Singer M 2008 'S6/1 Cellular energetic metabolism in sepsis' Elsevier BV S43-S43 , DOI
Carre JE, Affourtit C, Yu F & Moore AL 2004 'Kinetic studies on the purifed alternative oxidase protein from Arum maculatum and its regulation by organic acids' 163-163
Crichton PG, Affourtit C, Albury MS, Carre JE & Moore AL 2004 'Regulation of the plant alternative oxidase by pyruvate' 164-164

Other academic activities

Member of Early Career Researcher Group for Health

Member of Athena Swan Self Assessment Team (PDS, PMS, SoBS)