Dr Jane Carre
Daphne Jackson Postdoctoral Research Fellow
School of Biomedical Sciences (Faculty of Health)
2019-present Daphne Jackson Research Fellow (Kidney Research UK), School of Biomedical Sciences, University of Plymouth.
2015-2019 Career Break (Childcare).
2011-2015 Lecturer (Education) University of Exeter Medical School/Peninsula School of Medicine and Dentistry.
2005-2010 Senior Postdoctoral Research Associate, Wolfson Institute for Biomedical Research, University College London.
2001-2005 Postdoctoral Research Associate, Department of Biochemistry, University of Sussex.
2013-2015 Postgraduate Certificate in Academic Practice, University of Exeter.
1996-2000 DPhil, Biochemistry, University of Sussex.
1992-1996 BSc Hons, Biochemistry with European Studies, University of Sussex (Université de Bordeaux II).
AdvanceHE (Higher Education Academy), Fellow
Mitochondrial Physiology Society
Teaching has featured strongly throughout my research career, from supervising undergraduate project and placement students, to training clinicians and graduate students. I have enjoyed teaching undergraduate students in biochemistry and across the medical sciences, using a range of innovative and traditional learning approaches.
All cells require energy to function. In most cell types, this energy is provided through the activity of mitochondria. My overall research interest is how mitochondrial (dys)function and adaptation contribute to health and disease, with a current focus on muscle. Muscle weakness and wasting (atrophy) contribute to frailty in metabolic and immunological disorders, malignancies, infectious diseases, as well as in ageing.
Alongside exercise and nutrition, interest in mitochondrially-targeted therapeutics for muscle wasting conditions is increasing. The underlying basis of observed mitochondrial changes in these myopathies however is unclear. It is therefore not known at what stage each of these therapeutic approaches may be appropriate - or indeed harmful.
Through my current research, funded by Kidney Research UK, I aim to determine whether muscle mitochondrial changes seen in chronic kidney disease reflect dysfunction, or a cellular adaptation to altered energetic demand. By building our understanding of healthy and uraemic muscle cell bioenergetics, this research will help rationalise mitochondria as therapeutic targets in chronic kidney disease and could inform research into therapeutic approaches for other clinically-relevant situations, including critical illness.
Key publications are highlightedJournals
Other academic activities
Member of Early Career Researcher Group for Health
Member of Athena Swan Self Assessment Team (PDS, PMS, SoBS)