Dr Gyorgy Fejer
Lecturer in Environmental Pathogens
School of Biomedical & Healthcare Sciences (Plymouth University Peninsula Schools of Medicine and Dentistry)
PhD in medicine, Semmelweis Medical School, 1998
Residency in Microbiology, 1995
PGCAP in Teaching and Learning in Higher Education
Plymouth University, 2013
Molecular mechanisms of lung macrophage functions in health and disease
Macrophages are crucially involved in various diseases such as Infectious and environmental pathogen induced conditions, cancer and metabolic disorders and also in normal tissue homeostasis. These cells exhibit, depending on their anatomical location, distinct biological properties. Studies exploring macrophages are of high scientific and clinical interest, but are hampered by the limited life-span and restricted numbers of primary tissue macrophages that can be obtained for such experiments. We established a novel, continuously growing, non-transformed model of lung alveolar macrophages (AMs), cells that play key roles in important diseases such as lung infection, asthma and chronic obstructive pulmonary disease (COPD). This model can replace and reduce in vivo studies involving macrophages and can contribute to the saving of lives of a very high number of experimental animals. Importantly, using our new system the detailed molecular analysis of scarcely available alveolar macrophages is possible. This made possible the identification of several, previously unknown innate immune phenomena in AMs (Fejer et al; PNAS 2013). Our laboratory now analyses the underlying molecular details using methods of molecular immunology, cell biology and proteomics. These studies help to understand relevant mechanisms of AM biology and lung diseases and can contribute to the development of drugs that influence AM activity in various pathology states.
List of recent publications
1. Fejer G*, Wegener M, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Zs, Dölken L, Prazeres da Costa O, Branzk N, Huber M, Prasse A, Apte R, Galanos C and Freudenberg MA*
Nontransformed,GM-CSF dependent macrophage lines are a unique model to study tissue macrophage functions
Proc Natl Acad Sci U S A 2013 110(24):E2191-8. *corresponding author
Faculty 1000 recommended
2. Fejer G., Freudenberg M., Greber U. F. and Gyory I
Adenovirus triggered innate signalling pathways
European Journal of Microbiology and Immunology 2011 1 (4) 279–288
3. Keck S, Müller I, Fejer G, Savic I, Nielsen P, Galanos C, Huber M and Freudenberg MA
Absence of TRIF signaling in LPS-stimulated murine bone marrow-derived mast cells
Journal of Immunology, 2011 186(9):5478-88
4. Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber CA, Fejer G, Freudenberg MA, Davey GM, Vremec D, Kallies A, Wu L, Shortman K, Chaplin P, Suter M, O‘Keeffe M and Hochrein H
The CD8a+ subset of DCs in mouse and human BDCA3+ DCs are major producers of IFN-λ in response to poly IC
Journal of Experimental Medicine, 2010 207(12):2703-17
5. Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchapchet S, Keck S, Kalis C, Nielsen P, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA and Goebeler M
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel
Nature Immunology, 2010 11(9):814-9
Faculty 1000 recommended
6. Siegemund S, Hartl A, Buttlar H, Dautel F, Raue R, Freudenberg M, Fejer G, Herden F, Buttner M, Koehler G, Kirschning C, Sparwasser T and G Alber
Conventional bone marrow-derived dendritic cells contribute to Toll-like receptor-independent IFN-α/β production in response to inactivated parapoxvirus ovis
Journal of Virology, 2009 83(18):9411-9422
7. Fejer*, G., L. Drechsel, J. Liese , U. Schleicher, Zs. Ruzsics, J. Imelli, U. Greber, S. Keck, B. Hildenbrand, A. Krug , C. Bogdan and M. A. Freudenberg*
Key role of splenic myeloid DCs in the IFN-ab response to adenoviruses in vivo.
PLoS Pathogens, 2008 4(11):e1000208. *corresponding author
8. Fejer*, G., A. Koroknai, F. Banati, I. Gyory, D. Salamon, H. Wolf, H. H. Niller and J. Minarovits.
Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein Barr virus.
Journal of General Virology 2008 89:1364-1370. *corresponding author
9. Martin S, Dudda J, Bachtanian E, Lembo A, Liller S, Dürr C, Heimesaat MM, Bereswill, Fejer G, Vassileva R, JakobT, Freudenberg N, Termeer CC, Johner C, Galanos C and M. A. Freudenberg 2008
Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
Journal of Experimental Medicine 2008 205(9):2151-62
10. Freudenberg, M. A., S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler, and C. Galanos.
Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative
bacterial infections: Benefits and hazards of LPS hypersensitivity.
Immunobiology 2008 213:193-203.
11. Gerle#, B., A. Koroknai#, G. Fejer#, A. Bakos, F. Banati, K. Szenthe, H. Wolf, H. H. Niller, J. Minarovits, and D. Salamon. 2007. Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells.
Journal of Virology 2007 81:13242-13247. # Shared first author
12. Fejer, G., K. Szalay, I. Gyory, M. Fejes, E. Kusz, S. Nedieanu, T. Pali, T. Schmidt, B. Siklodi, G. Lazar, and E. Duda. Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock.
Journal of Immunology 2005 175:1498-1506.
13. Kalis, C., M. Gumenscheimer, N. Freudenberg, S. Tchaptchet, G. Fejer, A. Heit, S. Akira, C. Galanos, and M. A. Freudenberg
Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes.
Journal of Immunology 2005 174:4295-4300.