Dr Gyorgy Fejer
Profiles

Dr Gyorgy Fejer

Lecturer in Environmental Pathogens

School of Biomedical Sciences (Faculty of Health)

Lecturer in environmental pathogens

Qualifications

PhD in medicine, Semmelweis Medical School, 1998

Residency in Microbiology, 1995

PGCAP in Teaching and Learning in Higher Education
Plymouth University, 2013 

Professional membership

British Society for Immunology (BSI)

Key publications

Efrat S, Fejer G, Brownlee M & Horwitz MS 1995 'Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes' Proc Natl Acad Sci U S A 92, (15) 6947-6951 Author Site , DOI
Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ & Galanos C 2010 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 Author Site , DOI
Fejer G, Gyory I, Tufariello J & Horwitz MS 1994 'Characterization of transgenic mice containing adenovirus early region 3 genomic DNA' J Virol 68, (9) 5871-5881 Author Site , DOI
Fejer G, Koroknai A, Banati F, Györy I, Salamon D, Wolf H, Niller HH & Minarovits J 2008 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 Author Site , DOI
Fejér G, Medveczky MM, Horvath E, Lane B, Chang Y & Medveczky PG 2003 'The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication' J Gen Virol 84, (Pt 6) 1451-1462 Author Site , DOI
Fejér G, Szalay K, Gyory I, Fejes M, Kúsz E, Nedieanu S, Páli T, Schmidt T, Siklódi B & Lázár G 2005 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 Author Site , DOI
View all publications

Research interests

  

Molecular mechanisms of lung macrophage functions in health and disease

Macrophages are crucially involved in various diseases such as Infectious and environmental pathogen induced conditions, cancer and metabolic disorders and also in normal tissue homeostasis. These cells exhibit, depending on their anatomical location, distinct biological properties. Studies exploring macrophages are of high scientific and clinical interest, but are hampered by the limited life-span and restricted numbers of primary tissue macrophages that can be obtained for such experiments. We established a novel, continuously growing, non-transformed model of lung alveolar macrophages (AMs), cells that play key roles in important diseases such as lung infection, asthma and chronic obstructive pulmonary disease (COPD). This model can replace and reduce in vivo studies involving macrophages and can contribute to the saving of lives of a very high number of experimental animals. Importantly, using our new system the detailed molecular analysis of scarcely available alveolar macrophages is possible. This made possible the identification of several, previously unknown innate immune phenomena in AMs (Fejer et al; PNAS 2013). Our laboratory now analyses the underlying molecular details using methods of molecular immunology, cell biology and proteomics. These studies help to understand relevant mechanisms of AM biology and lung diseases and can contribute to the development of drugs that influence AM activity in various pathology states.

Key publications

Efrat S, Fejer G, Brownlee M & Horwitz MS 1995 'Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes' Proc Natl Acad Sci U S A 92, (15) 6947-6951 Author Site , DOI
Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ & Galanos C 2010 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 Author Site , DOI
Fejer G, Gyory I, Tufariello J & Horwitz MS 1994 'Characterization of transgenic mice containing adenovirus early region 3 genomic DNA' J Virol 68, (9) 5871-5881 Author Site , DOI
Fejer G, Koroknai A, Banati F, Györy I, Salamon D, Wolf H, Niller HH & Minarovits J 2008 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 Author Site , DOI
Fejér G, Medveczky MM, Horvath E, Lane B, Chang Y & Medveczky PG 2003 'The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication' J Gen Virol 84, (Pt 6) 1451-1462 Author Site , DOI
Fejér G, Szalay K, Gyory I, Fejes M, Kúsz E, Nedieanu S, Páli T, Schmidt T, Siklódi B & Lázár G 2005 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 Author Site , DOI

Key publications are highlighted

Journals
Articles
Wise EL, Márquez S, Mellors J, Paz V, Atkinson B, Gutierrez B, Zapata S, Coloma J, Pybus OG & Jackson SK 2020 'Oropouche virus cases identified in Ecuador using an optimised qRT-PCR informed by metagenomic sequencing' PLOS Neglected Tropical Diseases 14, (1) e0007897-e0007897 , DOI
Deville S, Honrath B, Tran QTD, Fejer G, Lambrichts I, Nelissen I, Dolga AM & Salvati A 2019 'Time-resolved characterization of the mechanisms of toxicity induced by silica and amino-modified polystyrene on alveolar-like macrophages' Archives of Toxicology 94, (1) 173-186 , DOI
Sattar AA, Abate W, Fejer G, Bradley G & Jackson SK 2019 'Evaluation of the proinflammatory effects of contaminated bathing water' Journal of Toxicology and Environmental Health, Part A 82, (20) 1076-1087 , DOI
Wise EL, Pullan ST, Márquez S, Paz V, Mosquera JD, Zapata S, Jackson SK, Fejer G, Trueba G & Logue CH 2018 'Isolation of Oropouche Virus from Febrile Patient, Ecuador' Emerging Infectious Diseases 24, (5) 935-937 , DOI PEARL
Woo M, Wood C, Kwon D, Park K-HP, Fejer G & Delorme V 2018 'Mycobacterium tuberculosis Infection and Innate Responses in a New Model of Lung Alveolar Macrophages' Frontiers in Immunology 9, , DOI PEARL
Stichling N, Suomalainen M, Flatt JW, Schmid M, Pacesa M, Hemmi S, Jungraithmayr W, Maler MD, Freudenberg MA & Plückthun A 2018 'Lung macrophage scavenger receptor SR-A6 (MARCO) is an adenovirus type-specific virus entry receptor' PLOS Pathogens 14, (3) e1006914-e1006914 , DOI PEARL
Boorsma CE, van der Veen TA, Putri KSS, de Almeida A, Draijer C, Mauad T, Fejer G, Brandsma C-A, van den Berge M & Bossé Y 2017 'A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages' Scientific Reports 7, (1) , DOI PEARL
Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I & Huber M 2017 'Erratum for Maler et al., “Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages”' mBio 8, (5) , DOI PEARL
Maler MD, Nielsen PJ, Stichling N, Cohen I, Ruzsics Z, Wood C, Engelhard P, Suomalainen M, Gyory I & Huber M 2017 'Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages' mBio 8, (4) , DOI PEARL
Rawson FJ, Hicks J, Dodd N, Abate W, Garrett DJ, Yip N, Fejer G, Downard AJ, Baronian KHR & Jackson SK 2015 'Fast, Ultrasensitive Detection of Reactive Oxygen Species Using a Carbon Nanotube Based-Electrocatalytic Intracellular Sensor' ACS Applied Materials & Interfaces 7, (42) 23527-23537 , DOI PEARL
Fejer G, Sharma S & Gyory I 2015 'Self-renewing macrophages--a new line of enquiries in mononuclear phagocytes' Immunobiology 220, (2) 169-174 Author Site , DOI
Fejer G, Wegner MD, Györy I, Cohen I, Engelhard P, Voronov E, Manke T, Ruzsics Z, Dölken L & Prazeres da Costa O 2013 'Nontransformed, GM-CSF-dependent macrophage lines are a unique model to study tissue macrophage functions' Proc Natl Acad Sci U S A 110, (24) E2191-E2198 Author Site , DOI
Fejer G, Freudenberg M, Greber UF & Gyory I 2011 'Adenovirus-triggered innate signalling pathways' Eur J Microbiol Immunol (Bp) 1, (4) 279-288 Author Site , DOI
Keck S, Müller I, Fejer G, Savic I, Tchaptchet S, Nielsen PJ, Galanos C, Huber M & Freudenberg MA 2011 'Absence of TRIF signaling in lipopolysaccharide-stimulated murine mast cells' J Immunol 186, (9) 5478-5488 Author Site , DOI
Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber CA, Fejer G, Freudenberg MA, Davey GM, Vremec D & Kallies A 2010 'Mouse CD8alpha+ DCs and human BDCA3+ DCs are major producers of IFN-lambda in response to poly IC' J Exp Med 207, (12) 2703-2717 Author Site , DOI PEARL
Schmidt M, Raghavan B, Müller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ & Galanos C 2010 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' Nat Immunol 11, (9) 814-819 Author Site , DOI
Siegemund S, Hartl A, von Buttlar H, Dautel F, Raue R, Freudenberg MA, Fejer G, Büttner M, Köhler G & Kirschning CJ 2009 'Conventional bone marrow-derived dendritic cells contribute to toll-like receptor-independent production of alpha/beta interferon in response to inactivated parapoxvirus ovis' J Virol 83, (18) 9411-9422 Author Site , DOI
Fejer G, Drechsel L, Liese J, Schleicher U, Ruzsics Z, Imelli N, Greber UF, Keck S, Hildenbrand B & Krug A 2008 'Key role of splenic myeloid DCs in the IFN-alphabeta response to adenoviruses in vivo' PLoS Pathog 4, (11) Author Site , DOI PEARL
Martin SF, Dudda JC, Bachtanian E, Lembo A, Liller S, Dürr C, Heimesaat MM, Bereswill S, Fejer G & Vassileva R 2008 'Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity' J Exp Med 205, (9) 2151-2162 Author Site , DOI PEARL
Fejer G, Koroknai A, Banati F, Györy I, Salamon D, Wolf H, Niller HH & Minarovits J 2008 'Latency type-specific distribution of epigenetic marks at the alternative promoters Cp and Qp of Epstein-Barr virus' J Gen Virol 89, (Pt 6) 1364-1370 Author Site , DOI
Freudenberg MA, Tchaptchet S, Keck S, Fejer G, Huber M, Schütze N, Beutler B & Galanos C 2008 'Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: benefits and hazards of LPS hypersensitivity' Immunobiology 213, (3-4) 193-203 Author Site , DOI
Gerle B, Koroknai A, Fejer G, Bakos A, Banati F, Szenthe K, Wolf H, Niller HH, Minarovits J & Salamon D 2007 'Acetylated histone H3 and H4 mark the upregulated LMP2A promoter of Epstein-Barr virus in lymphoid cells' J Virol 81, (23) 13242-13247 Author Site , DOI
Fejér G, Szalay K, Gyory I, Fejes M, Kúsz E, Nedieanu S, Páli T, Schmidt T, Siklódi B & Lázár G 2005 'Adenovirus infection dramatically augments lipopolysaccharide-induced TNF production and sensitizes to lethal shock' J Immunol 175, (3) 1498-1506 Author Site , DOI
Kalis C, Gumenscheimer M, Freudenberg N, Tchaptchet S, Fejer G, Heit A, Akira S, Galanos C & Freudenberg MA 2005 'Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes' J Immunol 174, (7) 4295-4300 Author Site , DOI
Osborne AR, Zhang H, Fejer G, Palubin KM, Niesen MI & Blanck G 2004 'Oct-1 maintains an intermediate, stable state of HLA-DRA promoter repression in Rb-defective cells: an Oct-1-containing repressosome that prevents NF-Y binding to the HLA-DRA promoter' J Biol Chem 279, (28) 28911-28919 Author Site , DOI
Gyory I, Wu J, Fejér G, Seto E & Wright KL 2004 'PRDI-BF1 recruits the histone H3 methyltransferase G9a in transcriptional silencing' Nat Immunol 5, (3) 299-308 Author Site , DOI
Kapustin GV, Fejér G, Gronlund JL, McCafferty DG, Seto E & Etzkorn FA 2003 'Phosphorus-based SAHA analogues as histone deacetylase inhibitors' Org Lett 5, (17) 3053-3056 Author Site , DOI
Fejér G, Medveczky MM, Horvath E, Lane B, Chang Y & Medveczky PG 2003 'The latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts preferentially with the terminal repeats of the genome in vivo and this complex is sufficient for episomal DNA replication' J Gen Virol 84, (Pt 6) 1451-1462 Author Site , DOI
Rezai-Zadeh N, Zhang X, Namour F, Fejer G, Wen Y-D, Yao Y-L, Gyory I, Wright K & Seto E 2003 'Targeted recruitment of a histone H4-specific methyltransferase by the transcription factor YY1' Genes Dev 17, (8) 1019-1029 Author Site , DOI
Györy I, Fejér G, Ghosh N, Seto E & Wright KL 2003 'Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines' J Immunol 170, (6) 3125-3133 Author Site , DOI
Seto E, Tsai SC, Weir YD & Fejer G 2002 'Mechanisms of histone deacetylases' FASEB JOURNAL 16, (4) A3-A3 Author Site
Yang W-M, Tsai S-C, Wen Y-D, Fejer G & Seto E 2002 'Functional domains of histone deacetylase-3' J Biol Chem 277, (11) 9447-9454 Author Site , DOI
Fejer G, Gyory I, Ruzsics Z, Toth S, Krajcsi P, Fejes M, Burgert HG, Kiss A, Benczik M & Falus A 1998 'Interleukin-6 activates the adenovirus early region 3 promoter' EUROPEAN CYTOKINE NETWORK 9, (3) 303-303 Author Site
Igaz P, Tóth S, Rose-John S, Madurka I, Fejér G, Szalai C & Falus A 1998 'Soluble interleukin 6 (IL-6) receptor influences the expression of the protooncogene junB and the production of fibrinogen in the HepG2 human hepatoma cell line and primary rat hepatocytes' Cytokine 10, (8) 620-626 Author Site , DOI
Igaz P, Fejér G, Szalai C, Tóth S & Falus A 1998 'Development of competitive mRNA PCR for the quantification of interleukin-6-responsive junB oncogene expression' Biotechniques 24, (5) 854-860 Author Site , DOI
Guida JD, Fejer G, Pirofski LA, Brosnan CF & Horwitz MS 1995 'Mouse adenovirus type 1 causes a fatal hemorrhagic encephalomyelitis in adult C57BL/6 but not BALB/c mice' J Virol 69, (12) 7674-7681 Author Site , DOI
Efrat S, Fejer G, Brownlee M & Horwitz MS 1995 'Prolonged survival of pancreatic islet allografts mediated by adenovirus immunoregulatory transgenes' Proc Natl Acad Sci U S A 92, (15) 6947-6951 Author Site , DOI
HORWITZ MS, FEJER G, GYORY I, TUFARIELLO J & EFRAT S 1995 'MULTIPLE FUNCTIONS OF ADENOVIRUS E3 IMMUNOREGULATORY GENES - EFFECTS ON ACUTE VIRAL PATHOGENESIS AND PROLONGATION OF SURVIVAL OF PANCREATIC-ISLET ALLOGRAFTS' JOURNAL OF CELLULAR BIOCHEMISTRY 279-279 Author Site
Horwitz MS, Tufariello J, Grunhaus A & Fejer G 1995 'Model systems for studying the effects of adenovirus E3 genes on virulence in vivo' Curr Top Microbiol Immunol 199 ( Pt 3), 195-211 Author Site , DOI
Horwitz MS, Tufariello J, Grunhaus A & Fejer G 1995 'Model systems for studying the effects of adenovirus E3 genes on virulence in vivo' Current Topics in Microbiology and Immunology 199, (III) 195-211 , DOI
Fejer G, Gyory I, Tufariello J & Horwitz MS 1994 'Characterization of transgenic mice containing adenovirus early region 3 genomic DNA' J Virol 68, (9) 5871-5881 Author Site , DOI
Fejér G, Berencsi G, Ruzsics Z, Belák S, Linné T & Nász I 1992 'Multiple enlargements in the right inverted terminal repeat of the DNA of canine adenovirus type 2' Acta Microbiol Hung 39, (2) 159-168 Author Site
Fejér G, Kiss A, Lengyel A, Ruzsics Z, Berencsi G & Nász I 1990 'Characterization of an intermediate adenovirus strain' Acta Microbiol Hung 37, (3) 315-318 Author Site
Kang WG, Berencsi G, Takács M, Ascher Z, Fejér G & Nász I 1989 'Molecular cloning and physical mapping of the DNA of human adenovirus type 35' Acta Microbiol Hung 36, (1) 67-75 Author Site
Kang WG, Berencsi G, Bánrévi A, Ascher Z, Fejér G, Takács M, Kiss A & Nász I 1989 'Relationship of E1 and E3 regions of human adenovirus 35 to those of human adenovirus subgroups A, C and D' Acta Microbiol Hung 36, (4) 445-457 Author Site
KANG WG, BERENCSI G, BANREVI A, ASCHER Z, FEJER G, TAKACS M, KISS A & NASZ I 1989 'RELATIONSHIP OF E1 AND E3 REGIONS OF HUMAN ADENOVIRUS-35 TO THOSE OF HUMAN ADENOVIRUS SUBGROUP-A, SUBGROUP-C AND SUBGROUP-D' ACTA MICROBIOLOGICA HUNGARICA 36, (4) 445-457 Author Site
KISS A, PIPIRAS E, ZAVIZION BA, BANREVI A, POPELLAR M, FEJER G, BERENCSI G & NASZ I 1988 'RABBIT-CELL CLONES TRANSFORMED BY THE ONCOGENE OF SIMIAN ADENOVIRUS 16' ACTA MICROBIOLOGICA HUNGARICA 35, (2) 211-211 Author Site
Adám E, Erdei J, Lengyel A, Fejér G, Fachet J & Nász I 1987 'Monoclonal antibodies to adenovirus type 35 hexon' Intervirology 27, (1) 9-16 Author Site , DOI
Conference Papers
Shawa I, Bennett K, Sheridan D, Felmlee D, Hegazy D, Ahmed A, Wood C, Jackson S, Fejer G & Cramp M 2018 'Upregulated innate immune responses in a hepatitis C virus exposed uninfected cohort' Elsevier BV S798-S798 , DOI
Wood C, Logue C, Silman N, Jackson S & Fejer G 2016 'A novel alveolar-like macrophage to study influenza A infection in vitro' 438-438
Khera S, Sharma V, Fejer G, Tyrrel S, Bennett A & Jackson S 2016 'Development and characterization of a novel cell-based biosensor for screening of inflammatory agents in bioaerosols' 1176-1176
Stichling N, Suomalainen M, Fejer G, Hemmi S & Greber U 2015 'Adenovirus binding to the scavenger receptor SR-A6 (MARCO) triggers the production of inflammatory cytokines in alveolar macrophages' A13-A13
Wegner MD, Engelhard P, Galanos C, Prasse A, Jakob T, Martin SF, Fejer G & Freudenberg MA 2014 'MPI-2 cells, a new model for tissue type macrophages' E24-E24
Fejer G, Wegner M, Gyoery I, Cohen I, Engelhard P, Voronov E, Manke T, Galanos C & Freudenberg M 2013 'Establishment of self-renewing, non-transformed, GM-CSF dependent macrophages, a new model to study lung alveolar macrophage functions' 33-33
Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber CA, Fejer G, Freudenberg MA, Davey GM, Vremec D & Kallies A 2011 'Murine CD8 alpha+ DCs and human CD141+DCs produce large amounts of IFN-lambda in response to dsRNA or DNA viruses' 65-65 , DOI
Schmidt M, Raghavan B, Verena M, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen P & Galanos C 2011 'Human Toll-like receptor 4: A crucial receptor for the development of contact eczema to metal haptens' S94-S94
Lauterbach H, Bathke B, Gilles S, Traidl-Hoffmann C, Luber C, Fejer G, Freudenberg M, Davey G, Vremec D & Kallies A 2011 'Murine CD8 alpha+ DCs and human BDCA3+DCs produce large amounts of IFN-lambda in response to poly IC and DNA viruses'
Schmidt M, Raghavan B, Mueller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kallis C, Nielsen PJ & Galanos C 2011 'Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel' 164-165
Gyory I, Fejer G & Wright KL 2003 'The transcription factor PRDI-BF1 establishes an inactive chromatin state by recruitment of histone methyltransferases' C100-C101