Professor Daniel Martin
Profiles

Professor Daniel Martin

Professor of Perioperative and Intensive Care Medicine

Peninsula Medical School (Faculty of Health)

Biography

Biography

I am an intensive care Consultant interested in oxygen physiology, in particular how we respond and adapt to low levels of oxygen. This interest arose from my involvement in a series of research expeditions to high altitude with the Xtreme Everest team. In 2007, as part of my PhD, a group of us took arterial blood samples from one another near the summit of Mount Everest, which had some of the lowest oxygen levels ever reported in humans. In our hunt for key adaptive processes we have measured our mitochondrial function and compared it to that of high altitude Sherpas; we have investigated the function of the microcirculation and conducted a wide range of other studies at various altitudes over the last 15 years. We are now in the process of translating what we have learnt into benefits for patients. This year we will begin a 16,500 patient study across 100 intensive care units in the UK to determine whether giving a little less oxygen than usual to patients on a mechanical ventilator will improve their survival. We have also been looking at the biological mechanisms we identified as important to the Sherpas at altitude in critically ill patients with multiple organ failure. Alongside these studies I am very interested in the benefit of exercise to high-risk patients, particularly those awaiting major surgery. We have used an exercise intervention to train patients waiting for a liver transplant and are about to embark upon a large study to formally evaluate the efficacy of exercise around the time of liver transplant. 

Aside from this research portfolio, I am the NIHR Clinical Research Network national deputy lead for anaesthesia, perioperative medicine and pain; the National Institute of Academic Anaesthesia academic training coordinator and Royal College of Anaesthetists Bernard Johnson advisor for academic training. I am passionate about promoting academic training for both doctors in training and allied health professionals. I supervise a number of higher degree students including scientists, medical doctors and allied health professionals. 

In 2015 I was awarded Officer of the Order of the British Empire (OBE), for services to the prevention of infectious diseases. This was the result of our work at the Royal Free Hospital in London, caring for patients with Ebola virus disease. 

Qualifications

BSc (1st class) University of Leicester 1994

MB ChB University of Leicester 1997

FRCA 2004

FFICM 2011

PhD in applied physiology, University College London 2013

Professional membership

  • Fellow of the Royal College of Anaesthetists
  • Fellow of the Faculty of Intensive Care Medicine
  • Fellow of the Royal Geographical Society
  • Member of the Physiological Society
  • Fellow of the Royal Geographical Society

Roles on external bodies

  • Board member, National Institute of Academic Anaesthesia
  • Academic Training Coordinator, National Institute for Academic Anaesthesia
  • Deputy Lead, National Institute for Health Research Clinical Research Network Specialty Group for Anaesthesia, Perioperative Medicine and Pain Management
  • Council member, Intensive Care Society 
  • Bernard Johnson Adviser Academic Anaesthesia, Royal College of Anaesthetists 
  • Editor in Chief, Journal of the Intensive Care Society
  • Member, Academy of Medical Royal Colleges Research Leads Group

Research

Research

Grants & contracts

I am the Chief Investigator of an NIHR HTA funded study to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for mecnanically ventilated adults in intensive care units. This study will recruit 16,500 patients from 100 hospitals in the UK, to determine whether giving less oxygen than usual improves survival. This will be the largest study ever conducted in critically ill patients in the UK and will link to large related study being conducted in other countries around the world, to additionally answer this question globally. 

Publications

Publications

Key publications

Key publications are highlighted

Journals
Articles
Fabes J, Ambler G, Shah B, Williams NR, Martin D, Davidson BR & Spiro M (2021) 'Protocol for a prospective double-blind, randomised, placebo-controlled feasibility trial of octreotide infusion during liver transplantation' BMJ Open 11, (12) , DOI Open access
Durey BJ, Fritche D, Martin DS & Best LMJ (2021) 'The Effect of Pre-operative Exercise Intervention on Patient Outcomes Following Bariatric Surgery: a Systematic Review and Meta-analysis' Obesity Surgery , DOI Open access
Martin DS (2021) 'Lifting the lid on perioperative goal-directed therapy' British Journal of Anaesthesia 127, (4) 508-510 , DOI
Wickham AJ, Highton DT, Clark S, Fallaha D, Wong DJN & Martin DS (2021) 'Treatment threshold for intra‐operative hypotension in clinical practice—a prospective cohort study in older patients in the UK' Anaesthesia , DOI Open access
Ballantine A, Martin D & Thakrar SV (2021) 'The coagulopathy of liver disease: a shift in thinking' British Journal of Hospital Medicine 82, (6) 1-9 , DOI Open access
Martin DS, McNeil M, Brew-Graves C, Filipe H, O’Driscoll R, Stevens JL, Burnish R, Cumpstey AF, Williams NR & Mythen MG (2021) 'A feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients' Journal of the Intensive Care Society 22, (4) 280-287 , DOI Open access
Cobb AB, Levett DZH, Mitchell K, Aveling W, Hurlbut D, Gilbert-Kawai E, Hennis PJ, Mythen MG, Grocott MPW & Martin DS (2021) 'Physiological responses during ascent to high altitude and the incidence of acute mountain sickness' Physiological Reports 9, (7) , DOI Open access
McKenna HT, O’Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP & Mythen MG (2021) 'Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness' Redox Biology 41, 101907-101907 , DOI Open access
Lalabekyan BB, Tetlow N, Moonesinghe R, Martin D, Burdett E, Otto J, Wyndham D, Bettini E, Kalavrezos N & Stephens RCM (2021) 'Cardiopulmonary exercise testing and cardiopulmonary morbidity in patients undergoing major head and neck surgery' British Journal of Oral and Maxillofacial Surgery 59, (3) 297-302 , DOI Open access
Thomson RJ, Hunter J, Dutton J, Schneider J, Khosravi M, Casement A, Dhadwal K & Martin D (2020) 'Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study' PLOS ONE 15, (12) e0243710-e0243710 , DOI Open access
Oldman AH, Martin DS, Feelisch M, Grocott MPW & Cumpstey AF (2020) 'Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review' British Journal of Anaesthesia 126, (3) 622-632 , DOI Open access
Young PJ, Bailey M, Bellomo R, Bernard S, Bray J, Jakkula P, Kuisma M, Mackle D, Martin D & Nolan JP (2020) 'Conservative or liberal oxygen therapy in adults after cardiac arrest' Resuscitation 157, 15-22 , DOI Open access
McKenna HT, Murray AJ & Martin DS (2020) 'Human adaptation to hypoxia in critical illness' Journal of Applied Physiology 129, (4) 656-663 , DOI Open access
Odor P, Bampoe S, Moonesinghe R, Andrade J, Pandit J & Lucas N (2020) 'General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multi-centre observational study' Anaesthesia , DOI Open access
O'Mahony HR & Martin DS (2020) 'An anaesthetic and intensive care perspective on infection control measures for the prevention of airborne transmission of SARS-CoV-2' British Journal of Hospital Medicine 81, (9) 1-9 , DOI Open access
Cumpstey AF, Oldman AH, Smith AF, Martin D & Grocott MPW (2020) 'Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review' Cochrane Database of Systematic Reviews , DOI Open access
Post B, Palmer E, Harris S, Singer M & Martin D (2020) 'Oxygenation of the critically ill in selected intensive care units in the UK: are we usual?' British Journal of Anaesthesia 125, (3) e277-e279 , DOI Open access
Martin D (2020) 'After the fire: Post-pandemic reflections' Journal of the Intensive Care Society 21, (3) 195-197 , DOI Open access
Montgomery H, Rehill N, Camporota L, Credland N, Grocott M, Hamilton M, Martin D, Patel B, Suntharalingam G & Szakmany T (2020) 'COVID-19: UK frontline intensivists' emerging learning' Journal of the Intensive Care Society 22, (3) 211-213 , DOI Open access
Coppel J, Bountziouka V, Martin D & Gilbert-Kawai E (2020) 'A comparison of the quality of image acquisition between two different sidestream dark field video-microscopes' Journal of Clinical Monitoring and Computing 35, (3) 577-583 , DOI Open access
Martin GS, Kaufman DA, Marik PE, Shapiro NI, Levett DZH, Whittle J, MacLeod DB, Chappell D, Lacey J & Woodcock T (2020) 'Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance' Perioperative Medicine 9, (1) , DOI Open access
Martin D, Platt S, Hampshire P & Meadows C (2020) 'COVID-19: An update from England’s high consequence infectious diseases intensive care unit leads' Journal of the Intensive Care Society 21, (2) 99-101 , DOI Open access
Wijeysundera DN, Beattie WS, Hillis GS, Abbott TEF, Shulman MA, Ackland GL, Mazer CD, Myles PS, Pearse RM & Cuthbertson BH (2020) 'Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study' British Journal of Anaesthesia 124, (3) 261-270 , DOI
Palmer E, Martin D, Singer M & Harris S (2020) 'Reply to Tasker and to Lellouche and L’Her' American Journal of Respiratory and Critical Care Medicine 201, (4) 499-499 , DOI Open access
Martin D (2020) 'JICS Foreword February 2020' Journal of the Intensive Care Society 21, (1) 1-1 , DOI
Flower L & Martin D (2020) 'Management of hypoxaemia in the critically ill patient' British Journal of Hospital Medicine 81, (1) 1-10 , DOI Open access
Morkane CM, Kearney O, Bruce DA, Melikian CN & Martin DS (2020) 'An Outpatient Hospital-based Exercise Training Program for Patients With Cirrhotic Liver Disease Awaiting Transplantation: A Feasibility Trial' Transplantation 104, (1) 97-103 , DOI
Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Grant D, Jenner W, Poudevigne M, Moyses H, Levett DZH & Cobb A (2020) 'Effects of dietary nitrate supplementation on microvascular physiology at 4559 m altitude – A randomised controlled trial (Xtreme Alps)' Nitric Oxide 94, 27-35 , DOI
Martin D, Koti R, Gurusamy K, Longworth L, Singh J, Froghi F, Soggiu F, Mallett S, Schofield N & Selves L (2019) 'The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial' HPB 22, (8) 1112-1120 , DOI Open access
Stevens JL, Feelisch M & Martin DS (2019) 'Perioperative Oxidative Stress' Anesthesia & Analgesia 129, (6) 1749-1760 , DOI Open access
Coppel J, Gilbert-Kawai E, Bottomley T, Sugarman J & Martin D (2019) 'The effect of normobaric hypoxic exposure on coagulation as measured by thromboelastography' Thrombosis Research 184, 105-109 , DOI Open access
Young PJ, Bagshaw SM, Bailey M, Bellomo R, Mackie D, Pilcher D, Landoni G, Nichol A & Martin D (2019) 'O-2, do we know what to do?' CRITICAL CARE AND RESUSCITATION 21, (4) 230-232 Author Site
Martin D (2019) 'This month in JICS' Journal of the Intensive Care Society 20, (4) 283-283 , DOI
Carey D, Thanaj M, Davies T, Gilbert-Kawai E, Mitchell K, Levett DZH, Mythen MG, Martin DS, Grocott MP & Chipperfield AJ (2019) 'Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to high altitude' Scientific Reports 9, (1) , DOI
Froghi F, Soggiu F, Ricciardi F, Gurusamy K, Martin DS, Singh J, Siddique S, Eastgate C, Ciaponi M & McNeil M (2019) 'Ward-based Goal-Directed Fluid Therapy (GDFT) in Acute Pancreatitis (GAP) trial: study protocol for a feasibility randomised controlled trial' BMJ Open 9, (10) e028783-e028783 , DOI Open access
Palmer E, Post B, Klapaukh R, Marra G, MacCallum NS, Brealey D, Ercole A, Jones A, Ashworth S & Watkinson P (2019) 'The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study' American Journal of Respiratory and Critical Care Medicine 200, (11) 1373-1380 , DOI Open access
Martin D (2019) 'This month in JICS' Journal of the Intensive Care Society 20, (3) 189-189 , DOI
Oldman AH, Cumpstey AF, Martin DS & Grocott MPW (2019) 'Data integrity issues: catalyst for a more robust approach to research on perioperative oxygen therapy?' Perioperative Medicine 8, (1) , DOI
Grocott MPW, Miller TE, Mythen MMG & Martin DS (2019) 'Perioperative oxygen therapy: meaningful outcomes and unintended consequences?' British Journal of Anaesthesia 123, (1) e6-e7 , DOI
Wythe S, Davies TW, O'Beirne J, Martin D & Gilbert-Kawai E (2019) 'Observational study of the microcirculation in patients with liver cirrhosis' JGH Open 3, (6) 518-524 , DOI
Martin D (2019) 'This month in JICS' Journal of the Intensive Care Society 20, (2) 91-91 , DOI
O’Brien KA, Atkinson RA, Richardson L, Koulman A, Murray AJ, Harridge SDR, Martin DS, Levett DZH, Mitchell K & Mythen MG (2019) 'Metabolomic and lipidomic plasma profile changes in human participants ascending to Everest Base Camp' Scientific Reports 9, (1) , DOI
Cumpstey AF, Minnion M, Fernandez BO, Mikus-Lelinska M, Mitchell K, Martin DS, Grocott MPW & Feelisch M (2019) 'Pushing arterial-venous plasma biomarkers to new heights: A model for personalised redox metabolomics?' Redox Biology 21, 101113-101113 , DOI
Martin D (2019) 'This month in JICS' Journal of the Intensive Care Society 20, (1) 1-1 , DOI
Martin DS, Brew-Graves C, McCartan N, Jell G, Potyka I, Stevens J, Williams NR, McNeil M, O’Driscoll BR & Mythen M (2019) 'Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients' BMJ Open 9, (1) e021674-e021674 , DOI Open access
Gardiner MD, Giblin V, Highton D, Jain A, Jeevan R, Jhanji S, Kwasnicki RM, Mosahebi A, Martin D & Sadideen H (2019) 'Variation in the perioperative care of women undergoing abdominal-based microvascular breast reconstruction in the United Kingdom (The optiFLAPP Study)' Journal of Plastic, Reconstructive & Aesthetic Surgery 72, (1) 35-42 , DOI
Martin D, Grocott M & Bellomo R (2018) 'Oxygenation targets in acutely ill patients: still a matter of debate' The Lancet 392, (10163) 2436-2436 , DOI
Stevens JL, McKenna H, Gurusamy KS, Van Schoor J, Grocott MPW, Jell G & Martin D (2018) 'Perioperative antioxidants for adults undergoing elective non-cardiac surgery' Cochrane Database of Systematic Reviews , DOI
Martin D (2018) 'This month in JICS' Journal of the Intensive Care Society 19, (4) 277-278 , DOI
Martin D, Lykoudis PM, Jones G, Highton D, Shaw A, James S, Wei Q & Fusai G (2018) 'Impact of postoperative intravenous fluid administration on complications following elective hepato-pancreato-biliary surgery' Hepatobiliary & Pancreatic Diseases International 17, (5) 402-407 , DOI
Davies T, Gilbert-Kawai E, Wythe S, Meale P, Mythen M, Levett D, Mitchell K, Grocott M, Clough G & Martin D (2018) 'Sustained vasomotor control of skin microcirculation in Sherpasversusaltitude-naive lowlanders: Experimental evidence from Xtreme Everest 2' Experimental Physiology 103, (11) 1494-1504 , DOI
Martin D & Peters MJ (2018) 'Might children rust? What are the risks of supplemental oxygen in acute illness' Archives of Disease in Childhood 104, (2) 106-107 , DOI Open access
Lacey JRN, Kidel C, van der Kaaij JM, Brinkman P, Gilbert-Kawai ET, Grocott MPW, Mythen MG & Martin DS (2018) 'The Smell of Hypoxia: using an electronic nose at altitude and proof of concept of its role in the prediction and diagnosis of acute mountain sickness' Physiological Reports 6, (17) e13854-e13854 , DOI
Stevens JL, McKenna H, Murray A, Jell G, Guliyeva M & Martin D (2018) 'Effects of major hepato-pancreatico-biliary surgery and general anaesthesia on skeletal-muscle mitochondrial respiration: a pilot study' British Journal of Anaesthesia 121, (2) e18-e18 , DOI
Martin D, McKenna H & Galley H (2018) 'Rhythm and cues: role of chronobiology in perioperative medicine' British Journal of Anaesthesia 121, (2) 344-349 , DOI
Morkane CM, McKenna H, Cumpstey AF, Oldman AH, Grocott MPW & Martin DS (2018) 'Intraoperative oxygenation in adult patients undergoing surgery (iOPS): a retrospective observational study across 29 UK hospitals' Perioperative Medicine 7, (1) , DOI
Myles PS, Bellomo R, Corcoran T, Forbes A, Peyton P, Story D, Christophi C, Leslie K, McGuinness S & Parke R (2018) 'Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery' New England Journal of Medicine 378, (24) 2263-2274 , DOI
McKenna H, van der Horst GTJ, Reiss I & Martin D (2018) 'Clinical chronobiology: a timely consideration in critical care medicine' Critical Care 22, (1) , DOI Open access
Murray AJ, Montgomery HE, Feelisch M, Grocott MPW & Martin DS (2018) 'Metabolic adjustment to high-altitude hypoxia: from genetic signals to physiological implications' Biochemical Society Transactions 46, (3) 599-607 , DOI
Froghi F, Koti R, Gurusamy K, Mallett S, Thorburn D, Selves L, James S, Singh J, Pinto M & Eastgate C (2018) 'Cardiac output Optimisation following Liver Transplant (COLT) trial: study protocol for a feasibility  randomised controlled trial' Trials 19, (1) , DOI
Asadi H, Martin D & McKenna H (2018) 'Tackling delirium: a crucial target for improving clinical outcomes' British Journal of Hospital Medicine 79, (3) 132-135 , DOI
Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK, Achatz E, Albert E & Andrews JS (2018) 'The 2018 Lake Louise Acute Mountain Sickness Score' High Altitude Medicine & Biology 19, (1) 4-6 , DOI Open access
Ince C, Boerma EC, Cecconi M, De Backer D, Shapiro NI, Duranteau J, Pinsky MR, Artigas A, Teboul J-L & Reiss IKM (2018) 'Second consensus on the assessment of sublingual microcirculation in critically ill patients: results from a task force of the European Society of Intensive Care Medicine' Intensive Care Medicine 44, (3) 281-299 , DOI
Dessain TE & Martin D (2018) 'Continuous renal replacement therapy for the critically ill patient' British Journal of Hospital Medicine 79, (1) C2-C7 , DOI
Cumpstey AF, Hennis PJ, Gilbert-Kawai ET, Fernandez BO, Poudevigne M, Cobb A, Meale P, Mitchell K, Moyses H & Pöhnl H (2017) 'Effects of dietary nitrate on respiratory physiology at high altitude - Results from the Xtreme Alps study' Nitric Oxide 71, 57-68 , DOI
Martin D & Grocott M (2017) 'Oxygen therapy and the Goldilocks principle' Journal of the Intensive Care Society 18, (4) 279-281 , DOI
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ, Dondorp AM & Bafi T (2017) 'Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis' Critical Care 21, (1) , DOI Open access
Davies T, Wythe S, O'Beirne J, Martin D & Gilbert-Kawai E (2017) 'Review article: the role of the microcirculation in liver cirrhosis' Alimentary Pharmacology & Therapeutics 46, (9) 825-835 , DOI
Wandrag L, Siervo M, Riley HL, Khosravi M, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZH & Montgomery HE (2017) 'Does hypoxia play a role in the development of sarcopenia in humans? Mechanistic insights from the Caudwell Xtreme Everest Expedition' Redox Biology 13, 60-68 , DOI
Tsai KJ, Dixon S, Hale LR, Darbyshire A, Martin D & de Mel A (2017) 'Biomimetic heterogenous elastic tissue development' npj Regenerative Medicine 2, (1) , DOI
Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL & Ament Z (2017) 'Metabolic basis to Sherpa altitude adaptation' Proceedings of the National Academy of Sciences 114, (24) 6382-6387 , DOI Open access
Luks AM, Levett D, Martin DS, Goss CH, Mitchell K, Fernandez BO, Feelisch M, Grocott MP & Swenson ER (2017) 'Changes in acute pulmonary vascular responsiveness to hypoxia during a progressive ascent to high altitude (5300 m)' Experimental Physiology 102, (6) 711-724 , DOI
Bates E & Martin D (2017) 'Immediate postoperative management and complications on the intensive care unit' British Journal of Hospital Medicine 78, (5) 273-277 , DOI
Srinivasan AJ, Morkane C, Martin DS & Welsby IJ (2017) 'Should modulation of p50 be a therapeutic target in the critically ill?' Expert Review of Hematology 10, (5) 449-458 , DOI
Gilbert-Kawai E, Coppel J, Court J, van der Kaaij J, Vercueil A, Feelisch M, Levett D, Mythen M, Grocott MP & Martin D (2017) 'Sublingual microcirculatory blood flow and vessel density in Sherpas at high altitude' Journal of Applied Physiology 122, (4) 1011-1018 , DOI
Griva K, Stygall J, Wilson MH, Martin D, Levett D, Mitchell K, Mythen M, Montgomery HE, Grocott MP & Aref-Adib G (2017) 'Caudwell Xtreme Everest: A prospective study of the effects of environmental hypoxia on cognitive functioning' PLOS ONE 12, (3) e0174277-e0174277 , DOI
Kemp HI, Bantel C, Gordon F, Brett SJ & Laycock HC (2017) 'Pain Assessment in INTensive care (PAINT): an observational study of physician-documented pain assessment in 45 intensive care units in the United Kingdom' Anaesthesia 72, (6) 737-748 , DOI
McKenna HT, Reiss IKM & Martin DS (2017) 'The significance of circadian rhythms and dysrhythmias in critical illness' Journal of the Intensive Care Society 18, (2) 121-129 , DOI
Martin DS, McKenna HT & Morkane CM (2016) 'Intraoperative Hyperoxemia' Anesthesia & Analgesia 123, (6) 1643-1643 , DOI
McKenna H & Martin D (2016) 'Surviving physiological stress: Can insights into human adaptation to austere environments be applied to the critical care unit?' Trends in Anaesthesia and Critical Care 11, 6-13 , DOI
Martin D, McKenna H & Livina V (2016) 'The human physiological impact of global deoxygenation' The Journal of Physiological Sciences 67, (1) 97-106 , DOI
Martin D (2016) 'Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries' British Journal of Anaesthesia 117, (5) 601-609 , DOI Open access
Hennis PJ, Mitchell K, Gilbert-Kawai E, Bountziouka V, Wade A, Feelisch M, Grocott MP & Martin DS (2016) 'Effects of dietary nitrate supplementation on symptoms of acute mountain sickness and basic physiological responses in a group of male adolescents during ascent to Mount Everest Base Camp' Nitric Oxide 60, 24-31 , DOI
Thiele RH, Raghunathan K, Brudney CS, Lobo DN, Martin D, Senagore A, Cannesson M, Gan TJ, Mythen MMG & Shaw AD (2016) 'American Society for Enhanced Recovery (ASER) and Perioperative Quality Initiative  (POQI) joint consensus statement on perioperative fluid management within an enhanced recovery pathway for colorectal surgery' Perioperative Medicine 5, (1) , DOI
Gilbert-Kawai E, Martin D, Grocott M & Levett D (2016) 'High altitude-related hypertensive crisis and acute kidney injury in an asymptomatic healthy individual' Extreme Physiology & Medicine 5, (1) , DOI
Lamb BW, Tan WS, Eneje P, Bruce D, Jones A, Ahmad I, Sridhar A, Baker H, Briggs TP & Hines JE (2016) 'Benefits of robotic cystectomy with intracorporeal diversion for patients with low cardiorespiratory fitness: A prospective cohort study' Urologic Oncology: Seminars and Original Investigations 34, (9) 417.e17-417.e23 , DOI
Gassmann NN, van Elteren HA, Goos TG, Morales CR, Rivera-Ch M, Martin DS, Cabala Peralta P, Passano del Carpio A, Aranibar Machaca S & Huicho L (2016) 'Pregnancy at high altitude in the Andes leads to increased total vessel density in healthy newborns' Journal of Applied Physiology 121, (3) 709-715 , DOI
Gilbert-Kawai E, Coppel J, Hennis P, Grocott M, Ince C & Martin D (2016) 'Changes in labial capillary density on ascent to and descent from high altitude' F1000Research 5, 2107-2107 , DOI
Lambden S, Martin D, Vanezis K, Lee B, Tomlinson J, Piper S, Boruc O, Mythen M & Leiper J (2016) 'Hypoxia causes increased monocyte nitric oxide synthesis which is mediated by changes in dimethylarginine dimethylaminohydrolase 2 expression in animal and human models of normobaric hypoxia' Nitric Oxide 58, 59-66 , DOI
Jacobs M, Rodger A, Bell DJ, Bhagani S, Cropley I, Filipe A, Gifford RJ, Hopkins S, Hughes J & Jabeen F (2016) 'Late Ebola virus relapse causing meningoencephalitis: a case report' The Lancet 388, (10043) 498-503 , DOI
Wickham A, Highton D & Martin D (2016) 'Care of elderly patients: a prospective audit of the prevalence of hypotension and the use of BIS intraoperatively in 25 hospitals in London' Perioperative Medicine 5, (1) , DOI
Martin D, Howard J, Agarwal B, Rajalingam Y, Athan B, Bhagani S, Cropley I, Hopkins S, Mepham S & Rodger A (2016) 'Ebola virus disease: the UK critical care perspective † †This Article is accompanied by Editorial Aew068' British Journal of Anaesthesia 116, (5) 590-596 , DOI
Uyeki TM, Mehta AK, Davey RT, Liddell AM, Wolf T, Vetter P, Schmiedel S, Grünewald T, Jacobs M & Arribas JR (2016) 'Clinical Management of Ebola Virus Disease in the United States and Europe' New England Journal of Medicine 374, (7) 636-646 , DOI
Smith R, Jones N, Martin D & Kipps C (2016) '‘Too much of a coincidence’: identical twins with exertional heatstroke in the same race' BMJ Case Reports bcr2015212592-bcr2015212592 , DOI
Nelson A, Otto J, Whittle J, Stephens RCM, Martin DS, Prowle JR & Ackland GL (2016) 'Subclinical cardiopulmonary dysfunction in stage 3 chronic kidney disease' Open Heart 3, (1) e000370-e000370 , DOI
Gilbert-Kawai E, Coppel J, Bountziouka V, Ince C & Martin D (2016) 'A comparison of the quality of image acquisition between the incident dark field and sidestream dark field video-microscopes' BMC Medical Imaging 16, (1) , DOI
Grocott MPW, Levett DZH, Martin DS, Wilson MH, Mackenney A, Dhillon S, Montgomery HE, Mythen MG & Mitchell K (2016) 'Caudwell Xtreme Everest: An Overview' 427-437 , DOI
Wilson AJ, Martin DS, Maddox V, Rattenbury S, Bland D, Bhagani S, Cropley I, Hopkins S, Mepham S & Rodger A (2015) 'Thromboelastography in the Management of Coagulopathy Associated With Ebola Virus Disease' Clinical Infectious Diseases 62, (5) 610-612 , DOI
Jacobs M, Aarons E, Bhagani S, Buchanan R, Cropley I, Hopkins S, Lester R, Martin D, Marshall N & Mepham S (2015) 'Post-exposure prophylaxis against Ebola virus disease with experimental antiviral agents: a case-series of health-care workers' The Lancet Infectious Diseases 15, (11) 1300-1304 , DOI
Martin D & Grocott M (2015) 'Recommendations for perioperative oxygenation' British Journal of Anaesthesia 115, (5) 802-802 , DOI
Wythe S, Davies T, Martin D, Feelisch M & Gilbert-Kawai E (2015) 'Getting the most from venous occlusion plethysmography: proposed methods for the analysis of data with a rest/exercise protocol' Extreme Physiology & Medicine 4, (1) , DOI
Whittle J, Alexander N, Stephens RCM, Otto JM, Martin DS, Sneyd JR, Struthers, Minto G & Ackland GL (2015) 'Sympathetic autonomic dysfunction and impaired cardiovascular performance in higher risk surgical patients: implications for perioperative sympatholysis' Open Heart 2, , DOI Open access
Sanborn MR, Edsell ME, Kim MN, Mesquita R, Putt ME, Imray C, Yow H, Wilson MH, Yodh AG & Grocott M (2015) 'Cerebral Hemodynamics at Altitude: Effects of Hyperventilation and Acclimatization on Cerebral Blood Flow and Oxygenation' Wilderness & Environmental Medicine 26, (2) 133-141 , DOI
Martin DS & Grocott MPW (2015) 'Oxygen therapy and anaesthesia: too much of a good thing?' Anaesthesia 70, (5) 522-527 , DOI
Gilbert-Kawai E, Sheperdigian A, Adams T, Mitchell K, Feelisch M, Murray A, Peters M, Gilbert-Kawai G, Montgomery H & Levett D (2015) 'Design and conduct of Xtreme Everest 2: An observational cohort study of Sherpa and lowlander responses to graduated hypobaric hypoxia' F1000Research 4, 90-90 , DOI
Martin DS, Cobb A, Meale P, Mitchell K, Edsell M, Mythen MG, Grocott MPW, Adams T, Biseker L & Booth A (2015) 'Systemic oxygen extraction during exercise at high altitude' British Journal of Anaesthesia 114, (4) 677-682 , DOI
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M & Akarsu-Ayazoglu T (2015) 'International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients*' Critical Care Medicine 43, (1) 48-56 , DOI
Levett DZH, Viganò A, Capitanio D, Vasso M, De Palma S, Moriggi M, Martin DS, Murray AJ, Cerretelli P & Grocott MPW (2014) 'Changes in muscle proteomics in the course of the Caudwell Research Expedition to Mt. Everest' PROTEOMICS 15, (1) 160-171 , DOI
Liew F & Martin D (2014) 'Acute respiratory distress syndrome on the intensive care unit' British Journal of Hospital Medicine 75, (12) 672-677 , DOI
Holloway CJ, Murray AJ, Mitchell K, Martin DS, Johnson AW, Cochlin LE, Codreanu I, Dhillon S, Rodway GW & Ashmore T (2014) 'Oral Coenzyme Q10 Supplementation Does Not Prevent Cardiac Alterations During a High Altitude Trek to Everest Base Camp' High Altitude Medicine & Biology 15, (4) 459-467 , DOI
Gilbert-Kawai ET, Milledge JS, Grocott MPW & Martin DS (2014) 'King of the Mountains: Tibetan and Sherpa Physiological Adaptations for Life at High Altitude' Physiology 29, (6) 388-402 , DOI
Martin DS (2014) 'Oxygen Therapy' Critical Care Medicine 42, (6) 1553-1554 , DOI
Gilbert-Kawai ET, Mitchell K, Martin D, Carlisle J & Grocott MPW (2014) 'Permissive hypoxaemia versus normoxaemia for mechanically ventilated critically ill patients' Cochrane Database of Systematic Reviews , DOI
Siervo M, Riley HL, Fernandez BO, Leckstrom CA, Martin DS, Mitchell K, Levett DZH, Montgomery HE, Mythen MG & Grocott MPW (2014) 'Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation' PLoS ONE 9, (4) e94915-e94915 , DOI
Martin D (2014) 'Intravenous fluids: the tale goes on' British Journal of Hospital Medicine 75, (1) 4-5 , DOI
Martin DS & Grocott MPW (2013) 'III. Oxygen therapy in anaesthesia: the yin and yang of O 2' British Journal of Anaesthesia 111, (6) 867-871 , DOI
Bigham S, Bigham C & Martin D (2013) 'Predictors of Outcome Post Cardiac Arrest' Journal of Intensive Care Medicine 33, (4) 248-255 , DOI
Martin DS, Gilbert-Kawai ET, Meale PM, Fernandez BO, Cobb A, Khosravi M, Mitchell K, Grocott MPW, Levett DZH & Mythen MG (2013) 'Design and conduct of ‘Xtreme Alps’: A double-blind, randomised controlled study of the effects of dietary nitrate supplementation on acclimatisation to high altitude' Contemporary Clinical Trials 36, (2) 450-459 , DOI
Martin DS, Gilbert-Kawai E, Levett DZH, Mitchell K, Kumar BC R, Mythen MG & Grocott MPW (2013) 'Xtreme Everest 2: unlocking the secrets of the Sherpa phenotype?' Extreme Physiology & Medicine 2, (1) , DOI
Martin DS, Levett DZH, Bezemer R, Montgomery HE, Grocott & and the Caudwell Xtreme Ev MPW (2013) 'The Use of Skeletal Muscle Near Infrared Spectroscopy and a Vascular Occlusion Test at High Altitude' High Altitude Medicine & Biology 14, (3) 256-262 , DOI
Gavlak JC, Stocks J, Laverty A, Fettes E, Bucks R, Sonnappa S, Cooper J, Grocott MP, Levett DZ & Martin DS (2013) 'The Young Everest Study: preliminary report of changes in sleep and cerebral blood flow velocity during slow ascent to altitude in unacclimatised children' Archives of Disease in Childhood 98, (5) 356-362 , DOI
Martin DS & Grocott MPW (2013) 'Oxygen Therapy in Critical Illness' Critical Care Medicine 41, (2) 423-432 , DOI
Martin D, O'Doherty A & Imray C (2012) 'The Prognostic Value of Cardiopulmonary Exercise Testing in Vascular Surgery Patients' European Journal of Vascular and Endovascular Surgery 44, (4) 457-457 , DOI
Martin D, Thompson A, Stewart I, Gilbert E, Hope K, Kawai G & Griffiths A (2012) 'A paradigm of fragile Earth in Priestley's bell jar' Extreme Physiology & Medicine 1, (1) , DOI
Grocott MPW, Martin DS & Mythen MG (2012) 'Enhanced recovery pathways as a way to reduce surgical morbidity' Current Opinion in Critical Care 18, (4) 385-392 , DOI
Sanborn MR, Edsell ME, Yow H, Martin DS, Imray C & Grocott M (2012) 'Changes in Peripheral and Cerebral Oxygenation With Altitude and Acclimatization' Wilderness & Environmental Medicine 23, (2) 193-194 , DOI
Adams T, Stacey E, Stacey S & Martin D (2012) 'Exertional heat stroke' British Journal of Hospital Medicine 73, (2) 72-78 , DOI
Martin D, Pate J, Vercueil A, Doyle P, Mythen M & Grocott M (2012) 'Reduced coagulation at high altitude identified by thromboelastography' Thrombosis and Haemostasis 107, (06) 1066-1071 , DOI
Levett DZ, Radford EJ, Menassa DA, Graber EF, Morash AJ, Hoppeler H, Clarke K, Martin DS, Ferguson-Smith AC & Montgomery HE (2011) 'Acclimatization of skeletal muscle mitochondria to high‐altitude hypoxia during an ascent of Everest' The FASEB Journal 26, (4) 1431-1441 , DOI
Levett DZ, Fernandez BO, Riley HL, Martin DS, Mitchell K, Leckstrom CA, Ince C, Whipp BJ, Mythen MG & Montgomery HE (2011) 'The role of nitrogen oxides in human adaptation to hypoxia' Scientific Reports 1, (1) , DOI
van der Kaaij JM, Martin DS, Mythen MG & Grocott MP (2011) 'Research on Mount Everest: Exploring adaptation to hypoxia to benefit the critically III patient' Netherlands Journal of Critical Care 15, (5) 240-248
Wilson MH, Edsell MEG, Davagnanam I, Hirani SP, Martin DS, Levett DZH, Thornton JS, Golay X, Strycharczuk L & Newman SP (2011) 'Cerebral Artery Dilatation Maintains Cerebral Oxygenation at Extreme Altitude and in Acute Hypoxia—An Ultrasound and MRI Study' Journal of Cerebral Blood Flow & Metabolism 31, (10) 2019-2029 , DOI
Levett DZH, Martin DS, Wilson MH, Mitchell K, Dhillon S, Rigat F, Montgomery HE, Mythen MG & Grocott MPW (2010) 'Design and conduct of Caudwell Xtreme Everest: an observational cohort study of variation in human adaptation to progressive environmental hypoxia' BMC Medical Research Methodology 10, (1) , DOI
Martin DS, Goedhart P, Vercueil A, Ince C, Levett DZH & Grocott MPW (2010) 'Changes in sublingual microcirculatory flow index and vessel density on ascent to altitude' Experimental Physiology 95, (8) 880-891 , DOI
Grocott MPW, Martin DS, Wilson MH, Mitchell K, Dhillon S, Mythen MG, Montgomery HE & Levett DZH (2010) 'Caudwell Xtreme Everest Expedition' High Altitude Medicine & Biology 11, (2) 133-137 , DOI
Martin DS, Levett DZH, Grocott MPW & Montgomery HE (2010) 'Variation in human performance in the hypoxic mountain environment' Experimental Physiology 95, (3) 463-470 , DOI
Martin DS, Khosravi M, Grocott MPW & Mythen MG (2010) 'Concepts in hypoxia reborn' Critical Care 14, (4) 315-315 , DOI
Grocott MPW, Martin DS & Levett DZH (2009) 'The authors reply' New England Journal of Medicine 360, (18)
Scrase E, Laverty A, Gavlak JCD, Sonnappa S, Levett DZH, Martin D, Grocott MPW & Stocks J (2009) 'The Young Everest Study: effects of hypoxia at high altitude on cardiorespiratory function and general well-being in healthy children' Archives of Disease in Childhood 94, (8) 621-626 , DOI
Martin DS, Ince C, Goedhart P, Levett DZH & Grocott MPW (2009) 'Abnormal blood flow in the sublingual microcirculation at high altitude' European Journal of Applied Physiology 106, (3) 473-478 , DOI
Grocott MPW, Martin DS, Levett DZH, McMorrow R, Windsor J & Montgomery HE (2009) 'Arterial Blood Gases and Oxygen Content in Climbers on Mount Everest' New England Journal of Medicine 360, (2) 140-149 , DOI
Martin DS, Levett DZH, Mythen M & Grocott MPW (2009) 'Changes in skeletal muscle oxygenation during exercise measured by near-infrared spectroscopy on ascent to altitude' Critical Care 13, (Suppl 5) S7-S7 , DOI
Bezemer R, Karemaker JM, Klijn E, Martin D, Mitchell K, Grocott M, Heger M & Ince C (2009) 'Simultaneous multi-depth assessment of tissue oxygen saturation in thenar and forearm using near-infrared spectroscopy during a simple cardiovascular challenge' Critical Care 13, (Suppl 5) S5-S5 , DOI
Martin D & Windsor J (2008) 'From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia' Postgraduate Medical Journal 84, (998) 622-627 , DOI
Martin D, McCorkell S, Vercueil A, Gunning P, Cox M, Dick J, Mythen M & Grocott M (2007) 'Increased Gastric–End Tidal PCO2 Gap during Exercise at High Altitude Measured by Gastric Tonometry' High Altitude Medicine & Biology 8, (1) 50-55 , DOI
Martin D & Smith M (2004) 'Medical management of severe traumatic brain injury' Hospital Medicine 65, (11) 674-680 , DOI
Martin D & Smith M (2003) 'Active hypothermia in the management of head injuries' Hospital Medicine 64, (1) 61-61 , DOI
Steeds R (2001) 'Analysis of the postulated interaction between the angiotensin II sub-type 1 receptor gene A1166C polymorphism and the insertion/deletion polymorphism of the angiotensin converting enzyme gene on risk of myocardial infarction' Atherosclerosis 154, (1) 123-128 , DOI
Rathbone B, Martin D, Stephens J, Thompson JR & Samani NJ (1996) 'Helicobacter pylori seropositivity in subjects with acute myocardial infarction' Heart 76, (4) 308-311 , DOI
Samani NJ, Martin DS, Brack M, Cullen J, Wallis R, Lodwick D, Chauhan A, Harley A, Thompson JR & Gershlick AH (1996) 'Apolipoprotein E polymorphism does not predict risk of restenosis after coronary angioplasty' Atherosclerosis 125, (2) 209-216 , DOI
Samani NJ, O'Toole L, Martin D, Rai H, Fletcher S, Lodwick D, Thompson JR, Morice AH, Channer K & Woods KL (1996) 'Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of and prognosis after myocardial infarction' Journal of the American College of Cardiology 28, (2) 338-344 , DOI
Adams M, Smith PD, Martin D, Thompson JR, Lodwick D & Samani NJ (1996) 'Genetic analysis of thermolabile methylenetetrahydrofolate reductase as a risk factor for myocardial infarction' QJM 89, (6) 437-444 , DOI
Samani NJ, Brack M, Cullen J, de Bono DP, Gershlick AH, Martin DS, Lodwick D, Swales JD, Chauhan A & Harley A (1995) 'Insertion/deletion polymorphism in the angiotensin-converting enzyme gene and risk of restenosis after coronary angioplasty' The Lancet 345, (8956) 1013-1016 , DOI
Samani N, Lodwick D, Martin D & Kimber P (1994) 'Resistance to activated protein C and risk of premature myocardial infarction' The Lancet 344, (8938) 1709-1710 , DOI
Conference Papers
Agarwal B, Saliba F, Tomescu DR, Banares Canizares R, Martin D, Stadlbauer V, Wright G, Sheikh M, Morgan C & Andreola F (2021) 'A multi-centre, randomized controlled study, to evaluate the safety and performance of the DIALIVE Liver Dialysis Device in patients with Acute on Chronic Liver Failure (ACLF) versus standard of care (SOC)' S194-S196
Canizares RB, Saliba F, Agarwal B, Tomescu DR, Martin D, Stadlbauer V, Wright G, Sheikh M, Morgan C & Andreola F (2021) 'Pathophysiological basis of resolution of Acute-on-Chronic Liver Failure (ACLF) induced by the novel liver dialysis device, DIALIVE' S209-S210
Personal

Personal

Other academic activities

I am also the Editor in chief of the Journal of the Intensive Care Society and Director of the Centre for Altitude, Space and Extreme environment medicine.

Additional information

When not at work, you are most likely to find me scrambling up a Tor on the Moor or heading out to sea with a strong south westerly wind across the starboard bow.