Dr Daniel Martin
Professor of Perioperative and Intensive Care Medicine
Peninsula Medical School (Faculty of Health)
I am an intensive care Consultant interested in oxygen physiology, in particular how we respond and adapt to low levels of oxygen. This interest arose from my involvement in a series of research expeditions to high altitude with the Xtreme Everest team. In 2007, as part of my PhD, a group of us took arterial blood samples from one another near the summit of Mount Everest, which had some of the lowest oxygen levels ever reported in humans. In our hunt for key adaptive processes we have measured our mitochondrial function and compared it to that of high altitude Sherpas; we have investigated the function of the microcirculation and conducted a wide range of other studies at various altitudes over the last 15 years. We are now in the process of translating what we have learnt into benefits for patients. This year we will begin a 16,500 patient study across 100 intensive care units in the UK to determine whether giving a little less oxygen than usual to patients on a mechanical ventilator will improve their survival. We have also been looking at the biological mechanisms we identified as important to the Sherpas at altitude in critically ill patients with multiple organ failure. Alongside these studies I am very interested in the benefit of exercise to high-risk patients, particularly those awaiting major surgery. We have used an exercise intervention to train patients waiting for a liver transplant and are about to embark upon a large study to formally evaluate the efficacy of exercise around the time of liver transplant.
Aside from this research portfolio, I am the NIHR Clinical Research Network national deputy lead for anaesthesia, perioperative medicine and pain; the National Institute of Academic Anaesthesia academic training coordinator and Royal College of Anaesthetists Bernard Johnson advisor for academic training. I am passionate about promoting academic training for both doctors in training and allied health professionals. I supervise a number of higher degree students including scientists, medical doctors and allied health professionals.
In 2015 I was awarded Officer of the Order of the British Empire (OBE), for services to the prevention of infectious diseases. This was the result of our work at the Royal Free Hospital in London, caring for patients with Ebola virus disease.
BSc (1st class) University of Leicester 1994
MB ChB University of Leicester 1997
PhD in applied physiology, University College London 2013
- Royal College of Anaesthetists
- Faculty of Intensive Care Medicine
- Fellow of the Royal Geographical Society
Roles on external bodies
- Board of the National Institute of Academic Anaesthesia
- Deputy Lead for the National Institute for Health Research Clinical Research Network Specialty Group for Anaesthesia, Perioperative Medicine and Pain Management
- Council of the Intensive Care Society
Grants & contracts
I am the Chief Investigator of an NIHR HTA funded study to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for mecnanically ventilated adults in intensive care units. This study will recruit 16,500 patients from 100 hospitals in the UK, to determine whether giving less oxygen than usual improves survival. This will be the largest study ever conducted in critically ill patients in the UK and will link to large related study being conducted in other countries around the world, to additionally answer this question globally.
Key publications are highlightedJournals
Other academic activities
I am also the Editor in chief of the Journal of the Intensive Care Society and Director of the Centre for Altitude, Space and Extreme environment medicine.
When not at work, you are most likely to find me scrambling up a Tor on the Moor or heading out to sea with a strong south westerly wind across the starboard bow.