Dr Daniel Martin
Profiles

Dr Daniel Martin

Professor of Perioperative and Intensive Care Medicine

Peninsula Medical School (Faculty of Health)

I am an intensive care Consultant interested in oxygen physiology, in particular how we respond and adapt to low levels of oxygen. This interest arose from my involvement in a series of research expeditions to high altitude with the Xtreme Everest team. In 2007, as part of my PhD, a group of us took arterial blood samples from one another near the summit of Mount Everest, which had some of the lowest oxygen levels ever reported in humans. In our hunt for key adaptive processes we have measured our mitochondrial function and compared it to that of high altitude Sherpas; we have investigated the function of the microcirculation and conducted a wide range of other studies at various altitudes over the last 15 years. We are now in the process of translating what we have learnt into benefits for patients. This year we will begin a 16,500 patient study across 100 intensive care units in the UK to determine whether giving a little less oxygen than usual to patients on a mechanical ventilator will improve their survival. We have also been looking at the biological mechanisms we identified as important to the Sherpas at altitude in critically ill patients with multiple organ failure. Alongside these studies I am very interested in the benefit of exercise to high-risk patients, particularly those awaiting major surgery. We have used an exercise intervention to train patients waiting for a liver transplant and are about to embark upon a large study to formally evaluate the efficacy of exercise around the time of liver transplant. 

Aside from this research portfolio, I am the NIHR Clinical Research Network national deputy lead for anaesthesia, perioperative medicine and pain; the National Institute of Academic Anaesthesia academic training coordinator and Royal College of Anaesthetists Bernard Johnson advisor for academic training. I am passionate about promoting academic training for both doctors in training and allied health professionals. I supervise a number of higher degree students including scientists, medical doctors and allied health professionals. 

In 2015 I was awarded Officer of the Order of the British Empire (OBE), for services to the prevention of infectious diseases. This was the result of our work at the Royal Free Hospital in London, caring for patients with Ebola virus disease. 

Qualifications

BSc (1st class) University of Leicester 1994

MB ChB University of Leicester 1997

FRCA 2004

FFICM 2011

PhD in applied physiology, University College London 2013

Professional membership

Royal College of Anaesthetists

Faculty of Intensive Care Medicine

Fellow of the Royal Geographical Society

Roles on external bodies

Board of the National Institute of Academic Anaesthesia

Deputy Lead for the National Institute for Health Research Clinical Research Network Specialty Group for Anaesthesia, Perioperative Medicine and Pain Management

Council of the Intensive Care Society 

Grants & contracts

I am the Chief Investigator of an NIHR HTA funded study to evaluate the clinical and cost-effectiveness of a conservative approach to oxygen therapy for mecnanically ventilated adults in intensive care units. This study will recruit 16,500 patients from 100 hospitals in the UK, to determine whether giving less oxygen than usual improves survival. This will be the largest study ever conducted in critically ill patients in the UK and will link to large related study being conducted in other countries around the world, to additionally answer this question globally. 

Key publications

Key publications are highlighted

Journals
Articles
McKenna HT, O’Brien KA, Fernandez BO, Minnion M, Tod A, McNally BD, West JA, Griffin JL, Grocott MP & Mythen MG 2021 'Divergent trajectories of cellular bioenergetics, intermediary metabolism and systemic redox status in survivors and non-survivors of critical illness' Redox Biology 101907-101907 , DOI
Oldman AH, Martin DS, Feelisch M, Grocott MPW & Cumpstey AF 2021 'Effects of perioperative oxygen concentration on oxidative stress in adult surgical patients: a systematic review' British Journal of Anaesthesia 126, (3) 622-632 , DOI
Thomson RJ, Hunter J, Dutton J, Schneider J, Khosravi M, Casement A, Dhadwal K & Martin D 2020 'Clinical characteristics and outcomes of critically ill patients with COVID-19 admitted to an intensive care unit in London: A prospective observational cohort study' PLOS ONE 15, (12) e0243710-e0243710 , DOI Open access
Young PJ, Bailey M, Bellomo R, Bernard S, Bray J, Jakkula P, Kuisma M, Mackle D, Martin D & Nolan JP 2020 'Conservative or liberal oxygen therapy in adults after cardiac arrest' Resuscitation 157, 15-22 , DOI Open access
McKenna HT, Murray AJ & Martin DS 2020 'Human adaptation to hypoxia in critical illness' Journal of Applied Physiology 129, (4) 656-663 , DOI
O'Mahony HR & Martin DS 2020 'An anaesthetic and intensive care perspective on infection control measures for the prevention of airborne transmission of SARS-CoV-2' British Journal of Hospital Medicine 81, (9) 1-9 , DOI Open access
Cumpstey AF, Oldman AH, Smith AF, Martin D & Grocott MPW 2020 'Oxygen targets in the intensive care unit during mechanical ventilation for acute respiratory distress syndrome: a rapid review' Cochrane Database of Systematic Reviews , DOI Open access
Post B, Palmer E, Harris S, Singer M & Martin D 2020 'Oxygenation of the critically ill in selected intensive care units in the UK: are we usual?' British Journal of Anaesthesia 125, (3) e277-e279 , DOI Open access
Lalabekyan BB, Tetlow N, Moonesinghe R, Martin D, Burdett E, Otto J, Wyndham D, Bettini E, Kalavrezos N & Stephens RCM 2020 'Cardiopulmonary exercise testing and cardiopulmonary morbidity in patients undergoing major head and neck surgery' British Journal of Oral and Maxillofacial Surgery , DOI Open access
Martin D 2020 'After the fire: Post-pandemic reflections' Journal of the Intensive Care Society 21, (3) 195-197 , DOI Open access
Montgomery H, Rehill N, Camporota L, Credland N, Grocott M, Hamilton M, Martin D, Patel B, Suntharalingam G & Szakmany T 2020 'COVID-19: UK frontline intensivists' emerging learning' Journal of the Intensive Care Society 175114372093173-175114372093173 , DOI Open access
Coppel J, Bountziouka V, Martin D & Gilbert-Kawai E 2020 'A comparison of the quality of image acquisition between two different sidestream dark field video-microscopes' Journal of Clinical Monitoring and Computing , DOI Open access
Martin GS, Kaufman DA, Marik PE, Shapiro NI, Levett DZH, Whittle J, MacLeod DB, Chappell D, Lacey J & Woodcock T 2020 'Perioperative Quality Initiative (POQI) consensus statement on fundamental concepts in perioperative fluid management: fluid responsiveness and venous capacitance' Perioperative Medicine 9, (1) , DOI Open access
Martin D, Platt S, Hampshire P & Meadows C 2020 'COVID-19: An update from England’s high consequence infectious diseases intensive care unit leads' Journal of the Intensive Care Society 21, (2) 99-101 , DOI Open access
Wijeysundera DN, Beattie WS, Hillis GS, Abbott TEF, Shulman MA, Ackland GL, Mazer CD, Myles PS, Pearse RM & Cuthbertson BH 2020 'Integration of the Duke Activity Status Index into preoperative risk evaluation: a multicentre prospective cohort study' British Journal of Anaesthesia 124, (3) 261-270 , DOI
Palmer E, Martin D, Singer M & Harris S 2020 'Reply to Tasker and to Lellouche and L’Her' American Journal of Respiratory and Critical Care Medicine 201, (4) 499-499 , DOI Open access
Flower L & Martin D 2020 'Management of hypoxaemia in the critically ill patient' British Journal of Hospital Medicine 81, (1) 1-10 , DOI Open access
Martin D, Koti R, Gurusamy K, Longworth L, Singh J, Froghi F, Soggiu F, Mallett S, Schofield N & Selves L 2019 'The cardiac output optimisation following liver transplant (COLT) trial: a feasibility randomised controlled trial' HPB 22, (8) 1112-1120 , DOI Open access
Stevens JL, Feelisch M & Martin DS 2019 'Perioperative Oxidative Stress' Anesthesia & Analgesia 129, (6) 1749-1760 , DOI Open access
Coppel J, Gilbert-Kawai E, Bottomley T, Sugarman J & Martin D 2019 'The effect of normobaric hypoxic exposure on coagulation as measured by thromboelastography' Thrombosis Research 184, 105-109 , DOI Open access
Froghi F, Soggiu F, Ricciardi F, Gurusamy K, Martin DS, Singh J, Siddique S, Eastgate C, Ciaponi M & McNeil M 2019 'Ward-based Goal-Directed Fluid Therapy (GDFT) in Acute Pancreatitis (GAP) trial: study protocol for a feasibility randomised controlled trial' BMJ Open 9, (10) e028783-e028783 , DOI Open access
Palmer E, Post B, Klapaukh R, Marra G, MacCallum NS, Brealey D, Ercole A, Jones A, Ashworth S & Watkinson P 2019 'The Association between Supraphysiologic Arterial Oxygen Levels and Mortality in Critically Ill Patients. A Multicenter Observational Cohort Study' American Journal of Respiratory and Critical Care Medicine 200, (11) 1373-1380 , DOI Open access
Martin DS, Brew-Graves C, McCartan N, Jell G, Potyka I, Stevens J, Williams NR, McNeil M, O’Driscoll BR & Mythen M 2019 'Protocol for a feasibility randomised controlled trial of targeted oxygen therapy in mechanically ventilated critically ill patients' BMJ Open 9, (1) e021674-e021674 , DOI Open access
Martin D & Peters MJ 2018 'Might children rust? What are the risks of supplemental oxygen in acute illness' Archives of Disease in Childhood 104, (2) 106-107 , DOI Open access
McKenna H, van der Horst GTJ, Reiss I & Martin D 2018 'Clinical chronobiology: a timely consideration in critical care medicine' Critical Care 22, (1) , DOI Open access
Roach RC, Hackett PH, Oelz O, Bärtsch P, Luks AM, MacInnis MJ, Baillie JK, Achatz E, Albert E & Andrews JS 2018 'The 2018 Lake Louise Acute Mountain Sickness Score' High Altitude Medicine & Biology 19, (1) 4-6 , DOI Open access
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, van der Voort PHJ, Dondorp AM & Bafi T 2017 'Mildly elevated lactate levels are associated with microcirculatory flow abnormalities and increased mortality: a microSOAP post hoc analysis' Critical Care 21, (1) , DOI Open access
Horscroft JA, Kotwica AO, Laner V, West JA, Hennis PJ, Levett DZH, Howard DJ, Fernandez BO, Burgess SL & Ament Z 2017 'Metabolic basis to Sherpa altitude adaptation' Proceedings of the National Academy of Sciences 114, (24) 6382-6387 , DOI Open access
Martin D 2016 'Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries' British Journal of Anaesthesia 117, (5) 601-609 , DOI Open access
Odor P, Bampoe S, Moonesinghe R, Andrade J, Pandit J & Lucas N 2020 'General anaesthetic and airway management practice for obstetric surgery in England: a prospective, multi-centre observational study' Anaesthesia , DOI Open access
Uyeki TM, Mehta AK, Davey RT, Liddell AM, Wolf T, Vetter P, Schmiedel S, Grünewald T, Jacobs M & Arribas JR 2016 'Clinical Management of Ebola Virus Disease in the United States and Europe' New England Journal of Medicine 374, (7) 636-646 , DOI
Vellinga NAR, Boerma EC, Koopmans M, Donati A, Dubin A, Shapiro NI, Pearse RM, Machado FR, Fries M & Akarsu-Ayazoglu T 2015 'International Study on Microcirculatory Shock Occurrence in Acutely Ill Patients*' Critical Care Medicine 43, (1) 48-56 , DOI
Bigham S, Bigham C & Martin D 2013 'Predictors of Outcome Post Cardiac Arrest' Journal of Intensive Care Medicine 33, (4) 248-255 , DOI

Other academic activities

I am also the Editor in chief of the Journal of the Intensive Care Society and Director of the Centre for Altitude, Space and Extreme environment medicine.

Additional information

When not at work, you are most likely to find me scrambling up a Tor on the Moor or heading out to sea with a strong south westerly wind across the starboard bow.