
Profiles
Dr Claire Adams
Laboratory Manager
Peninsula Medical School (Faculty of Health)
Dr Claire Adams can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Brain tumour
- Biobanking
- Laboratory methods
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
Laboratory Manager for the Biomedical Research laboratories at the Faculty of Health.
Biobank Manager for the Plymouth Brain Tumour Bank.
HTA Person designate
Chair of the Health and Safety sub-committee for the Schools of Medicine, Dentistry and Biomedical Science
Qualifications
NEBOSH National General Certificate in Occupational Health and Safety
HCPC registered Clinical Scientist in Histocompatibility and Immunogenetics.PhD in Antibody Engineering (University of Bath).
BSc (Hons) Biological and Medicinal Chemistry (Exeter University).
Professional membership
Fellow of the Institute of Biomedical Science
British Association of Cancer Research (BACR)
UK Pharmacogenetics and Stratified Medicine Network
Key publications
(2020) 'A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours' International Journal of Molecular Sciences 21, (4) 1273-1273 , DOI Open access
Teaching
Teaching
Teaching interests
BIOM5001- MSc Cancer Genomics module
BHCS3005 - Final year Transplantation teaching
Research
Research
Research interests
Research expertise in Renal and Stem Cell Transplantation, Immunogenetics, Cancer research, Biomarkers, Immunology and Biobanking.
At present, I work within Prof Oliver Hanemann's Brain Tumour Research group immunophenotyping and genotyping brain tumours to aid the develop of personalised medicine.
Publications
Publications
Key publications
(2020) 'A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours' International Journal of Molecular Sciences 21, (4) 1273-1273 , DOI Open access
Key publications are highlighted
Journals
Articles
(2022) 'miR-497 and 219 in blood aid meningioma classification' Journal of Neuro-Oncology 160, (1) 137-147 , DOI
(2021) 'Fibulin-2: A Novel Biomarker for Differentiating Grade II from Grade I Meningiomas' International Journal of Molecular Sciences 22, (2) 560-560 , DOI Open access
(2020) 'GATA-4, a potential novel therapeutic target for high-grade meningioma, regulates miR-497, a potential novel circulating biomarker for high-grade meningioma' EBioMedicine 59, 102941-102941 , DOI Open access
(2020) 'The Potential of MLN3651 in Combination with Selumetinib as a Treatment for Merlin-Deficient Meningioma' Cancers 12, (7) 1744-1744 , DOI Open access
(2020) 'A Rapid Robust Method for Subgrouping Non-NF2 Meningiomas According to Genotype and Detection of Lower Levels of M2 Macrophages in AKT1 E17K Mutated Tumours' International Journal of Molecular Sciences 21, (4) 1273-1273 , DOI Open access
(2020) 'Constitutive activation of the EGFR–STAT1 axis increases proliferation of meningioma tumor cells' Neuro-Oncology Advances 2, (1) , DOI Open access
(2019) 'CBMT-06. HIGH LEVELS OF GATA-4 IN MALIGNANT MENINGIOMA LEAD TO LOWER miR-497~195 CLUSTER EXPRESSION IN TISSUE AND BLOOD' Neuro-Oncology 21, (Supplement_6) vi33-vi34 , DOI
(2018) 'Proteomic analysis discovers the differential expression of novel proteins and phosphoproteins in meningioma including NEK9, HK2 and SET and deregulation of RNA metabolism' EBioMedicine , DOI Open access
(2018) 'PO-511 High miR-9 levels represent a novel prognostic biomarker to predict development of malignant meningioma' ESMO Open 3, A430-A430 , DOI Open access
(2017) 'Cellular prion protein (PrPC) in the development of Merlin-deficient tumours' Oncogene , DOI Open access
(2017) 'Global Proteome and Phospho-proteome Analysis of Merlin-deficient Meningioma and Schwannoma Identifies PDLIM2 as a Novel Therapeutic Target' EBioMedicine , DOI Open access
(2015) 'Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus' Gastroenterology 148, (2) 367-378 , DOI Open access
(2013) 'Serum neopterin as an indicator of increased risk of renal allograft rejection' Transplant Immunology 28, 81-85 , DOI
(2008) 'The value of serum neopterin, interferon-gamma levels and interleukin-12B polymorphisms in predicting acute renal allograft rejection' Clinical and Experimental Immunology 152, (2) 239-244 , DOI
(2005) 'Direct quantitation of T cell signaling by laser scanning cytometry' Journal of Immunological Methods 301, (1-2) 140-153 , DOI
(2004) 'Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry' J Immunol , DOI
(2004) 'Tracking lymphocytes in vivo' ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS 52, (3) 173-187
(2003) 'Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation' Immunology 108, (3) 274-287 , DOI Open access
Chapters
(2004) 'Tracking Antigen-Specific Lymphocytes In Vivo' Cell Migration in Inflammation and Immunity 133-146 , DOI
'Tracking Antigen-Specific Lymphocytes In Vivo' Cell Migration in Inflammation and Immunity Humana Press 133-146 , DOI
Conference Papers
(2018) 'High miR-9 levels represent a novel prognostic biomarker to predict development of malignant meningioma' 25th Biennial Congress of the European Association for Cancer Research (EACR25) Amsterdam 6-/-0/20187-/-0/2018Open access
Presentations and posters
'BIOM-56. MIR-497 AND 219 IN BLOOD AID MENINGIOMA CLASSIFICATIONMIR-497 AND 219 IN BLOOD AID MENINGIOMA CLASSIFICATION' , DOI
'Circulating miR-9 levels as a novel prognostic biomarker for highergrade meningioma' Open access
'CSIG-27. PROTEOMIC ANALYSIS OF GENETICALLY STRATIFIED MENINGIOMA' , DOI
'P02.09 Proteomic analysis of meningioma discovers new pathways and their activation including NEK9 and AKT' , DOI
'P12.08 Proteome and phosphoproteome analysis identifies STAT1 as a novel target in different grade meningiomas' , DOI
'PO-162 The transcription factor GATA4 is overexpressed in malignant meningioma enhancing proliferation via downregulation of miR-15 family members' , DOI
'PO-522 Global proteome and phosphoprotein profiling of meningiomas reveals novel potential therapeutic targets and biomarkers' , DOI
'Proteomic analysis of genetically stratified meningioma' , DOI
'The transcription factor GATA4 is overexpressed in malignant meningioma enhancing proliferation via downregulation of miR-15 family members' Open access
'OPTC-1. Proteomic analysis of genetically stratified low-grade meningioma' , DOI
'P09.07 Constitutive activation of the EGFR-STAT1 axis increases proliferation of meningioma tumour cells' , DOI
'OS08.5.A Proteomic analysis of meningioma' , DOI
'Proteomic analysis of genetically stratified low-grade meningioma' , DOI