- A226, 22 Portland Square, Drake Circus, Plymouth, Devon, PL4 8AA
- +44 1752 584901
- chris.harris@plymouth.ac.uk
Profiles
Professor Christopher Harris
Professor of Neuroscience
Qualifications
Qualifications:
1982-1986 Ph.D. Experimental Psychology City University of New York
1981 1986 M.A., Psychology City University of New York
1973-1974 M.Sc., D.I.C., Applied Optics Imperial College, London
1970-1973 B.Sc. (Hons), A.R.C.S. Physics Imperial College, London
Research interests
Clinical
Eye movement disorders - paediatric & adult
Movement disorders- paediatric & adult
Neurometabolic disease
Modelling of pathology
Basic Science
Visual development
Evo-devo
(In)decision-making
Systems modelling
Biological Inspired Robotics
Optimal control
Dimensional reduction
Self-organisation & development
Research groups
- Centre for Research in Brain, Cognition and Behaviour (CBCB)
- Brain
- Computer Science and Informatics
- Theoretical & Computational Neuroscience
Key publications are highlighted
Journals
Articles
2017
'The effect of gaze angle on visual acuity in infantile nystagmus'
Investigative Ophthamoloy and Visual Science
PEARL
2015
'Investigating decision rules with a new experimental design: the EXACT paradigm'
Frontiers in Behavioral Neuroscience
9,
, DOI
PEARL
2015
'A Computational Model of Innate Directional Selectivity Refined by Visual Experience'
Scientific Reports
5,
(1)
, DOI
PEARL
2014
'Surgical interventions for nystagmus developing in the first year of life'
Cochrane Database of Systematic Reviews
2014,
(7)
, DOI
2014
'Grating Visual Acuity in Infantile Nystagmus in the Absence of Image Motion'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
55,
(4)
2682-2686
, DOI
PEARL
2014
'A proto-architecture for innate directionally selective visual maps'
PLoS One
9,
(7)
, DOI
PEARL
2014
'Do muscle synergies reduce the dimensionality of behavior?'
Front Comput Neurosci
8,
, DOI
PEARL
2013
'Stress and Visual Function in Infantile Nystagmus Syndrome'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
54,
(13)
7943-7951
, DOI
PEARL
2013
'Surgical interventions for nystagmus developing in the first year of life'
Cochrane Database of Systematic Reviews
2013,
(3)
, DOI
2013
'The distribution of quick phase interval durations in human optokinetic nystagmus'
Exp Brain Res
224,
(2)
179-187
, DOI
PEARL
2012
'On the convergence of time interval moments: caveat sciscitator'
J Neurosci Methods
205,
(2)
345-356
, DOI
2012
'Infantile Nystagmus Syndrome: What Can fMRI Tell Us?'
JOURNAL OF PEDIATRIC OPHTHALMOLOGY & STRABISMUS
49,
(3)
189-189
2009
'Biomimetics of human movement: functional or aesthetic?'
Bioinspiration & Biomimetics
4,
2008
'A randomized controlled trial of miglustat in Gaucher disease type 3'
Annals of Neurology
64,
(5)
514-522
, DOI
2007
'Allelic variation of the FRMD7 gene in congenital idiopathic nystagmus'
ARCHIVES OF OPHTHALMOLOGY
125,
(9)
1255-1263
, DOI
2007
'Infantile nystagmus adapts to visual demand'
Perception
36,
(2)
315-315
2007
'Infantile nystagmus adapts to visual demand'
Investigative Ophthalmology & Visual Science
48,
(5)
2089-2094
2007
'The importance of correct phenotyping in Gaucher disease'
Journal of Child Neurology
22,
(8)
1056-1057
2006
'A distal model of congenital nystagmus as nonlinear adaptive oscillations'
Nonlinear Dynamics
44,
(1-4)
367-380
2006
'Fine mapping of the X-linked recessive congenital idiopathic nystagmus locus at Xq24-q26.3'
Molecular Vision
12,
(136-38)
1211-1216
2006
'Infant saccades are not slow'
Developmental Medicine and Child Neurology
48,
(8)
662-667
2006
'The main sequence of saccades optimizes speed-accuracy trade-off'
Biological Cybernetics
95,
(1)
21-29
2005
'EYE MOVEMENTS AS 'NEUROMARKERS' IN NEUROMETABOLIC DISEASES'
JOURNAL OF INHERITED METABOLIC DISEASE
28,
149-149
2005
'Saccades are not special: they are the same as finger movements'
SPATIAL VISION
18,
(4)
499-500
2005
'SACCADIC EYE MOVEMENTS IN D409H-N370S GAUCHER HETEROZYGOTES'
JOURNAL OF INHERITED METABOLIC DISEASE
28,
150-150
2004
'Joubert syndrome: long-term follow-up'
Dev Med Child Neurol
46,
(10)
694-699
2004
'Paediatric non-neuronopathic Gaucher disease: recommendations for treatment and monitoring'
EUROPEAN JOURNAL OF PEDIATRICS
163,
(2)
67-75
, DOI
2004
'Pediatric non-neuronopathic Gaucher disease: presentation, diagnosis and assessment. Consensus statements'
EUROPEAN JOURNAL OF PEDIATRICS
163,
(2)
58-66
, DOI
2004
'Bone conduction auditory brainstem responses in infants'
Journal of Laryngology and Otology
118,
(2)
117-122
2004
'Deterioration of the auditory brainstem response in children with type 3 Gaucher disease'
Neurology
63,
(2)
385-387
2004
'Exploring smoothness and discontinuities in human motor behaviour with Fourier analysis'
Mathematical Biosciences
188,
99-116
2004
'Optimal impedance control for task achievement in the presence of signal-dependent noise'
Journal of Neurophysiology
92,
(2)
1199-1215
2003
'Morbus Gaucher. Auditory brainstem response and eye movement in diagnosis of Morbus Gaucher type 3'
Monatsschrift fur Kinderheilkunde
151,
(8)
854-862
, DOI
2003
'A model of neuronopathic Gaucher disease'
Journal of Inherited Metabolic Disease
26,
(7)
629-639
2003
'Familial vestibulocerebellar disorder maps to chromosome 13q31-q33: a new nystagmus locus'
Journal of Medical Genetics
40,
(1)
37-41
2003
'Morbus Gaucher. Auditory brainstern response and eye movement in diagnosis of Morbus Gaucher type 3'
Monatsschrift Kinderheilkunde
151,
(8)
854-862
2003
'Ocular tilt reaction due to a mesencephalic lesion in juvenile polyarteritis nodosa'
American Journal of Ophthalmology
135,
(2)
249-251
2003
'Vertical optokinetic nystagmus and saccades in normal human subjects'
Investigative Ophthalmology & Visual Science
44,
(9)
3833-3841
2002
'Adaptive control of saccades in children with dancing eye syndrome'
Neurobiology of Eye Movements: from Molecules to Behavior
956,
449-452
2002
'Temporal uncertainty in reading the neural code (proportional noise)'
Biosystems
67,
(1-3)
85-94
2002
'Verbal overshadowing in voice recognition'
Applied Cognitive Psychology
16,
(8)
973-980
2001
'Familial vestibulocerebellar disorder maps to chromosome 13q31-q33: a new nystagmus locus'
AMERICAN JOURNAL OF HUMAN GENETICS
69,
(4)
654-654
2001
'Diagnosing children presenting with asymmetric pendular nystagmus'
Dev Med Child Neurol
43,
(9)
622-627
2001
'Audiometric abnormalities in children with Gaucher disease type 3'
Neuropediatrics
32,
(3)
136-141
, DOI
2001
'Comparison of the main sequence of reflexive saccades and the quick phases of optokinetic nystagmus'
British Journal of Ophthalmology
85,
(12)
1477-1483
2001
'Outcome of children presenting with asymmetric pendular nystagmus'
Developmental Medicine and Child Neurology
43,
622-627
2001
'Spontaneous reversal of nystagmus in the dark'
British Journal of Ophthalmology
85,
(4)
428-431
2000
'Chiasmal maldevelopment('achiasmia') indicated by VEP and eye movement studies though not by MRI scanning: A case study'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
41,
(4)
S702-S702
2000
'Spectral characteristics of optokinetic quick phases'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
41,
(4)
S700-S700
2000
'The temporal main sequence optokinetic nystagmus'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
41,
(4)
S701-S701
2000
'A study of EEG, electroretinogram, visual evoked potential, and eye movements in classical lissencephaly'
Dev Med Child Neurol
42,
(1)
48-52
2000
'A study of EEG, electroretinogram, visual evoked potential, and eye movements in classical lissencephaly'
Developmental Medicine & Child Neurology
42,
(1)
48-52
, DOI
2000
'Abnormal supranuclear eye movements in the child - a practical guide to examination and interpretation'
Survey of Ophthalmology
44,
479-506
2000
'Abnormal vertical optokinetic nystagmus in infants and children'
British Journal of Ophalmology
84,
451-455
2000
'Reverse and converse ocular bobbing with synkinetic blinking and opsoclonus in a child with Epstein-Barr virus encephalitis after bone marrow transplant for MPS I'
British Journal of Ophthalmology
84,
1207-1208
2000
'Vertical or asymmetric nystagmus need not imply neurologic disease'
British Journal of Ophthalmology
84,
175-180
1999
'The spectral main sequence of human saccades'
J Neurosci
19,
(20)
9098-9106
1999
'Saccadic strategies in children with hemianopia - Reply'
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
41,
(6)
429-430
, DOI
1999
'Fourier analysis of saccades in chronic sixth nerve palsy with botulinum toxin'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
40,
(4)
S61-S61
1999
'A study of EEG, ERG, VEP and eye movements in isolated lissencephaly'
Developmental Medicine & Child Neurology
42,
48-52
1999
'Ocular motor abnormalities in Gaucher disease'
Neuropediatrics
30,
289-293
1999
'Visual-evoked potential evidence of chiasmal hypoplasia'
Ophthalmology
106,
2354-2361
1998
'Saccadic strategies in children with hemianopia'
Dev Med Child Neurol
40,
(9)
626-630
1998
'Delayed visual maturation: an update'
Dev Med Child Neurol
40,
(2)
130-136
1998
'Familial congenital saccade initiation failure and isolated cerebellar vermis hypoplasia'
Developmental Medicine and Child Neurology
40,
775-779
1998
'On the optimal control of behaviour: a stochastic perspective'
Journal of Neuroscience Methods
83,
73-88
1998
'The Fourier analysis of biological transients'
Journal of Neuroscience Methods
83,
15-34
1997
'Epileptic nystagmus in infancy'
J Neurol Sci
151,
(1)
111-114
1997
'Smooth pursuit development in infants'
Aust N Z J Ophthalmol
25,
(3)
199-206
1997
'Eyemovement abnormalities in a case of Tourette syndrome'
Developmental Medicine & Child Neurology
39,
(4)
270-273
, DOI
1997
'Saccadic eye movement strategies in children with homonymous hemianopia'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
38,
(4)
3050-3050
1997
'Spectral analysis of cross modulation products in 'beat' VEPs to dichoptic two frequency stimulation'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
38,
(4)
4613-4613
1997
'Accelerating slow phases in epileptic nystagmus: implications for congenital nystagmus'
PERCEPTION
26,
(6)
780-780
1997
'Epileptic nystagmus: evidence of cortical oculomotor function from early infancy'
PERCEPTION
26,
(6)
763-764
1997
'Eye movement recording in non-infantile Gaucher disease: a preliminary report'
Gaucher Clinical Perspectives
5,
7-10
1997
'Monocular optokinetic symmetry in early onset esotropia'
PERCEPTION
26,
(6)
789-789
1997
'Paradoxical monocular OKN asymmetry in an achiasmic acallosal child'
PERCEPTION
26,
(6)
782-782
1997
'Saccadic strategies in hemianopic children'
PERCEPTION
26,
(6)
780-780
1997
'Spectral power and time-frequency distributions of beat VEPs'
PERCEPTION
26,
(6)
775-776
1996
'A new remote sensing technique for measuring head position using a scanning laser system'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
37,
(3)
1261-1261
1996
'Eye movements in children with Down's Syndrome'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
37,
(3)
1279-1279
1996
'Monocular optokinetic symmetry'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
37,
(3)
1036-1036
1996
'Intermittent horizontal saccade failure ('ocular motor apraxia') in children'
Br J Ophthalmol
80,
(2)
151-158
1996
'Achiasmia in a case of midline craniofacial cleft with seesaw nystagmus'
British Journal of Ophthalmology
80,
1023-1027
1996
'Delayed visual maturation in infants: A disorder of figure—Ground separation?'
Brain Research Bulletin
40,
(5-6)
365-369
, DOI
1996
'Neural network simulations of the primate oculomotor system .2. Frames of reference - Commentary'
BRAIN RESEARCH BULLETIN
40,
(5-6)
344-344
, DOI
1996
'The role of ERG/VEP and eye movement recordings in children with ocular motor apraxia'
Eye (Lond)
10 ( Pt 1),
53-60
, DOI
1995
'Neuroradiological and eye movement correlates in children with intermittent saccade failure: "ocular motor apraxia"'
Neuropediatrics
26,
(6)
298-305
, DOI
1995
'Electrophysiological and eye-movement abnormalities in children with the Bardet-Biedl syndrome'
J Pediatr Ophthalmol Strabismus
32,
(6)
364-367
1995
'The optokinetic response differences between congenital profound and nonprofound unilateral visual deprivation'
Ophthalmology
102,
(11)
1615-1622
1995
'ISOLATED DELAYED VISUAL MATURATION - AN OCULOMOTOR IMMATURITY'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
36,
(4)
S352-S352
1995
'Does saccadic undershoot minimize saccadic flight-time? A Monte-Carlo study'
Vision Res
35,
(5)
691-701
1994
'OCULOMOTOR AND NEURORADIOLOGICAL CORRELATES IN CONGENITAL SACCADE PALSY (OCULAR MOTOR APRAXIA)'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
35,
(4)
2034-2034
1994
'SACCADES IN 2 CONTRASTING HEMIDECORTICATE CASES - IMPLICATIONS FOR BLINDSIGHT'
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
35,
(4)
1545-1545
1994
'Vertical saccade palsy: a presenting sign of Niemann-Pick type IIS'
European Journal of Neurology
1,
93-95
1993
'Are express saccades anticipatory?'
Behavior & Brain Sciences
16,
593-594
1993
'Eye movement and electrophysiological findings in an infant with hemispheric pathology'
Developmental Medicine & Child Neurology
35,
431-448
1993
'Eye movements in a familial vestibulocerebellar disorder'
Neuropediatrics
24,
117-122
1993
'Eye movements in children with opsoclonus-polymyoclonus'
Neuropediatrics
24,
218-223
1993
'Human ocular motor neural integrator failure'
Neuro-ophthalmology
24,
25-34
1993
'Oculomotor signs in infantile Gaucher disease'
Neuro-Ophthalmology
13,
151-155
1993
'The development of saccadic accuracy in the first 7 months'
Clinical Visual Sciences
8,
85-96
1992
'Aspects of albinism'
Ophthalmic Paediatrics and Genetics
13,
89-100
1992
'Eye movement tics'
British Journal of Ophthalmology
76,
697-699
1992
'Nystagmus in infancy'
British Journal of Ophthalmology
76,
434-437
1992
'The objective assessment of abnormal eye movements in infants and young children'
Australian and New Zealand Journal of Ophthalmology
20,
185-195
1992
'The use of video in assessing and illustrating abnormal eye movements in young children'
Journal of Audiovisual Media in Medicine
15,
113-116
1990
'Fourier analysis of primate saccades'
Journal of Neurophysiology
63,
877-886
1990
'Refixation stability in infants'
Infant Behavior and Development
13,
321-342
1989
'The ethology of saccades: a non cognitive model'
Biological Cybernetics
60,
401-410
1989
'The ethology of saccades: a non-cognitive model'
Biol Cybern
60,
(6)
401-410
1988
'The distribution of fixation durations in infants and naive adults'
Vision Res
28,
(3)
419-432
1988
'The distribution of fixations in infants and naive adults'
Vision Research
28,
419-432
1984
'Artificial eye for assessing corneal reflection eye trackers'
Behavioral Research Methods and Instrumentation,
16,
437-438
1984
'Characteristics of saccades in human infants'
Vision Research
24,
1771-1780
1984
'Instrument considerations in measuring fast eye movements'
Behavioral Research Methods and Instrumentation
16,
341-350
1983
'Linearizing the z axis of an oscilloscope display'
Behavioral Research Methods and Instrumentation
15,
622-622
1981
'A method for calibrating an eye monitoring system for use with infants'
Behavioral Research Methods and Instrumentation
13,
11-17
Reviews
2013
'Latent Nystagmus'
Optometry Today
54,
49-53
2013
'Optokinetic nystagmus'
Optometry Today
53,
71-76
Letters
2014
'Author response: Grating visual acuity in infantile nystagmus in the absence of image motion'
Invest Ophthalmol Vis Sci
55,
(8)
4955-4957
, DOI
PEARL
1997
'Opsoclonus: brainstem or cerebellum?'
Neuroophthalmology
18,
95-96
1993
'Autosomal recessive cerebellar hypoplasia'
Pediatric Neurology
9,
247-247
1992
'Ocular motility anomalies in developmental misdirection of the optic chiasm'
American Journal of Ophthalmology
113,
601-602
Books
Harris CM; Gottlob I; Sanders J
2012
The Challenge of Nystagmus.
Nystagmus Network Press
Chapters
2012
'Infantile nystagmus: an adaptationist approach'
in Harris C; Gottlob I; Sanders J
The Challenge of Nystagmus
27-48
2012
'The impact of stress on visual performance in congenital nystagmus'
in Gottlob I; Harris C; Sanders J
The Challenge of Nystagmus
239-260
2011
'Oculomotor developmental pathology: an evo-devo perpsective'
in Liversedge S; Gilchrist I; Everling S
Oxford Handbook of Eye Movements
Oxford University Press
663-686
2002
'Time-optimality and the spectral overlap of saccadic eye movements'
Neurobiology of Eye Movements: From Molecules to Behavior
Neurobiology of Eye Movements: From Molecules to Behavior
414-417
2000
'Eye Movement Disorders'
in Moore A
Fundamentals of Clinical Ophthalmology: Paediatrics
1997
'Nystagmus and eye movement disorders'
Paediatric Ophthalmology 2nd ed
869-896
1997
'Other eye movement disorders'
in Taylor D
Paediatric Ophthalmology 2nd ed
897-924
1995
'An ERG, VEP and eye movement assessment of children with Bardet-Biedl syndrome'
in Lennerstrand G
Update on Strabismus and Pediatric Ophthalmology
549-552
1995
'Problems in modelling congenital nystagmus: towards a new model'
in Findlay JM; Walker RW; Kentridge RW
Eye Movement Research: Mechanisms, Processes and Applications
Elsevier
239-253
1995
'The development of eye movements in infancy'
in Lennerstrand G
Update on Strabismus and Pediatric Ophthalmology
140-143
1993
'On the reversibility of Markov scanning in free viewing'
in Brogan D; Gale A; Carr K
Vision Search 2
Taylor & Francis
123-135
1990
'Does foveal immaturity influence the infant's consistency of point of regard'
in Groner R; d'Ydewalle G; Parham R
From eye to mind: Information acquisition in perception, search and reading
Elsevier Science
80-90
Conference Papers
2013
'Visual acuity in infantile nystagmus in the absence of image motion'
2013
'Developing Learnability - the Case for Reduced Dimensionality'
2012
'Biomimetics of choice behaviour for autonomous agents'
FIRA-TAROS 2012
Bristol
96-104
2012
'Effect of physical variation on the reduced dimensional control of a mass-spring-damper chain system'
Development and Learning and Epigenetic Robotics (ICDL), 2012 IEEE International Conference
1-2
2009
'DOES FISHER INFORMATION CONSTRAIN HUMAN MOTOR CONTROL?'
414-420
2008
'Biomimetics and proportional noise in motor control'
37-43
2008
'Using optimality to predict photoreceptor distribution in the retina'
408-415
2005
'Boundary conditions in human movement I: Constraining constraints'
629-633
2005
'Boundary conditions in human movement II: The fourier approach'
634-637
2005
'Boundary conditions in human movement III: Fourier analysis of reaching'
638-640
2004
'Relation among duration, position variance, and muscle activity in human arm movement control'
2859-2863
Patents
2007
METHOD AND APPARATUS FOR CONFIGURING A COMMUNICATION CHANNEL.
EP1929674
Other academic activities
Clinical assessment of eye movement disorders.
Honorary Professor of Neuroscience
Royal Eye Infirmary
Plymouth Hospitals NHS Trust