Dr Chloe Milsom
Lecturer in Biomedical Sciences (Education)
Peninsula Medical School (Faculty of Health)
Lecturer in Biomedical Sciences - Genomics & Personalised Medicine
B.Sc. (Hons) Genetics, University of Leeds
Ph.D. Medical Sciences, McMaster University (Ontario, Canada)
Postgraduate Certificate in Clinical Education (Pg Cert Clin Ed), University of Plymouth
I joined PMSD in September 2017. I am very excited to be a member of the teaching team and to be able to share some of my research knowledge.
I have 15 years of experience in cancer research. I obtained a PhD in Medical Sciences from McMaster University (Hamilton, Ontario, Canada) in 2009, where I was also a teaching assistant (PBL facilitator) in the School of Nursing. The focus of my research thesis was the regulation of tumour angiogenesis and tumour growth by oncogenes, the coagulation system and cancer stem cells. My first postdoctoral position was in a preclinical translational laboratory at Sunnybrook Research Institute (Toronto, Ontario, Canada), where I worked on developing effective and less toxic therapies for early and late stage metastatic cancers. My second postdoctoral position was at the Stem Cell and Cancer Stem Cell Research Institute (Hamilton, Ontario), where I was able to contribute to two very interesting research articles published in Cell Reports, before returning to the UK in June 2015.
I have contributed to 30 publications and presented my work at several national and international conferences. I have been the recipient of several competitive federal (Canada), provincial (Ontario) and international research fellowships. In 2010, I was awarded one of the L’Oreal Canada for Women in Science Research Excellence Fellowships with support from the Canadian Commission for UNESCO.
Fellow of the Higher Education Academy
I am interested in how to implement active learning, how to give meaningful feedback and how to develop my teaching practice through reflection.
Kwan V., Meka DP., White SH., Hung CL., Holzapfel NT., Walker S., Murtaza N., Unda BK., Schwanke B., Yuen RK., Habing K., Milsom C., Hope KJ., Truant R., Scherer SW., Calderon de Anda F., Singh KK. (2016) DIXDC1 Phosphorylation and Control of Dendritic Morphology are Impaired by Rare Genetic Variants. Cell Rep. 17(7): 1892-1904.
Lee JH., Mitchell RR., McNicol JD., Shapovalova Z., Laronde S.,Tanasijevic B., Milsom C., Casado F., Fiebig-Comyn A., Collins TJ., Singh KK and Bhatia M. (2015) Single Transcription Factor Conversion of Human Blood Fate to NPCs with CNS and ONS Developmental Capacity. Cell Rep.11(9):1367-76.
Magnus N., Meehan B., Garnier D., Hashemi M., Montermini L., Lee TH., Milsom C., Pawlinski R., Ohlfest J,Anderson M., Mackman N. and Rak J. (2014) The Contribution of Tumour and Host Tissue Factor Expression to Oncogene-Driven Gliomagenesis. Biochem. Biophy. Res. Commun. 454(2): 262-8.
Magnus N., Garnier D., Meehan B., McGraw S, LeeT.H., Caron M., Bourque G., Milsom C., Trasler J., Pawlinski R., Mackman N., Jabado N. and Rak J. (2014) Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations.Proc Natl Acad Sci USA 111(9): 3544-9.
Milsom C., Lee C., Hackl C.,Man S. and Kerbel R.S. (2013) Differential Post-Surgical Metastasis and Survival in SCID, NOD-SCID andNOD-SCID-IL-2R g null Mice with Parental and Subline Variants of Human Breast Cancer: Implications for Host Defense Mechanisms Regulating Metastasis. PLoS ONE 2013; 8(8): e71270.
Garnier D., Magnus N., Lee TH., Bentley V., Meehan B., Milsom C., Montermini L., Kislinger T. and Rak J. (2012) Cancer Cells Induced to Express Mesechymal Phenotype Release Exosome-Like Extracellular Vesicles Carrying Tissue Factor. J Biol Chem. 287(52):43565-72.
Garnier D., Magnus N., D’Asti E., Hashemi M., Meehan B., Milsom C., and Rak J. (2012) Genetic pathways lining hemostasis and cancer. Throm. Res. 129 Suppl 1:S22-9.
Hackl C., Francia G., Milsom C., Man S., Xu P. and KerbelR.S. (2011) Metronomic Oral Topotecan Prolongs Survival and Reduces Liver Metastasis in Orthotopic and Adjuvant Colon Cancer Models. Gut . 62(2): 259-71.
Voloshin T.,Gingis-Veltski S., Bril R., Benayoun L., Munster M., Milsom C., Man S., Kerbel R.S. and Shaked Y. (2011) G-CSF Supplementation with Chemotherapy can Promote Revascularization and Subsequent Tumor Regrowth. Blood.118(12):3426-35.
Garnier D*., MilsomC*., Magnus N., Meehen B., Weitz J., Yu J. and Rak. J. (2010) Role of the tissue factor pathway in the biology of tumour initiating cell. Thromb. Res. 125(S2): S44-50 *Joint first authorship.
Yu J., Xing R., Milsom C. and Rak J. (2010) Modulation of the Oncogene-Dependent Tissue Factor Expression by Kinase Suppressor of Ras 1. Thromb.Res. 126(1): 6-10.
Milsom C., Magnus N., Meehan B., Al-Nadawi K.,Garnier D., and Rak J. (2009) Tissue Factor and Cancer Stem Cells. Is there a Linkage? Arterioscler. Thromb. Vasc. Biol. 29: 2005-2014.
Rak J., Milsom C., Magnus N., and Yu J. (2009) Tissue Factor in Tumour Progression. Best Pract. Res. Clin. Haemotol. 22(1): 71-83.
Milsom C. and Rak J. (2008) Tissue Factor and Cancer. Pathophysiol. Haemost. Thromb . 36(3-4): 160-76.
Milsom C., Yu J., May L., Magnus N., and Rak J. (2008) Diverse Roles of Tissue Factor Expressing Cell Subsets Involved in Tumour Progression. Semin. Thromb. Hemost. 34 (2): 170-81.
Milsom C., Yu J., May L., Magnus N., and Rak J. (2008) Epidermal Growth Factor Receptor-Dependent Upregulation of Tissue Factor is Modified by Epithelial to Mesenchymal Transitions-Implications for Tumour Angiogenesis. Cancer Res. 15; 68(24): 10068-76.
Yu J*.,May L*., Milsom C*., Anderson G.M., Weitz J., Luyendyk J., Broze G.,Mackman N., and Rak J. (2008) Contribution of Host-Derived Tissue Factor to Tumour Growth and Neovascularization. Arterioscler. Thromb. Vasc. Biol. 28(11): 1975-81. *Joint first authorship.
Rak J., Milsom C., and Yu J. (2008) Tissue Factor inCancer. Curr. Opin. Hematol. 15 (5): 522-8.
Rak J., Milsom C., and Yu J. (2008) Vascular Determinants of Cancer Stem Cell Dormancy- Do Age and Coagulation System Play a Role? ActaPathol. Microbiol. Immunol. Scand. 116 (7/8): 660-76.
Yu J*.,May L*., Milsom C*., Anderson G.M., Weitz J., Luyendyk J., Broze G.,Mackman N., and Rak J. (2008) Contribution of Host-Derived Tissue Factor to Tumour Growth and Neovascularization. Arterioscler.Thromb. Vasc. Biol.28(11):1975-81. *Joint first authorship.
Milsom C ., Yu J., May L., Meehan B.,Magnus N., Al-Nedawi K., Luyendyk J., Weitz J., Klement P., Broze G., MackmanN., and Rak J. (2007) The role of tumor-and host-related tissue factor pools in oncogene-driven tumor progression. Thromb.Res. (120) Suppl. 2: S82-S91.
Milsom C ., Anderson G.M., Weitz J., and Rak J. (2007) Elevated Tissue Factor Procoagulant Activity in CD133-Positive Cancer Cells. J. Thromb. Haemost. 5 (12): 2550-2.
Klement H., St. Croix B., MilsomC., May L., Guo Q., Yu J., Klement P., and Rak J. (2007) Atherosclerosis and Vascular Aging as Modifiers of Tumor Progression, Angiogenesis and Responsiveness to Therapy. Am. J.Pathol. 171(4):1342-51.
Rak J., MilsomC., May L., and Yu J. (2007)Oncogene-Directed Therapies as Modulators of Cancer Coagulopathy. Angiogenesis and Tumour-Vascular Interface. Curr. Signal Transduct. Ther. 2(2): 157-163.
Rak J., Milsom C., May L., Klement P., and Yu J. (2006) Tissue Factor in Cancer and Angiogenesis. The Molecular Link between Genetic Tumor Progression. Tumor Neovascularization and Cancer Coagulopathy. Semin. Thromb. Hemost. 32(1):54-70.
Milsom C. and Rak J. (2005) Regulation of Tissue Factor and Angiogenesis Related Genes by Changes in Cell Shape.Biochem.Biophys. Res. Commun. 2; 337(4):1267-75.
Kalas W., Yu J., Milsom C., Rosenfeld J., Benezra R., Bornstein P., Rak J. (2005) Oncogenes and Angiogenesis: Down-Regulation of Thrombospondin-1 in Normal Fibroblasts Exposed to Factors from Cancer Cells Harboring Mutant Ras. Cancer Res. 1; 65(19):8878-86.
Yu J., May L., Lhotak V., Milsom C., Li Y., Shahrzad S.,Shirasawa S., Weitz J., Coomber B., Micelef J., Guha A., Klement P., Mackman N and Rak J. (2005) Oncogenic Events Regulate Tissue Factor Expression. Haematol. Reports 1(19):18-20.
Isles AR., Ma D., Milsom C., Skynner M., Cui W., Clarke J., Kevern EB. and Allen N. (2001) Conditional Ablation of Neurones in Transgenic Mice. Journal of Neurobiology Jun 5;47(3):183-93.