Dr Anthony Uren
Profiles

Dr Anthony Uren

Lecturer in Biomedical Sciences (Blood Science)

School of Biomedical Sciences (Faculty of Health)

Research

Research

Research interests

We use a combination of cancer informatics, comparative genomics and mouse models to identify the mutations that contribute cancer and to dissect the genetic interactions between them.

Publications

Publications

Key publications

Dawes JC & Uren AG (2021) 'Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas' Frontiers in Immunology 12, , DOI Open access
Dawes JC, Webster P, Iadarola B, Garcia-Diaz C, Dore M, Bolt BJ, Dewchand H, Dharmalingam G, McLatchie AP & Kaczor J (2020) 'LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites' Mobile DNA 11, (1) , DOI
Webster P, Dawes JC, Dewchand H, Takacs K, Iadarola B, Bolt BJ, Caceres JJ, Kaczor J, Dharmalingam G & Dore M (2018) 'Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates' Nature Communications 9, (1) , DOI
Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M & Berns A (2009) 'A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites' Nature Protocols 4, (5) 789-798 , DOI
Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E & Cox T (2008) 'Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks' Cell 133, (4) 727-741 , DOI

Key publications are highlighted

Journals
Articles
Van de Pette M, Dimond A, Galvão AM, Millership SJ, To W, Prodani C, McNamara G, Bruno L, Sardini A & Webster Z (2022) 'Epigenetic changes induced by in utero dietary challenge result in phenotypic variability in successive generations of mice' Nature Communications 13, (1) , DOI
Dawes JC & Uren AG (2021) 'Forward and Reverse Genetics of B Cell Malignancies: From Insertional Mutagenesis to CRISPR-Cas' Frontiers in Immunology 12, , DOI Open access
Guerrero A, Guiho R, Herranz N, Uren A, Withers DJ, Martínez-Barbera JP, Tietze LF & Gil J (2020) 'Galactose‐modified duocarmycin prodrugs as senolytics' Aging Cell 19, (4) , DOI
Dawes JC, Webster P, Iadarola B, Garcia-Diaz C, Dore M, Bolt BJ, Dewchand H, Dharmalingam G, McLatchie AP & Kaczor J (2020) 'LUMI-PCR: an Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites' Mobile DNA 11, (1) , DOI
Guerrero A, Herranz N, Sun B, Wagner V, Gallage S, Guiho R, Wolter K, Pombo J, Irvine EE & Innes AJ (2019) 'Cardiac glycosides are broad-spectrum senolytics' Nature Metabolism 1, (11) 1074-1088 , DOI
Webster P, Dawes JC, Dewchand H, Takacs K, Iadarola B, Bolt BJ, Caceres JJ, Kaczor J, Dharmalingam G & Dore M (2019) 'Author Correction: Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates' Nature Communications 10, (1) , DOI
Webster P, Dawes JC, Dewchand H, Takacs K, Iadarola B, Bolt BJ, Caceres JJ, Kaczor J, Dharmalingam G & Dore M (2018) 'Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates' Nature Communications 9, (1) , DOI
Van de Pette M, Abbas A, Feytout A, McNamara G, Bruno L, To WK, Dimond A, Sardini A, Webster Z & McGinty J (2017) 'Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults' Cell Reports 18, (5) 1090-1099 , DOI
Curry E, Green I, Chapman-Rothe N, Shamsaei E, Kandil S, Cherblanc FL, Payne L, Bell E, Ganesh T & Srimongkolpithak N (2015) 'Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells' Clinical Epigenetics 7, (1) , DOI
Westerman BA, Blom M, Tanger E, van der Valk M, Song J-Y, van Santen M, Gadiot J, Cornelissen-Steijger P, Zevenhoven J & Prosser HM (2012) 'GFAP-Cre-Mediated Transgenic Activation of Bmi1 Results in Pituitary Tumors' PLoS ONE 7, (5) e35943-e35943 , DOI
March HN, Rust AG, Wright NA, ten Hoeve J, de Ridder J, Eldridge M, van der Weyden L, Berns A, Gadiot J & Uren A (2011) 'Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis' Nature Genetics 43, (12) 1202-1209 , DOI
Vassiliou GS, Cooper JL, Rad R, Li J, Rice S, Uren A, Rad L, Ellis P, Andrews R & Banerjee R (2011) 'Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice' Nature Genetics 43, (5) 470-475 , DOI
Mattison J, Kool J, Uren AG, de Ridder J, Wessels L, Jonkers J, Bignell GR, Butler A, Rust AG & Brosch M (2010) 'Novel Candidate Cancer Genes Identified by a Large-Scale Cross-Species Comparative Oncogenomics Approach' Cancer Research 70, (3) 883-895 , DOI
Kool J, Uren AG, Martins CP, Sie D, de Ridder J, Turner G, van Uitert M, Matentzoglu K, Lagcher W & Krimpenfort P (2010) 'Insertional Mutagenesis in Mice Deficient for <i>p15<sup>Ink4b</sup>, p16<sup>Ink4a</sup>, p21<sup>Cip1</sup></i>, and <i>p27<sup>Kip1</sup></i> Reveals Cancer Gene Interactions and Correlations with Tumor Phenotypes' Cancer Research 70, (2) 520-531 , DOI
Uren AG, Mikkers H, Kool J, van der Weyden L, Lund AH, Wilson CH, Rance R, Jonkers J, van Lohuizen M & Berns A (2009) 'A high-throughput splinkerette-PCR method for the isolation and sequencing of retroviral insertion sites' Nature Protocols 4, (5) 789-798 , DOI
Uren A & Berns A (2009) 'Jump-starting cancer gene discovery' Nature Biotechnology 27, (3) 251-252 , DOI
Csikós T, Reijmers RM, Uren AG, Spaargaren M & Pals ST (2008) 'Instant conditional transgenesis in the mouse hematopoietic compartment' Journal of Immunological Methods 339, (2) 259-263 , DOI
Uren AG, Kool J, Matentzoglu K, de Ridder J, Mattison J, van Uitert M, Lagcher W, Sie D, Tanger E & Cox T (2008) 'Large-Scale Mutagenesis in p19ARF- and p53-Deficient Mice Identifies Cancer Genes and Their Collaborative Networks' Cell 133, (4) 727-741 , DOI
de Ridder J, Kool J, Uren A, Bot J, Wessels L & Reinders M (2007) 'Co-occurrence analysis of insertional mutagenesis data reveals cooperating oncogenes' Bioinformatics 23, (13) i133-i141 , DOI
de Ridder J, Uren A, Kool J, Reinders M & Wessels L (2006) 'Detecting Statistically Significant Common Insertion Sites in Retroviral Insertional Mutagenesis Screens' PLoS Computational Biology 2, (12) e166-e166 , DOI
Uren AG, Kool J, Berns A & van Lohuizen M (2005) 'Retroviral insertional mutagenesis: past, present and future' Oncogene 24, (52) 7656-7672 , DOI
Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL & Choo KHA (2000) 'Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype' Current Biology 10, (21) 1319-1328 , DOI
Uren AG, O'Rourke K, Aravind L, Pisabarro MT, Seshagiri S, Koonin EV & Dixit VM (2000) 'Identification of Paracaspases and Metacaspases' Molecular Cell 6, (4) 961-967 , DOI
Uren A (2000) 'Identification of Paracaspases and Metacaspases Two Ancient Families of Caspase-like Proteins, One of which Plays a Key Role in MALT Lymphoma' Molecular Cell 6, (4) 961-967 , DOI
Speliotes EK, Uren A, Vaux D & Horvitz HR (2000) 'The Survivin-like C. elegans BIR-1 Protein Acts with the Aurora-like Kinase AIR-2 to Affect Chromosomes and the Spindle Midzone' Molecular Cell 6, (2) 211-223 , DOI
Uren AG, Beilharz T, O’Connell MJ, Bugg SJ, van Driel R, Vaux DL & Lithgow T (1999) 'Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division' Proceedings of the National Academy of Sciences 96, (18) 10170-10175 , DOI
Hawkins CJ, Ekert PG, Uren AG, Holmgreen SP & Vaux DL (1998) 'Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells' Cell Death &amp; Differentiation 5, (7) 569-576 , DOI
Uren AG, Coulson EJ & Vaux DL (1998) 'Conservation of baculovirus inhibitor of apoptosis repeat proteins (BIRPs) in viruses, nematodes, vertebrates and yeasts' Trends in Biochemical Sciences 23, (5) 159-162 , DOI
Hawkins CJ, Uren AG, Häcker G, Medcalf RL & Vaux DL (1996) 'Inhibition of interleukin 1β-converting enzyme-mediated apoptosis of mammalian cells by baculovirus IAP' Proceedings of the National Academy of Sciences 93, (24) 13786-13790 , DOI
Nicholson GA (1996) 'Motor neurone disease and the life of motor neurones' Medical Journal of Australia 165, (4) 180-181 , DOI
UREN A (1996) 'TRAF proteins and meprins share a conserved domain' Trends in Biochemical Sciences 21, (7) 244-245 , DOI
Uren AG, Pakusch M, Hawkins CJ, Puls KL & Vaux DL (1996) 'Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors' Proceedings of the National Academy of Sciences 93, (10) 4974-4978 , DOI
Uren AG & Vaux DL (1996) 'Molecular and clinical aspects of apoptosis' Pharmacology &amp; Therapeutics 72, (1) 37-50 , DOI
Chapters
Uren AG & Vaux DL (1997) 'Viral Inhibitors of Apoptosis' Vitamins &amp; Hormones Elsevier 175-193 , DOI
Conference Papers
Vassiliou G, Cooper J, Rad R, Rice S, Arends M, Wright P, Rad L, Banerjee R, Yusa K & Ellis P (2010) 'A CONDITIONAL KNOCK-IN ALLELE OF THE TYPE A CYTOPLASMIC NUCLEOPHOSMIN MUTATION COOPERATES WITH A NOVEL SLEEPING BEAUTY TRANSPOSON TO CAUSE ACUTE MYELOID LEUKAEMIA IN MICE' 240-241
Berns A, Uren A, Kool J, De Ridder J, Mattison J, Jonkers J, Wessels L, Adams D & Van Lohuizen M (2009) '336 Identification of cancer genes and their collaborative networks by large-scale mutagenesis in tumour prone mice' Elsevier BV 81-81 , DOI