Dr Ann Rigby-Jones
Profiles

Dr Ann Rigby-Jones

Lecturer in Pharmacology (Education)

Peninsula Medical School (Faculty of Health)

Biography

Biography

Lecturer in Pharmacology

Qualifications

  • Postgraduate Certification in Academic Practice (PgCAP) 2013 University of Plymouth 
  • PhD in Medical Studies for a thesis entitled: The Pharmacokinetics and Pharmacodynamics of Propofol in the Critically Ill Child 

    Peninsula Medical School, Universities of Exeter & Plymouth, 2005

  • BSc (Combined Honours) Cell Biology & Immunology with Chemistry. University of Plymouth, 1997



Professional membership

  • Member of the Royal Society of Chemistry (MRSC)
  • Senior Fellow of the Higher Education Academy (SFHEA)
  • Member of the UK Society for Intravenous Anaesthesia (UK SIVA)

Roles on external bodies

Chair of the Professionalism Workstream of the PA Schools Council 

Teaching

Teaching

Teaching interests

My current roles include:

  • Curriculum Lead for Pharmacology & Therapeutics for our MSc Physician Associate Studies programme
  • Module Lead for Personal and Professional Development (MSc Physician Associate Studies)
  • Module Lead for BMBS Student Selected Component 1 (SSC1) 
  • Academic Lead for Intercalation (BMBS)
  • Chair of the Medical School Teaching, Learning and Quality Committee
  • Enquiry Based Learning Facilitator for Year 1 BMBS students
  • Life Science Resource Centre facilitator for Year 2 BMBS students
  • Developing and delivering plenaries for the BMBS and MSc Physician Associate programmes
  • Special Study Unit (SSU) facilitator
    • SSU 1-3 Year 1 BMS students
    • Doctors as Educations - A Year 2 longitudinal SSU in which BMBS students are given the task of developing their own teaching and learning resource, reflecting on their own experiences of teaching and learning and deepening their understanding of pedagogy.
  • I contributing to question writing and exam paper review for the Applied Medical Knowledge module (BMBS) and Foundations of Clinical Medicine module (MSc Physician Associate Studies).

Research

Research

Research interests

Current Research Interests
Population pharmacokinetics & pharmacodynamics, novel drug compounds, anaesthetic drug use in patients at the extremes of weight (paediatric critical care, bariatric surgery patients), health hazards related to use of medical plastics and dental composites (toxicokinetics)

DOCTORAL & POST-DOCTORAL RESEARCH EXPERIENCE

2000-2004 The Pharmacokinetics (PK) and Pharmacodynamics (PD) of Propofol in the Critically Ill Child, a collaboration with Professor Wolf, University of Bristol. I developed a novel solid phase extraction procedure for propofol quantification from 0.1mL whole blood. Three studies were conducted; an initial population PK study in 21 critically ill neonates, infants and children, a follow-up population PK-PD study in 10 infants and children and finally, a population analysis of pooled data (our own PK data plus data provided by 6 international research groups). These studies greatly extended the knowledge of paediatric propofol PK and PD, particularly for the smallest patients.

2003-2006 Pharmacokinetic and Pharmacodynamic Studies of Remifentanil in Paediatric Intensive Care, a collaboration with Professor Wolf, University of Bristol. I developed a novel high performance liquid chromatography assay allowing simultaneously quantification of remifentanil, fentanyl and midazolam from 0.9mL of whole blood. ‘Sparse sampling’ combined with NONMEM population modelling allowed optimal information yield from a restricted total blood sample volume whilst maximising model predictive performance. This study has provided the first description of paediatric remifentanil pharmacokinetics following infusion and has produced a model of drug disposition that can be applied to post-cardiac surgery children aged from 1 month to 9 years of age.

2005-2006 Ketamine Pharmacokinetics in Healthy Volunteers, a collaboration with Dr Absalom, University of Cambridge. I developed a new population based pharmacokinetic model for ketamine in healthy volunteers from pooled data. Retrospective evaluation shows that the predictive accuracy of our new model improves on previous inadequate models (based on suboptimal sampling schemes and non-physiological assumptions). Our new model will shortly undergo prospective evaluation prior to clinical deployment.

Industry-funded Pharmacokinetic-Pharmacodynamic Modelling Projects

2007-2008
I worked with Labopharm, Canada, assisting with the pre-clinical development of a new formulation of propofol.

2008-2012
In collaboration with the pharmaceutical industry (Maruishi, Japan) and with Veeda Clinical Research centre (Plymouth), I provided pharmacokinetic-pharmacodynamic analysis of data from Phase 1 clinical trials of a new sedative-hypnotic drug (MR04A3) and comparator compounds.

Research degrees awarded to supervised students

I am Director of Studies for a postgraduate research student, Mrs Anfal Alwadi. Anfal is investigating dental composites as a potential source of human exposure to bisphenol A and plasticiser phthalates.

Publications

Publications

Key publications

Key publications are highlighted

Journals
Articles
Sneyd J, Gambus P & Rigby-Jones A (2021) 'The current status of perioperative hypnotics, the role of benzodiazepines and the case for remimazolam' British Journal of Anaesthesia , DOI Open access
Absalom AR, Rigby-Jones A, Rushton AR & Sneyd J (2020) 'De-mystifying the ‘Mixifusor’' Paediatric Anaesthesia 30, (12) 1292-1298 , DOI Open access
Sneyd J & Rigby-Jones A (2020) 'Remimazolam; a role for anaesthesia/ sedation?' Current Opinion in Anaesthesiology , DOI Open access
Rose RJ, Priston MJ, Rigby-Jones AE & Sneyd JR (2012) 'The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions' Anaesthesia 67, (5) 514-520 Author Site , DOI
Sneyd JR, Rigby-Jones AE, Cross M, Tominaga H, Shimizu S, Ohkura T & Grimsehl K (2012) 'First human administration of MR04A3: a novel water-soluble nonbenzodiazepine sedative' Anesthesiology 116, (2) 385-395 Author Site , DOI Open access
Rigby-Jones AE & Sneyd JR (2012) 'Pharmacokinetics and pharmacodynamics--is there anything new?' Anaesthesia 67, (1) 5-11 Author Site , DOI
Rigby-Jones AE & Sneyd JR (2011) 'Propofol and children--what we know and what we do not know' Paediatr Anaesth 21, (3) 247-254 Author Site , DOI Open access
Sneyd JR & Rigby-Jones AE (2010) 'New drugs and technologies, intravenous anaesthesia is on the move (again)' Br J Anaesth 105, (3) 246-254 Author Site , DOI Open access
Rigby-Jones AE, Sneyd JR, Vijn P, Boen P & Cross M (2010) 'First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial' BMC Anesthesiol 10, Author Site , DOI Open access
Rose RJ, Priston MJ, Rigby-Jones AE & Sneyd JR (2009) 'Effect of temperature on plasticizer release [di(2-ethylhexyl)phthalate] from TIVA infusion sets' BRITISH JOURNAL OF ANAESTHESIA 102, (4) 581-582 Author Site
Rigby-Jones AE, Sneyd JR, Ravenelle F, Vachon P, Le Garrec D, Gori S, Lessard D & Smith DC (2008) 'Pharmacokinetics and anaesthetic effects of propofol-PM: a novel water soluble propofol formulation' ANAESTHESIA 63, (12) 1392-1393 Author Site , DOI
Ravenelle F, Vachon P, Rigby-Jones AE, Sneyd JR, Le Garrec D, Gori S, Lessard D & Smith DC (2008) 'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation' Br J Anaesth 101, (2) 186-193 Author Site , DOI
Priston MJ, Hughes J, Rigby-Jones AE & Sneyd JR (2007) 'Plasticizer release (DEHP) from TIVA infusion sets' BRITISH JOURNAL OF ANAESTHESIA 99, (5) 765P-765P Author Site
Sneyd JR & Rigby-Jones AE (2007) 'Effect site: who needs it?' Br J Anaesth 98, (6) 701-704 Author Site , DOI
Rigby-Jones AE, Priston MJ, Sneyd JR, McCabe AP, Davis GI, Tooley MA, Thorne GC & Wolf AR (2007) 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' Br J Anaesth 99, (2) 252-261 Author Site , DOI
Sneyd JR & Rigby-Jones AE (2007) 'Effect site: who needs it?' British Journal of Anaesthesia 98, (6) 701-704
Priston MJ, Hughes J, Rigby-Jones AE & Sneyd JR (2007) 'Plasticizer release (DEHP) from TIVA infusion sets' British Journal of Anaesthesia 99, (5) 765P-765P
Rigby-Jones AE, Priston MJ, Sneyd JR, Mccabe AP, Davis GI, Tooley MA, Thorne GC & Wolf AR (2007) 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' British Journal of Anaesthesia 99, (2) 252-261
Rigby-Jones AE, Priston MJ, Thorne GC, Tooley MA, Sneyd JR & Wolf AR (2005) 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' BRITISH JOURNAL OF ANAESTHESIA 95, (4) 578P-579P Author Site
Rigby-Jones AE, Priston MJ, Thorne GC, Tooley MA, Sneyd JR & Wolf AR (2005) 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' British Journal of Anaesthesia 95, (4) 578P-579P
Murray DM, Thorne GC, Rigby-Jones AE, Tonucci D, Grimes S, Tooley MA & Wolf AR (2004) 'Electroencephalograph variables, drug concentrations and sedation scores in children emerging from propofol infusion anaesthesia' Paediatric Anaesthesia 14, (2) 143-151 , DOI
Murray DM, Thorne GC, Rigby-Jones AE, Tonucci D, Grimes S, Tooley MA & Wolf AR (2004) 'Electroencephalograph variables, drug concentrations and sedation scores in children emerging from propofol infusion anaesthesia' Paediatric Anaesthesia 14, (2) 143-151
Sewell GJ, Rigby-Jones AE & Priston MJ (2003) 'Stability of intravesical epirubicin infusion: a sequential temperature study' J Clin Pharm Ther 28, (5) 349-353 Author Site , DOI Open access
Rigby-Jones AE, Nolan JA, Priston MJ, Wright PMC, Sneyd JR & Wolf AR (2002) 'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit' Anesthesiology 97, (6) 1393-1400 Author Site , DOI
Murray DM, Rigby-Jones AE, Tonucci D, Grimes SB, Thorne GC, Tooley MA & Wolf AR (2002) 'Propofol blood levels, clinical sedation scores and electrophysiological variables in children emerging from propofol infusion anaesthesia' BRITISH JOURNAL OF ANAESTHESIA 88, (2) 318P-318P Author Site
Murray DM, Rigby-Jones AE, Tonucci D, Grimes SB, Thorne GC, Tooley MA & Wolf AR (2002) 'Propofol blood levels, clinical sedation scores and electrophysiological variables in children emerging from propofol infusion anaesthesia' British Journal of Anaesthesia 88, (2) 318P-318P
Rigby-Jones AE, Nolan JA, Priston MJ, Wright PMC, Sneyd JR & Wolf AR (2002) 'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit' Anesthesiology 97, (6) 1393-1400
Letters
Rigby-Jones A & Sneyd JR (2008) 'Cardiovascular changes after achieving constant effect site concentration of propofol' Anaesthesia 63, (7) Author Site , DOI
Personal

Personal

Other academic activities

I regularly provide reviews for the journals; British Journal of Anaesthesia, Anaesthesia and Anesthesiology. I am a member of the population pharmacokinetic-pharmacodynamic review team for the journal, Pediatric Anesthesia.