Dr Ann Rigby-Jones
Profiles

Dr Ann Rigby-Jones

Lecturer in Pharmacology

Peninsula Medical School (Plymouth University Peninsula Schools of Medicine and Dentistry)

Role

Lecturer in Pharmacology

Qualifications

PhD in Medical Studies for a thesis entitled:
The Pharmacokinetics and Pharmacodynamics of Propofol in the Critically Ill Child
Peninsula Medical School, Universities of Exeter & Plymouth, 2005

BSc (Combined Honours) Cell Biology & Immunology with Chemistry
University of Plymouth, 1997

Professional membership

  • Member of the Royal Society of Chemistry (MRSC)
  • Fellow of the Higher Education Academy (FHEA)
  • Member of the UK Society for Intravenous Anaesthesia (UK SIVA)

Teaching interests

My current roles include:

  • Lead for Pharmacology for our PGDip Physician Associate programme
  • Problem Based Learning Facilitator for Year 1 BMBS students
  • Life Science Resource Centre facilitator for Year 2 BMBS students
  • Developing and delivering plenaries for the BMBS programme
  • Consolidation Week facilitator (Year 1 & Year 2 BMBS students)
  • Special Study Unit (SSU) facilitator
    • SSU 1 - The formative, introductory SSU completed by Year 1 BMS students
    • Working Together for Patients - A Year 3 SSU where BMBS students spend some time working with Professions Allied to Medicine to deepen their understanding of the work of multidisciplinary teams.
    • I am lead for the Research in Action SSU - A Year 3/4 longitudinal SSU where BMBS students spend time in a research environment, experiencing and developing skills for writing proposals, funding grant applications and displaying their work in a poster format.
    • Doctors as Teachers - A Year 3/4 longitudinal SSU in which BMBS students are given the task of developing their own teaching and learning resource, reflecting on their own experiences of teaching and learning and deepening their understanding of pedagogy.
  • Contributing to question writing and exam paper review for the Applied Medical Knowledge module.
  • Curriculum development for our postgraduate Physician Associate programme.

Research interests

Current Research Interests
Population pharmacokinetics & pharmacodynamics, novel drug compounds, anaesthetic drug use in patients at the extremes of weight (paediatric critical care, bariatric surgery patients),  health hazards related to use of medical plastics and dental composites (toxicokinetics)

DOCTORAL & POST-DOCTORAL RESEARCH EXPERIENCE

2000-2004 The Pharmacokinetics (PK) and Pharmacodynamics (PD) of Propofol in the Critically Ill Child, a collaboration with Professor Wolf, University of Bristol. I developed a novel solid phase extraction procedure for propofol quantification from 0.1mL whole blood. Three studies were conducted; an initial population PK study in 21 critically ill neonates, infants and children, a follow-up population PK-PD study in 10 infants and children and finally, a population analysis of pooled data (our own PK data plus data provided by 6 international research groups). These studies greatly extended the knowledge of paediatric propofol PK and PD, particularly for the smallest patients.

2003-2006 Pharmacokinetic and Pharmacodynamic Studies of Remifentanil in Paediatric Intensive Care, a collaboration with Professor Wolf, University of Bristol. I developed a novel high performance liquid chromatography assay allowing simultaneously quantification of remifentanil, fentanyl and midazolam from 0.9mL of whole blood. ‘Sparse sampling’ combined with NONMEM population modelling allowed optimal information yield from a restricted total blood sample volume whilst maximising model predictive performance. This study has provided the first description of paediatric remifentanil pharmacokinetics following infusion and has produced a model of drug disposition that can be applied to post-cardiac surgery children aged from 1 month to 9 years of age.

2005-2006 Ketamine Pharmacokinetics in Healthy Volunteers, a collaboration with Dr Absalom, University of Cambridge. I developed a new population based pharmacokinetic model for ketamine in healthy volunteers from pooled data. Retrospective evaluation shows that the predictive accuracy of our new model improves on previous inadequate models (based on suboptimal sampling schemes and non-physiological assumptions). Our new model will shortly undergo prospective evaluation prior to clinical deployment.

Industry-funded Pharmacokinetic-Pharmacodynamic Modelling Projects

2007-2008
I worked with Labopharm, Canada, assisting with the pre-clinical development of a new formulation of propofol.

2008-2012
In collaboration with the pharmaceutical industry (Maruishi, Japan) and with Veeda Clinical Research centre (Plymouth), I provided pharmacokinetic-pharmacodynamic analysis of data from Phase 1 clinical trials of a new sedative-hypnotic drug (MR04A3) and comparator compounds.

Research degrees awarded to supervised students

I currently co-supervise one Mphil/PhD student, Mr Stephen Wileman.  Steve is looking at dental composites as a potential source of human exposure to bisphenol A and plasticiser phthalates.

Studies conducted as part of Steve's work will measure plasticiser concentrations in saliva and urine before and after sealant placement in child dental patients.  Other sources of plasticiser exposure will be estimated from data gathered via a questionnaire. Baseline plasticiser concentrations in a group of adult volunteers will also be measured and correlations sought across different biological matrices in the same volunteer.  The expression of specific genes associated with endocrine pathways will be measured and correlations with plasticiser concentration evaluated, as others have recently demonstrated.  Full ethical approval for two clinical trials has now been granted and participant recruitment is under way (as of Jan 2012) and sample collection will begin shortly.

Key publications are highlighted

Journals
Articles
Sneyd JR, Rigby-Jones AE, Cross M, Tominaga H, Shimizu S, Ohkura T & Grimsehl K 2012 'First human administration of MR04A3: a novel water-soluble nonbenzodiazepine sedative' Anesthesiology 116, (2) 385-395 Author Site , DOI PEARL
Rigby-Jones AE & Sneyd JR 2012 'Pharmacokinetics and pharmacodynamics--is there anything new?' Anaesthesia 67, (1) 5-11 Author Site , DOI
Rose RJ, Priston MJ, Rigby-Jones AE & Sneyd JR 2012 'The effect of temperature on di(2-ethylhexyl) phthalate leaching from PVC infusion sets exposed to lipid emulsions' Anaesthesia 67, (5) 514-520 Author Site , DOI
Rigby-Jones AE & Sneyd JR 2011 'Propofol and children--what we know and what we do not know' Paediatr Anaesth 21, (3) 247-254 Author Site , DOI PEARL
Rigby-Jones AE, Sneyd JR, Vijn P, Boen P & Cross M 2010 'First administration to man of Org 25435, an intravenous anaesthetic: A Phase 1 Clinical Trial' BMC Anesthesiol 10, Author Site , DOI PEARL
Sneyd JR & Rigby-Jones AE 2010 'New drugs and technologies, intravenous anaesthesia is on the move (again)' Br J Anaesth 105, (3) 246-254 Author Site , DOI PEARL
Ravenelle F, Vachon P, Rigby-Jones AE, Sneyd JR, Le Garrec D, Gori S, Lessard D & Smith DC 2008 'Anaesthetic effects of propofol polymeric micelle: a novel water soluble propofol formulation' Br J Anaesth 101, (2) 186-193 Author Site , DOI
Rigby-Jones A & Sneyd JR 2008 'Cardiovascular changes after achieving constant effect site concentration of propofol' Anaesthesia 63, (7) Author Site , DOI
Sneyd JR & Rigby-Jones AE 2007 'Effect site: who needs it?' Br J Anaesth 98, (6) 701-704 Author Site , DOI
Sneyd JR & Rigby-Jones AE 2007 'Effect site: who needs it?' British Journal of Anaesthesia 98, (6) 701-704
Priston MJ, Hughes J, Rigby-Jones AE & Sneyd JR 2007 'Plasticizer release (DEHP) from TIVA infusion sets' British Journal of Anaesthesia 99, (5) 765P-765P
Rigby-Jones AE, Priston MJ, Sneyd JR, McCabe AP, Davis GI, Tooley MA, Thorne GC & Wolf AR 2007 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' Br J Anaesth 99, (2) 252-261 Author Site , DOI
Rigby-Jones AE, Priston MJ, Sneyd JR, Mccabe AP, Davis GI, Tooley MA, Thorne GC & Wolf AR 2007 'Remifentanil-midazolam sedation for paediatric patients receiving mechanical ventilation after cardiac surgery' British Journal of Anaesthesia 99, (2) 252-261
Rigby-Jones AE, Priston MJ, Thorne GC, Tooley MA, Sneyd JR & Wolf AR 2005 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' British Journal of Anaesthesia 95, (4) 578P-579P
Murray DM, Thorne GC, Rigby-Jones AE, Tonucci D, Grimes S, Tooley MA & Wolf AR 2004 'Electroencephalograph variables, drug concentrations and sedation scores in children emerging from propofol infusion anaesthesia' Pediatric Anesthesia 14, (2) 143-151 , DOI
Murray DM, Thorne GC, Rigby-Jones AE, Tonucci D, Grimes S, Tooley MA & Wolf AR 2004 'Electroencephalograph variables, drug concentrations and sedation scores in children emerging from propofol infusion anaesthesia' Paediatric Anaesthesia 14, (2) 143-151
Sewell GJ, Rigby-Jones AE & Priston MJ 2003 'Stability of intravesical epirubicin infusion: a sequential temperature study' J Clin Pharm Ther 28, (5) 349-353 Author Site PEARL
Rigby-Jones AE, Nolan JA, Priston MJ, Wright PMC, Sneyd JR & Wolf AR 2002 'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit' Anesthesiology 97, (6) 1393-1400 Author Site
Rigby-Jones AE, Nolan JA, Priston MJ, Wright PMC, Sneyd JR & Wolf AR 2002 'Pharmacokinetics of propofol infusions in critically ill neonates, infants, and children in an intensive care unit' Anesthesiology 97, (6) 1393-1400
Murray DM, Rigby-Jones AE, Tonucci D, Grimes SB, Thorne GC, Tooley MA & Wolf AR 2002 'Propofol blood levels, clinical sedation scores and electrophysiological variables in children emerging from propofol infusion anaesthesia' BRITISH JOURNAL OF ANAESTHESIA 88, (2) 318P-318P Author Site
Murray DM, Rigby-Jones AE, Tonucci D, Grimes SB, Thorne GC, Tooley MA & Wolf AR 2002 'Propofol blood levels, clinical sedation scores and electrophysiological variables in children emerging from propofol infusion anaesthesia' British Journal of Anaesthesia 88, (2) 318P-318P
Conference Papers
Rose RJ, Priston MJ, Rigby-Jones AE & Sneyd JR 2009 'Effect of temperature on plasticizer release [di(2-ethylhexyl)phthalate] from TIVA infusion sets' //0 //0 581-582
Rigby-Jones AE, Sneyd JR, Ravenelle F, Vachon P, Le Garrec D, Gori S, Lessard D & Smith DC 2008 'Pharmacokinetics and anaesthetic effects of propofol-PM: a novel water soluble propofol formulation' //0 //0 1392-1393 , DOI
Priston MJ, Hughes J, Rigby-Jones AE & Sneyd JR 2007 'Plasticizer release (DEHP) from TIVA infusion sets' //0 //0 765P-765P
Rigby-Jones AE, Priston MJ, Thorne GC, Tooley MA, Sneyd JR & Wolf AR 2005 'Population pharmacokinetics of remifentanil in critically ill post cardiac neonates, infants and children' //0 //0 578P-579P

Other academic activities

I regularly provide reviews for the journals; British Journal of Anaesthesia, Anaesthesia and Anesthesiology.  I am a member of the population pharmacokinetic-pharmacodynamic review team for the journal, Pediatric Anesthesia.