Dr Andrew Foey
Profiles

Dr Andrew Foey

Associate Professor of Immunology

School of Biomedical Sciences (Faculty of Health)

Andrew can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Immunology
  • Inflammation
  • Mucosal immunity
  • Rheumatoid arthritis
  • Crohn's disease
  • Chronic periodontitis
  • Macrophage cells
  • Probiotics-immunomodulation
Biography

Biography

Present:

Programme Lead, BSc (Hons) Human Biosciences (2016-date)
School Post-Graduate Research Coordinator (2020-date)
School Programme Committee Chair (2019-date)
School Teaching & Learning Committee member (2014-date)
Pathway lead: Infection & Immunity (2010-date)
Faculty Academic Offences Committee member (2020-date)

Past:
School of Biomedical & Biological Sciences Safety Officer (2009-2016)
Member of Biomedical Research Governance Sub-committee (CRTB, SoBHCS, PUPSMD) (2013-2016)
School Admissions Tutor (2014-2016 - 3 recruitment cycles)

Qualifications

2018   Senior Fellow of the Higher Education Academy (SFHEA PR144988 - 03/05/18)
2007    Fellow of the Higher Education Academy (FHEA No.32432).
2006    PG Cert. Learning & Teaching in Higher Education.    University of Plymouth.
1996    PhD    "Modulation of pro-inflammatory cytokine expression by intracellular cations." University of Bath.
1989    B.Sc. (Hons.) Applied Biological Sciences. Bristol Polytechnic.
1986    HND Applied Biology. Bristol Polytechnic.

 

Expertise

Cytokine Immunopathology in inflammatory conditions, monocyte /macrophage biology, probiotics as immunomodulators, cell-to-cell interactions, cell signalling, apoptosis and cell cytometry.

 

Previous appointments

Lecturer in Immunology, School of Biological & Biomedical Sciences, University of Plymouth, Plymouth, UK. Sept. 2005 - July 2017.

MRC Career Development Fellowship in Nutritional Immunology, MRC Human Nutrition Research Unit, Cambridge, UK. May 2004 – July 2005.

Senior Research Fellow, Kennedy Institute of Rheumatology, Imperial College, London, UK. July 1996 – December 2003.

Post Doctoral Research Scientist, Bath Institute for Rheumatic Diseases, Bath, UK. October 1995 – June 1996.

Research Assistant and SERC CASE PhD Studentship, Bath Institute for Rheumatic Diseases, Bath, UK. January 1992 – September 1995.

Research Scientist Industrial Placement, Boots Pharmaceuticals, Nottingham, UK. July 1994 – December 1994.

Research Assistant, MRC Tuberculosis and Related Infections Unit, RPMS Hammersmith Hospital, London, UK. September 1989 – December 1991.

Research Assistant, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK. June 1991 – December 1991.

Research Assistant, CDE Porton Down, Salisbury, UK. July 1987 – September 1988.

 

Professional membership

British Society for Immunology

Teaching

Teaching

Teaching interests

Teaching Prizes:

Inaugural Immunology Teaching Excellence Award 2017, British Society for Immunology.

Module leader:
BHCS1006: Infection & Immunity
BHCS2008: Methods in Infection & Immunity
BHCS2019: Methods in Human Biosciences
DIET210/BIOL2420: Nutritional Immunology & Biomedicine
BHCS3006: Cellular Basis of Immunity
BHCS5008: Infection & Immunity         

Also teach on modules:
BHCS1001: Biomedical Investigation & Experimentation
BHCS1002: Human Anatomy & Physiology - Cells to Systems
BHCS1004: Introduction to Human Pathology
BHCS1005: Human Disease
BHCS2001: Biology of Disease
BHCS2002: Evidence-Based Practice in Biomedical Science
BHCS2004: Cell Biology in Health & Disease
BHCS2006: Infection, Immunity & Disease
BHCS2007: Diagnostic & Clinical Biomedicine
BIOM2010: Infection Sciences in Health & Disease
BHCS2018: Systems Physiology: Function & Dysfunction
BHCS2022: Nutritional Science 1
BHCS2025: Nutritional Science 2    
BIOL210: Molecular & Genetic Basis of Disease
BHCS3005: Transplantation & Transfusion Science
BHCS3008: Current Developments in Biomedical Science
BHCS3010: Haematology & Transfusion Medicine
BHCS3011: Clinical Immunology & Biochemical Screening
BIO5131: Postgraduate Research Skills & Methods
BIOM5002: Contemporary Applications of Cell Biology
BIOM5005: Project Design & Development
BIOM5009: Haematology & Transfusion      

Honours & masters degree Research Project Supervision:
BHCS3001: Personal Research Project
BIOM5006: Masters Research Project 

Modules no longer taught:
BIOL1404: Human Life Cycles
BIOL2416: Methods in Biomedical Science

SSU provision for PCMD Medical students:
BS020: The immune system: it really is a case of "we are what we eat."
BS013: Cellular & molecular mechanisms underlying inflammatory immunopathologies. 

Mucosal Immunology Master Class:
Organisation of workshop and delivery of lectures for Immunology grounding of probiotic scientists for enhanced participation in the International Probiotic Conference, Budapest 22nd to 25th June 2015.

Plenary teaching to Peninsula School of Dentistry, Dental Practicioners

  • MSc Periodontology, Periodontal Microbiology & Immunology, February 2019

Staff serving as external examiners

Nottingham Trent University 2014-2018. Biomedical Sciences Undergraduate Programmes.
Teeside University 2019. CertHE Health Sciences Programme Approval Event.
Brighton & Sussex Medical School 2019-2023. BMBS.

Research

Research

Research interests

Macrophages are fundamental cells to innate immune mechanisms. They exist in two main subsets which are determined by the tissue environment; where both differentiation and activation signals play a role in determining subset effector functionality. M1-like macrophages are pro-inflammatory and display anti-tumour effects whereas the M2-like macrophage subset is anti-inflammatory, regulatory and pro-tumoural. It is unclear whether these two subsets represent distinct canonical forms of macrophage subset or whether there is a sliding scale of effector function between these two extremes. If the latter scenario exists, it is likely that the macrophages display a level of plasticity, hence macrophage function can be manipulated/controlled. The regulation of macrophage function represents a realistic cell-based therapeutic regimen and would be of benefit in the treatment of many diseases where the immunopathological mechanisms are predominated by dysfunctional macrophages.

The focus of this research has centred on the role of mucosal macrophages in driving homeostatic healthy immune function and immunopathological mechanisms upon disruption of mucosal tolerance. The disease states currently under investigation include oral pathologies (chronic periodontitis, oral squamous cell carcinoma) and gastro-intestinal tract pathologies (Crohn’s disease, ulcerative colitis). Harnessing of both microbial (commensal and pathological) and dietary effects will allow for the regulation of macrophage function and may ameliorate the symptoms of such pro-inflammatory and suppressive disease states.

Current avenues of research endeavour include:

1)     Immunomodulatory role of probiotics – centred around the modulation of pro-inflammatory and anti-inflammatory cytokine production by specific macrophage subsets and upon contact-mediated interaction with gut epithelial cells.

2)     Mechanisms of endotoxin tolerance mediated by oral pathogens and the relative subset sensitivities to tolerance-induction.

3)     Application of oral pathogens and their PAMPs in immune-deviation in pro-inflammatory and suppressive immunopathologies.

4)     Negative regulation and manipulation of macrophage plasticity in Crohn’s disease.

5)     Immune cell cross-talk mechanisms involved in perpetuation of mucosal pathologies.

6)     Role of oligosaccharides/b-glucans as modulators of macrophage-mediated immunity.

7)     Dietary microparticles: immune activators or tolerance inducers?

Potential New Positions:

Self-funded PhD and ResM applicants are encouraged to apply. If you are interested in my areas of research, please e-mail me.

Research groups

Research degrees awarded to supervised students

PhD Supervision

Dr Alexander Strachan, 2020. University of Plymouth. Tolerogenic mechanisms associated with chronic Porphyromonas gingivalis infection: good for whom, host or pathogen? Co-supervised with Dr Zveta Zaric and Dr Vehid Salih (UoP).

Dr Barbara Durante, 2019. University of Plymouth. The effect of antimicrobial peptides (AMPs) as modulators of macrophage-driven innate immunity. Co-supervised with Professor Mathew Upton (UoP).

Dr Khalid Al-Shagdhali, 2018. University of Plymouth. Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments. Co-supervised with Dr Jane Beal (UoP).

Dr Abbas Al-Shabany, 2016. University of Plymouth. Pharmacological modulation of NAD alters TNFa responses in macrophage subsets. Co-supervised with Dr Richard Billington, DoS (UoP).

Dr Neama Habil, 2013. University of Plymouth. Probiotic modulation of mucosal immune responses in an in vitro co-culture model. Co-supervised with Dr Jane Beal (UoP).

Dr Holger Kuhlwein, 2013. University of Plymouth. Effect of dietary b-glucan supplementation on growth, intestinal functionality and disease progression in selected cyprinids (Cyprinus carpio and Danio rerio). Co-supervised with Professor Simon Davies, DoS (UoP).

Dr Angela Cooper, 2013. University of Plymouth. Long-chain fatty acids and endoplasmic reticulum stress in pancreatic beta cells: the role of protein kinase R (PKR). Co-supervised with Dr John Moody, DoS (UoP) and Professor Noel Morgan (University of Exeter).

Dr Matthew Owen, 2011. University of Plymouth. The effect of dietary inclusion of category 3 animal by-product meals on rainbow trout (O. mykiss Walbaum) mineralised tissues and immune function. Co-supervised with Professor Simon Davies, DoS (UoP) and Dr Simon Fox (UoP).

Dr Sally Owen, 2005. Imperial College London. The role of cytokine-stimulated T cells in mediating inflammatory cytokine responses in Rheumatoid Arthritis. Co-supervised with Professor Fionula Brennan, DoS (ICL).

ResM Supervision

Helene Stern, 2020. University of Plymouth. Investigating the role of Signal Regulatory Protein a in regulating macrophage subset activity in homeostasis and inflammation. Co-supervised with Dr Kris Jeremy (UoP).

MSc Project Supervision

James Nwaduba, 2019. University of Plymouth. Polarisation of M1 and M2 macrophages and presence of gingival fibroblasts and oral keratinocytes regulate overall macrophage TNFa production in vitro. Co-supervised with Dr Vehid Salih (UoP).

James Butler, 2018. University of Plymouth. Live and heat-killed probiotic Lactobacillus casei strain Shirota modulation of macrophage immune defences: stimulation versus suppression. Co-supervised with Dr Jane Beal.

Olivia Waring, 2016. University of Plymouth. Proteomic profiling of LPS-stimulated M1 and M2 macrophage responses. Co-supervised with Dr Kris Jeremy (UoP) and Dr Vikram Sharma (UoP).


Grants & contracts

Northcott Devon Medical Foundation Grant: 2019-2020 (£9,985). “Understanding the role of CD47 in colorectal cancer and the use of CD47 monoclonal antibodies for potential cancer immunotherapy.” (Principle Applicant: Dr Tracey Madgett, Co-applicants: Dr Kris Jeremy and Dr Andrew Foey).

PostGraduate Scholarship: PhD Studentship Grant: 2015-2018 (£70,000). “The effect of AMPs as modulators of macrophage-driven innate immunity.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Dr Mathew Upton).

Iraqi Embassy PhD Studentship Grant: 2014-2017 (£70,000). “Modulation of macrophage and epithelial cell immune defences by probiotic bacteria: immune stimulation versus suppression.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Dr Jane Beal).

Peninsula School of Medicine & Dentistry PhD Studentship Grant: 2014-2017 (£70,000). “Tolerogenic mechanisms associated with chronic Porphyromonas gingivalis infection: good for whom, host or pathogen?.” (Principle Applicant: Dr Sveta Zaric, Co-applicant: Dr Andrew Foey and Professor Simon Jackson).

Saudi Embassy PhD Studentship Grant: 2013-2015 (£70,000). “Regulation of macrophage subsets in homeostatic and inflammatory mucosal environments.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Dr Jane Beal, Dr Chris Hayward).

Iraqi Embassy PhD Studentship Grant: 2011-2014 (£70,000). “NAD levels modulate macrophage subset immune responses.” (Principle Applicant: Dr Richard Billington, Co-applicant: Dr Andrew Foey).

University of Basrah Personal Post-Doctoral Training Sabbatical: Sept/Oct. 2011 (£3,000). “PAMPs and PRRs drive mucosal immune responses: tolerance, activation or pathology?” (Principle Applicant: Dr Andrew Foey, Co-applicants: Professor Awatif Al-Muhsin, Professor Ihsan Al-Saimary).

Peninsula Dental School PhD Studentship Grant: 2009-2012 (£77,666). “Neoplastic cell, macrophage & T cell interaction involvement in oral squamous cell carcinoma.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Professor StJohn Crean).

Iraqi Embassy PhD Studentship Grant: 2009-2012 (£69,490). “Probiotic modulation of mucosal immune responses in an in vitro co-culture model.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Dr Jane Beal).

PostGraduate Scholarship: PhD Studentship Grant: 2008-2011 (£72,620). “Modulation of the inflammatory response to pathogenic oral bacteria by the oral mucosal immune system.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Professor StJohn Crean).

Iraqi Embassy & HEIF3 Research Studentship with DDRC Grant: 2008-2011 (£60,000). “Mechanism by which HBO therapy may resolve the inflammation in chronic wounds.” (Principle Applicant: Dr John Moody, Co-applicant: Dr Andrew Foey).

Seale Hayne Educational Trust. 2007 for 1 year. (£5,900). “In vitro modelling of the gut immune system.” (Principle Applicant: Dr Andrew Foey).

University of Plymouth, Vice Chancellor’s Research & Innovation Fellowship. 2007 for 1 year. (£6,000). “Macrophage bacterial sensing in the gut: NOD-ing off is good for you!” (Principle Applicant: Dr Andrew Foey).

Wellcome Trust Project Grant: for 3 years + 6 month extension. 1999 to 2003 (£159,821). “T cell regulation of macrophage IL-10: cognate ligand-receptor interactions and resulting signalling pathways.” (Principle Applicant: Dr Andrew Foey, Co-applicant: Professor Fionula Brennan).


Publications

Publications

Key publications

Key publications are highlighted

Journals
Articles
Rawling M, Leclercq E, Foey A, Castex M & Merrifield D (2021) 'A novel dietary multi-strain yeast fraction modulates intestinal toll-like-receptor signalling and mucosal responses of rainbow trout (Oncorhynchus mykiss)' PLoS One , DOI Open access
Hradicka P, Beal J, Kassayova M, Foey A & Demeckova V (2020) 'A Novel Lactic Acid Bacteria Mixture: Macrophage-Targeted Prophylactic Intervention in Colorectal Cancer Management' Microorganisms 8, (3) 387-387 , DOI Open access
Mcilwaine C, Strachan A, Harrington Z, Jerreat M, Belfield LA, Sandor V, Foey A & Zaric S (2019) 'Comparative analysis of total salivary lipopolysaccharide chemical and biological properties with periodontal status' Archives of Oral Biology 110, 104633-104633 , DOI Open access
Al-Shaghdali K, Durante B, Hayward C, Beal J & Foey A (2019) 'Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip' PLoS ONE 14, (5) e0214681-e0214681 , DOI Open access
Strachan A, Harrington Z, McIlwaine C, Jerreat M, Belfield LA, Kilar A, Jackson SK, Foey A & Zaric S (2018) 'Subgingival lipid A profile and endotoxin activity in periodontal health and disease' Clinical Oral Investigations Author Site , DOI Open access
Llewellyn A & Foey A (2017) 'Probiotic Modulation of Innate Cell Pathogen Sensing and Signaling Events' Nutrients 9, (10) 1156-1156 , DOI Open access
Foey AD, Habil N, Al-Shaghdali K & Crean S (2016) 'Porphyromonas gingivalis-stimulated macrophage subsets exhibit differential induction and responsiveness to interleukin-10' Archives of Oral Biology 73, 282-288 , DOI Open access
Standen BT, Peggs DL, Rawling MD, Foey A, Davies SJ, Santos GA & Merrifield DL (2016) 'Dietary administration of a commercial mixed-species probiotic improves growth performance and modulates the intestinal immunity of tilapia, Oreochromis niloticus' Fish & Shellfish Immunology 49, 427-435 , DOI Open access
Al-Shabany AJ, Moody AJ, Foey AD & Billington RA (2016) 'Intracellular NAD+ levels are associated with LPS-induced TNF-α release in pro-inflammatory macrophages' Bioscience Reports 36, (1) 0-0 , DOI Open access
D Foey A (2016) 'Macrophages: Tissue-Resident Determinants of Immunomodulation' Immunotherapy: Open Access 01, (01) , DOI
Ringo E, Zhou Z, Vecino JLG, Wadsworth S, Romero J, Krogdahl A, Olsen RE, Dimitroglou A, Foey A & Davies S (2015) 'Effect of dietary components on the gut microbiota ofaquatic animals. A never-ending story?' AQUACULTURE NUTRITION 22, (2) 219-282 Author Site , DOI Open access
D Foey A (2015) 'Macrophage Polarisation: A collaboration of Differentiation, Activation and Pre-Programming?' Journal of Clinical & Cellular Immunology 06, (01) , DOI
Habil N, Abate W, Beal J & Foey AD (2014) 'Heat-killed probiotic bacteria differentially regulate colonic epithelial cell production of human β-defensin-2: dependence on inflammatory cytokines' Benef Microbes 5, (4) 483-495 Author Site , DOI Open access
Alshaghdali K, Hayward C, Beal J & Foey A (2014) 'Macrophage subsets exhibit selective endotoxin tolerance induced by Escherichia coli LPS' IMMUNOLOGY 143, 99-99 Author Site
Kühlwein H, Merrifield DL, Rawling MD, Foey AD & Davies SJ (2014) 'Effects of dietary β-(1,3)(1,6)-D-glucan supplementation on growth performance, intestinal morphology and haemato-immunological profile of mirror carp (Cyprinus carpio L.)' J Anim Physiol Anim Nutr (Berl) 98, (2) 279-289 Author Site , DOI Open access
Standen BT, Rawling MD, Davies SJ, Castex M, Foey A, Gioacchini G, Carnevali O & Merrifield DL (2013) 'Probiotic Pediococcus acidilactici modulates both localised intestinal- and peripheral-immunity in tilapia (Oreochromis niloticus)' Fish Shellfish Immunol 35, (4) 1097-1104 Author Site , DOI Open access
Hardy H, Harris J, Lyon E, Beal J & Foey AD (2013) 'Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology' Nutrients 5, (6) 1869-1912 Author Site , DOI Open access
Foey AD & Crean S (2013) 'Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis' PLoS One 8, (7) Author Site , DOI Open access
Habil N, Beal J & Foey AD (2012) 'Lactobacillus casei strain Shirota selectively modulates macrophage subset cytokine production' International Journal of Probiotics and Prebiotics 7, (1) 1-12 Open access
Merry R, Belfield L, McArdle P, McLennan A, Crean S & Foey A (2012) 'Oral health and pathology: a macrophage account' Br J Oral Maxillofac Surg 50, (1) 2-7 Author Site , DOI Open access
Foey AD (2011) 'Butyrate regulation of distinct macrophage subsets: Opposing effects on M1 and M2 macrophages' International Journal of Probiotics and Prebiotics 6, (3-4) 147-158 Open access
Habil N, Al-Murrani W, Beal J & Foey AD (2011) 'Probiotic bacterial strains differentially modulate macrophage cytokine production in a strain-dependent and cell subset-specific manner' Benef Microbes 2, (4) 283-293 Author Site , DOI Open access
Buckley J, Maunder RJ, Foey A, Pearce J, Val AL & Sloman KA (2010) 'Biparental mucus feeding: a unique example of parental care in an Amazonian cichlid' J Exp Biol 213, (Pt 22) 3787-3795 Author Site , DOI Open access
Merrifield DL, Dimitroglou A, Foey A, Davies SJ, Baker RTM, Bogwald J, Castex M & Ringo E (2010) 'The current status and future focus of probiotic and prebiotic applications for salmonids' AQUACULTURE 302, (1-2) 1-18 Author Site , DOI
Brennan FM, Smith NMG, Owen S, Li C, Amjadi P, Green P, Andersson A, Palfreeman AC, Hillyer P & Foey A (2008) 'Resting CD4+ effector memory T cells are precursors of bystander-activated effectors: a surrogate model of rheumatoid arthritis synovial T-cell function' Arthritis Res Ther 10, (2) Author Site , DOI Open access
Foey A (2007) 'Concise clinical immunology for Healthcare professionals' Journal of Advanced Nursing 60, (2) 232-233
Staples KJ, Smallie T, Williams LM, Foey A, Burke B, Foxwell BMJ & Ziegler-Heitbrock L (2007) 'IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3' Journal of Immunology 178, (8) 4779-4785
Zhang Z, Panesar M, Isomaki P, Foey A, Owen S, Douglas J, McClinton C, Russell A, Vyse T & Dazzi F (2007) 'Sustained downregulation of TCRz defines a transition from antigen mode to inflammation mode during T cell differentiation' Blood 109, 4328-4335
Zhang ZL, Gorman CL, Vermi AC, Monaco C, Foey A, Owen S, Amjadi P, Vallance A, McClinton C & Marelli-Berg F (2007) 'TCR zeta(dim) lymphocytes define populations of circulating effector cells that migrate to inflamed tissues' Blood 109, (10) 4328-4335
Staples KJ, Smallie T, Williams L, Foey A, Burke B, Foxwell B & Ziegler-Heitbrock L (2007) 'Interleukin-10 induces interleukin-10 in primary human monocyte-derived macrophages via the transcription factor Stat3' Journal of Immunology 178(8), 4779-4785
Brennan FM, Foey AD & Feldmann M (2006) 'The importance of T cell interactions with macrophages in rheumatoid cytokine production' Current Concepts in Autoimmunity and Chronic Inflamation 305, 177-194
Zhang Z, Panesar M, Amjadi P, Foey A, Owen S, Dazzi F, Brennan FM & Cope AP (2005) 'Sustained downregulation of the TCR zeta chain defines a transition from antigen mode to inflammation mode during terminal T-cell differentiation' Arthritis Research & Therapy 7, S30-S30
Foey (2004) 'Conventional PKC and atypical PKCzeta differentially regulate macrophage production of TNF and IL-10' Immunology 112 (1), 44-53 , DOI
Beech J, Amjadi P, Owen S, Foey A & Brennan F (2004) 'BYSTANDER ACTIVATED LYMPHOCYTES: A PHENOTYPIC COMPARISON WITH RHEUMATOID SYNOVIAL LYMPHOCYTES' RHEUMATOLOGY 43, 19-20 Author Site
Owen S, Amjadi P, Green P, Foey A & Brennan F (2004) 'BYSTANDER-ACTIVATED LYMPHOCYTES IN INFLAMMATION: A NATURAL PROCESS?' RHEUMATOLOGY 43, 28-28 Author Site
Foey AD & Brennan FM (2004) 'Conventional protein kinase C and atypical protein kinase C zeta differentially regulate macrophage production of tumour necrosis factor-alpha and interleukin-10' Immunology 112, (1) 44-53
Ozegbe P, Foey AD, Ahmed S & Williams RO (2004) 'Impact of cAMP on the T-cell response to type II collagen' Immunology 111, (1) 35-40
Foey AD, Field S, Ahmed S, Jain A, Feldmann M, Brennan FM & Williams R (2003) 'Impact of VIP and cAMP on the regulation of TNF-alpha and IL-10 production: implications for rheumatoid arthritis' Arthritis Research & Therapy 5, (6) R317-R328 Open access
Brennan FM & Foey AD (2002) 'Cytokine regulation in RA synovial tissue: role of T cell: macrophage contact dependent interaction :Invited review chapter' Arthritis Research 4, S177-S182
Foey A, Green P, Foxwell B, Feldmann M & Brennan F (2002) 'Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis' Arthritis Research 4, (1) 64-70 Open access
Foey A, Green P, Foxwell B, Feldmann M & Brennan F (2002) 'Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis' ARTHRITIS RESEARCH & THERAPY 4, (1) Author Site
Brennan F & Foey A (2002) 'Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions' Arthritis Res 4 Suppl 3, S177-S182 Author Site , DOI Open access
Foey AD, Feldmann M & Brennan FM (2001) 'CD40 ligation induces macrophage IL-10 and TNF-alpha production: Differential use of the P13K and p42/44 MAPK-pathways' Cytokine 16, (4) 131-142
Foey AD, Feldmann M & Brennan FM (2000) 'Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin 10 expression' Cytokine 12, (10) 1496-1505 Author Site , DOI
Foey AD, Parry SL, Williams LM, Feldmann M, Foxwell BM & Brennan FM (1998) 'Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-alpha: role of the p38 and p42/44 mitogen-activated protein kinases' J Immunol 160, (2) 920-928 Author Site
Foey AD, Crawford A & Hall ND (1997) 'Modulation of cytokine production by human mononuclear cells following impairment of Na, K-ATPase activity' Biochim Biophys Acta 1355, (1) 43-49 Author Site , DOI
Foey AD, Crawford A & Hall ND (1996) 'Dysfunctional Na/K-ATPase activity in rheumatoid synovial lining cells results in a defect in fas-mediated apoptosis' ARTHRITIS AND RHEUMATISM 39, (9) 628-628 Author Site
FOEY A, CRAWFORD A & HALL N (1995) 'OUABAIN EXPERTS DIFFERENTIAL-EFFECTS ON CYTOKINE PRODUCTION BY MONOCYTES AND FIBROBLASTS' ARTHRITIS AND RHEUMATISM 38, (9) 714-714 Author Site
Maubach K, Foey AD & Hall ND (1993) 'Impaired activity of thiol-dependent ATPases in rheumatoid mononuclear cell membranes' Agents Actions 39 Spec No, C107-C109 Author Site , DOI
Chapters
Foey A & Picchietti S (2014) 'Immune Defences of Teleost Fish' Aquaculture Nutrition John Wiley & Sons, Ltd 14-52 , DOI
Foey AD (2014) 'Macrophages — Masters of Immune Activation, Suppression and Deviation' Immune Response Activation InTech , DOI
Foey A (2012) 'Mucosal macrophages: Phenotype and functionality in homeostasis and pathology' Handbook of Macrophages: Life Cycle, Functions and Diseases 121-145
Conference Papers
Al-Shabany A, Moody AJ, Foey AD & Billington RA (2014) 'Pharmacological modulation of NAD alters TNF-alpha responses in macrophage subsets' 180-180 Open access
Alshaghdali K, Haywood C, Beal J & Foey A (2014) 'Macrophage subsets exhibit selective endotoxin tolerance induced by Escherichia coli LPS' 29-29
Al-Shabany A, Moody J, Foey AD & Billington RA (2013) 'NAD levels modulate macrophage subset responses' 92-92
Habil N, Al-Shamgani H, Beal J & Foey A (2011) 'Probiotics modulate epithelial cell barrier properties influenced by co-culture with macrophages' 131-131
Buckley J, Maunder R, Foey AD, Pearce J & Sloman K (2009) 'Bi-parental mucus feeding: A unique example of parental care in an Amazonian cichlid' S94-S94 , DOI
Foey AD (2008) 'Macrophage phenotype determines NOD2 regulation of PAMP-induced cytokine profile' 88-88
Personal

Personal

Reports & invited lectures

"Macrophages: masters of homeostasis pathology in Crohn's Disease." Gastroenterology Forum, 10th July 2018, Gastroenterology Department, Derriford Hospital, Plymouth, UK.

"Oral LPS: Macrophage subsets are differentially sensitive to endotoxin tolerance." BSODR Annual Meeting, 6th-8th September 2017, Plymouth, UK.

"Macrophages: immune activation vs immune suppression in response to P.gingivalis." Annual Research Conference, Centre for Biomedical Research, Plymouth, 3rd September 2015.

"Epithelial cell production of beta-defensin-2: the inter-relationship between probiotic bacteria and inflammatory cytokines." International Probiotic Conference, Budapest, 25th June 2015.

"Mmmmmm! Lumenal tasting and antigen presentation." Immunology Master Class Workshop. International Probiotic Conference, Budapest, 22nd June 2015.

"Mucosal Immunology - from outside to inside." Immunology Master Class Workshop. International Probiotic Conference, Budapest, 22nd June 2015.

"Modulation of macrophage-epithelial cell co-cultures by Lactobacillus casei strain Shirota: effect on inflammatory cytokines, barrier integrity and bacterial sensing." International Probiotic Conference, Budapest, 26th June 2014.

"Macrophages: the Jekyll and Hyde of inflammation." PUPSMD School Seminar Series, Plymouth, 5th February 2014.

"Probiotic modulation of macrophage responses: relevance to mucosal immunity." Keynote Speaker at Probiotic and prebiotic immunomodulation in medical, vetinary and aquaculture sciences: the future. NEMO Conference, Keele University, Keele, 10th September 2012.

"Differential suppression of macrophage subsets by Porphyromonas gingivalis." International Association of Dental Research, Annual Meeting, Barcelona, 14th July 2010.

"Oral mucosal immune dysfunction in RAS and OSCC: the macrophages are key!" Orthognathic Surgery, South West Regional Study Day, Lyngford House, Taunton, Somerset, 14th December 2009.

"Macrophage effector phenotypes: the cellular switch in inflammatory fate!" Faculty of Science Seminar Series, University of the West of England, Bristol, 25th March 2009.

"Macrophage effector phenotypes: priming, activation & apoptosis - the fine balance between tolerance & inflammatory immunopathology." POSReF, Institute of Biomedical & Clinical Science, University of Exeter, Ashburton, 25th June 2008.

"Nutritional modulation of innate immunity: macrophage effector functions - the switch between tolerance an immunopathology." Food Biosciences Research Seminar, University of Reading, 10th October 2007.

“Endogenous calcium microparticles: Immunomodulators of innate immunity.” Endogenous microparticles: Form and function, Cambridge , 14th March 2005 .

“Distinct macrophage populations display differential effector responses upon TLR ligation.” British Society for Immunology Annual Meeting, Harrogate, 7th December 2004.

“Pro-inflammatory macrophages: partial differentiation or preferential pathway?” International Cytokine Society Annual Meeting, Trinity College, Dublin, 22nd September 2003.

“T cell/macrophage contact and macrophage differentiation regulate cytokine expression in chronic inflammation.” Rheumatology Seminar Series, School of Clinical Medical Sciences, University of Newcastle, 7th July 2003.

“Cytokine regulation in chronic inflammation: role of T cell/macrophage contact-dependent interactions and mechanism of macrophage differentiation.” Infection and Immunity Seminar Series, Institute of Child Health, UCL, London, 10th June 2003.

"Macrophage differentiation and cytokine regulation." Joint presentation with Professor Fionula Brennan. Cytokines and Vascular Biology Meeting, Kennedy Institute of Rheumatology, London, 9th December 2002.

“Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions.” Professor Siamon Gordon Laboratory, Sir William Dunn School of Pathology, University of Oxford, 1st November 2002.

“ Cytokine-stimulated T cells induce IL-10 production by M-CSF-primed monocytes in a PI3K-dependent manner similar to that of RA-SMCs.” 3rd International IL-10 Workshop on IL-10, Berlin, 4th-7th April 2001.

“CD40 ligation induces macrophage IL-10 production.” Cell Contact Interactions in Rheumatology meeting, Kennedy Institute of Rheumatology, London, 1st-2nd June 2000.

“The cognate interaction of CD40L with CD40 on macrophages mediates interleukin-10 expression: Cytokine profile is determined by differentiation status.” 2nd International IL-10 Workshop, Milan, Italy, 27th-29th May 1999.

“Role played by cognate interaction between T cells and macrophages in the production of macrophage IL-10.” The Anthony Nolan Research Institute, Royal Free Hospital, London, March 1999.

"Control of expression of monocyte Interleukin-10: Role of the MAP-kinases and cognate cellular interactions." Royal National Hospital for Rheumatic Diseases and the University of Bath, Bath, March 1998.

“Role of p38 and p42/44 MAP kinase pathways in the regulation of LPS-induced IL-10 by peripheral blood monocytes.” 1st International IL-10 Workshop. Strathclyde University, Glasgow, 10th-13th September, 1997.

"Cation control of cytokine expression and effects on Fas-mediated apoptosis within the rheumatoid synovium." Department of Microbiology and Immunology, Leicester University, June 1996.

"Regulation of pro-inflammatory cytokine expression by an impairment in function of the sodium pump in cells of the rheumatoid synovial lining layer." British Society for Rheumatology, Brighton, May 1996.

Other academic activities

Commisioned to write a book on "Nutritional Immunology." To be published in 2015. Wiley - Blackwell publishing, UK.

MPhil - PhD Conversion Internal examiner:
Oct 2015  "Evaluation of phytoestrogens on PC3 and MCF-7 cell viability and motility." Safaa Salman Mezban School of Biomedical & Healthcare Sciences, University of Plymouth.

Oct 2016   "Innate immune responses in a new model of alveolar macrophages to infection with influenza virus." Conor Wood. School of Biomedical & Healthcare Sciences, University of Plymouth.

MPhil - PhD Conversion External examiner:
June 2009    "Structural and functional studies of the peroxiredoxin-sulfiredoxin enzyme system: do inhibitors of this system induce apoptosis in inflammatory cells?" Katarine Szabo Inflammation & Musculoskeletal Diseases Research Group, University of Exeter.

September 2009 "The effects of hyperbaric oxygen on the mechanisms of antibiotic resistance in chronic wound bacteria." Lindsey Glew. School of Biological Sciences and The Hyperbaric Medical Centre, University of Plymouth.

January 2014 "PAMP-induce signalling in mammalian trigeminal neurons: consequences for oral infection and mechanisms of chronic orofacial pain." Martin Helley
Plymouth University Peninsula Schools of Medicine & Dentistry, University of Plymouth.

PhD External examiner:

November 2012 "Influence of ageing on immune responses to selected probiotics." Jialu You, Food & Nutritional Sciences, University of Reading.

PhD Internal examiner:

February 2018 "The effects of phytoestrogens on preferential metastasis to bone." Safaa Mezban.

MD Examiner:

September 2015 "The biology of mantle cell lymphoma: exploring the gender difference in mantle cell lymphoma." Dr Nimish Shah. PUPSMD, Derriford Hospital.

Reviewer

Journals: Past & Present:     

  • Biochemical Pharmacology 
  • Arthritis Research
  • Annals of the Rheumatic Diseases 
  • Journal of Gene Medicine 
  • Journal Pharmacy/Pharmacology 
  • Cytokine
  • Journal of Gene Medicine 
  • Immunobiology 
  • International Immunology 
  • Genes and Immunity
  • Scandinavian Journal of Rheumatology
  • European Journal of Immunology
  • Journal of Rheumatology/Rheumatology
  • Clinical and Experimental Immunology
  • Infection & Immunity
  • PLOSone
  • Clinical & Vaccine Immunology 

Granting Agencies: Review applications to the Hong Kong Research Grants Council Universities Grants Committee, Biology and Medicine Panel; MRC and BBSRC. Research project reviewer for Asthma UK.

Current Editor: Editorial Board Member (elected Sept. 2013) for ISRN Immunology, Hindawi Publishing Corporation.

Editorial Board Member (elected Aug. 2015) Journal - Immunotherapy: Open Access.

Professional Training:

University of Plymouth On-line training:

  • Recruitment & Selection. Certificate 04/10/10.
  • Health & Safety E-learning. Certificate 13/05/12.
  • Diversity in the workplace. Certificate 06/01/15.
  • Unconscious Bias. Certificate January 2017.

University of Plymouth Training Courses:

  • Supervising Postgraduate Research Students. Professor Mick Fuller 14/06/06.
  • Role of the Internal Examiner. Professor Mick Fuller 2012.
  • Safe Handling of Cryogenic Liquids. JHW Associates Health & Safety Consultancy & Training 12/07/06.

MRC Career Development Fellowship training:

  • Supervising PhD students. Cambridge 26/05/04.
  • Writing Project Proposals. Dr Philip Hills, Addenbrooke's Hospital, Cambridge 09/06/04.
  • Career Development Fellowship Induction. Patrick Moriarty, Cambridge 26/10/04.