Dr Andrew Foey
Associate Professor of Immunology
School of Biomedical Sciences (Faculty of Medicine and Dentistry)
Member of Biomedical Research Governance Sub-committee (CRTB, SoBHCS, PUPSMD) (2013-2016)
School Admissions Tutor (2014-2016 - 3 recruitment cycles)
2018 Senior Fellow of the Higher Education Academy (SFHEA PR144988 - 03/05/18)
2007 Fellow of the Higher Education Academy (FHEA No.32432).
2006 PG Cert. Learning & Teaching in Higher Education. University of Plymouth.
1996 PhD "Modulation of pro-inflammatory cytokine expression by intracellular cations." University of Bath.
1989 B.Sc. (Hons.) Applied Biological Sciences. Bristol Polytechnic.
1986 HND Applied Biology. Bristol Polytechnic.
Cytokine Immunopathology in inflammatory conditions, monocyte /macrophage biology, probiotics as immunomodulators, cell-to-cell interactions, cell signalling, apoptosis and cell cytometry.
Lecturer in Immunology, School of Biological & Biomedical Sciences, University of Plymouth, Plymouth, UK. Sept. 2005 - July 2017.
MRC Career Development Fellowship in Nutritional Immunology, MRC Human Nutrition Research Unit, Cambridge, UK. May 2004 – July 2005.
Senior Research Fellow, Kennedy Institute of Rheumatology, Imperial College, London, UK. July 1996 – December 2003.
Post Doctoral Research Scientist, Bath Institute for Rheumatic Diseases, Bath, UK. October 1995 – June 1996.
Research Assistant and SERC CASE PhD Studentship, Bath Institute for Rheumatic Diseases, Bath, UK. January 1992 – September 1995.
Research Scientist Industrial Placement, Boots Pharmaceuticals, Nottingham, UK. July 1994 – December 1994.
Research Assistant, MRC Tuberculosis and Related Infections Unit, RPMS Hammersmith Hospital, London, UK. September 1989 – December 1991.
Research Assistant, Nuffield Department of Surgery, John Radcliffe Hospital, Oxford, UK. June 1991 – December 1991.
Research Assistant, CDE Porton Down, Salisbury, UK. July 1987 – September 1988.
BHCS1006 Infection & Immunity
DIET210/BIOL2420 Nutritional Immunology & Biomedicine
Also teach on modules:
BHCS1001 Biomedical Investigation & Experimentation
BHCS2018 Systems Physiology: Function & Dysfunction
BHCS3011 Clinical Immunology & Biochemical Screening
Honours & Masters degree Research Project Supervision:
BHCS3001 Personal Research Project
BIOM5006 Masters Research Project
SSU provision for PCMD Medical students:
BS020 The immune system: it really is a case of "we are what we eat."
BS013 Cellular & molecular mechanisms underlying inflammatory immunopathologies.
Staff serving as external examiners
Nottingham Trent University 2014-2018. Biomedical Sciences Undergraduate Programmes.
Macrophages are fundamental cells to innate immune mechanisms. They exist in two main subsets which are determined by the tissue environment; where both differentiation and activation signals play a role in determining subset effector functionality. M1-like macrophages are pro-inflammatory and display anti-tumour effects whereas the M2-like macrophage subset is anti-inflammatory, regulatory and pro-tumoural. It is unclear whether these two subsets represent distinct canonical forms of macrophage subset or whether there is a sliding scale of effector function between these two extremes. If the latter scenario exists, it is likely that the macrophages display a level of plasticity, hence macrophage function can be manipulated/controlled. The regulation of macrophage function represents a realistic cell-based therapeutic regimen and would be of benefit in the treatment of many diseases where the immunopathological mechanisms are predominated by dysfunctional macrophages.
The focus of this research has centred on the role of mucosal macrophages in driving homeostatic healthy immune function and immunopathological mechanisms upon disruption of mucosal tolerance. The disease states currently under investigation include oral pathologies (chronic periodontitis, oral squamous cell carcinoma) and gastro-intestinal tract pathologies (Crohn’s disease, ulcerative colitis). Harnessing of both microbial (commensal and pathological) and dietary effects will allow for the regulation of macrophage function and may ameliorate the symptoms of such pro-inflammatory and suppressive disease states.
Current avenues of research endeavour include:
1) Immunomodulatory role of probiotics – centred around the modulation of pro-inflammatory and anti-inflammatory cytokine production by specific macrophage subsets and upon contact-mediated interaction with gut epithelial cells.
2) Mechanisms of endotoxin tolerance mediated by oral pathogens and the relative subset sensitivities to tolerance-induction.
3) Application of oral pathogens and their PAMPs in immune-deviation in pro-inflammatory and suppressive immunopathologies.
4) Negative regulation and manipulation of macrophage plasticity in Crohn’s disease.
5) Immune cell cross-talk mechanisms involved in perpetuation of mucosal pathologies.
6) Role of oligosaccharides/b-glucans as modulators of macrophage-mediated immunity.
7) Dietary microparticles: immune activators or tolerance inducers?
Potential New Positions:
Self-funded PhD and ResM applicants are encouraged to apply. If you are interested in my areas of research, please e-mail me.
Citations as per November 2018. H-index = 23 (May 2019) RG=29.44, Impact Points=98.76.
Al-Shagdhali, K., Durante, B., Hayward, C., Beal, J. and Foey, A. (2019): Macrophage subsets exhibit distinct E. coli-LPS tolerisable cytokines associated with the negative regulators, IRAK-M and Tollip. PLoS ONE (Manuscript accepted for publication 17/05/19).
Rawling, M.D., Leclercq, E., Foey, A.D., Merrifield, D.L. and Castex, M. (2019?): The effects of feeding a multi strain yeast fraction continuously and pulsed on rainbow trout (Oncorhynchus mykiss) mucosal immune response and growth performance. [Manuscript in preparation].
Strachan, A., Harrington, Z., McIlwaine, C., Jerreat, M., Kilar, A., Belfield, L., Jackson, S., Foey, A. and Zaric, S. (2018): Subgingival lipid A profile and endotoxin activity in periodontal health and disease. Clinical Oral Investigations. (Published online: 12th December 2018) [doi.org/10.1007/s00784-018-2771-9].
Foey, A.D. (2018): Probiotics: microbial experts in immunomodulation of mucosal macrophage-driven responses. Immunotherapy: Open Access 4: e108. [doi:10.4172/2471-9552.1000e108].
Llewellyn, A. and Foey, A. (2017): Probiotic modulation of innate cell pathogen sensing and signaling events. Nutrients 9:1156. [Citations: 2, JIF 3.270, doi:10.3390/nu9101156].
Foey, A.D., Habil, N., Al-Shaghdali, K. and Crean, S.J. (2017): Porphyromonas gingivalis-stimulated macrophage subsets exhibit differential induction and responsiveness to interleukin-10. Archives of Oral Biology 73:282-288. [Citations: 5, JIF: 1.733, Doi: 10.1016/j.archoralbio.2016.10.029].
Al-Shabany, A.J., Moody, A.J., Foey, A.D. and Billington, R.A. (2016): Intracellular NAD+ levels are associated with LPS-induced TNF release in pro-inflammatory macrophages. Bioscience Reports 36(1):e00301. [Citations:12, JIF: 2.637].
Foey, A.D. (2015): Macrophages: Tissue-resident determinants of immunomodulation. Immunotherapy: Open Access 1: 1-3.
Standen, B., Peggs, D., Rawling, M., Foey, A., Davis, S., Santos, G. and Merrifield, D. (2016): Dietary administration of a commercial mixed-species probiotic improves growth performance and modulates the intestinal immunity of tilapia, Oreochronis niloticus. Fish & Shellfish Immunology 49:427-435. [Citations: 18, JIF: 2.67, Doi:10.1016/j.fsi.2015.11.037].
Foey, A.D. (2015): Macrophage polarisation: a collaboration of differentiation, activation and pre-programming? Journal of Clinical & Cellular Immunology. 6:293. [Citations:7, JIF: 3.146, Doi:10.4172/2155-9899.1000293].
Habil, N., Abate Woldie, W., Beal, J. and Foey, A.D. (2014): Heat killed probiotic bacteria differentially regulate colonic epithelial cell production of human beta-defensin-2: dependence on inflammatory cytokines. Beneficial Microbes 5(4):483-495. [Citations: 19, JIF: 3.301, Doi:10.3920/BM2013.0061].
Foey, A.D. (2014): Macrophages: masters of immune activation, suppression and deviation. In. Immunostimulation. Ed. Duc, H.T. Chapter 5, pp. 121-149. Publishers: InTech Europe, Croatia. ISBN 980-953-307-1094-2. [Citations: 2, Doi:10.5772/57541].
Foey, A.D. and Crean, S.J. (2013): Macrophage subset sensitivity to endotoxin tolerisation by Porphyromonas gingivalis. PLoS ONE 8(7):e67955 [Citations: 20, JIF: 4.100, Doi:10.1371/journal.pone.0067955].
Hardy, H., Harris, J., Lyon, E., Beal, J. and Foey, A.D. (2013): Probiotics, prebiotics and immunomodulation of gut mucosal defences: homeostasis and immunopathology. (Special issue: Nutrients & Immune function). Nutrients 5(6): 1869-1912. [Citations: 198, JIF: 3.270, Doi:10.3390/nu5061869].
Standen, B., Rawling, M.D., Davies, S.J., Castex, M., Foey, A., Gioacchini, G., Carnevali, O. and Merrifield, D.L. (2013): Probiotic Pediococcus acidilactici modulates both localised intestinal- and peripheral-immunity in tilapia (Oreochromis niloticus). Fish & Shellfish Immunology 35(4):1097-1104. [Citations: 81, JIF: 2.964, Doi:10.1016/j.fsi.2013.07.018].
Kuhlwein, H., Merrifield, D.L., Rawling, M.D., Foey, A.D. and Davies, S.J. (2013): Effects of dietary β-(1,3)(1,6)-D-glucan supplementation on growth performance, intestinal morphology and haemato-immunological profile of mirror carp (Cyprinus carpio L.). J. Anim. Physiol. Anim. Nutr. (Berl). 98:279-289. [Citations: 43, JIF: 0.855, Doi:10.111/jpn.12078].
Ringo, E., Zhou, Z., Gonzalez Vecino, J.L., Wadsworth, S., Romero, J., Krogdahl, A., Olsen, R.E., Dimitroglou, A., Foey, A., Davies, S., Owen, M., Lauzon, H.L., Lovmo, L., De Schryver, P., Bossier, P., Sperstad, S. and Merrifield, D.L. (2015): Effect of dietary components on the gut microbiota of aquatic animals. A never ending story? Aquaculture Nutrition 1-64. [Citations: 74, Doi: 10.1111/anu.12346].
Foey, A. and Picchietti, S. (2014): Immune defences of teleost fish. In. Probiotics, prebiotics and gut health in aquaculture nutrition. Eds. Merrifield, D. and Ringo, E. Chapter 2, pp. 14-52. Wiley-Blackwell Publishing [Citations: 10].
Foey, A. (2012): Mucosal macrophages: phenotype and functionality in homeostasis and pathology. In. Handbook of macrophages: life cycle, functions and diseases. Eds. Takahashi, R. and Kai, H. Chapter 4, pp. 121-146. Nova Science Publishers Inc., NY, USA. ISBN 978-1-62081-162-7. [Citations: 4].
Habil, N., Beal, J. and Foey, A.D. (2012): Lactobacillus casei strain Shirota selectively modulates macrophage subset cytokine production. Int. J. Probiotics & Prebiotics 7(1):1-12. [Citations: 9].
Merry, R., Belfield, L., McArdle, P., McLennan, A., Crean, S-J. and Foey, A. (2012): Oral health and pathology; a macrophage account. Br. J. Oral & Maxillofacial Surg. 50:2-7. [Citations: 29, JIF: 2.712, Doi:10.1016/bjoms.2010.10.020].
Habil, N., Al-Murrani, W., Beal, J. and Foey, A.D. (2011): Probiotic bacterial strains differentially modulate macrophage cytokine production in a strain-dependent and cell subset-specific manner. Beneficial Microbes 2(4):283-293. [Citations: 33, JIF: 3.301, Doi:10.3920/BM2011.0027].
Foey, A.D. (2011): Butyrate regulation of distinct macrophage subsets: opposing effects on M1 and M2 macrophages. Int. J. Probiotics & Prebiotics 6(3/4):147-158. [Citations: 4].
Buckley, J., Maunder, R.J., Foey, A., Pearce, J., Val, A.L. and Sloman, K.A. (2010): Biparental mucus feeding: a unique example of parental care in an Amazonian cichlid. J. Exp. Biol. 213:3787-3795. [Citations: 42, JIF: 3.000, Doi:10.1242/jeb.042929].
Merrifield, D.L., Dimitroglou, A., Foey, A., Davies, S.J., Baker, R.T.M., Bogwald, J., Castex, M. and Ringo, E. (2010): The current status and future focus of probiotic and prebiotic applications for salmonids. Aquaculture 302(1-2): 1-18. [Citations: 534, JIF: 2.041].
Brennan, F.M., Smith, N.M.G., Owen, S.H., Li, C., Amjadi, P., Green, P., Andersson, A., Palfreeman, A.C., Hillyer, P., Foey, A., Beech, J. and Feldmann, M. (2008): Resting CD4+ effector-memory T cells are precursors of bystander-activated effectors: a surrogate model of RA synovial T cell function. Arthritis Research & Therapy 10: R36. [Citations: 40, JIF 4.271, Doi:10.1186/ar2390].
Staples, KJ, Smallie, T, Williams, L, Foey, A, Burke, B, Foxwell, B. and Ziegler-Heitbrock, L. (2007): Interleukin-10 induces interleukin-10 in primary human monocyte-derived macrophages via the transcription factor Stat3. Journal of Immunology 178(8):4779-4785. [Citations: 123, JIF 5.745, Doi:0022-1767/07 DoP: 15/04/07].
Zhang, Z., Panesar, M., Isomaki, P., Foey, A., Owen, S., Douglas, J., McClinton, C., Russell, A., Vyse, T., Dazzi, F., Brennan, F. and Cope, A.P. (2007): Sustained downregulation of TCRz defines a transition from antigen mode to inflammation mode during T cell differentiation. Blood 109:4328-4335. [Citations: 42, JIF 10.558, Doi:10.1182/blood-2006-12-064170 DoP: 25/01/07].
Brennan, F.M., Foey, A.D. and Feldmann, M. (2006): The importance of T cell interactions with macrophages in rheumatoid cytokine production. Current Concepts in Autoimmunity and Chronic Inflammation, Current Topics in Microbiology and Immunology CTMI 305: 177-194. [Citations: 38, JIF 4.93, ISSN:0070-217x, ISBN:3-54029713-8].
Foey, A.D., Foxwell, B.M.J. and Brennan, F.M. (2004): Conventional PKC and cAMP-dependent atypical PKCzeta differentially regulate macrophage production of TNFα and IL-10. Immunology 112:44-53. [Citations: 42, JIF 3.705, Doi:10.1111/j.1365-2567.2004.01852-x DoP: 17/02/04].
Ozegbe, P., Foey, A.D., Ahmed, S. and Williams, R.O. (2004): Impact of cAMP on the T cell response to type II collagen. Immunology 111:35-40. [Citations: 25, JIF 3.705, Doi:10.1046/j.1365-2567.2003.01768-x].
Foey, A.D., Field, S., Ahmed, S., Jain, A., Feldmann, M., Brennan, F.M. and Williams, R.O. (2003): Impact of VIP and cAMP on the regulation of TNFα and IL-10 production: implications for rheumatoid arthritis. Arthritis Research and Therapy 5:R317-R328. [Citations: 62, JIF 4.271, Doi:10.1186/ar999 DoP: 03/09/03].
Brennan, F.M. and Foey, A.D. (2002): Cytokine regulation in RA synovial tissue: role of T cell: macrophage contact dependent interactions. Arthritis Research 4:S177-S182. [Citations: 42, JIF 3.436, ISSN:1465-9905/9913 DoP: 09/05/02].
Foey, A.D., Green, P., Foxwell, B.M.J., Feldmann, M. and Brennan, F.M. (2002): Cytokine-stimulated T cells induce macrophage IL-10 production dependent on phosphatidylinositol 3-kinase and p70S6K: implications for rheumatoid arthritis. Arthritis Research 4: 64-70. [Citations: 51, JIF 3.436, ISSN:1465-9905/9913 DoP: 10/10/01].
Foey, A.D., Feldmann, M. and Brennan, F.M. (2001): CD40 ligation induces macrophage IL-10 and TNFα production: Differential use of the PI3K and p42/44 MAPK-pathways. Cytokine 16: 131-142. [Citations: 54, JIF 3.537, Doi:10.1006/cyto.2001.0954 DoP: 21/11/01].
Foey, A.D., Feldmann, M. and Brennan, F.M. (2000): Route of monocyte differentiation determines their cytokine production profile: CD40 ligation induces interleukin-10 expression. Cytokine 12: 1496-1505. [Citations: 31, JIF 3.537, Doi:10.1006/cyto.2000.0750].
Foey, A.D., Parry, S.L., Williams, L.M., Feldmann, M., Foxwell, B.M.J. and Brennan, F.M. (1998): Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: Role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160: 920-928. [Citations: 382, JIF 5.745, Doi:0022-1767/98].
Foey, A.D., Crawford, A. and Hall, N.D. (1997): Modulation of cytokine production by human mononuclear cells following impairment of Na,K-ATPase activity. Biochem. Biophys. Acta. Mol. Cell Res. 1355: 43-49. [Citations: 24, JIF 4.733].
Maubach, K., Foey, A.D. and Hall, N.D. (1993): Impaired activity of thiol-dependent ATPases in rheumatoid mononuclear cell membranes. Agents and Actions 39: C107-C109. [Citations: 6].Published Abstracts
Hradicka, P., Beal, J., Foey, A. and Demeckova, V. (2018): Immunomodulatory effects of lactobacillus strains: emphasis on identification of probiotic candidates with anti-tumour responses. 25th Biennial Congress of the European Association for Cancer Research, Amstredam, The Netherlands. 30th June - 3rd July 2018. Doi: 10.1136/esmoopen-2018-EACR25.799.
Al-Abdulwahid, L., Beal, J. and Foey, A. (2017): Selective ability of probiotics to prime or tolerise distinct macrophage subsets in a strain-specific manner. International Cytokine Conference, Japan.
Hradicka, P., Beal, J., Foey, A. and Demeckova, V. (2017): Selection of probiotic candidates for the re-programming of macrophage subset-driven pro-tumour responses: an in vitro approach utilising macrophage subsets. Proceedings of International Probiotic & Prebiotic Conference p89-90. Budapest, 20th-22nd June 2017. ISBN 978-80-89589-16-6.
Foey, A.D., Habil, N. and Beal, J. (2015): Epithelial cell production of beta-defensin-2: the inter-relationship between probiotic bacteria and inflammatory cytokines. Proceedings of International Probiotic & Prebiotic Conference p54. ISBN 978-80-89589-11-1.
Al-Shabany, A., Moody, A.J., Foey, A.D. and Billington, R.A. (2014): Pharmacological modulation of NAD alters TNFα responses in macrophage subsets. Immunology 143(S1):180.
Al-Shaghdali, K., Haywood, C., Beal, J. and Foey, A. (2014): Macrophage subsets exhibit selective endotoxin tolerance induced by Escherichia coli LPS. Immunology 143(S1):29.
Foey, A.D., Habil, N. and Beal, J. (2014): Modulation of macrophage-epithelial cell co-cultures by Lactobacillus casei strain Shirota: effect on inflammatory cytokines, barrier integrity and bacterial sensing. Proceedings of International Probiotic & Prebiotic Conference p27-28. ISBN 978-80-89589-09-8.
Al-Shabany, A., Moody, A.J., Foey, A.D. and Billington, R.A. (2013): NAD levels modulate macrophage subset responses. Immunology 140(S1): 92.
Habil, N., Al-Shamgani, H., Beal, J. and Foey, A. (2011): Probiotics modulate epithelial cell barrier properties influenced by co-culture with macrophages. Immunology 135 (S1): 131.
Buckley, J., Maunder, R., Foey, A.D., Pearce, J. and Sloman, K. (2009): Bi-parental mucus feeding: a unique example of parental care in an Amazonian cichlid. Comparative Biochemistry & Physiology A - Molecular & Integrative Physiology 153A: S94.
Foey, A. (2008): Macrophage phenotype determines NOD2 regulation of PAMP-induced cytokine profile. Immunology 125 (S1): 88.
Foey, A. (2008): Butyrate differentially regulates macrophage inflammatory responses to bacterial stimulation: a cautionary tale for probiotic development. Int. J. Probiotics & Prebiotics 3 (3): 180.
Foey, A. (2008): Macrophage phenotype, the key to the gut mucosal immune system NOD-ing off to commensal bacteria. Int. J. Probiotics & Prebiotics 3 (3): 180.
Zhang, Z., Panesar, M., Amjadi, P., Foey, A.D., Owen, S., Dazzi, F., Brennan, F.M. and Cope, A.P. (2005): Sustained downregulation of the TCRzeta chain defines a transition from antigen mode to inflammation mode during T cell differentiation. Arthritis Res. & Ther. 7(S1):S30.
Zhang, Z., Panesar, M., Amjadi, P., Foey, A., Clark, J.M., Isomaki, P., Dazzi, F., Brennan, F.M. and Cope, A.P. (2004): Does sustained downregulation of TCRz define a transition from antigen mode to inflammation mode during T cell differentiation? Immunology 113: 112 (suppl.).
Foey, A.D., Sacre, S., Powell, J., Foxwell, B. and Brennan, F.M. (2004): Distinct macrophage populations display differential effector responses upon TLR ligation. Immunology 113: 5 (suppl.).
Foey, A.D., Sacre, S., Amjadi, P. and Brennan, F.M. (2003): Pro-inflammatory macrophages: partial differentiation or preferential pathway? Immunology 110: 115 (suppl.). Eur. Cyt. Netw. 14(S3):58.
Brennan, F.M., Foey, A.D., Owen, S., Green, P., Foxwell, B. and Feldmann, M. (2003): TNF regulation in chronic inflammation: the involvement of a newly defined population of T cells. Eur. Cyt. Netw. 14:9.
Beech, J.T., Amjadi, P., Owen, S., Foey, A.D. and Brennan, F.M. (2003): Bystander activated lymphocytes: a phenotypic comparison with rheumatoid synovial lymphocytes. Eur. Cyt. Netw. 14:57 and Rheumatology 43(S2):19-20 (2004).
Owen, S., Amjadi, P., Green, P., Foey, A.D. and Brennan, F.M. (2003): Bystander activated lymphocytes in inflammation: a natural process? Eur. Cyt. Netw. 14:60. Immunology 110: 113 (suppl. 1) and Rheumatology 43(S2):28 (2004).
Feldmann, M., Foey, A.D., Andreakos, E., Bondeson, J., Horwood, N., Foxwell, B.M.J. and Brennan, F.M. (2002): TNFα regulation in rheumatoid arthritis. J. Interfer. Cyt. Res. 22(S1):S40.
Foey, A.D., Feldmann, M. and Brennan, F.M. (2000): Ligation of macrophage CD40 induces the anti-inflammatory cytokines IL-10 and sTNF-Rp75: priming determines cytokine profile and dependence on endogenous/exogenous cytokines. Minerva Biotecnologica J. Biotech. Mol. Biol. 12: 141.
Foey, A.D., Feldmann, M. and Brennan, F.M. (1999): The cognate interaction of CD40L with CD40 on macrophages mediates interleukin-10 expression: Cytokine profile is determined by differentiation status. Genes and Immunity 1: 75.
Foey, A.D., Williams, L.M., Parry, S.L., Feldmann, M., Foxwell, B.M.J. and Brennan, F.M. (1997): Differential regulation of LPS induced IL-10 by the p38 and p42/44 MAP kinase pathways in peripheral blood monocytes. Immunology 92 (S1): 64.
Foey, A.D., Crawford, A. and Hall, N.D. (1996): Dysfunctional Na/K-ATPase activity in rheumatoid synovial lining cells results in a defect in Fas-mediated apoptosis. Arthritis and Rheumatism 39: 132.
Foey, A.D., Clay, K., Crawford, A. and Hall, N.D. (1995): Ouabain inhibition of the Na/K-ATPase induces pro-inflammatory cytokine expression in PBMCs and synovial fibroblast cells. Arthritis and Rheumatism 38: 94.
Foey, A.D., Clay, K. and Hall, N.D. (1994): Impaired Na/K-ATPase activity in rheumatoid mononuclear cells (MNCs) influences pro-inflammatory cytokine expression. Arthritis and Rheumatism 37:385.
Clay, K., Foey, A.D. and Hall, N.D. (1994): The expression of oestrogen receptor and p29 antigen in rheumatoid arthritis. Arthritis and Rheumatism 37:314.
Foey, A.D., Clay, K., Crawford, A. and Hall, N.D. (1994): Abnormal [Na+]I fluxes influence the expression of pro-inflammatory cytokines in RA. Immunology (op20).
Unpublished abstracts / conference procedings
Stern, H., Bruce, L., Jeremy, K. and Foey, A. (2019): SIRPa-CD47 ligation negatively regulates TLR-mediated TNFa production in macrophage subsets. BSI Inflammation Affinity Group & Edinburgh Immunology Group Conference. Inflammation: From Initiation to Restoration. 24th-26th April, Edinburgh, UK.
Zaric, S., Strachan, A., Harrington, Z., McIlwaine, C., Jerreat, M., Kilar, A., Belfield, L., Jackson, S., Foey, A. (2018): Specificity of innate immune responses to LPS in the oral mucosa - clinical consequences. Toll 2018: Editing Innate Immunity, 6th-9th June, Porto, Portugal.
Strachan, A., Harrington, Z., McIlwaine, C., Jerreat, M., Kilar, A., Jackson, S., Foey, A., Zaric, S. (2017): Development and evaluation of a novel, lipid-A based biosensor for personalised and predictive periodontal therapy. BSODR Annual Meeting, 6th-8th September, Plymouth, UK.
Khorsandi, A., Strachan, A., Harrington, Z., McIlwaine, C., Jerreat, M., Kilar, A., Jackson, S., Foey, A., Fox, S., Zaric, S. (2017): Monitoring salivary LPS activity for preventative, participatory, point-of-care periodontal therapy. BSODR Annual Meeting, 6th-8th September, Plymouth, UK.
Durante, B., Upton, M. & Foey, A.D. (2016): Antimicrobial peptides differentially modulate macrophage subset effector responses. Innate Immunity Symposium. BSI & NVVI Joint Conference, 6th-9th December, Liverpool, UK.
Al-Shaghdali, K., Hayward, C., Beal, J. & Foey, A.D. (2016): Endotoxin tolerisation differentially modulates macrophage cytokine production and IRAK-M expression in a subset-dependent manner. Innate Immunity Symposium. BSI & NVVI Joint Conference, 6th-9th December, Liverpool, UK.
Strachan, A., Jackson, S.J., Foey, A.D. & Zaric, S. (2016): Porphyromonas gingivalis lipopolysaccharide isoforms differentially modulate cytokine secretion and tolerisation responses in M1 and M2 macrophages. Innate Immunity Symposium. BSI & NVVI Joint Conference, 6th-9th December, Liverpool, UK.
Al-Abdulwahid, L.S., Beal, J. & Foey, A.D. (2016): Live probiotics activate cytokine production in the presence or absence of E.coli strain K12 lipopolysaccharide. Innate Immunity Symposium. BSI & NVVI Joint Conference, 6th-9th December, Liverpool, UK.
Waring, O., Foey, A.D., Jeremy, K. (2016): A proteomic profile of M1 and M2 polarised macrophages differentiated from the THP-1 cell line. Innate Immunity Symposium. BSI & NVVI Joint Conference, 6th-9th December, Liverpool, UK.
Al-Shaghdali, K., Hayward, C., Beal, J. and Foey, A. (2016): Negative regulatory molecules involved in endotoxin tolerance induced macrophage subsets. 9th Saudi Students' Conference, 13th-14th February, ICC Birmingham, UK.
Strachan, A.J., Jackson, S.K., Harrington, Z., McIlwaine, C., Foey, A.D. and Zaric, S. (2015): Porphyromonas gingivalis LPS isoforms initiate cytokine tolerisation responses in M1 and M2 macrophages. British Society for Oral and Dental Research 2015, Cardiff, UK.
Strachan, A., Foey, A., Harrington, Z., McIlwaine, C., Jerreat, M., Belfield, L., Coulter, W. and Zaric, S. (2015): Subgingival LPS isoforms in patients with chronic periodontitis. PgLondon2015 2nd International Conference on Porphyromonas Gingivalis & Related Species in Oral Diseases, London, UK.
Al-Shaghdali, K., Hayward, C., Beal, J. and Foey, A. (2014): Macrophage subsets exhibit selective endotoxin tolerance induced by Escherichia coli LPS. 9th European Mucosal Immunology Group (EMIG) Meeting, 9th-12th October, Glasgow, UK.
Strachan, A.J., Foey, A.D., Jackson, S.K. and Zaric, S. (2014): Macrophage response to lipopolysaccharide isoforms isolated from the periodontal pathogen Porphyromonas gingivalis. PUPSMD Annual Graduate Research Event, St Mellion, Cornwall.
Al-Shabany, A., Moody, A.J., Foey, A. and Billington, R. (2013): NAD levels in pro- and anti-inflammatory macrophages. Centre for Research in Translatable Biomedicine, Plymouth, 4th July.
Habil, N., Beal, J. and Foey, A. (2013): Lactic acid bacteria selectively modulate the endogenous cytokine activity regulating TLR expression induced by TNFα and IL-1β in epithelial cells. Society for Applied Microbiology Summer conference, Cardiff, 1st-4th July.
Standen, B., Rawling, M.D., Davies, S.J., Castex, M., Foey, A., Gioacchini, G., Carnevali, O. and Merrifield, D.L. (2012): Dietary probiotic Pediococcus acidilactici stimulates localised intestinal immunity in tilapia (Oreochronis niloticus). Probiotic and prebiotic immunomodulators in medical, vetinary and aquaculture sciences: the future. NEMO Conference, Keele University, 10th-11th Sept.
Sattar, A., Habil, N., Jackson, S., Foey, A. and Bradley, G. (2012): Endotoxin activity of Bacteroides lipopolysaccharides from contaminated marine bathing waters. American Society for Microbiology, Annual Conference, San Francisco, USA, 18th-22nd June.
Habil, N., Beal, J. and Foey, A. (2011): Probiotic bacterial species selectively modulate gut epithelial cell expression of beta defensin 2. International Probiotic Conference, Slovakia, 13th - 15th June.
Belfield, L., Bennett, J., Crean, S-J. and Foey, A. (2010): Macrophage subset cytokine responses to the oral pathogen genus Prevotella. International Association of Dental Research, Barcelona, Spain, 14th - 17th July.
Merry, R., Bennett, J., Crean, S-J. and Foey, A. (2010): Differential sensitivity of macrophage subsets to anti-inflammatory cytokines in periodontitis. International Association of Dental Research, Barcelona, Spain, 14th - 17th July.
Foey, A. and Crean, S-J. (2010): Differential suppression of macrophage subsets by Porphyromonas gingivalis. International Association of Dental Research, Barcelona, Spain, 14th - 17th July.
Habil, N., Beal, J. and Foey, A. (2010): The immunomodulatory effects of Lactobacillus casei strain Shirota on monocyte, M1- and M2-macrophage cytokine production. International Probiotic Conference, Slovakia, 15th - 17th June.
Merry, R., Hanemann, O., Bennett, J. and Foey, A. (2010): The role of tumour associated macrophages in driving oral squamous cell carcinoma. PCMD Annual Graduate School Research Event, Torquay, UK, 11th-12th March.
Belfield, L., Foey, A. and Crean, S-J. (2009): Differential effector responses of macrophage subsets to Porphyromonas gingivalis. British Society for Dental Research, Glasgow, UK, Sept.
Foey, A. (2007): Macrophage phenotype, the key to the gu mucosal immune system NOD-ing off to commensal bacteria. International Yakult Symposium, Verona, Italy, 21st-24th November.
Foey, A. (2007): Butyrate differentially regulates macrophage inflammatory responses to bacterial stimulation: a cautionary tale for probiotic development. International Yakult Symposium, Verona, Italy, 21st-24th November.
Foey, A.D., Clay, K., Crawford, A. and Hall, N.D. (1994): Aberrant cytokine production by rheumatoid mononuclear cells may result from impaired sodium pump activity. British Society for Rheumatology, Heberden Round - Prof. P.J. Maddison, Bath, 22nd-23rd September 1994.
Foey, A.D., Clay, K., Crawford, A. and Hall, N.D. (1994): Impaired sodium pump activity on rheumatoid mononuclear cells can modulate inflammatory cytokine production. Inflammation and Rheumatology Association.
Reports & invited lectures
"Macrophages: masters of homeostasis pathology in Crohn's Disease." Gastroenterology Forum, 10th July 2018, Gastroenterology Department, Derriford Hospital, Plymouth, UK.
"Oral LPS: Macrophage subsets are differentially sensitive to endotoxin tolerance." BSODR Annual Meeting, 6th-8th September 2017, Plymouth, UK.
"Macrophages: immune activation vs immune suppression in response to P.gingivalis." Annual Research Conference, Centre for Biomedical Research, Plymouth, 3rd September 2015.
"Epithelial cell production of beta-defensin-2: the inter-relationship between probiotic bacteria and inflammatory cytokines." International Probiotic Conference, Budapest, 25th June 2015.
"Mmmmmm! Lumenal tasting and antigen presentation." Immunology Master Class Workshop. International Probiotic Conference, Budapest, 22nd June 2015.
"Mucosal Immunology - from outside to inside." Immunology Master Class Workshop. International Probiotic Conference, Budapest, 22nd June 2015.
"Modulation of macrophage-epithelial cell co-cultures by Lactobacillus casei strain Shirota: effect on inflammatory cytokines, barrier integrity and bacterial sensing." International Probiotic Conference, Budapest, 26th June 2014.
"Macrophages: the Jekyll and Hyde of inflammation." PUPSMD School Seminar Series, Plymouth, 5th February 2014.
"Probiotic modulation of macrophage responses: relevance to mucosal immunity." Keynote Speaker at Probiotic and prebiotic immunomodulation in medical, vetinary and aquaculture sciences: the future. NEMO Conference, Keele University, Keele, 10th September 2012.
"Differential suppression of macrophage subsets by Porphyromonas gingivalis." International Association of Dental Research, Annual Meeting, Barcelona, 14th July 2010.
"Oral mucosal immune dysfunction in RAS and OSCC: the macrophages are key!" Orthognathic Surgery, South West Regional Study Day, Lyngford House, Taunton, Somerset, 14th December 2009.
"Macrophage effector phenotypes: the cellular switch in inflammatory fate!" Faculty of Science Seminar Series, University of the West of England, Bristol, 25th March 2009.
"Macrophage effector phenotypes: priming, activation & apoptosis - the fine balance between tolerance & inflammatory immunopathology." POSReF, Institute of Biomedical & Clinical Science, University of Exeter, Ashburton, 25th June 2008.
"Nutritional modulation of innate immunity: macrophage effector functions - the switch between tolerance an immunopathology." Food Biosciences Research Seminar, University of Reading, 10th October 2007.
“Endogenous calcium microparticles: Immunomodulators of innate immunity.” Endogenous microparticles: Form and function, Cambridge , 14th March 2005 .
“Distinct macrophage populations display differential effector responses upon TLR ligation.” British Society for Immunology Annual Meeting, Harrogate, 7th December 2004.
“Pro-inflammatory macrophages: partial differentiation or preferential pathway?” International Cytokine Society Annual Meeting, Trinity College, Dublin, 22nd September 2003.
“T cell/macrophage contact and macrophage differentiation regulate cytokine expression in chronic inflammation.” Rheumatology Seminar Series, School of Clinical Medical Sciences, University of Newcastle, 7th July 2003.
“Cytokine regulation in chronic inflammation: role of T cell/macrophage contact-dependent interactions and mechanism of macrophage differentiation.” Infection and Immunity Seminar Series, Institute of Child Health, UCL, London, 10th June 2003.
"Macrophage differentiation and cytokine regulation." Joint presentation with Prof. Fionula Brennan. Cytokines and Vascular Biology Meeting, Kennedy Institute of Rheumatology, London, 9th December 2002.
“ Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions.” Prof. Siamon Gordon Laboratory, Sir William Dunn School of Pathology, University of Oxford, 1st November 2002.
“ Cytokine-stimulated T cells induce IL-10 production by M-CSF-primed monocytes in a PI3K-dependent manner similar to that of RA-SMCs.” 3rd International IL-10 Workshop on IL-10, Berlin, 4th-7th April 2001.
“CD40 ligation induces macrophage IL-10 production.” Cell Contact Interactions in Rheumatology meeting, Kennedy Institute of Rheumatology, London, 1st-2nd June 2000.
“The cognate interaction of CD40L with CD40 on macrophages mediates interleukin-10 expression: Cytokine profile is determined by differentiation status.” 2nd International IL-10 Workshop, Milan, Italy, 27th-29th May 1999.
“Role played by cognate interaction between T cells and macrophages in the production of macrophage IL-10.” The Anthony Nolan Research Institute, Royal Free Hospital, London, March 1999.
"Control of expression of monocyte Interleukin-10: Role of the MAP-kinases and cognate cellular interactions." Royal National Hospital for Rheumatic Diseases and the University of Bath, Bath, March 1998.
“Role of p38 and p42/44 MAP kinase pathways in the regulation of LPS-induced IL-10 by peripheral blood monocytes.” 1st International IL-10 Workshop. Strathclyde University, Glasgow, 10th-13th September, 1997.
"Cation control of cytokine expression and effects on Fas-mediated apoptosis within the rheumatoid synovium." Department of Microbiology and Immunology, Leicester University, June 1996.
"Regulation of pro-inflammatory cytokine expression by an impairment in function of the sodium pump in cells of the rheumatoid synovial lining layer." British Society for Rheumatology, Brighton, May 1996.
Other academic activities
Commisioned to write a book on "Nutritional Immunology." To be published in 2015. Wiley - Blackwell publishing, UK.
MPhil - PhD Conversion Internal examiner:
Oct 2015 "Evaluation of phytoestrogens on PC3 and MCF-7 cell viability and motility." Safaa Salman Mezban
School of Biomedical & Healthcare Sciences, University of Plymouth.
Oct 2016 "Innate immune responses in a new model of alveolar macrophages to infection with influenza virus." Conor Wood. School of Biomedical & Healthcare Sciences, University of Plymouth.
MPhil - PhD Conversion External examiner:
June 2009 "Structural and functional studies of the peroxiredoxin-sulfiredoxin enzyme system: do inhibitors of this system induce apoptosis in inflammatory cells?" Katarine Szabo
Inflammation & Musculoskeletal Diseases Research Group, University of Exeter.
Sept. 2009 "The effects of hyperbaric oxygen on the mechanisms of antibiotic resistance in chronic wound bacteria." Lindsey Glew. School of Biological Sciences and The Hyperbaric Medical Centre, University of Plymouth.
Jan. 2014 "PAMP-induce signalling in mammalian trigeminal neurons: consequences for oral infection and mechanisms of chronic orofacial pain." Martin Helley
Plymouth University Peninsula Schools of Medicine & Dentistry, University of Plymouth.
PhD External examiner:
Nov. 2012 "Influence of ageing on immune responses to selected probiotics." Jialu You
Food & Nutritional Sciences, University of Reading.
PhD Internal examiner:
Feb. 2018 "The effects of phytoestrogens on preferential metastasis to bone." Safaa Mezban.
Sept. 2015 "The biology of mantle cell lymphoma: exploring the gender difference in mantle cell lymphoma." Dr Nimish Shah. PUPSMD, Derriford Hospital.
Journals: Past & Present: Biochemical Pharmacology
Annals of the Rheumatic Diseases
Journal of Gene Medicine
Journal of Gene Medicine
Genes and Immunity
Scandinavian Journal of Rheumatology
European Journal of Immunology
Journal of Rheumatology/Rheumatology
Clinical and Experimental Immunology
Infection & Immunity
Clinical & Vaccine Immunology
Granting Agencies: Review applications to the Hong Kong Research Grants Council Universities Grants Committee, Biology and Medicine Panel; MRC and BBSRC. Research project reviewer for Asthma UK.
Current Editor: Editorial Board Member (elected Sept. 2013) for ISRN Immunology, Hindawi Publishing Corporation.
Editorial Board Member (elected Aug. 2015) Journal - Immunotherapy: Open Access.
University of Plymouth On-line training:
- Recruitment & Selection. Certificate 04/10/10.
- Health & Safety E-learning. Certificate 13/05/12.
- Diversity in the workplace. Certificate 06/01/15.
- Unconscious Bias. Certificate January 2017.
University of Plymouth Training Courses:
- Supervising Postgraduate Research Students. Prof Mick Fuller 14/06/06.
- Role of the Internal Examiner. Prof Mick Fuller 2012.
- Safe Handling of Cryogenic Liquids. JHW Associates Health & Safety Consultancy & Training 12/07/06.
MRC Career Development Fellowship training:
- Supervising PhD students. Cambridge 26/05/04.
- Writing Project Proposals. Dr Philip Hills, Addenbrooke's Hospital, Cambridge 09/06/04.
- Career Development Fellowship Induction. Patrick Moriarty, Cambridge 26/10/04.