Dr Alexander Besinis
Profiles

Dr Alexander Besinis

Lecturer in Mechanical Engineering

School of Engineering

Qualifications

2006- 2010:  PhD in Biomaterials, The University of Sheffield

2005-2006:   MSc in Medical Engineering, The University of Liverpool

2001-2005: BSc (Hons) in Biomedical Technology Engineering (First Class), Athens University of Applied Sciences

Professional membership

Fellow of the Higher Education Academy   

Member of United Kingdom Society for Biomaterials 

Member of International Association for Dental Research

Member of the British Society for Oral and Dental Research 

Research interests

My research interests focus on advanced engineering materials and the use of nanotechnology to build novel composites, biomaterials and implants with improved mechanical and physical properties.

 

Key areas of interest are:

 

  •  Synthesis and advanced material characterisation of novel nanoparticles.
  •  Investigation of the mechanical and physical properties of metals, ceramics, elastomers and composite materials.
  •  Recovery of the micromechanical properties of demineralised bone and teeth following infiltration with engineered nanomaterials.
  •  Remineralisation of bone and teeth using colloidal nanosolutions.
  •  Application of nanocoatings to titanium alloy medical implants to improve biocompatibility and osseointegration.
  •  Use of nanotechnology with oral tissues, implants, maxillofacial prostheses and medical devices to inhibit biofilm formation and achieve infection control. 
  •  Evaluation of the antibacterial effect of nanomaterials against pathogenic bacteria and fungi.
  •  Investigation of nanomaterials behaviour in complex biological media (blood, urine, oral saliva).
  •  Use of single atomic layer of graphite (graphene) in medical applications.

1. Besinis A, Hadi SD, Le HR, Tredwin C, Handy RD. Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings. Nanotoxicology. 2017;3:327-338.  

2.  Besinis A , van Noort R, Martin N. The use of acetone to enhance the infiltration of HA nanoparticles into a demineralized dentin collagen matrix. Dental Materials. 2016;32:385-393.

3. Vassallo J, Besinis A, Boden R, Handy RD. Evaluation of the minimum inhibition concentration (MIC) assay for environmental assessment of nanomaterials. Toxicology Letters. 2016;258:265-266.

4.  Besinis A , De Peralta T, Tredwin CJ, Handy RD. Review of nanomaterials in dentistry: Interactions with the oral microenvironment, clinical applications, hazards and benefits. ACS Nano. 2015;9:2255-2289.

5. Besinis A, Hadi S, Le H, Tredwin C, Handy R. Bacterial toxicity comparison between silver, titanium dioxide and hydroxyapatite nanoparticles.  Journal of Dental Research.  2015;94 (Spec Iss B):58

6. Salaie RN, Besinis A, Le H, Tredwin C, Handy R. Biocompatibility of surface-modified titanium implants with silver and hydroxyapatite nanoparticles.  Journal of Dental Research.  2015;94 (Spec Iss B):66

7.  Besinis A , Fleck O, Handy R. Effect of TiO2 nanoparticles on the mechanical properties of demineralised dentine. Journal of Dental Research. 2015;94 (Spec Iss A):3592    

8.  Besinis A , van Noort R, Martin N. Remineralization potential of fully demineralized dentin infiltrated with silica and hydroxyapatite nanoparticles. Dental Materials. 2014;30:249-262.
 
9.  Besinis A , De Peralta T, Handy R. Inhibition of biofilm formation and antibacterial properties of a silver nano-coating on human dentine. Nanotoxicology. 2014;8:745-754.
 
10.  Besinis A , De Peralta T, Handy R. The antibacterial effects of Ag, TiO2 and SiO2 nanoparticles compared to the dental disinfectant chlorhexidine on Streptococcus mutans using a suite of bioassays. Nanotoxicology. 2014;8:1-16.

11. Besinis A , Meran Z, De Peralta T, Handy R. Antifungal properties and biocompatibility of nano-silver coatings on maxillofacial prosthetics. Journal of Dental Research. 2014;93(Spec Iss B):304  

12. Besinis A , De Peralta T, Handy R. Antibacterial and anti-biofilm activity of a silver nanoparticles dentin coating. Journal of Dental Research. 2013;92 (Spec IssA):1646         

13.  Besinis A , van Noort R, Martin N. Infiltration of demineralized dentin with silica and hydroxyapatite nanoparticles. Dental Materials. 2012;28:1012-1023.

14. Besinis A , De Peralta T, Handy R. Comparative efficacy of nanoparticulate and non-nanoparticulate agents against cariogenic bacteria. Journal of Dental Research. 2011;90 (Spec Iss B):312          

15. Besinis A , De Peralta T, Handy R. Use of nanoparticles as antimicrobials in dentistry: A pilot study. Journal of Dental Research. 2011;90 (Spec Iss B):124

16. Besinis A , van Noort R, Martin N. Dentine infiltration with nanoparticles to promote remineralisation. Journal of Dental Research. 2009;88 (Spec Iss B):24

17. Besinis A , van Noort R, Martin N. Infiltration of demineralised bovine dentine with nano-particulate solutions. Journal of Dental Research. 2009;88 (Spec Iss A):2111

18. Besinis A , van Noort R, Martin N. Production and characterisation of nanoparticulate calcium hydroxyapatite. Tissue Engineering Part A. 2009;15(5):1-29

19. Besinis A , van Noort R, Martin N. Production and characterisation of sol-gel hydroxyapatite nanoparticles. Journal of Dental Research. 2008;87 (Spec Iss C):276