Dr Adam Streeter
Profiles

Dr Adam Streeter

Research Fellow in Medical Statistics

Peninsula Medical School (Faculty of Health)

Biography

Biography

Research Fellow in the Medical Statistics group at the Peninsula Medical School.

Chief Investigator on the STOPFlu project: Statin Treatment OPtions during vaccination against inFluenza: an observational study of the interaction between statins and influenza vaccination.

I have a background in clinical trials and observational studies, with a special interest in utilising health records and registry data for research. While clinical trials remain the gold standard for evidence, patient health records can provide valuable insight into drug safety, advancing future therapies and ensuring existing therapies deliver optimal benefit to the patient. They may also help to make clinical trials more efficient, potentially reducing the number of patients needed for recruitment to, often costly, clinical trials.

The STOPFlu study, which I am leading in collaboration with colleagues at Exeter University, is one such study based on health registry data, from the Clinical Practice Research Datalink. The health records have been pseudonymised (i.e. records stripped of any identifiable information and assigned a non-identifiable number), and linkage provided between primary care and hospital records. Current research suggests statins and the flu vaccine may have health benefits beyond their intended purpose. The study will look at the interaction between statins and the flu vaccine, and how the benefits from both therapies can be maximised.

I am also working with the Cure Parkinson’s Disease Trust and colleagues on a novel, drug-repurposing study for treating Parkinson’s disease.

I also contribute statistical support to the ENRICH oncology trial of drug ibrutinib against Mantle-cell lymphoma and have supported the ongoing RAW (resection after Whipple) study, as well as the recently concluded TARS, quite-smoking study and e-CoachER, exercise-referral study.

Past research projects have included the Health Lifestyles Programme (HeLP – cluster RCT in schools) and the EarlyBird cohort study.

 

I supervise two statistical PhD projects, one researching compositional data analysis and one researching Bayesian cluster-RCTs, and one MD (RAW study).

Qualifications

PhD Medical Sciences (Statistics) - University of Exeter

MSc Applied Statistics - Sheffield Hallam University

Professional membership

Associate Fellow of the Higher Education Academy

Roles on external bodies

I am currently a Biostatistician at the Universitätsklinikum Münster, Germany. I retain a funded contract with the University of Plymouth for leading the STOPFlu project.

Key publications

Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
View all publications
Teaching

Teaching

Teaching interests

I teach the Evidence-Based Medicine module to Bachelor of Medicine / Bachelor of Surgery undergraduates. I have also designed and created innovative on-line vidcasts, for which I have co-led the development of a simulation programme to illustrate the statistics of diagnostic studies.

I am also a tutor for postgraduate research students, providing statistical support for their dissertation projects in the Faculty of Health.

Research

Research

Research interests

I have ongoing interests in both studies using Real-World Data, specifically health registries, and Clinical Trials. My trial experience covers early to main phase (phase 0 and pharmacodynamic to III), both pharmaceutical and behavioural.

Other research

NIHR - School of Public Health Research funded research into health care quality in later life (specifically using electronic health records)

Grants & contracts

NIHR Research for Patient Benefit grant: the STOPFlu study

Publications

Publications

Key publications

Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI

Key publications are highlighted

Journals
Articles
MacCormick A, Puckett M, Streeter A & Aroori S (2021) 'The impact of myosteatosis on outcomes following surgery for gastro-intestinal malignancy: A systematic review and meta-analysis' Journal of Clinical Oncology 39, (15_suppl) e15540-e15540 , DOI
Timme M, Borkert J, Nagelmann N, Streeter A, Karch A & Schmeling A (2021) 'Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging' International Journal of Legal Medicine 135, (4) 1599-1609 , DOI
Tomlinson DR, Biscombe K, True J, Hosking J & Streeter AJ (2021) 'Identification of deliberate catheter motion at the left atrial posterior wall during pulmonary vein isolation: Validity of respiratory motion adjustment' Journal of Cardiovascular Electrophysiology 32, (4) 994-1004 , DOI Open access
Rodgers LR, Streeter AJ, Lin N, Hamilton W & Henley WE (2021) 'Impact of influenza vaccination on amoxicillin prescriptions in older adults: A retrospective cohort study using primary care data' PLoS One 16, (1) , DOI Open access
Taylor A, Thompson TP, Ussher M, Aveyard P, Murray RL, Harris T, Creanor S, Green C, Streeter AJ & Chynoweth J (2020) 'Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study' BMJ OPEN 10, (12) Author Site Publisher Site , DOI Open access
Taylor A, Taylor RS, Ingram W, Dean SG, Jolly K, Mutrie N, Lambert J, Yardley L, Streeter A & Greaves C (2020) 'Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic health conditions: the e-coachER trial' Br J Sports Med Author Site Publisher Site Open access
Taylor AH, Taylor RS, Ingram WM, Anokye N, Dean S, Jolly K, Mutrie N, Lambert J, Yardley L & Greaves C (2020) 'Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT' Health Technology Assessment 24, (63) 1-106 , DOI Open access
Tan HK, Streeter A, Cramp ME & Dhanda AD (2020) 'Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis' World Journal of Hepatology 12, (7) 389-398 , DOI Open access
Mullin S, Smith L, Lee K, D’Souza G, Woodgate P, Elflein J, Hällqvist J, Toffoli M, Streeter A & Hosking J (2020) 'Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations' JAMA Neurology , DOI Open access
Tomlinson DR, Myles M, Stevens KN & Streeter A (2019) 'Transmural unipolar electrogram change occurs within 7s at the left atrial posterior wall during pulmonary vein isolation' Pacing and Clinical Electrophysiology , DOI Open access
Hanemann CO, Ammoun S, Evans G, Hilton DA, Streeter A & Hayward C (2019) 'Phase 0 trial investigating the intra-tumoural concentration and activity of Sorafenib in Neurofibromatosis type 2' Journal of Neurology, Neurosurgery and Psychiatry , DOI Open access
Wyatt K, LLoyd J, Creanor ES, Green C, Dean SG, Hillsdon M, Abraham C, Tomlinson R, Pearson V & Taylor RS (2018) 'Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost-effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children' Public Health Resarch 6, (1) Open access
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
(2015) 'Corrigenda' The Journal of Clinical Endocrinology & Metabolism 100, (2) 763-763 , DOI
Jeffery A, Streeter AJ, Hosking J, Wilkin TJ & Nelson SM (2015) 'Anti-Müllerian hormone in children: a ten-year prospective longitudinal study (EarlyBird 39)' Journal of Pediatric Endocrinology and Metabolism 28, (9-10) , DOI
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ (2014) 'Divergence between HbA1c and fasting glucose through childhood: implications for diagnosis of impaired fasting glucose ( EarlyBird 52)' PEDIATRIC DIABETES 15, (3) 214-219 Author Site , DOI
Streeter AJ, Hosking J, Metcalf BS, Jeffery AN, Voss LD & Wilkin TJ (2013) 'Body fat in children does not adversely influence bone development: a 7-year longitudinal study (EarlyBird 18)' Pediatr Obes 8, (6) 418-427 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ (2013) 'Evidence of early beta-cell deficiency among children who show impaired fasting glucose: 10-yr cohort study (EarlyBird 56)' Pediatr Diabetes 14, (7) 481-489 Author Site , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ (2012) 'Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536-541' Diabetes Care 35, (9) e69-e69 , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ (2012) 'Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)' Diabetes Care 35, (3) 536-541 Author Site , DOI Open access
Conference Papers
Taylor A, Streeter A, Thompson T, Creanor S, Ingram W, Aveyard P, Ussher M, Harris T, Murray R & Greaves C (2021) 'A multi-centre Trial of physical Activity assisted Reduction of Smoking (TARS): Baseline characteristics, and health trainer led intervention engagement' S176-S176
Taylor A, Streeter A, Ingram W, Lambert J, Dean S, Taylor R, Jolly K, Mutrie N & Greaves C (2021) 'The mediating effects of theory linked process measures on 12 month accelerometer recorded physical activity within the e-coacher RCT involving primary care exercise referral participants' S177-S178
Streeter AJ & Henley WE (2018) 'Evidence from a quasi-experimental study for the effectiveness of the influenza vaccination against myocardial infarction in UK adults aged at least 65 y' 13-13 Open access
Henley WE & Streeter AJ (2018) 'Real-world effectiveness of influenza vaccination in older adults in the UK from 1997-2012: A quasi-experimental cohort study' 13-14 Open access
Mostazir MBA, Metcalf BS, Hosking J, Streeter AJ, Jeffery AN, Voss LD & Wilkin TJ (2011) 'Children of higher income families eat 'better' and are taller, but they are metabolically less healthy' S354-S354
Hosking J, Metcalf BS, Streeter AJ, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ (2011) 'HbA(1c) does not detect glucose impairment in youth' S351-S351
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Mostazir MBA, Voss LD & Wilkin TJ (2011) 'Insulin resistance rises from mid-childhood, before the onset of puberty: longitudinal data from The EarlyBird Study' S350-S350
Streeter AJ, Hosking J, Metcalf BS, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ (2011) 'Obesity of the bone: the relationships between body mass, adiposity and bone density in children: a 7-year longitudinal study' S517-S518
Wilkin TJ, Jeffery AN, Metcalf BS, Hosking J, Fremeaux AE & Voss LD (2010) 'Insulin demand, beta cell response and glucose control among contemporary children - an eight-year longitudinal study'
Posters
Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE 'Pneumococcal Vaccine Effectiveness and Its Interaction With Age: A UK Population Based Study in Older Adults' Author Site Open access
Jones BG, Streeter AJ, Baker A, Moyeed R & Creanor S Jones BG, Streeter AJ, Baker A, Moyeed R & Creanor S 'Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review' , DOI Open access