Dr Adam Streeter
Profiles

Dr Adam Streeter

Visiting Research Fellow

Peninsula Medical School (Faculty of Health)

Dr Adam Streeter can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
  • Applied statistics
  • Before-and-after studies
  • Big Data
  • Case–control studies
  • Clinical trials
  • Cohort studies
  • Cross-sectional studies
  • Epidemiology
  • Experimental methods
  • Longitudinal research
  • Meta-analysis
  • Observational methods
Biography

Biography

Research Fellow in the Medical Statistics group at the Peninsula Medical School.

Chief Investigator on the STOPFlu project: Statin Treatment OPtions during vaccination against inFluenza: an observational study of the interaction between statins and influenza vaccination.

I have a background in clinical trials and observational studies, with a special interest in utilising health records and registry data for research. While clinical trials remain the gold standard for evidence, patient health records can provide valuable insight into drug safety, advancing future therapies and ensuring existing therapies deliver optimal benefit to the patient. They may also help to make clinical trials more efficient, potentially reducing the number of patients needed for recruitment to, often costly, clinical trials.

The STOPFlu study, which I am leading in collaboration with colleagues at Exeter University, is one such study based on health registry data, from the Clinical Practice Research Datalink. The health records have been pseudonymised (i.e. records stripped of any identifiable information and assigned a non-identifiable number), and linkage provided between primary care and hospital records. Current research suggests statins and the flu vaccine may have health benefits beyond their intended purpose. The study will look at the interaction between statins and the flu vaccine, and how the benefits from both therapies can be maximised.

I am also working with the Cure Parkinson’s Disease Trust and colleagues on a novel, drug-repurposing study for treating Parkinson’s disease.

I also contribute statistical support to the ENRICH oncology trial of drug ibrutinib against Mantle-cell lymphoma and have supported the ongoing RAW (resection after Whipple) study, as well as the recently concluded TARS, quit-smoking study and e-CoachER, exercise-referral study.

Past research projects include the Health Lifestyles Programme (HeLP – cluster RCT in schools) and the EarlyBird cohort study.

 

I supervise two statistical PhD projects, one researching compositional data analysis and one researching Bayesian cluster-RCTs, and two MD projects (RAW study).

Qualifications

PhD Medical Sciences (Statistics) - University of Exeter

MSc Applied Statistics - Sheffield Hallam University

Professional membership

Associate Fellow of the Higher Education Academy

Roles on external bodies

I am currently a Biostatistician at the Universitätsklinikum Münster, Germany. I retain a funded contract with the University of Plymouth for leading the STOPFlu project.

Key publications

Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
View all publications
Teaching

Teaching

Teaching interests

I teach the Evidence-Based Medicine module to Bachelor of Medicine / Bachelor of Surgery undergraduates. I have also designed and created innovative on-line vidcasts, for which I have co-led the development of a simulation programme to illustrate the statistics of diagnostic studies.

I am also a tutor for postgraduate research students, providing statistical support for their dissertation projects in the Faculty of Health.

Research

Research

Research interests

I have ongoing interests in both studies using Real-World Data, specifically health registries, and Clinical Trials. My trial experience covers early to main phase (phase 0 and pharmacodynamic to III), both pharmaceutical and behavioural.

Other research

NIHR - School of Public Health Research funded research into health care quality in later life (specifically using electronic health records)

Grants & contracts

NIHR Research for Patient Benefit grant: the STOPFlu study

Publications

Publications

Key publications

Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access

Key publications are highlighted

Journals
Articles
Timme M, Viktorov J, Steffens L, Streeter A, Karch A & Schmeling A (2023) 'Dental age assessment in the living: a comparison of two common stage classifications for assessing radiographic visibility of the root canals in mandibular third molars' International Journal of Legal Medicine , DOI
Wulms N, Eppe S, Dehghan-Nayyeri M, Streeter AJ, Bonberg N, Berger K, Sundermann B & Minnerup H (2023) 'The R package for DICOM to brain imaging data structure conversion' Scientific Data 10, (1) , DOI
(2023) 'Abstracts of ICPE 2023, the 39th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE), Halifax, Canada, 25–27 August 2023' Pharmacoepidemiology and Drug Safety 32, (S1) 3-612 , DOI
Russell TB, Labib PL, Ausania F, Pando E, Roberts KJ, Kausar A, Mavroeidis VK, Marangoni G, Thomasset SC & Frampton AE (2023) 'Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple's (RAW) study' European Journal of Surgical Oncology 49, (9) 106919-106919 , DOI
Russell TB, Labib PL, Denson J, Ausania F, Pando E, Roberts KJ, Kausar A, Mavroeidis VK, Marangoni G & Thomasset SC (2023) 'Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study' HPB 25, (7) 788-797 , DOI
Lambert J, Taylor A, Streeter A, Greaves C, Ingram WM, Dean S, Jolly K, Mutrie N, Price L & Campbell J (2023) 'Adding web-based support to exercise referral schemes improves symptoms of depression in people with elevated depressive symptoms: A secondary analysis of the e-coachER randomised controlled trial' Mental Health and Physical Activity 25, , DOI Open access
Timme M, Viktorov J, Steffens L, Streeter A, Karch A & Schmeling A (2023) 'Third molar eruption in orthopantomograms as a feature for forensic age assessment—a comparison study of different classification systems' International Journal of Legal Medicine 137, (3) 765-772 , DOI
Taylor A (2023) 'Effectiveness and cost-effectiveness of behavioural support for prolonged abstinence for smokers wishing to reduce but not quit: Randomised controlled Trial of physical Activity assisted Reduction of Smoking (TARS)' Addiction , DOI Open access
MacCormick A, Streeter A, Puckett M & Aroori S (2023) 'The impact of myosteatosis on outcomes following surgery for gastrointestinal malignancy: a meta-analysis' The Annals of The Royal College of Surgeons of England 105, (3) 203-211 , DOI Open access
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S (2023) 'Can We Get Consensus on the Best Surgical Approach to Symptomatic Gallstones and Common Bile Duct Stones? Results from a Prospective Multi-centre UK Wide Study (P-ALICE)' HPB 25, S514-S514 , DOI
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S (2023) 'Laparoscopic Common Bile Duct Exploration: Results From a Prospective Multi-centre Prospective UK-wide Study (P-ALiCE)' HPB 25, S264-S265 , DOI
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S (2023) 'Outcomes of Laparoscopic Common Bile Duct Exploration: Results from a Multi-centre UK-wide Study (R-ALiCE)' HPB 25, S211-S211 , DOI
Streeter AJ, Rodgers LR, Masoli J, Lin NX, Blé A, Hamilton W & Henley WE (2022) 'Real-world effectiveness of pneumococcal vaccination in older adults: Cohort study using the UK Clinical Practice Research Datalink' PLoS ONE 17, (10) , DOI Open access
Lambert J, Taylor A, Streeter A, Greaves C, Ingram WM, Dean S, Jolly K, Mutrie N, Taylor RS & Yardley L (2022) 'A process evaluation, with mediation analysis, of a web-based intervention to augment primary care exercise referral schemes: the e-coachER randomised controlled trial' International Journal of Behavioral Nutrition and Physical Activity 19, (1) , DOI Open access
(2022) 'ABSTRACTS of ICPE 2022, the 38th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE), Copenhagen, Denmark, 26–28 August, 2022' Pharmacoepidemiology and Drug Safety 31, (S2) 3-628 , DOI
Elston J, Gradinger FP, Streeter AJ, Macey S & Martin S (2022) 'Effectiveness of a targeted telephone-based case management service on activity in an Emergency Department in the UK: a pragmatic difference-in-differences evaluation' BMC Health Services Research 22, (1) , DOI Open access
Streeter AJ, Rodgers LR, Hamilton F, Masoli JAH, Ble A, Hamilton WT & Henley WE (2022) 'Influenza vaccination reduced myocardial infarctions in UK older adults: a prior event rate ratio study' Journal of Clinical Epidemiology , DOI Open access
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S (2022) 'A UK survey on variation in the practice of management of choledocholithiasis and laparoscopic common bile duct exploration (ALiCE Survey)' Surgical Endoscopy 36, (8) 5882-5896 , DOI Open access
Timme M, Borkert J, Nagelmann N, Streeter A, Karch A & Schmeling A (2021) 'Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging' International Journal of Legal Medicine 135, (4) 1599-1609 , DOI
Streeter A, Baker A, Moyeed R & Creanor S (2021) 'Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review' Systematic Reviews , DOI Open access
Tomlinson DR, Biscombe K, True J, Hosking J & Streeter AJ (2021) 'Identification of deliberate catheter motion at the left atrial posterior wall during pulmonary vein isolation: Validity of respiratory motion adjustment' Journal of Cardiovascular Electrophysiology 32, (4) 994-1004 , DOI Open access
Rodgers LR, Streeter AJ, Lin N, Hamilton W & Henley WE (2021) 'Impact of influenza vaccination on amoxicillin prescriptions in older adults: A retrospective cohort study using primary care data' PLoS One 16, (1) , DOI Open access
Taylor A, Thompson TP, Ussher M, Aveyard P, Murray RL, Harris T, Creanor S, Green C, Streeter AJ & Chynoweth J (2020) 'Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study' BMJ OPEN 10, (12) Author Site Publisher Site , DOI Open access
Taylor A, Taylor RS, Ingram W, Dean SG, Jolly K, Mutrie N, Lambert J, Yardley L, Streeter A & Greaves C (2020) 'Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic health conditions: the e-coachER trial' Br J Sports Med Author Site Publisher Site Open access
Taylor AH, Taylor RS, Ingram WM, Anokye N, Dean S, Jolly K, Mutrie N, Lambert J, Yardley L & Greaves C (2020) 'Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT' Health Technology Assessment 24, (63) 1-106 , DOI Open access
Tan HK, Streeter A, Cramp ME & Dhanda AD (2020) 'Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis' World Journal of Hepatology 12, (7) 389-398 , DOI Open access
Tan HK, Streeter A, Cramp ME & Dhanda AD (2020) 'Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis' World Journal of Hepatology 12, (7) 390-399 , DOI Open access
Mullin S, Smith L, Lee K, D’Souza G, Woodgate P, Elflein J, Hällqvist J, Toffoli M, Streeter A & Hosking J (2020) 'Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations' JAMA Neurology , DOI Open access
Tomlinson DR, Myles M, Stevens KN & Streeter A (2019) 'Transmural unipolar electrogram change occurs within 7s at the left atrial posterior wall during pulmonary vein isolation' Pacing and Clinical Electrophysiology , DOI Open access
Hanemann CO, Ammoun S, Evans G, Hilton DA, Streeter A & Hayward C (2019) 'Phase 0 trial investigating the intra-tumoural concentration and activity of Sorafenib in Neurofibromatosis type 2' Journal of Neurology, Neurosurgery and Psychiatry , DOI Open access
Wyatt K, LLoyd J, Creanor ES, Green C, Dean SG, Hillsdon M, Abraham C, Tomlinson R, Pearson V & Taylor RS (2018) 'Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost-effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children' Public Health Resarch 6, (1) Open access
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS (2017) 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE (2017) 'Adjusting for unmeasured confounding in nonrandomized longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
(2015) 'Corrigenda' The Journal of Clinical Endocrinology & Metabolism 100, (2) 763-763 , DOI
Jeffery A, Streeter AJ, Hosking J, Wilkin TJ & Nelson SM (2015) 'Anti-Müllerian hormone in children: a ten-year prospective longitudinal study (EarlyBird 39)' Journal of Pediatric Endocrinology and Metabolism 28, (9-10) , DOI
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T (2014) 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ (2014) 'Divergence between HbA1c and fasting glucose through childhood: implications for diagnosis of impaired fasting glucose ( EarlyBird 52)' PEDIATRIC DIABETES 15, (3) 214-219 Author Site , DOI
Streeter AJ, Hosking J, Metcalf BS, Jeffery AN, Voss LD & Wilkin TJ (2013) 'Body fat in children does not adversely influence bone development: a 7-year longitudinal study (EarlyBird 18)' Pediatr Obes 8, (6) 418-427 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ (2013) 'Evidence of early beta-cell deficiency among children who show impaired fasting glucose: 10-yr cohort study (EarlyBird 56)' Pediatr Diabetes 14, (7) 481-489 Author Site , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ (2012) 'Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536–541' Diabetes Care 35, (9) e69-e69 , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ (2012) 'Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)' Diabetes Care 35, (3) 536-541 Author Site , DOI Open access
Conference Papers
Streeter AJ, Walker SJ, Rodgers L, Shelley A, Wellaway I, Hamilton F, Hamilton W & Henley W (2022) 'Assessing the effect of statin use on influenza vaccine effectiveness: A prior event rate ratio analysis in primary care data' 609-610
Streeter AJ & Henley WE (2018) 'Evidence from a quasi-experimental study for the effectiveness of the influenza vaccination against myocardial infarction in UK adults aged at least 65 y' 13-13 Open access
Henley WE & Streeter AJ (2018) 'Real-world effectiveness of influenza vaccination in older adults in the UK from 1997-2012: A quasi-experimental cohort study' 13-14 Open access
Mostazir MBA, Metcalf BS, Hosking J, Streeter AJ, Jeffery AN, Voss LD & Wilkin TJ (2011) 'Children of higher income families eat 'better' and are taller, but they are metabolically less healthy' S354-S354
Hosking J, Metcalf BS, Streeter AJ, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ (2011) 'HbA<sub>1c</sub> does not detect glucose impairment in youth' S351-S351
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Mostazir MBA, Voss LD & Wilkin TJ (2011) 'Insulin resistance rises from mid-childhood, before the onset of puberty: longitudinal data from The EarlyBird Study' S350-S350
Streeter AJ, Hosking J, Metcalf BS, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ (2011) 'Obesity of the bone: the relationships between body mass, adiposity and bone density in children: a 7-year longitudinal study' S517-S518
Wilkin TJ, Jeffery AN, Metcalf BS, Hosking J, Fremeaux AE & Voss LD (2010) 'Insulin demand, beta cell response and glucose control among contemporary children - an eight-year longitudinal study'
Reports
Taylor AH, Thompson TP, Streeter A, Chynoweth J, Snowsill T, Ingram W, Ussher M, Aveyard P, Murray RL & Harris T Motivational support intervention to reduce smoking and increase physical activity in smokers not ready to quit: the TARS RCT. National Institute for Health and Care Research , DOI Open access
Presentations and posters
Taylor A, Streeter A, Thompson T, Creanor S, Ingram W, Aveyard P, Ussher M, Harris T, Murray R & Greaves C Taylor A, Streeter A, Thompson T, Creanor S, Ingram W, Aveyard P, Ussher M, Harris T, Murray R & Greaves C 'A multi-centre Trial of physical Activity assisted Reduction of Smoking (TARS): Baseline characteristics, and health trainer led intervention engagement' Author Site Open access
Tanase A, Aroori S, Dhanda A, Cramp M & Streeter A Tanase A, Aroori S, Dhanda A, Cramp M & Streeter A 'A UK Survey on Variation in Practice of Management of Choledocholithiasis and Laparoscopic Common Bile Duct Exploration (ALiCE Survey)' , DOI
Tanase A, Aroori S, Dhanda A, Cramp M & Streeter A Tanase A, Aroori S, Dhanda A, Cramp M & Streeter A 'HPB O07 Complication profile of laparoscopic common bile duct exploration: Results from R-ALiCE Study' , DOI
Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE 'Pneumococcal Vaccine Effectiveness and Its Interaction With Age: A UK Population Based Study in Older Adults' Author Site Open access
MacCormick A, Puckett M, Streeter A & Aroori S MacCormick A, Puckett M, Streeter A & Aroori S 'The impact of myosteatosis on outcomes following surgery for gastro-intestinal malignancy: A systematic review and meta-analysis' , DOI
Taylor A, Streeter A, Ingram W, Lambert J, Dean S, Taylor R, Jolly K, Mutrie N & Greaves C Taylor A, Streeter A, Ingram W, Lambert J, Dean S, Taylor R, Jolly K, Mutrie N & Greaves C 'The mediating effects of theory linked process measures on 12 month accelerometer recorded physical activity within the e-coacher RCT involving primary care exercise referral participants' Author Site Open access
Jones BG, Streeter AJ, Baker A, Moyeed R & Creanor S Jones BG, Streeter AJ, Baker A, Moyeed R & Creanor S 'Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review' , DOI Open access
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S 'Trans-cystic versus Trans-choledochal Approach for Treating Common Bile Duct Stones: Which Approach Is Better? Results from R-ALICE Study' , DOI
Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S Tanase A, Dhanda A, Cramp M, Streeter A & Aroori S 'Variations in the Trans-choledochal Laparoscopic Bile Duct Exploration: Is this Time for Consensus Guidelines? Results from a Retrospective Multi-centre Study (R-ALICE)' , DOI