Dr Adam Streeter
Profiles

Dr Adam Streeter

Research Fellow in Medical Statistics

Peninsula Medical School (Faculty of Health)

Research Fellow in the Medical Statistics group at the Peninsula School of Medicine and Dentistry.

Chief Investigator on the STOPFlu project: Statin Treatment OPtions during vaccination against inFluenza: an observational study of the interaction between statins and influenza vaccination.

I have a background in clinical trials and observational studies, with a special interest in utilising health records and registry data for research. While clinical trials remain the gold standard for evidence, patient health records can provide valuable insight into drug safety, advancing future therapies and ensuring existing therapies deliver optimal benefit to the patient. They may also help to make clinical trials more efficient, potentially reducing the number of patients needed for recruitment to, often costly, clinical trials.

The STOPFlu study, which I am leading in collaboration with colleagues at Exeter University, is one such study based on health registry data, from the Clinical Practice Research Datalink. The health records have been pseudonymised (i.e. records stripped of any identifiable information and assigned a non-identifiable number), and linkage provided between primary care and hospital records. Current research suggests statins and the flu vaccine may have health benefits beyond their intended purpose. The study will look at the interaction between statins and the flu vaccine, and how the benefits from both therapies can be maximised.

I am also working with the Cure Parkinson’s Disease Trust and colleagues, Dr. Stephen Mullin (Plymouth University) and Professor Anthony Schapira (UCL) on a novel, drug-repurposing study for treating Parkinson’s disease.

I also contribute statistical support to the ENRICH oncology trial of drug ibrutinib against Mantle-cell lymphoma and have supported the ongoing RAW (resection after Whipple) study, as well as the recently concluded TARS, quite-smoking study and e-CoachER, exercise-referral study.

Past research projects have included the Health Lifestyles Programme (HeLP – cluster RCT in schools) and the EarlyBird cohort study.

 

I supervise two statistical PhD projects, one researching compositional data analysis and one researching Bayesian cluster-RCTs, and one MD (RAW study).

Qualifications

PhD Medical Sciences (Statistics) - University of Exeter

MSc Applied Statistics - Sheffield Hallam University

Professional membership

Associate Fellow of the Higher Education Academy

Roles on external bodies

I am currently a Biostatistician at the Universitätsklinikum Münster, Germany. I retain a funded contract with the University of Plymouth for leading the STOPFlu project.

Key publications

Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T 2014 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE 2017 'Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS 2017 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
View all publications

Teaching interests

I teach the Evidence-Based Medicine module to Bachelor of Medicine / Bachelor of Surgery undergraduates. I have also designed and created innovative on-line vidcasts, for which I have co-led the development of a simulation programme to illustrate the statistics of diagnostic studies.

I am also a tutor for postgraduate research students, providing statistical support for their dissertation projects in the Faculty of Health.

Research interests


I have ongoing interests in both studies using Real-World Data, specifically health registries, and Clinical Trials. My trial experience covers early to main phase (phase 0 and pharmacodynamic to III), both pharmaceutical and behavioural.

Other research

NIHR - School of Public Health Research funded research into health care quality in later life (specifically using electronic health records)

Grants & contracts

NIHR Research for Patient Benefit grant: the STOPFlu study

Key publications

Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T 2014 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE 2017 'Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS 2017 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access

Key publications are highlighted

Journals
Articles
Taylor A, Taylor RS, Ingram W, Dean SG, Jolly K, Mutrie N, Lambert J, Yardley L, Streeter A & Greaves C 2020 'Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic health conditions: the e-coachER trial' Br J Sports Med Author Site Publisher Site Open access
Taylor AH, Taylor RS, Ingram WM, Anokye N, Dean S, Jolly K, Mutrie N, Lambert J, Yardley L & Greaves C 2020 'Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT' Health Technology Assessment 24, (63) 1-106 , DOI Open access
Tan HK, Streeter A, Cramp ME & Dhanda AD 2020 'Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis' World Journal of Hepatology 12, (7) 389-398 , DOI
Mullin S, Smith L, Lee K, D’Souza G, Woodgate P, Elflein J, Hällqvist J, Toffoli M, Streeter A & Hosking J 2020 'Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations' JAMA Neurology , DOI Open access
Taylor A, Thompson TP, Ussher M, Aveyard P, Murray RL, Harris T, Creanor S, Green C, Streeter AJ & Chynoweth J 2020 'Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study' BMJ OPEN 10, (12) Author Site , DOI
Tomlinson DR, Myles M, Stevens KN & Streeter A 2019 'Transmural unipolar electrogram change occurs within 7s at the left atrial posterior wall during pulmonary vein isolation' Pacing and Clinical Electrophysiology , DOI Open access
Hanemann CO, Ammoun S, Evans G, Hilton DA, Streeter A & Hayward C 2019 'Phase 0 trial investigating the intra-tumoural concentration and activity of Sorafenib in Neurofibromatosis type 2' Journal of Neurology, Neurosurgery and Psychiatry , DOI Open access
Wyatt K, LLoyd J, Creanor ES, Green C, Dean SG, Hillsdon M, Abraham C, Tomlinson R, Pearson V & Taylor RS 2018 'Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost-effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children' Public Health Resarch 6, (1) Open access
Lloyd J, Creanor E, Logan S, Green C, Dean SG, Hillsdon M, Abrahan C, Tomlinson R, Pearson V & Taylor RS 2017 'Effectiveness of the Healthy Lifestyles Programme (HeLP) to prevent obesity in UK primary-school children: a cluster randomised controlled trial' The Lancet Child & Adolescent Health , DOI Open access
Streeter AJ, Lin NX, Crathorne L, Haasova M, Hyde C, Melzer D & Henley WE 2017 'Adjusting for unmeasured confounding in non-randomised longitudinal studies: a methodological review' Journal of Clinical Epidemiology Author Site , DOI Open access
2015 'Corrigenda' The Journal of Clinical Endocrinology & Metabolism 100, (2) 763-763 , DOI
Jeffery A, Streeter AJ, Hosking J, Wilkin TJ & Nelson SM 2015 'Anti-Müllerian hormone in children: a ten-year prospective longitudinal study (EarlyBird 39)' J Pediatr Endocrinol Metab 28, (9-10) 1153-1162 Author Site , DOI
Pinkney J, Streeter A, Hosking J, Mostazir M, Jeffery A & Wilkin T 2014 'Adiposity, chronic inflammation, and the prepubertal decline of sex hormone binding globulin in children: evidence for associations with the timing of puberty (Earlybird 58)' J Clin Endocrinol Metab 99, (9) 3224-3232 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ 2014 'Divergence between HbA1c and fasting glucose through childhood: implications for diagnosis of impaired fasting glucose (Early Bird 52)' Pediatr Diabetes 15, (3) 214-219 Author Site , DOI
Streeter AJ, Hosking J, Metcalf BS, Jeffery AN, Voss LD & Wilkin TJ 2013 'Body fat in children does not adversely influence bone development: a 7-year longitudinal study (EarlyBird 18)' Pediatr Obes 8, (6) 418-427 Author Site , DOI
Hosking J, Metcalf BS, Jeffery AN, Streeter AJ, Voss LD & Wilkin TJ 2013 'Evidence of early beta-cell deficiency among children who show impaired fasting glucose: 10-yr cohort study (EarlyBird 56)' Pediatr Diabetes 14, (7) 481-489 Author Site , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ 2012 'Response to Comment on: Jeffery et al. Age Before Stage: Insulin Resistance Rises Before the Onset of Puberty: A 9-Year Longitudinal Study (EarlyBird 26). Diabetes Care 2012;35:536-541' Diabetes Care 35, (9) e69-e69 , DOI
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Voss LD & Wilkin TJ 2012 'Age before stage: insulin resistance rises before the onset of puberty: a 9-year longitudinal study (EarlyBird 26)' Diabetes Care 35, (3) 536-541 Author Site , DOI Open access
Conference Papers
Streeter AJ & Henley WE 2018 'Evidence from a quasi-experimental study for the effectiveness of the influenza vaccination against myocardial infarction in UK adults aged at least 65 y' 13-13 Open access
Henley WE & Streeter AJ 2018 'Real-world effectiveness of influenza vaccination in older adults in the UK from 1997-2012: A quasi-experimental cohort study' 13-14 Open access
Mostazir MBA, Metcalf BS, Hosking J, Streeter AJ, Jeffery AN, Voss LD & Wilkin TJ 2011 'Children of higher income families eat 'better' and are taller, but they are metabolically less healthy' S354-S354
Hosking J, Metcalf BS, Streeter AJ, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ 2011 'HbA(1c) does not detect glucose impairment in youth' S351-S351
Jeffery AN, Metcalf BS, Hosking J, Streeter AJ, Mostazir MBA, Voss LD & Wilkin TJ 2011 'Insulin resistance rises from mid-childhood, before the onset of puberty: longitudinal data from The EarlyBird Study' S350-S350
Streeter AJ, Hosking J, Metcalf BS, Mostazir MBA, Jeffery AN, Voss LD & Wilkin TJ 2011 'Obesity of the bone: the relationships between body mass, adiposity and bone density in children: a 7-year longitudinal study' S517-S518
Wilkin TJ, Jeffery AN, Metcalf BS, Hosking J, Fremeaux AE & Voss LD 2010 'Insulin demand, beta cell response and glucose control among contemporary children - an eight-year longitudinal study'
Posters
Jones BG, Streeter A, Baker A, Moyeed R & Creanor S Jones BG, Streeter A, Baker A, Moyeed R & Creanor S 'Bayesian Statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review' Author Site Open access
Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE Streeter AJ, Masoli JAH, Ble A, Melzer D & Henley WE 'Pneumococcal Vaccine Effectiveness and Its Interaction With Age: A UK Population Based Study in Older Adults' Author Site Open access