Applications are invited for a 3.5-years PhD studentship. The studentship will start on 1 October 2020.
Fundamental understanding of protein dynamics, energy landscape and conformational changes, is central to deeper insights into a protein’s specific biochemical functions (such as allosteric signalling, enzyme catalysis etc.). This could aid in drug discovery, novel protein engineering and distinguishing between normal and pathogenic conformational changes for disease diagnostics applications. In this project we aim to investigate a novel approach for the detection of protein dynamics and interactions on the surface of graphene (and related two-dimensional materials, G2DM) through direct comparison of Molecular Dynamics Simulations (MDS) with experimental results obtained from our G2DM based sensors developed at the University of Plymouth in collaboration with the University of Cambridge.
For the MDS we will employ the Kohn–Sham (KS) formalism of the density functional theory approach to perform the in-silicio study of the graphene-protein system. The KS approach has proven to be one of the most efficient and reliable first-principles methods for investigating material properties and processes that exhibit quantum mechanical behaviour. The pioneering nature of this research will enable the student to use BigDFT massively parallel electronic structure code to simulate the graphene-protein sensor, based on the High Performance Computing Cluster at the University of Plymouth, as well as making comparisons with cutting-edge experimental measurements. Accurate comparisons between MDS and experimental results has the potential to lead to a breakthrough in our understanding of protein dynamics and conformational states, thus opening a plethora of applications in diagnostics, prognostics and therapeutics particularly for Alzheimer’s, cancer and cardiovascular diseases.
Applicants should have (at least) a first or upper second class honours degree in an appropriate subject and preferably a relevant MSc or MRes qualification. Some experience of quantum mechanics or solid-state physics and scientific programming using a language such as python, C or Fortran is desirable.
The studentship is supported for 3.5 years and includes full home/EU tuition fees plus a stipend of £15,285 per annum. The studentship will only fully fund those applicants who are eligible for home/EU fees with relevant qualifications. Applicants normally required to cover overseas fees would have to cover the difference between the home/EU and the overseas tuition fee rates (approximately £12,405 per annum).
If you wish to discuss this project further informally, please contact Dr Shakil Awan (firstname.lastname@example.org) or Dr Vincent Drach (Vincent.email@example.com). However, applications must be made in accordance with the details shown below.
General information about applying for a research degree at University of Plymouth is available at: https://www.plymouth.ac.uk/student-life/your-studies/doctoral-college/applicants-and-enquirers. You can apply via the online application available on the link above and by clicking 'Apply now'.
Please mark your application FAO Doctoral College and clearly state that you are applying for a PhD studentship within the School of Engineering, Computing and Mathematics.
For more information on the admissions process contact the Doctoral College firstname.lastname@example.org.
The closing date for applications is 12 noon on Friday 1 May 2020. Shortlisted candidates will be invited for interview in the last week of May. We regret that we may not be able to respond to all applications. Applicants who have not received an offer of a place by the 2nd week of June should consider their application has been unsuccessful on this occasion.